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PubMed:23069675 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 97-246 DRI_Challenge denotes Developing brain is highly susceptible to hypoxic-ischemic (HI) injury leading to severe neurological disabilities in surviving infants and children.
T2 247-397 DRI_Outcome denotes Previously, we have reported induction of neuronal pentraxin 1 (NP1), a novel neuronal protein of long-pentraxin family, following HI neuronal injury.
T3 398-490 DRI_Outcome denotes Here, we investigated how this specific signal is propagated to cause the HI neuronal death.
T4 491-701 DRI_Approach denotes We used wild-type (WT) and NP1 knockout (NP1-KO) mouse hippocampal cultures, modeled in vitro following exposure to oxygen glucose deprivation (OGD), and in vivo neonatal (P9-10) mouse model of HI brain injury.
T5 702-907 DRI_Outcome denotes Our results show induction of NP1 in primary hippocampal neurons following OGD exposure (4-8 h) and in the ipsilateral hippocampal CA1 and CA3 regions at 24-48 h post-HI compared to the contralateral side.
T6 908-1041 DRI_Outcome denotes We also found increased PTEN activity concurrent with OGD time-dependent (4-8 h) dephosphorylation of Akt (Ser473) and GSK-3β (Ser9).
T7 1042-1147 DRI_Challenge denotes OGD also caused a time-dependent decrease in the phosphorylation of Bad (Ser136), and Bax protein levels.
T8 1148-1421 DRI_Background denotes Immunofluorescence staining and subcellular fractionation analyses revealed increased mitochondrial translocation of Bad and Bax proteins from cytoplasm following OGD (4 h) and simultaneously increased release of Cyt C from mitochondria followed by activation of caspase-3.
T9 1422-1659 DRI_Background denotes NP1 protein was immunoprecipitated with Bad and Bax proteins; OGD caused increased interactions of NP1 with Bad and Bax, thereby, facilitating their mitochondrial translocation and dissipation of mitochondrial membrane potential (ΔΨ(m)).
T10 1660-1858 DRI_Approach denotes This NP1 induction preceded the increased mitochondrial release of cytochrome C (Cyt C) into the cytosol, activation of caspase-3 and OGD time-dependent cell death in WT primary hippocampal neurons.
T11 1859-2116 DRI_Background denotes In contrast, in NP1-KO neurons there was no translocation of Bad and Bax from cytosol to the mitochondria, and no evidence of ΔΨ(m) loss, increased Cyt C release and caspase-3 activation following OGD; which resulted in significantly reduced neuronal death.
T12 2117-2240 DRI_Outcome denotes Our results indicate a regulatory role of NP1 in Bad/Bax-dependent mitochondrial release of Cyt C and caspase-3 activation.
T13 2241-2445 DRI_Outcome denotes Together our findings demonstrate a novel mechanism by which NP1 regulates mitochondria-driven hippocampal cell death; suggesting NP1 as a potential therapeutic target against HI brain injury in neonates.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 540-545 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T3 670-675 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Critical role of neuronal pentraxin 1 in mitochondria-mediated hypoxic-ischemic neuronal injury.
T2 97-246 Sentence denotes Developing brain is highly susceptible to hypoxic-ischemic (HI) injury leading to severe neurological disabilities in surviving infants and children.
T3 247-397 Sentence denotes Previously, we have reported induction of neuronal pentraxin 1 (NP1), a novel neuronal protein of long-pentraxin family, following HI neuronal injury.
T4 398-490 Sentence denotes Here, we investigated how this specific signal is propagated to cause the HI neuronal death.
T5 491-701 Sentence denotes We used wild-type (WT) and NP1 knockout (NP1-KO) mouse hippocampal cultures, modeled in vitro following exposure to oxygen glucose deprivation (OGD), and in vivo neonatal (P9-10) mouse model of HI brain injury.
T6 702-907 Sentence denotes Our results show induction of NP1 in primary hippocampal neurons following OGD exposure (4-8 h) and in the ipsilateral hippocampal CA1 and CA3 regions at 24-48 h post-HI compared to the contralateral side.
T7 908-1041 Sentence denotes We also found increased PTEN activity concurrent with OGD time-dependent (4-8 h) dephosphorylation of Akt (Ser473) and GSK-3β (Ser9).
T8 1042-1147 Sentence denotes OGD also caused a time-dependent decrease in the phosphorylation of Bad (Ser136), and Bax protein levels.
T9 1148-1421 Sentence denotes Immunofluorescence staining and subcellular fractionation analyses revealed increased mitochondrial translocation of Bad and Bax proteins from cytoplasm following OGD (4 h) and simultaneously increased release of Cyt C from mitochondria followed by activation of caspase-3.
T10 1422-1659 Sentence denotes NP1 protein was immunoprecipitated with Bad and Bax proteins; OGD caused increased interactions of NP1 with Bad and Bax, thereby, facilitating their mitochondrial translocation and dissipation of mitochondrial membrane potential (ΔΨ(m)).
T11 1660-1858 Sentence denotes This NP1 induction preceded the increased mitochondrial release of cytochrome C (Cyt C) into the cytosol, activation of caspase-3 and OGD time-dependent cell death in WT primary hippocampal neurons.
T12 1859-2116 Sentence denotes In contrast, in NP1-KO neurons there was no translocation of Bad and Bax from cytosol to the mitochondria, and no evidence of ΔΨ(m) loss, increased Cyt C release and caspase-3 activation following OGD; which resulted in significantly reduced neuronal death.
T13 2117-2240 Sentence denotes Our results indicate a regulatory role of NP1 in Bad/Bax-dependent mitochondrial release of Cyt C and caspase-3 activation.
T14 2241-2445 Sentence denotes Together our findings demonstrate a novel mechanism by which NP1 regulates mitochondria-driven hippocampal cell death; suggesting NP1 as a potential therapeutic target against HI brain injury in neonates.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9140 17-37 GeneOrGeneProduct denotes neuronal pentraxin 1 NCBIGene:18164
9141 63-95 DiseaseOrPhenotypicFeature denotes hypoxic-ischemic neuronal injury MESH:D020925
9142 139-167 DiseaseOrPhenotypicFeature denotes hypoxic-ischemic (HI) injury MESH:D020925
9143 186-211 DiseaseOrPhenotypicFeature denotes neurological disabilities MESH:D009461
9144 289-309 GeneOrGeneProduct denotes neuronal pentraxin 1 NCBIGene:266777
9145 311-314 GeneOrGeneProduct denotes NP1 NCBIGene:266777
9146 378-396 DiseaseOrPhenotypicFeature denotes HI neuronal injury MESH:D020925
9147 472-489 DiseaseOrPhenotypicFeature denotes HI neuronal death MESH:D020925
9148 518-521 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9149 532-535 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9150 540-545 OrganismTaxon denotes mouse NCBITaxon:10090
9151 607-613 ChemicalEntity denotes oxygen MESH:D010100
9152 614-621 ChemicalEntity denotes glucose MESH:D005947
9153 670-675 OrganismTaxon denotes mouse NCBITaxon:10090
9154 685-700 DiseaseOrPhenotypicFeature denotes HI brain injury MESH:D020925
9155 732-735 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9156 833-836 GeneOrGeneProduct denotes CA1 NCBIGene:12346
9157 841-844 GeneOrGeneProduct denotes CA3 NCBIGene:12350
9158 932-936 GeneOrGeneProduct denotes PTEN NCBIGene:19211
9159 1010-1013 GeneOrGeneProduct denotes Akt NCBIGene:11651
9160 1015-1021 SequenceVariant denotes Ser473 p|AellelS|473
9161 1027-1033 GeneOrGeneProduct denotes GSK-3β NCBIGene:56637
9162 1035-1039 SequenceVariant denotes Ser9 p|AellelS|9
9163 1110-1113 GeneOrGeneProduct denotes Bad NCBIGene:12015
9164 1115-1121 SequenceVariant denotes Ser136 p|AellelS|136
9165 1128-1131 GeneOrGeneProduct denotes Bax NCBIGene:12028
9166 1265-1268 GeneOrGeneProduct denotes Bad NCBIGene:12015
9167 1273-1276 GeneOrGeneProduct denotes Bax NCBIGene:12028
9168 1361-1366 GeneOrGeneProduct denotes Cyt C NCBIGene:13063
9169 1411-1420 GeneOrGeneProduct denotes caspase-3 NCBIGene:12367
9170 1422-1425 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9171 1462-1465 GeneOrGeneProduct denotes Bad NCBIGene:12015
9172 1470-1473 GeneOrGeneProduct denotes Bax NCBIGene:12028
9173 1521-1524 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9174 1530-1533 GeneOrGeneProduct denotes Bad NCBIGene:12015
9175 1538-1541 GeneOrGeneProduct denotes Bax NCBIGene:12028
9176 1665-1668 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9177 1727-1739 GeneOrGeneProduct denotes cytochrome C NCBIGene:13063
9178 1741-1746 GeneOrGeneProduct denotes Cyt C NCBIGene:13063
9179 1780-1789 GeneOrGeneProduct denotes caspase-3 NCBIGene:12367
9180 1875-1878 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9181 1920-1923 GeneOrGeneProduct denotes Bad NCBIGene:12015
9182 1928-1931 GeneOrGeneProduct denotes Bax NCBIGene:12028
9183 2007-2012 GeneOrGeneProduct denotes Cyt C NCBIGene:13063
9184 2025-2034 GeneOrGeneProduct denotes caspase-3 NCBIGene:12367
9185 2101-2115 DiseaseOrPhenotypicFeature denotes neuronal death MESH:D009410
9186 2159-2162 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9187 2166-2169 GeneOrGeneProduct denotes Bad NCBIGene:12015
9188 2170-2173 GeneOrGeneProduct denotes Bax NCBIGene:12028
9189 2209-2214 GeneOrGeneProduct denotes Cyt C NCBIGene:13063
9190 2219-2228 GeneOrGeneProduct denotes caspase-3 NCBIGene:12367
9191 2302-2305 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9192 2371-2374 GeneOrGeneProduct denotes NP1 NCBIGene:18164
9193 2417-2432 DiseaseOrPhenotypicFeature denotes HI brain injury MESH:D020925

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 17-25 DiseaseOrPhenotypicFeature denotes neuronal 0004466
T2 80-88 DiseaseOrPhenotypicFeature denotes neuronal 0004466
T3 89-95 DiseaseOrPhenotypicFeature denotes injury 0021178
T4 161-167 DiseaseOrPhenotypicFeature denotes injury 0021178
T5 289-297 DiseaseOrPhenotypicFeature denotes neuronal 0004466
T6 325-333 DiseaseOrPhenotypicFeature denotes neuronal 0004466
T7 381-389 DiseaseOrPhenotypicFeature denotes neuronal 0004466
T8 390-396 DiseaseOrPhenotypicFeature denotes injury 0021178
T9 475-483 DiseaseOrPhenotypicFeature denotes neuronal 0004466
T10 688-700 DiseaseOrPhenotypicFeature denotes brain injury 0043510
T11 694-700 DiseaseOrPhenotypicFeature denotes injury 0021178
T12 759-766 DiseaseOrPhenotypicFeature denotes neurons 0004466
T13 1850-1857 DiseaseOrPhenotypicFeature denotes neurons 0004466
T14 1882-1889 DiseaseOrPhenotypicFeature denotes neurons 0004466
T15 2101-2109 DiseaseOrPhenotypicFeature denotes neuronal 0004466
T16 2420-2432 DiseaseOrPhenotypicFeature denotes brain injury 0043510
T17 2426-2432 DiseaseOrPhenotypicFeature denotes injury 0021178

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 17-37 GeneOrGeneProduct denotes neuronal pentraxin 1
T2 41-53 GeneOrGeneProduct denotes mitochondria
T3 54-62 GeneOrGeneProduct denotes mediated
T4 108-113 GeneOrGeneProduct denotes brain
T5 117-123 GeneOrGeneProduct denotes highly
T6 199-211 GeneOrGeneProduct denotes disabilities
T7 289-309 GeneOrGeneProduct denotes neuronal pentraxin 1
T8 311-314 GeneOrGeneProduct denotes NP1
T9 319-324 GeneOrGeneProduct denotes novel
T10 325-341 GeneOrGeneProduct denotes neuronal protein
T11 345-349 GeneOrGeneProduct denotes long
T12 350-359 GeneOrGeneProduct denotes pentraxin
T13 518-521 GeneOrGeneProduct denotes NP1
T14 522-530 GeneOrGeneProduct denotes knockout
T15 532-535 GeneOrGeneProduct denotes NP1
T16 688-693 GeneOrGeneProduct denotes brain
T17 732-735 GeneOrGeneProduct denotes NP1
T18 833-836 GeneOrGeneProduct denotes CA1
T19 841-844 GeneOrGeneProduct denotes CA3
T20 864-868 GeneOrGeneProduct denotes post
T21 902-906 GeneOrGeneProduct denotes side
T22 932-936 GeneOrGeneProduct denotes PTEN
T23 937-945 GeneOrGeneProduct denotes activity
T24 966-970 GeneOrGeneProduct denotes time
T25 1027-1032 GeneOrGeneProduct denotes GSK-3
T26 1060-1064 GeneOrGeneProduct denotes time
T27 1128-1139 GeneOrGeneProduct denotes Bax protein
T28 1234-1247 GeneOrGeneProduct denotes mitochondrial
T29 1248-1261 GeneOrGeneProduct denotes translocation
T30 1273-1285 GeneOrGeneProduct denotes Bax proteins
T31 1291-1300 GeneOrGeneProduct denotes cytoplasm
T32 1361-1366 GeneOrGeneProduct denotes Cyt C
T33 1372-1384 GeneOrGeneProduct denotes mitochondria
T34 1397-1407 GeneOrGeneProduct denotes activation
T35 1411-1420 GeneOrGeneProduct denotes caspase-3
T36 1422-1433 GeneOrGeneProduct denotes NP1 protein
T37 1470-1482 GeneOrGeneProduct denotes Bax proteins
T38 1521-1524 GeneOrGeneProduct denotes NP1
T39 1571-1584 GeneOrGeneProduct denotes mitochondrial
T40 1585-1598 GeneOrGeneProduct denotes translocation
T41 1618-1631 GeneOrGeneProduct denotes mitochondrial
T42 1665-1668 GeneOrGeneProduct denotes NP1
T43 1702-1715 GeneOrGeneProduct denotes mitochondrial
T44 1727-1739 GeneOrGeneProduct denotes cytochrome C
T45 1741-1746 GeneOrGeneProduct denotes Cyt C
T46 1757-1764 GeneOrGeneProduct denotes cytosol
T47 1766-1776 GeneOrGeneProduct denotes activation
T48 1780-1789 GeneOrGeneProduct denotes caspase-3
T49 1798-1802 GeneOrGeneProduct denotes time
T50 1813-1817 GeneOrGeneProduct denotes cell
T51 1862-1870 GeneOrGeneProduct denotes contrast
T52 1875-1878 GeneOrGeneProduct denotes NP1
T53 1903-1916 GeneOrGeneProduct denotes translocation
T54 1937-1944 GeneOrGeneProduct denotes cytosol
T55 1952-1964 GeneOrGeneProduct denotes mitochondria
T56 2007-2012 GeneOrGeneProduct denotes Cyt C
T57 2025-2034 GeneOrGeneProduct denotes caspase-3
T58 2035-2045 GeneOrGeneProduct denotes activation
T59 2093-2100 GeneOrGeneProduct denotes reduced
T60 2159-2162 GeneOrGeneProduct denotes NP1
T61 2184-2197 GeneOrGeneProduct denotes mitochondrial
T62 2209-2214 GeneOrGeneProduct denotes Cyt C
T63 2219-2228 GeneOrGeneProduct denotes caspase-3
T64 2229-2239 GeneOrGeneProduct denotes activation
T65 2254-2262 GeneOrGeneProduct denotes findings
T66 2277-2282 GeneOrGeneProduct denotes novel
T67 2302-2305 GeneOrGeneProduct denotes NP1
T68 2306-2315 GeneOrGeneProduct denotes regulates
T69 2316-2328 GeneOrGeneProduct denotes mitochondria
T70 2348-2352 GeneOrGeneProduct denotes cell
T71 2371-2374 GeneOrGeneProduct denotes NP1
T72 2420-2425 GeneOrGeneProduct denotes brain

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 17-37 GeneOrGeneProduct denotes neuronal pentraxin 1
T2 41-53 GeneOrGeneProduct denotes mitochondria
T3 108-113 GeneOrGeneProduct denotes brain
T4 289-309 GeneOrGeneProduct denotes neuronal pentraxin 1
T5 311-314 GeneOrGeneProduct denotes NP1
T6 319-324 GeneOrGeneProduct denotes novel
T7 325-341 GeneOrGeneProduct denotes neuronal protein
T8 350-359 GeneOrGeneProduct denotes pentraxin
T9 518-521 GeneOrGeneProduct denotes NP1
T10 522-530 GeneOrGeneProduct denotes knockout
T11 532-535 GeneOrGeneProduct denotes NP1
T12 688-693 GeneOrGeneProduct denotes brain
T13 732-735 GeneOrGeneProduct denotes NP1
T14 841-844 GeneOrGeneProduct denotes CA3
T15 864-868 GeneOrGeneProduct denotes post
T16 902-906 GeneOrGeneProduct denotes side
T17 932-936 GeneOrGeneProduct denotes PTEN
T18 1027-1032 GeneOrGeneProduct denotes GSK-3
T19 1128-1139 GeneOrGeneProduct denotes Bax protein
T20 1234-1247 GeneOrGeneProduct denotes mitochondrial
T21 1248-1261 GeneOrGeneProduct denotes translocation
T22 1273-1285 GeneOrGeneProduct denotes Bax proteins
T23 1361-1366 GeneOrGeneProduct denotes Cyt C
T24 1372-1384 GeneOrGeneProduct denotes mitochondria
T25 1411-1420 GeneOrGeneProduct denotes caspase-3
T26 1422-1433 GeneOrGeneProduct denotes NP1 protein
T27 1470-1482 GeneOrGeneProduct denotes Bax proteins
T28 1521-1524 GeneOrGeneProduct denotes NP1
T29 1571-1584 GeneOrGeneProduct denotes mitochondrial
T30 1585-1598 GeneOrGeneProduct denotes translocation
T31 1618-1631 GeneOrGeneProduct denotes mitochondrial
T32 1665-1668 GeneOrGeneProduct denotes NP1
T33 1702-1715 GeneOrGeneProduct denotes mitochondrial
T34 1727-1739 GeneOrGeneProduct denotes cytochrome C
T35 1741-1746 GeneOrGeneProduct denotes Cyt C
T36 1780-1789 GeneOrGeneProduct denotes caspase-3
T37 1813-1817 GeneOrGeneProduct denotes cell
T38 1875-1878 GeneOrGeneProduct denotes NP1
T39 1903-1916 GeneOrGeneProduct denotes translocation
T40 1952-1964 GeneOrGeneProduct denotes mitochondria
T41 2007-2012 GeneOrGeneProduct denotes Cyt C
T42 2025-2034 GeneOrGeneProduct denotes caspase-3
T43 2093-2100 GeneOrGeneProduct denotes reduced
T44 2159-2162 GeneOrGeneProduct denotes NP1
T45 2184-2197 GeneOrGeneProduct denotes mitochondrial
T46 2209-2214 GeneOrGeneProduct denotes Cyt C
T47 2219-2228 GeneOrGeneProduct denotes caspase-3
T48 2277-2282 GeneOrGeneProduct denotes novel
T49 2302-2305 GeneOrGeneProduct denotes NP1
T50 2316-2328 GeneOrGeneProduct denotes mitochondria
T51 2348-2352 GeneOrGeneProduct denotes cell
T52 2371-2374 GeneOrGeneProduct denotes NP1
T53 2420-2425 GeneOrGeneProduct denotes brain

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 63-70 DiseaseOrPhenotypicFeature denotes hypoxic DISEASE
T2 71-79 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T3 89-95 DiseaseOrPhenotypicFeature denotes injury D014947
T4 139-146 DiseaseOrPhenotypicFeature denotes hypoxic DISEASE
T5 147-155 DiseaseOrPhenotypicFeature denotes ischemic DISEASE
T6 161-167 DiseaseOrPhenotypicFeature denotes injury D014947
T7 390-396 DiseaseOrPhenotypicFeature denotes injury D014947
T8 484-489 DiseaseOrPhenotypicFeature denotes death D003643
T9 688-700 DiseaseOrPhenotypicFeature denotes brain injury D001930
T10 1818-1823 DiseaseOrPhenotypicFeature denotes death D003643
T11 2110-2115 DiseaseOrPhenotypicFeature denotes death D003643
T12 2353-2358 DiseaseOrPhenotypicFeature denotes death D003643
T13 2420-2432 DiseaseOrPhenotypicFeature denotes brain injury D001930

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 17-37 GeneOrGeneProduct denotes neuronal pentraxin 1
T2 289-309 GeneOrGeneProduct denotes neuronal pentraxin 1
T3 311-314 GeneOrGeneProduct denotes NP1
T4 325-341 GeneOrGeneProduct denotes neuronal protein
T5 350-359 GeneOrGeneProduct denotes pentraxin
T6 518-521 GeneOrGeneProduct denotes NP1
T7 532-535 GeneOrGeneProduct denotes NP1
T8 732-735 GeneOrGeneProduct denotes NP1
T9 841-844 GeneOrGeneProduct denotes CA3
T10 932-936 GeneOrGeneProduct denotes PTEN
T11 1010-1013 GeneOrGeneProduct denotes Akt
T12 1027-1032 GeneOrGeneProduct denotes GSK-3
T13 1128-1139 GeneOrGeneProduct denotes Bax protein
T14 1273-1285 GeneOrGeneProduct denotes Bax proteins
T15 1361-1366 GeneOrGeneProduct denotes Cyt C
T16 1411-1420 GeneOrGeneProduct denotes caspase-3
T17 1422-1433 GeneOrGeneProduct denotes NP1 protein
T18 1470-1482 GeneOrGeneProduct denotes Bax proteins
T19 1521-1524 GeneOrGeneProduct denotes NP1
T20 1665-1668 GeneOrGeneProduct denotes NP1
T21 1727-1739 GeneOrGeneProduct denotes cytochrome C
T22 1741-1746 GeneOrGeneProduct denotes Cyt C
T23 1780-1789 GeneOrGeneProduct denotes caspase-3
T24 1875-1878 GeneOrGeneProduct denotes NP1
T25 2007-2012 GeneOrGeneProduct denotes Cyt C
T26 2025-2034 GeneOrGeneProduct denotes caspase-3
T27 2159-2162 GeneOrGeneProduct denotes NP1
T28 2209-2214 GeneOrGeneProduct denotes Cyt C
T29 2219-2228 GeneOrGeneProduct denotes caspase-3
T30 2302-2305 GeneOrGeneProduct denotes NP1
T31 2371-2374 GeneOrGeneProduct denotes NP1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 89-95 DiseaseOrPhenotypicFeature denotes injury 0021178
T2 161-167 DiseaseOrPhenotypicFeature denotes injury 0021178
T3 390-396 DiseaseOrPhenotypicFeature denotes injury 0021178
T4 635-638 DiseaseOrPhenotypicFeature denotes OGD 0008150
T5 688-700 DiseaseOrPhenotypicFeature denotes brain injury 0043510
T6 777-780 DiseaseOrPhenotypicFeature denotes OGD 0008150
T7 962-965 DiseaseOrPhenotypicFeature denotes OGD 0008150
T8 1042-1045 DiseaseOrPhenotypicFeature denotes OGD 0008150
T9 1311-1314 DiseaseOrPhenotypicFeature denotes OGD 0008150
T10 1484-1487 DiseaseOrPhenotypicFeature denotes OGD 0008150
T11 1794-1797 DiseaseOrPhenotypicFeature denotes OGD 0008150
T12 2056-2059 DiseaseOrPhenotypicFeature denotes OGD 0008150
T13 2420-2432 DiseaseOrPhenotypicFeature denotes brain injury 0043510

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 63-95 DiseaseOrPhenotypicFeature denotes hypoxic-ischemic neuronal injury DISEASE
T2 139-167 DiseaseOrPhenotypicFeature denotes hypoxic-ischemic (HI) injury DISEASE
T3 186-211 DiseaseOrPhenotypicFeature denotes neurological disabilities DISEASE
T4 390-396 DiseaseOrPhenotypicFeature denotes injury D014947
T5 484-489 DiseaseOrPhenotypicFeature denotes death D003643
T6 688-700 DiseaseOrPhenotypicFeature denotes brain injury D001930
T7 1818-1823 DiseaseOrPhenotypicFeature denotes death D003643
T8 2110-2115 DiseaseOrPhenotypicFeature denotes death D003643
T9 2353-2358 DiseaseOrPhenotypicFeature denotes death D003643
T10 2420-2432 DiseaseOrPhenotypicFeature denotes brain injury D001930

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 63-95 DiseaseOrPhenotypicFeature denotes hypoxic-ischemic neuronal injury DISEASE
T2 139-167 DiseaseOrPhenotypicFeature denotes hypoxic-ischemic (HI) injury DISEASE
T3 186-211 DiseaseOrPhenotypicFeature denotes neurological disabilities DISEASE
T4 688-700 DiseaseOrPhenotypicFeature denotes brain injury D001930
T5 2420-2432 DiseaseOrPhenotypicFeature denotes brain injury D001930

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 607-613 ChemicalEntity denotes oxygen D010100|http://purl.obolibrary.org/obo/CHEBI_25805
T3 614-621 ChemicalEntity denotes glucose D005947|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T6 1361-1364 ChemicalEntity denotes Cyt http://purl.obolibrary.org/obo/CHEBI_16040
T7 1727-1739 ChemicalEntity denotes cytochrome C http://purl.obolibrary.org/obo/CHEBI_18070
T8 1741-1744 ChemicalEntity denotes Cyt http://purl.obolibrary.org/obo/CHEBI_16040
T9 2007-2010 ChemicalEntity denotes Cyt http://purl.obolibrary.org/obo/CHEBI_16040
T10 2209-2212 ChemicalEntity denotes Cyt http://purl.obolibrary.org/obo/CHEBI_16040

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 540-545 OrganismTaxon denotes mouse
T2 670-675 OrganismTaxon denotes mouse

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T10 2209-2212 ChemicalEntity denotes Cyt http://purl.obolibrary.org/obo/CHEBI_16040
T9 2007-2010 ChemicalEntity denotes Cyt http://purl.obolibrary.org/obo/CHEBI_16040
T8 1741-1744 ChemicalEntity denotes Cyt http://purl.obolibrary.org/obo/CHEBI_16040
T7 1727-1739 ChemicalEntity denotes cytochrome C http://purl.obolibrary.org/obo/CHEBI_18070
T6 1361-1364 ChemicalEntity denotes Cyt http://purl.obolibrary.org/obo/CHEBI_16040
T3 614-621 ChemicalEntity denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|D005947
T1 607-613 ChemicalEntity denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805|D010100
T31 2371-2374 GeneOrGeneProduct denotes NP1
T30 2302-2305 GeneOrGeneProduct denotes NP1
T29 2219-2228 GeneOrGeneProduct denotes caspase-3
T28 2209-2214 GeneOrGeneProduct denotes Cyt C
T27 2159-2162 GeneOrGeneProduct denotes NP1
T26 2025-2034 GeneOrGeneProduct denotes caspase-3
T25 2007-2012 GeneOrGeneProduct denotes Cyt C
T24 1875-1878 GeneOrGeneProduct denotes NP1
T23 1780-1789 GeneOrGeneProduct denotes caspase-3
T22 1741-1746 GeneOrGeneProduct denotes Cyt C
T21 1727-1739 GeneOrGeneProduct denotes cytochrome C
T20 1665-1668 GeneOrGeneProduct denotes NP1
T19 1521-1524 GeneOrGeneProduct denotes NP1
T18 1470-1482 GeneOrGeneProduct denotes Bax proteins
T17 1422-1433 GeneOrGeneProduct denotes NP1 protein
T16 1411-1420 GeneOrGeneProduct denotes caspase-3
T15 1361-1366 GeneOrGeneProduct denotes Cyt C
T14 1273-1285 GeneOrGeneProduct denotes Bax proteins
T13 1128-1139 GeneOrGeneProduct denotes Bax protein
T12 1027-1032 GeneOrGeneProduct denotes GSK-3
T11 1010-1013 GeneOrGeneProduct denotes Akt
T2376 932-936 GeneOrGeneProduct denotes PTEN
T21268 841-844 GeneOrGeneProduct denotes CA3
T91838 732-735 GeneOrGeneProduct denotes NP1
T3981 532-535 GeneOrGeneProduct denotes NP1
T23161 518-521 GeneOrGeneProduct denotes NP1
T5 350-359 GeneOrGeneProduct denotes pentraxin
T4 325-341 GeneOrGeneProduct denotes neuronal protein
T99941 311-314 GeneOrGeneProduct denotes NP1
T2 289-309 GeneOrGeneProduct denotes neuronal pentraxin 1
T36603 17-37 GeneOrGeneProduct denotes neuronal pentraxin 1
T54247 2420-2432 DiseaseOrPhenotypicFeature denotes brain injury D001930
T47700 688-700 DiseaseOrPhenotypicFeature denotes brain injury D001930
T79043 186-211 DiseaseOrPhenotypicFeature denotes neurological disabilities DISEASE
T39620 139-167 DiseaseOrPhenotypicFeature denotes hypoxic-ischemic (HI) injury DISEASE
T24541 63-95 DiseaseOrPhenotypicFeature denotes hypoxic-ischemic neuronal injury DISEASE
T488 670-675 OrganismTaxon denotes mouse
T52378 540-545 OrganismTaxon denotes mouse

Allie

Id Subject Object Predicate Lexical cue
SS1_23069675_1_0 139-155 expanded denotes hypoxic-ischemic
SS2_23069675_1_0 157-159 abbr denotes HI
SS1_23069675_2_0 289-309 expanded denotes neuronal pentraxin 1
SS2_23069675_2_0 311-314 abbr denotes NP1
SS1_23069675_4_0 499-508 expanded denotes wild-type
SS2_23069675_4_0 510-512 abbr denotes WT
SS1_23069675_4_1 518-530 expanded denotes NP1 knockout
SS2_23069675_4_1 532-538 abbr denotes NP1-KO
SS1_23069675_4_2 607-633 expanded denotes oxygen glucose deprivation
SS2_23069675_4_2 635-638 abbr denotes OGD
SS1_23069675_10_0 1727-1739 expanded denotes cytochrome C
SS2_23069675_10_0 1741-1746 abbr denotes Cyt C
AE1_23069675_1_0 SS1_23069675_1_0 SS2_23069675_1_0 abbreviatedTo hypoxic-ischemic,HI
AE1_23069675_2_0 SS1_23069675_2_0 SS2_23069675_2_0 abbreviatedTo neuronal pentraxin 1,NP1
AE1_23069675_4_0 SS1_23069675_4_0 SS2_23069675_4_0 abbreviatedTo wild-type,WT
AE1_23069675_4_1 SS1_23069675_4_1 SS2_23069675_4_1 abbreviatedTo NP1 knockout,NP1-KO
AE1_23069675_4_2 SS1_23069675_4_2 SS2_23069675_4_2 abbreviatedTo oxygen glucose deprivation,OGD
AE1_23069675_10_0 SS1_23069675_10_0 SS2_23069675_10_0 abbreviatedTo cytochrome C,Cyt C

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1234-1247 HP_0001427 denotes mitochondrial
T2 1571-1584 HP_0001427 denotes mitochondrial
T3 1618-1631 HP_0001427 denotes mitochondrial
T4 1702-1715 HP_0001427 denotes mitochondrial
T5 2184-2197 HP_0001427 denotes mitochondrial