Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-39 |
Sentence |
denotes |
Non-coding RNAs in Alzheimer's disease. |
T2 |
40-152 |
Sentence |
denotes |
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common dementia among the elderly. |
T3 |
153-320 |
Sentence |
denotes |
Accumulating research indicates that noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are increasingly being implicated in AD. |
T4 |
321-443 |
Sentence |
denotes |
MiRNAs are conserved small ncRNAs that control gene expression post-transcriptionally while lncRNAs function in many ways. |
T5 |
444-714 |
Sentence |
denotes |
Recent profiling research in human or mouse models suggests that miRNAs are aberrantly expressed in AD, and these have been implicated in the regulation of amyloid-β (Aβ) peptide, tau, inflammation, cell death, and other aspects which are the main pathomechanisms of AD. |
T6 |
715-823 |
Sentence |
denotes |
In addition, regulation of miRNAs varies in blood, and cerebral spinal fluid may indicate alterations in AD. |
T7 |
824-907 |
Sentence |
denotes |
Together with brain-specific miRNAs, these miRNAs could be potential AD biomarkers. |
T8 |
908-970 |
Sentence |
denotes |
All the above may provide the basis for new approaches for AD. |
T9 |
971-1147 |
Sentence |
denotes |
Here, we review current findings regarding ncRNA research in human and mouse models to provide a strong basis for future study aiming at promising contributions of ncRNA in AD. |
T1 |
0-39 |
Sentence |
denotes |
Non-coding RNAs in Alzheimer's disease. |
T2 |
40-152 |
Sentence |
denotes |
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common dementia among the elderly. |
T3 |
153-320 |
Sentence |
denotes |
Accumulating research indicates that noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are increasingly being implicated in AD. |
T4 |
321-443 |
Sentence |
denotes |
MiRNAs are conserved small ncRNAs that control gene expression post-transcriptionally while lncRNAs function in many ways. |
T5 |
444-714 |
Sentence |
denotes |
Recent profiling research in human or mouse models suggests that miRNAs are aberrantly expressed in AD, and these have been implicated in the regulation of amyloid-β (Aβ) peptide, tau, inflammation, cell death, and other aspects which are the main pathomechanisms of AD. |
T6 |
715-823 |
Sentence |
denotes |
In addition, regulation of miRNAs varies in blood, and cerebral spinal fluid may indicate alterations in AD. |
T7 |
824-907 |
Sentence |
denotes |
Together with brain-specific miRNAs, these miRNAs could be potential AD biomarkers. |
T8 |
908-970 |
Sentence |
denotes |
All the above may provide the basis for new approaches for AD. |
T9 |
971-1147 |
Sentence |
denotes |
Here, we review current findings regarding ncRNA research in human and mouse models to provide a strong basis for future study aiming at promising contributions of ncRNA in AD. |