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PubMed:23184951 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 151-393 DRI_Background denotes Laboratory of genetics and physiology 2 (LGP2) is a member of the RIG-I-like receptor family of cytoplasmic pattern recognition receptors that detect molecular signatures of virus infection and initiate antiviral signal transduction cascades.
T2 394-562 DRI_Background denotes The ATP hydrolysis activity of LGP2 is essential for antiviral signaling, but it has been unclear how the enzymatic properties of LGP2 regulate its biological response.
T3 563-695 DRI_Background denotes Quantitative analysis of the dsRNA binding and enzymatic activities of LGP2 revealed high dsRNA-independent ATP hydrolysis activity.
T4 696-1007 DRI_Background denotes Biochemical assays and single-molecule analysis of LGP2 and mutant variants that dissociate basal from dsRNA-stimulated ATP hydrolysis demonstrate that LGP2 utilizes basal ATP hydrolysis to enhance and diversify its RNA recognition capacity, enabling the protein to associate with intrinsically poor substrates.
T5 1008-1217 DRI_Challenge denotes This property is required for LGP2 to synergize with another RIG-I-like receptor, MDA5, to potentiate IFNβ transcription in vivo during infection with encephalomyocarditis virus or transfection with poly(I:C).
T6 1218-1417 DRI_Background denotes These results demonstrate previously unrecognized properties of LGP2 ATP hydrolysis and RNA interaction and provide a mechanistic basis for a positive regulatory role for LGP2 in antiviral signaling.

sentences

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2).
T2 151-393 Sentence denotes Laboratory of genetics and physiology 2 (LGP2) is a member of the RIG-I-like receptor family of cytoplasmic pattern recognition receptors that detect molecular signatures of virus infection and initiate antiviral signal transduction cascades.
T3 394-562 Sentence denotes The ATP hydrolysis activity of LGP2 is essential for antiviral signaling, but it has been unclear how the enzymatic properties of LGP2 regulate its biological response.
T4 563-695 Sentence denotes Quantitative analysis of the dsRNA binding and enzymatic activities of LGP2 revealed high dsRNA-independent ATP hydrolysis activity.
T5 696-1007 Sentence denotes Biochemical assays and single-molecule analysis of LGP2 and mutant variants that dissociate basal from dsRNA-stimulated ATP hydrolysis demonstrate that LGP2 utilizes basal ATP hydrolysis to enhance and diversify its RNA recognition capacity, enabling the protein to associate with intrinsically poor substrates.
T6 1008-1217 Sentence denotes This property is required for LGP2 to synergize with another RIG-I-like receptor, MDA5, to potentiate IFNβ transcription in vivo during infection with encephalomyocarditis virus or transfection with poly(I:C).
T7 1218-1417 Sentence denotes These results demonstrate previously unrecognized properties of LGP2 ATP hydrolysis and RNA interaction and provide a mechanistic basis for a positive regulatory role for LGP2 in antiviral signaling.

Allie

Id Subject Object Predicate Lexical cue
SS1_23184951_0_0 103-142 expanded denotes laboratory of genetics and physiology 2
SS2_23184951_0_0 144-148 abbr denotes LGP2
SS1_23184951_1_0 151-190 expanded denotes Laboratory of genetics and physiology 2
SS2_23184951_1_0 192-196 abbr denotes LGP2
AE1_23184951_0_0 SS1_23184951_0_0 SS2_23184951_0_0 abbreviatedTo laboratory of genetics and physiology 2,LGP2
AE1_23184951_1_0 SS1_23184951_1_0 SS2_23184951_1_0 abbreviatedTo Laboratory of genetics and physiology 2,LGP2

CHEMDNER-training-test

Id Subject Object Predicate Lexical cue
T1 398-401 ABBREVIATION denotes ATP
T2 671-674 ABBREVIATION denotes ATP
T3 816-819 ABBREVIATION denotes ATP
T4 868-871 ABBREVIATION denotes ATP
T1 0-3 ABBREVIATION denotes ATP

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 325-340 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T2 1144-1153 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 247-258 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 788-793 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T2 862-867 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T3 1207-1211 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775