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PubMed:2314899 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 238-241 gene:7193 denotes TRE
T1 96-117 disease:C0023493 denotes human T-cell leukemia
T2 238-241 gene:11181 denotes TRE
T3 96-117 disease:C0023493 denotes human T-cell leukemia
T4 307-329 gene:1385 denotes transactivator protein
T5 96-117 disease:C0023493 denotes human T-cell leukemia
R1 T0 T1 associated_with TRE,human T-cell leukemia
R2 T2 T3 associated_with TRE,human T-cell leukemia
R3 T4 T5 associated_with transactivator protein,human T-cell leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-3 protein denotes Tax
T2 36-52 protein denotes cellular factors
T3 56-80 DNA denotes Tax-response element DNA
T4 96-148 DNA denotes human T-cell leukemia virus type I (HTLV-I) promoter
T5 238-241 DNA denotes TRE
T6 243-263 DNA denotes Tax-response element
T7 291-329 protein denotes virally encoded transactivator protein
T8 330-333 protein denotes Tax
T9 373-389 protein denotes nuclear proteins
T10 415-473 cell_line denotes HTLV-I immortalized Tax-expressing human T-lymphocyte line
T11 524-531 DNA denotes TRE-DNA
T12 570-581 protein denotes Tax-protein
T13 785-801 protein denotes nuclear proteins
T14 880-896 DNA denotes TRE-DNA fragment
T15 906-930 protein denotes TRE-DNA binding proteins
T16 1084-1097 protein denotes 50 kD protein
T17 1189-1196 DNA denotes TRE-DNA
T18 1250-1253 DNA denotes TRE
T19 1298-1330 protein denotes 32, 36 to 42 and 110 kD proteins
T20 1354-1366 protein denotes 50 kD factor
T21 1462-1483 DNA denotes cAMP-response element
T22 1484-1487 DNA denotes CRE
T23 1514-1535 DNA denotes 21 base-pair sequence
T24 1582-1585 DNA denotes TRE
T25 1688-1725 protein denotes cAMP response element binding protein
T26 1727-1731 protein denotes CREB
T27 1752-1775 protein denotes protein-TRE-DNA complex
T28 1797-1800 protein denotes Tax

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 109-117 HP_0001909 denotes leukemia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
2314899-1#215#237#gene1385 307-329 gene1385 denotes transactivator protein
2314899-1#4#25#diseaseC0023493 96-117 diseaseC0023493 denotes human T-cell leukemia
215#237#gene13854#25#diseaseC0023493 2314899-1#215#237#gene1385 2314899-1#4#25#diseaseC0023493 associated_with transactivator protein,human T-cell leukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-91 Sentence denotes Tax-independent binding of multiple cellular factors to Tax-response element DNA of HTLV-I.
S2 92-334 Sentence denotes The human T-cell leukemia virus type I (HTLV-I) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE (Tax-response element) that is responsive to the virally encoded transactivator protein Tax.
S3 335-582 Sentence denotes We have identified and separated four nuclear proteins from C81-66-45 cells, an HTLV-I immortalized Tax-expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the TRE-DNA, none of which are identical with the Tax-protein.
S4 583-667 Sentence denotes The proteins identified have molecular weights of about 32, 36 to 42, 50 and 110 kD.
S5 668-726 Sentence denotes Four different methods were used to identify the proteins.
S6 727-897 Sentence denotes First, from different cell lines three or all four of the nuclear proteins were specifically cross-linked by UV irradiation to the radioactively labeled TRE-DNA fragment.
S7 898-1067 Sentence denotes Second, TRE-DNA binding proteins sedimented through a glycerol density gradient at rates corresponding to proteins of native molecular weights of 35 to 50 kD and 110 kD.
S8 1068-1197 Sentence denotes Third, only the 50 kD protein was retained on a biotinylated DNA-streptavidin matrix when the DNA fragment contained the TRE-DNA.
S9 1198-1367 Sentence denotes Fourth, extensive purification by several cycles of TRE-DNA affinity chromatography resulted in the 32, 36 to 42 and 110 kD proteins and to less extent the 50 kD factor.
S10 1368-1457 Sentence denotes Two abundant proteins of 75 and 80 kD were competed out by poly[d(I-C)] in all reactions.
S11 1458-1657 Sentence denotes The cAMP-response element CRE, TGACGTCA, present in the 21 base-pair sequence, appears to be essential for specific protein-TRE-DNA interactions because mutation of the two G's destroys this complex.
S12 1658-1810 Sentence denotes This result suggests that the cAMP response element binding protein, CREB, is involved in the protein-TRE-DNA complex and in mediating the Tax response.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 56-90 NP denotes Tax-response element DNA of HTLV-I
C2 195-218 NP denotes a 21-base pair sequence
C3 238-264 NP denotes TRE (Tax-response element)
C4 265-269 NP denotes that
C5 287-333 NP denotes the virally encoded transactivator protein Tax
C6 368-389 NP denotes four nuclear proteins
C7 395-410 NP denotes C81-66-45 cells
C8 412-473 NP denotes an HTLV-I immortalized Tax-expressing human T-lymphocyte line
C9 501-505 NP denotes that
C10 520-531 NP denotes the TRE-DNA
C11 541-546 NP denotes which
C12 566-581 NP denotes the Tax-protein
C13 583-606 NP denotes The proteins identified
C14 713-725 NP denotes the proteins
C15 781-801 NP denotes the nuclear proteins
C16 906-930 NP denotes TRE-DNA binding proteins
C17 1080-1097 NP denotes the 50 kD protein
C18 1185-1196 NP denotes the TRE-DNA
C19 1350-1366 NP denotes the 50 kD factor
C20 1458-1487 NP denotes The cAMP-response element CRE
C21 1489-1497 NP denotes TGACGTCA
C22 1510-1535 NP denotes the 21 base-pair sequence
C23 1644-1656 NP denotes this complex
C24 1684-1725 NP denotes the cAMP response element binding protein
C25 1727-1731 NP denotes CREB
C26 1748-1775 NP denotes the protein-TRE-DNA complex
R1 C3 C2 coref-ident TRE (Tax-response element),a 21-base pair sequence
R2 C4 C2 coref-relat that,a 21-base pair sequence
R3 C8 C7 coref-appos an HTLV-I immortalized Tax-expressing human T-lymphocyte line,C81-66-45 cells
R4 C9 C7 coref-relat that,C81-66-45 cells
R5 C10 C1 coref-ident the TRE-DNA,Tax-response element DNA of HTLV-I
R6 C11 C6 coref-relat which,four nuclear proteins
R7 C12 C5 coref-ident the Tax-protein,the virally encoded transactivator protein Tax
R8 C13 C6 coref-ident The proteins identified,four nuclear proteins
R9 C14 C13 coref-ident the proteins,The proteins identified
R10 C15 C14 coref-ident the nuclear proteins,the proteins
R11 C16 C15 coref-ident TRE-DNA binding proteins,the nuclear proteins
R12 C18 C10 coref-ident the TRE-DNA,the TRE-DNA
R13 C19 C17 coref-ident the 50 kD factor,the 50 kD protein
R14 C21 C20 coref-appos TGACGTCA,The cAMP-response element CRE
R15 C22 C2 coref-ident the 21 base-pair sequence,a 21-base pair sequence
R16 C25 C24 coref-appos CREB,the cAMP response element binding protein
R17 C26 C23 coref-ident the protein-TRE-DNA complex,this complex

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-3 protein_molecule denotes Tax
T2 36-52 protein_family_or_group denotes cellular factors
T3 56-59 protein_molecule denotes Tax
T4 84-90 virus denotes HTLV-I
T5 96-130 virus denotes human T-cell leukemia virus type I
T6 132-138 virus denotes HTLV-I
T7 197-218 polynucleotide denotes 21-base pair sequence
T8 238-241 DNA_domain_or_region denotes TRE
T9 243-246 protein_molecule denotes Tax
T10 291-329 protein_family_or_group denotes virally encoded transactivator protein
T11 330-333 protein_molecule denotes Tax
T12 373-389 protein_family_or_group denotes nuclear proteins
T13 415-421 virus denotes HTLV-I
T14 435-438 protein_molecule denotes Tax
T15 524-527 DNA_domain_or_region denotes TRE
T16 570-573 protein_molecule denotes Tax
T17 785-801 protein_family_or_group denotes nuclear proteins
T18 836-850 other_name denotes UV irradiation
T19 880-883 DNA_domain_or_region denotes TRE
T20 906-909 DNA_domain_or_region denotes TRE
T21 1084-1097 protein_molecule denotes 50 kD protein
T22 1116-1152 other_name denotes biotinylated DNA-streptavidin matrix
T23 1189-1192 DNA_domain_or_region denotes TRE
T24 1250-1253 DNA_domain_or_region denotes TRE
T25 1354-1366 protein_molecule denotes 50 kD factor
T26 1427-1439 other_organic_compound denotes poly[d(I-C)]
T27 1462-1483 DNA_domain_or_region denotes cAMP-response element
T28 1484-1487 DNA_domain_or_region denotes CRE
T29 1489-1497 polynucleotide denotes TGACGTCA
T30 1514-1535 DNA_domain_or_region denotes 21 base-pair sequence
T31 1574-1582 other_name denotes protein-
T32 1582-1585 DNA_domain_or_region denotes TRE
T33 1611-1619 other_name denotes mutation
T34 1631-1632 nucleotide denotes G
T35 1688-1725 protein_family_or_group denotes cAMP response element binding protein
T36 1727-1731 protein_molecule denotes CREB
T37 1752-1760 protein_complex denotes protein-
T38 1760-1763 DNA_domain_or_region denotes TRE
T39 1797-1800 protein_molecule denotes Tax