PubMed:2320800 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2320800","sourcedb":"PubMed","sourceid":"2320800","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2320800","text":"Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.\nA sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide. Postrenal failure was excluded by echography. A prerenal component could have contributed to renal failure because of a transient hypotension, due to an increasing ascitis, occurring just before anuria. However, correction of the hemodynamic parameters did not improve renal function. Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies. We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension. We recommend careful use of ifosfamide in patients pretreated with nephrotoxic chemotherapy and inadequate renal 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