PubMed:2307933 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2307933","sourcedb":"PubMed","sourceid":"2307933","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2307933","text":"Naive and memory T cells show distinct pathways of lymphocyte recirculation.\nIn this report, we have addressed two questions concerning immunological memory: the way in which naive and memory T cells recirculate through the body, and the intrinsic rate of division within the naive and memory populations. We identified naive and memory T cells in sheep by their cell surface phenotype and their ability to respond to recall antigen. Memory T cells were CD2hi, CD58hi, CD44hi, CD11ahi, and CD45R-, as pertains in man. T cells that crossed from blood to the tissues of the hind leg and accumulated in the popliteal afferent lymph were all of memory phenotype. Conversely, T cells in efferent lymph, 90% of which entered the lymph node (LN) via high endothelial venules (HEV), were mostly of the naive phenotype (CD2lo, CD58lo, CD44lo, CD11alo, and CD45R+). The marked enrichment of these two phenotypes in different recirculatory compartments indicated that memory T cells selectively traffic from blood to peripheral tissues to LN (via afferent lymph), whereas naive T cells selectively traffic from blood to LN (via HEV). We argue that the differential use of these two recirculation pathways probably optimizes lymphocyte interactions with antigen. The nonrandom distribution of T cell subsets in various recirculatory compartments may be related to the relative proportion of memory cells in each subset. In particular, gamma/delta T cells in blood were almost exclusively of memory phenotype, and accumulated preferentially in afferent, but not in efferent, lymph. Finally, using the bromo-deoxyuridine labeling technique, we found that at least a sizeable proportion of memory T cells, whether in blood or afferent lymph, were a dividing population of cells, whereas naive T cells were a nondividing population. This result supports an alternative model of lymphocyte memory that assumes that maintenance of memory requires persistent antigenic stimulation.","tracks":[{"project":"NEUROSES","denotations":[{"id":"T1","span":{"begin":10,"end":16},"obj":"PATO_0000201"},{"id":"T2","span":{"begin":150,"end":156},"obj":"PATO_0000201"},{"id":"T3","span":{"begin":185,"end":191},"obj":"PATO_0000201"},{"id":"T4","span":{"begin":286,"end":292},"obj":"PATO_0000201"},{"id":"T5","span":{"begin":330,"end":336},"obj":"PATO_0000201"},{"id":"T6","span":{"begin":434,"end":440},"obj":"PATO_0000201"},{"id":"T7","span":{"begin":641,"end":647},"obj":"PATO_0000201"},{"id":"T8","span":{"begin":957,"end":963},"obj":"PATO_0000201"},{"id":"T9","span":{"begin":1379,"end":1385},"obj":"PATO_0000201"},{"id":"T10","span":{"begin":1479,"end":1485},"obj":"PATO_0000201"},{"id":"T11","span":{"begin":1675,"end":1681},"obj":"PATO_0000201"},{"id":"T12","span":{"begin":1873,"end":1879},"obj":"PATO_0000201"},{"id":"T13","span":{"begin":1913,"end":1919},"obj":"PATO_0000201"},{"id":"T15","span":{"begin":248,"end":252},"obj":"PATO_0000161"},{"id":"T16","span":{"begin":248,"end":252},"obj":"PATO_0001470"},{"id":"T17","span":{"begin":1365,"end":1375},"obj":"PATO_0001470"},{"id":"T18","span":{"begin":1661,"end":1671},"obj":"PATO_0001470"},{"id":"T19","span":{"begin":425,"end":432},"obj":"CHEBI_59132"},{"id":"T20","span":{"begin":1242,"end":1249},"obj":"CHEBI_59132"},{"id":"T21","span":{"begin":513,"end":516},"obj":"CHEBI_37684"},{"id":"T22","span":{"begin":585,"end":596},"obj":"PATO_0002270"},{"id":"T23","span":{"begin":1501,"end":1512},"obj":"PATO_0002270"},{"id":"T24","span":{"begin":743,"end":747},"obj":"PATO_0000469"},{"id":"T25","span":{"begin":860,"end":866},"obj":"PATO_0000465"},{"id":"T26","span":{"begin":1006,"end":1016},"obj":"PATO_0002107"},{"id":"T27","span":{"begin":1265,"end":1277},"obj":"PATO_0000060"},{"id":"T28","span":{"begin":1423,"end":1428},"obj":"CHEBI_30212"},{"id":"T29","span":{"begin":1429,"end":1434},"obj":"CHEBI_36375"},{"id":"T30","span":{"begin":1588,"end":1593},"obj":"CHEBI_22927"},{"id":"T31","span":{"begin":1588,"end":1593},"obj":"CHEBI_47265"}],"attributes":[{"subj":"T1","pred":"source","obj":"NEUROSES"},{"subj":"T2","pred":"source","obj":"NEUROSES"},{"subj":"T3","pred":"source","obj":"NEUROSES"},{"subj":"T4","pred":"source","obj":"NEUROSES"},{"subj":"T5","pred":"source","obj":"NEUROSES"},{"subj":"T6","pred":"source","obj":"NEUROSES"},{"subj":"T7","pred":"source","obj":"NEUROSES"},{"subj":"T8","pred":"source","obj":"NEUROSES"},{"subj":"T9","pred":"source","obj":"NEUROSES"},{"subj":"T10","pred":"source","obj":"NEUROSES"},{"subj":"T11","pred":"source","obj":"NEUROSES"},{"subj":"T12","pred":"source","obj":"NEUROSES"},{"subj":"T13","pred":"source","obj":"NEUROSES"},{"subj":"T15","pred":"source","obj":"NEUROSES"},{"subj":"T16","pred":"source","obj":"NEUROSES"},{"subj":"T17","pred":"source","obj":"NEUROSES"},{"subj":"T18","pred":"source","obj":"NEUROSES"},{"subj":"T19","pred":"source","obj":"NEUROSES"},{"subj":"T20","pred":"source","obj":"NEUROSES"},{"subj":"T21","pred":"source","obj":"NEUROSES"},{"subj":"T22","pred":"source","obj":"NEUROSES"},{"subj":"T23","pred":"source","obj":"NEUROSES"},{"subj":"T24","pred":"source","obj":"NEUROSES"},{"subj":"T25","pred":"source","obj":"NEUROSES"},{"subj":"T26","pred":"source","obj":"NEUROSES"},{"subj":"T27","pred":"source","obj":"NEUROSES"},{"subj":"T28","pred":"source","obj":"NEUROSES"},{"subj":"T29","pred":"source","obj":"NEUROSES"},{"subj":"T30","pred":"source","obj":"NEUROSES"},{"subj":"T31","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NEUROSES","color":"#d993ec","default":true}]}]}}