PubMed:23174226
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23174226","sourcedb":"PubMed","sourceid":"23174226","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23174226","text":"The influence of promoter -202 A/C polymorphism (rs2854744) of the IGFBP-3 gene on erectile dysfunction risk and serum levels of IGF-I and IGFBP-3.\nPURPOSE: We studied whether the IGFBP-3 gene polymorphism rs2854744 is associated with erectile dysfunction.\nMATERIALS AND METHODS: We investigated the association of this polymorphism with erectile dysfunction in 176 cases and 352 controls. We genotyped rs2854744 using polymerase chain reaction-restriction fragment length polymorphism. Circulating concentrations of IGF-I and IGFBP-3 were also measured.\nRESULTS: Allelic frequencies were 0.474 (A allele) and 0.526 (C allele) in men with erectile dysfunction, and 0.457 (A allele) and 0.543 (C allele) in normal controls (adjusted OR 1.74, 95% CI 0.82-2.43, p = 0.08). The frequency of the IGFBP-3 A-202C polymorphism genotype was 0.273 (CC), 0.506 (AC) and 0.221 (AA) in the case group, and 0.296 (CC), 0.494 (AC) and 0.210 (AA) in the control group (chi-square test p = 0.08). Neither the IGFBP-3 A-202C polymorphism nor serum IGF-I and IGFBP-3 levels were significantly associated with the risk of erectile dysfunction. Carriers of the AA genotype had the highest age adjusted serum IGFBP-3. This demonstrated a stepwise decrease in the presence of 1 or 2 copies of the C allele (mean ± SD 4,541 ± 796.2, 3,552 ± 642.4 and 3,314 ± 669.3 ng/ml, respectively). There was a positive correlation between serum IGFBP-3 and serum IGF-I concentrations (Spearman correlation coefficient r = 0.34, p for trend = 0.001).\nCONCLUSIONS: The IGFBP-3 gene A-202C polymorphism does not modulate the risk of erectile dysfunction.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":235,"end":255},"obj":"HP_0000802"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":992,"end":999},"obj":"gene:3486"},{"id":"T1","span":{"begin":1102,"end":1122},"obj":"disease:C0242350"},{"id":"T2","span":{"begin":1030,"end":1035},"obj":"gene:3479"},{"id":"T3","span":{"begin":1102,"end":1122},"obj":"disease:C0242350"},{"id":"T4","span":{"begin":1040,"end":1047},"obj":"gene:3486"},{"id":"T5","span":{"begin":1102,"end":1122},"obj":"disease:C0242350"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"23174226-0#49#58#geners2854744","span":{"begin":49,"end":58},"obj":"geners2854744"},{"id":"23174226-0#83#103#diseaseC0242350","span":{"begin":83,"end":103},"obj":"diseaseC0242350"}],"relations":[{"id":"49#58#geners285474483#103#diseaseC0242350","pred":"associated_with","subj":"23174226-0#49#58#geners2854744","obj":"23174226-0#83#103#diseaseC0242350"}],"attributes":[{"subj":"23174226-0#49#58#geners2854744","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"23174226-0#83#103#diseaseC0242350","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"23174226-0#67#74#gene3486","span":{"begin":67,"end":74},"obj":"gene3486"},{"id":"23174226-0#129#134#gene3479","span":{"begin":129,"end":134},"obj":"gene3479"},{"id":"23174226-0#139#146#gene3486","span":{"begin":139,"end":146},"obj":"gene3486"},{"id":"23174226-0#83#103#diseaseC0242350","span":{"begin":83,"end":103},"obj":"diseaseC0242350"}],"relations":[{"id":"67#74#gene348683#103#diseaseC0242350","pred":"associated_with","subj":"23174226-0#67#74#gene3486","obj":"23174226-0#83#103#diseaseC0242350"},{"id":"129#134#gene347983#103#diseaseC0242350","pred":"associated_with","subj":"23174226-0#129#134#gene3479","obj":"23174226-0#83#103#diseaseC0242350"},{"id":"139#146#gene348683#103#diseaseC0242350","pred":"associated_with","subj":"23174226-0#139#146#gene3486","obj":"23174226-0#83#103#diseaseC0242350"}],"attributes":[{"subj":"23174226-0#67#74#gene3486","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23174226-0#129#134#gene3479","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23174226-0#139#146#gene3486","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23174226-0#83#103#diseaseC0242350","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PubTator4TogoVar","denotations":[{"id":"7","span":{"begin":49,"end":58},"obj":"SNP"},{"id":"35","span":{"begin":206,"end":215},"obj":"SNP"},{"id":"38","span":{"begin":403,"end":412},"obj":"SNP"}],"attributes":[{"id":"A7","pred":"resolved_to","subj":"7","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"id":"A35","pred":"resolved_to","subj":"35","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"id":"A38","pred":"resolved_to","subj":"38","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"subj":"7","pred":"source","obj":"PubTator4TogoVar"},{"subj":"35","pred":"source","obj":"PubTator4TogoVar"},{"subj":"38","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"PubTatorOnTogoVar","denotations":[{"id":"7","span":{"begin":49,"end":58},"obj":"SNP"},{"id":"35","span":{"begin":206,"end":215},"obj":"SNP"},{"id":"38","span":{"begin":403,"end":412},"obj":"SNP"},{"id":"T1","span":{"begin":49,"end":58},"obj":"SNP"},{"id":"T1","span":{"begin":206,"end":215},"obj":"SNP"},{"id":"T2","span":{"begin":403,"end":412},"obj":"SNP"}],"attributes":[{"id":"A7","pred":"resolved_to","subj":"7","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"id":"A35","pred":"resolved_to","subj":"35","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"id":"A38","pred":"resolved_to","subj":"38","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs2854744;VariantGroup:0;CorrespondingGene:3486;RS#:2854744;CorrespondingSpecies:9606"},{"subj":"7","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"35","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"38","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T1","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T1","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T2","pred":"source","obj":"PubTatorOnTogoVar"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93e7ec","default":true},{"id":"DisGeNET","color":"#ecd793"},{"id":"DisGeNET5_variant_disease","color":"#bc93ec"},{"id":"DisGeNET5_gene_disease","color":"#93eca2"},{"id":"PubTator4TogoVar","color":"#ec939d"},{"id":"PubTatorOnTogoVar","color":"#93b7ec"}]}]}}