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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-159 Sentence denotes Intra-peritoneal sRAGE treatment induces alterations in cellular distribution of CD19(+), CD3 (+) and Mac-1 (+) cells in lymphoid organs and peritoneal cavity.
T2 160-295 Sentence denotes Receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that binds a variety of pro-inflammatory ligands.
T3 296-397 Sentence denotes Its soluble form, sRAGE, can compete for ligand binding and thereby have an anti-inflammatory effect.
T4 398-545 Sentence denotes We have recently reported that sRAGE also exerts pro-inflammatory and chemotactic properties suggesting a dual role for sRAGE in immune modulation.
T5 546-660 Sentence denotes Our present aim was to analyse the immunomodulatory properties of sRAGE in vivo with respect to acquired immunity.
T6 661-787 Sentence denotes Naive mice were treated intra-peritoneally with sRAGE and cells from peritoneal lavage, spleens and bone marrow were examined.
T7 788-958 Sentence denotes Mice treated with sRAGE displayed an increased leucocyte count in the peritoneal cavity, enlarged spleens and increased cellularity compared with vehicle-treated animals.
T8 959-1152 Sentence denotes Furthermore, sRAGE-treated mice had a significantly increased frequency and number of CD19(+) B cells in spleen and a reduced frequency of CD19(+) B cells in bone marrow compared with controls.
T9 1153-1447 Sentence denotes Functionally, splenocytes from sRAGE-treated mice showed elevated IgG production and up to a four-fold increased IgM secretion compared with control animals and produced significantly higher levels of interleukin-10, interferon-γ and interleukin-6 in response to lipopolysaccharide stimulation.
T10 1448-1655 Sentence denotes Our results suggest that sRAGE has immunomodulatory properties, since intra-peritoneal administration of sRAGE into healthy mice leads to rearrangements in cellular composition in the bone marrow and spleen.
T11 1656-1754 Sentence denotes Moreover, the administration of sRAGE directs B cells into the spleen and towards differentiation.
T12 1755-1845 Sentence denotes Our novel findings indicate that sRAGE exerts an effect on the cells of adaptive immunity.
T1 0-159 Sentence denotes Intra-peritoneal sRAGE treatment induces alterations in cellular distribution of CD19(+), CD3 (+) and Mac-1 (+) cells in lymphoid organs and peritoneal cavity.
T2 160-295 Sentence denotes Receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that binds a variety of pro-inflammatory ligands.
T3 296-397 Sentence denotes Its soluble form, sRAGE, can compete for ligand binding and thereby have an anti-inflammatory effect.
T4 398-545 Sentence denotes We have recently reported that sRAGE also exerts pro-inflammatory and chemotactic properties suggesting a dual role for sRAGE in immune modulation.
T5 546-660 Sentence denotes Our present aim was to analyse the immunomodulatory properties of sRAGE in vivo with respect to acquired immunity.
T6 661-787 Sentence denotes Naive mice were treated intra-peritoneally with sRAGE and cells from peritoneal lavage, spleens and bone marrow were examined.
T7 788-958 Sentence denotes Mice treated with sRAGE displayed an increased leucocyte count in the peritoneal cavity, enlarged spleens and increased cellularity compared with vehicle-treated animals.
T8 959-1152 Sentence denotes Furthermore, sRAGE-treated mice had a significantly increased frequency and number of CD19(+) B cells in spleen and a reduced frequency of CD19(+) B cells in bone marrow compared with controls.
T9 1153-1447 Sentence denotes Functionally, splenocytes from sRAGE-treated mice showed elevated IgG production and up to a four-fold increased IgM secretion compared with control animals and produced significantly higher levels of interleukin-10, interferon-γ and interleukin-6 in response to lipopolysaccharide stimulation.
T10 1448-1655 Sentence denotes Our results suggest that sRAGE has immunomodulatory properties, since intra-peritoneal administration of sRAGE into healthy mice leads to rearrangements in cellular composition in the bone marrow and spleen.
T11 1656-1754 Sentence denotes Moreover, the administration of sRAGE directs B cells into the spleen and towards differentiation.
T12 1755-1845 Sentence denotes Our novel findings indicate that sRAGE exerts an effect on the cells of adaptive immunity.

Allie

Id Subject Object Predicate Lexical cue
SS1_23086479_1_0 160-204 expanded denotes Receptor for advanced glycation end products
SS2_23086479_1_0 206-210 abbr denotes RAGE
AE1_23086479_1_0 SS1_23086479_1_0 SS2_23086479_1_0 abbreviatedTo Receptor for advanced glycation end products,RAGE