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PubMed:23075850 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
23075850_0 1310-1316 ProteinMutation denotes G2019S rs34637584
23075850_1 1173-1179 ProteinMutation denotes G2019S rs34637584
23075850_2 854-860 ProteinMutation denotes G2019S rs34637584
23075850_3 527-533 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 28-33 D006801 denotes human
T2 73-78 PR:Q5S006 denotes LRRK2
T3 73-78 PR:000003033 denotes LRRK2
T4 73-78 PR:Q5S007 denotes LRRK2
T5 176-181 D006801 denotes human
T6 202-208 GO:0007568 denotes ageing
T7 286-292 GO:0007568 denotes ageing
T8 387-407 GO:0006997 denotes nuclear organization
T9 426-432 GO:0007568 denotes ageing
T11 471-478 6308 denotes leucine
T12 471-478 SO:0001437 denotes leucine
T10 471-478 CHEBI:15603 denotes leucine
T13 471-478 D007930 denotes leucine
T14 471-478 CHEBI:25017 denotes leucine
T15 471-478 D007930 denotes leucine
T16 484-490 SO:0001068 denotes repeat
T17 501-506 PR:Q5S006 denotes LRRK2
T18 501-506 PR:000003033 denotes LRRK2
T19 501-506 PR:Q5S007 denotes LRRK2
T20 517-525 SO:0000109 denotes mutation
T25 535-542 4919 denotes glycine
T23 535-542 SO:0001443 denotes glycine
T21 535-542 CHEBI:15428 denotes glycine
T22 535-542 CHEBI:57305 denotes glycine
T24 535-542 D005998 denotes glycine
T26 535-542 D005998 denotes glycine
T27 535-542 CHEBI:29947 denotes glycine
T30 546-552 9671 denotes serine
T32 546-552 SO:0001444 denotes serine
T28 546-552 D012694 denotes serine
T29 546-552 CHEBI:17822 denotes serine
T31 546-552 D012694 denotes serine
T33 546-552 CHEBI:17115 denotes serine
T34 553-565 SO:1000002 denotes substitution
T37 569-579 SO:0001237 denotes amino acid
T36 569-579 CHEBI:33704 denotes amino acid
T38 569-579 CHEBI:33709 denotes amino acid
T44 634-653 D010300 denotes Parkinson's disease
T45 634-653 D010300 denotes Parkinson's disease
T48 679-684 UBERON:0007023 denotes adult
T49 685-697 GO:0022008 denotes neurogenesis
T50 701-705 PR:000005054 denotes mice
T52 701-705 O89094 denotes mice
T51 701-705 D051379 denotes mice
T53 701-705 10095 denotes mice
T58 795-814 D010300 denotes Parkinson's disease
T59 795-814 D010300 denotes Parkinson's disease
T62 848-853 PR:Q5S006 denotes LRRK2
T63 848-853 PR:000003033 denotes LRRK2
T64 848-853 PR:Q5S007 denotes LRRK2
T65 862-870 SO:0000109 denotes mutation
T66 874-879 D006801 denotes human
T67 880-896 CL:0000047 denotes neural-stem-cell
T70 898-901 CL:0000047 denotes NSC
T69 898-901 617394 denotes NSC
T71 945-959 D004198 denotes susceptibility
T72 945-959 D004198 denotes susceptibility
T73 1027-1043 GO:0005635 denotes nuclear-envelope
T74 1027-1056 GO:0006998 denotes nuclear-envelope organization
T77 1105-1112 D004194 denotes Disease
T78 1105-1112 D004194 denotes Disease
T79 1167-1172 PR:Q5S006 denotes LRRK2
T80 1167-1172 PR:000003033 denotes LRRK2
T81 1167-1172 PR:Q5S007 denotes LRRK2
T82 1181-1189 SO:0000109 denotes mutation
T83 1199-1208 SO:0000817 denotes wild-type
T88 1224-1243 D010300 denotes Parkinson's disease
T89 1224-1243 D010300 denotes Parkinson's disease
T92 1304-1309 PR:Q5S006 denotes LRRK2
T93 1304-1309 PR:000003033 denotes LRRK2
T94 1304-1309 PR:Q5S007 denotes LRRK2
T95 1318-1326 SO:0000109 denotes mutation
T96 1330-1335 D006801 denotes human
T97 1336-1345 P02301 denotes embryonic
T98 1336-1345 PR:000029532 denotes embryonic
T99 1370-1375 D006801 denotes human
T100 1376-1381 UBERON:6110636 denotes brain
T101 1376-1381 UBERON:0000955 denotes brain
T102 1382-1388 UBERON:0000479 denotes tissue
T103 1396-1412 GO:0005635 denotes nuclear-envelope
T110 1448-1467 D010300 denotes Parkinson's disease
T111 1448-1467 D010300 denotes Parkinson's disease
T116 1513-1520 GO:0005634 denotes nucleus
T115 1513-1520 UBERON:0000125 denotes nucleus
T114 1513-1520 CHEBI:33252 denotes nucleus
T117 1537-1544 32644 denotes unknown
T118 1554-1563 GO:0043226 denotes organelle
T123 1567-1586 D010300 denotes Parkinson's disease
T124 1567-1586 D010300 denotes Parkinson's disease
T131 1634-1653 D010300 denotes Parkinson's disease
T132 1634-1653 D010300 denotes Parkinson's disease

Allie

Id Subject Object Predicate Lexical cue
SS1_23075850_3_0 471-499 expanded denotes leucine-rich repeat kinase 2
SS2_23075850_3_0 501-506 abbr denotes LRRK2
SS1_23075850_4_0 743-773 expanded denotes induced pluripotent stem cells
SS2_23075850_4_0 775-780 abbr denotes iPSCs
SS1_23075850_4_1 880-896 expanded denotes neural-stem-cell
SS2_23075850_4_1 898-901 abbr denotes NSC
AE1_23075850_3_0 SS1_23075850_3_0 SS2_23075850_3_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_23075850_4_0 SS1_23075850_4_0 SS2_23075850_4_0 abbreviatedTo induced pluripotent stem cells,iPSCs
AE1_23075850_4_1 SS1_23075850_4_1 SS2_23075850_4_1 abbreviatedTo neural-stem-cell,NSC

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-79 DRI_Background denotes Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.
T2 80-209 DRI_Challenge denotes Nuclear-architecture defects have been shown to correlate with the manifestation of a number of human diseases as well as ageing.
T3 210-363 DRI_Challenge denotes It is therefore plausible that diseases whose manifestations correlate with ageing might be connected to the appearance of nuclear aberrations over time.
T4 364-706 DRI_Approach denotes We decided to evaluate nuclear organization in the context of ageing-associated disorders by focusing on a leucine-rich repeat kinase 2 (LRRK2) dominant mutation (G2019S; glycine-to-serine substitution at amino acid 2019), which is associated with familial and sporadic Parkinson's disease as well as impairment of adult neurogenesis in mice.
T5 707-915 DRI_Challenge denotes Here we report on the generation of induced pluripotent stem cells (iPSCs) derived from Parkinson's disease patients and the implications of LRRK2(G2019S) mutation in human neural-stem-cell (NSC) populations.
T6 916-1104 DRI_Background denotes Mutant NSCs showed increased susceptibility to proteasomal stress as well as passage-dependent deficiencies in nuclear-envelope organization, clonal expansion and neuronal differentiation.
T7 1105-1357 DRI_Background denotes Disease phenotypes were rescued by targeted correction of the LRRK2(G2019S) mutation with its wild-type counterpart in Parkinson's disease iPSCs and were recapitulated after targeted knock-in of the LRRK2(G2019S) mutation in human embryonic stem cells.
T8 1358-1477 DRI_Challenge denotes Analysis of human brain tissue showed nuclear-envelope impairment in clinically diagnosed Parkinson's disease patients.
T9 1478-1763 DRI_Outcome denotes Together, our results identify the nucleus as a previously unknown cellular organelle in Parkinson's disease pathology and may help to open new avenues for Parkinson's disease diagnoses as well as for the potential development of therapeutics targeting this fundamental cell structure.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 634-643 HP_0001300 denotes Parkinson
T2 795-804 HP_0001300 denotes Parkinson
T3 1224-1233 HP_0001300 denotes Parkinson
T4 1448-1457 HP_0001300 denotes Parkinson
T5 1567-1576 HP_0001300 denotes Parkinson
T6 1634-1643 HP_0001300 denotes Parkinson

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
23075850-6#68#74#geners34637584 1173-1179 geners34637584 denotes G2019S
23075850-6#205#211#geners34637584 1310-1316 geners34637584 denotes G2019S
23075850-6#119#138#diseaseC0030567 1224-1243 diseaseC0030567 denotes Parkinson's disease
68#74#geners34637584119#138#diseaseC0030567 23075850-6#68#74#geners34637584 23075850-6#119#138#diseaseC0030567 associated_with G2019S,Parkinson's disease
205#211#geners34637584119#138#diseaseC0030567 23075850-6#205#211#geners34637584 23075850-6#119#138#diseaseC0030567 associated_with G2019S,Parkinson's disease

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23075850-6#62#67#gene120892 1167-1172 gene120892 denotes LRRK2
23075850-6#199#204#gene120892 1304-1309 gene120892 denotes LRRK2
23075850-6#119#138#diseaseC0030567 1224-1243 diseaseC0030567 denotes Parkinson's disease
62#67#gene120892119#138#diseaseC0030567 23075850-6#62#67#gene120892 23075850-6#119#138#diseaseC0030567 associated_with LRRK2,Parkinson's disease
199#204#gene120892119#138#diseaseC0030567 23075850-6#199#204#gene120892 23075850-6#119#138#diseaseC0030567 associated_with LRRK2,Parkinson's disease