PubMed:23049543 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":144},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":145,"end":155},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":156,"end":354},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":355,"end":363},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":364,"end":516},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":517,"end":604},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":605,"end":736},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":737,"end":745},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":746,"end":855},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":856,"end":953},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":954,"end":1048},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1049,"end":1070},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1071,"end":1201},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1202,"end":1214},"obj":"Sentence"},{"id":"TextSentencer_T15","span":{"begin":1215,"end":1448},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":144},"obj":"Sentence"},{"id":"T2","span":{"begin":145,"end":155},"obj":"Sentence"},{"id":"T3","span":{"begin":156,"end":354},"obj":"Sentence"},{"id":"T4","span":{"begin":355,"end":363},"obj":"Sentence"},{"id":"T5","span":{"begin":364,"end":516},"obj":"Sentence"},{"id":"T6","span":{"begin":517,"end":604},"obj":"Sentence"},{"id":"T7","span":{"begin":605,"end":736},"obj":"Sentence"},{"id":"T8","span":{"begin":737,"end":745},"obj":"Sentence"},{"id":"T9","span":{"begin":746,"end":855},"obj":"Sentence"},{"id":"T10","span":{"begin":856,"end":953},"obj":"Sentence"},{"id":"T11","span":{"begin":954,"end":1048},"obj":"Sentence"},{"id":"T12","span":{"begin":1049,"end":1070},"obj":"Sentence"},{"id":"T13","span":{"begin":1071,"end":1201},"obj":"Sentence"},{"id":"T14","span":{"begin":1202,"end":1214},"obj":"Sentence"},{"id":"T15","span":{"begin":1215,"end":1448},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":219,"end":222},"obj":"gene:1401"},{"id":"T1","span":{"begin":331,"end":353},"obj":"disease:C0010054"},{"id":"T2","span":{"begin":219,"end":222},"obj":"gene:1401"},{"id":"T3","span":{"begin":331,"end":353},"obj":"disease:C0010068"},{"id":"T4","span":{"begin":255,"end":273},"obj":"gene:1401"},{"id":"T5","span":{"begin":331,"end":353},"obj":"disease:C0010054"},{"id":"T6","span":{"begin":255,"end":273},"obj":"gene:1401"},{"id":"T7","span":{"begin":331,"end":353},"obj":"disease:C0010068"},{"id":"T8","span":{"begin":275,"end":278},"obj":"gene:1401"},{"id":"T9","span":{"begin":281,"end":296},"obj":"disease:C0011860"},{"id":"T10","span":{"begin":275,"end":278},"obj":"gene:1401"},{"id":"T11","span":{"begin":298,"end":301},"obj":"disease:C0011860"},{"id":"T12","span":{"begin":275,"end":278},"obj":"gene:1401"},{"id":"T13","span":{"begin":331,"end":353},"obj":"disease:C0010054"},{"id":"T14","span":{"begin":275,"end":278},"obj":"gene:1401"},{"id":"T15","span":{"begin":331,"end":353},"obj":"disease:C0010068"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}

{"project":"Allie","denotations":[{"id":"SS1_23049543_2_0","span":{"begin":255,"end":273},"obj":"expanded"},{"id":"SS2_23049543_2_0","span":{"begin":275,"end":278},"obj":"abbr"},{"id":"SS1_23049543_2_1","span":{"begin":281,"end":296},"obj":"expanded"},{"id":"SS2_23049543_2_1","span":{"begin":298,"end":301},"obj":"abbr"},{"id":"SS1_23049543_9_0","span":{"begin":1010,"end":1025},"obj":"expanded"},{"id":"SS2_23049543_9_0","span":{"begin":1027,"end":1030},"obj":"abbr"}],"relations":[{"id":"AE1_23049543_2_0","pred":"abbreviatedTo","subj":"SS1_23049543_2_0","obj":"SS2_23049543_2_0"},{"id":"AE1_23049543_2_1","pred":"abbreviatedTo","subj":"SS1_23049543_2_1","obj":"SS2_23049543_2_1"},{"id":"AE1_23049543_9_0","pred":"abbreviatedTo","subj":"SS1_23049543_9_0","obj":"SS2_23049543_9_0"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":304,"end":311},"obj":"HP_0001513"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"23049543-8#47#56#geners1130864","span":{"begin":1262,"end":1271},"obj":"geners1130864"},{"id":"23049543-8#62#69#diseaseC0028754","span":{"begin":1277,"end":1284},"obj":"diseaseC0028754"},{"id":"23049543-8#115#122#diseaseC0028754","span":{"begin":1330,"end":1337},"obj":"diseaseC0028754"},{"id":"23049543-8#188#191#diseaseC0011860","span":{"begin":1403,"end":1406},"obj":"diseaseC0011860"}],"relations":[{"id":"47#56#geners113086462#69#diseaseC0028754","pred":"associated_with","subj":"23049543-8#47#56#geners1130864","obj":"23049543-8#62#69#diseaseC0028754"},{"id":"47#56#geners1130864115#122#diseaseC0028754","pred":"associated_with","subj":"23049543-8#47#56#geners1130864","obj":"23049543-8#115#122#diseaseC0028754"},{"id":"47#56#geners1130864188#191#diseaseC0011860","pred":"associated_with","subj":"23049543-8#47#56#geners1130864","obj":"23049543-8#188#191#diseaseC0011860"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"23049543-0#18#21#gene1401","span":{"begin":18,"end":21},"obj":"gene1401"},{"id":"23049543-0#71#74#gene1401","span":{"begin":71,"end":74},"obj":"gene1401"},{"id":"23049543-0#92#107#diseaseC0011860","span":{"begin":92,"end":107},"obj":"diseaseC0011860"},{"id":"23049543-0#111#118#diseaseC0028754","span":{"begin":111,"end":118},"obj":"diseaseC0028754"},{"id":"23049543-0#92#107#diseaseC0011860","span":{"begin":92,"end":107},"obj":"diseaseC0011860"},{"id":"23049543-0#111#118#diseaseC0028754","span":{"begin":111,"end":118},"obj":"diseaseC0028754"},{"id":"23049543-7#82#85#gene1401","span":{"begin":1153,"end":1156},"obj":"gene1401"},{"id":"23049543-7#19#41#diseaseC0010054","span":{"begin":1090,"end":1112},"obj":"diseaseC0010054"},{"id":"23049543-7#19#41#diseaseC0010068","span":{"begin":1090,"end":1112},"obj":"diseaseC0010068"},{"id":"23049543-7#19#41#diseaseC1956346","span":{"begin":1090,"end":1112},"obj":"diseaseC1956346"}],"relations":[{"id":"18#21#gene140192#107#diseaseC0011860","pred":"associated_with","subj":"23049543-0#18#21#gene1401","obj":"23049543-0#92#107#diseaseC0011860"},{"id":"18#21#gene1401111#118#diseaseC0028754","pred":"associated_with","subj":"23049543-0#18#21#gene1401","obj":"23049543-0#111#118#diseaseC0028754"},{"id":"18#21#gene140192#107#diseaseC0011860","pred":"associated_with","subj":"23049543-0#18#21#gene1401","obj":"23049543-0#92#107#diseaseC0011860"},{"id":"18#21#gene1401111#118#diseaseC0028754","pred":"associated_with","subj":"23049543-0#18#21#gene1401","obj":"23049543-0#111#118#diseaseC0028754"},{"id":"71#74#gene140192#107#diseaseC0011860","pred":"associated_with","subj":"23049543-0#71#74#gene1401","obj":"23049543-0#92#107#diseaseC0011860"},{"id":"71#74#gene1401111#118#diseaseC0028754","pred":"associated_with","subj":"23049543-0#71#74#gene1401","obj":"23049543-0#111#118#diseaseC0028754"},{"id":"71#74#gene140192#107#diseaseC0011860","pred":"associated_with","subj":"23049543-0#71#74#gene1401","obj":"23049543-0#92#107#diseaseC0011860"},{"id":"71#74#gene1401111#118#diseaseC0028754","pred":"associated_with","subj":"23049543-0#71#74#gene1401","obj":"23049543-0#111#118#diseaseC0028754"},{"id":"82#85#gene140119#41#diseaseC0010054","pred":"associated_with","subj":"23049543-7#82#85#gene1401","obj":"23049543-7#19#41#diseaseC0010054"},{"id":"82#85#gene140119#41#diseaseC0010068","pred":"associated_with","subj":"23049543-7#82#85#gene1401","obj":"23049543-7#19#41#diseaseC0010068"},{"id":"82#85#gene140119#41#diseaseC1956346","pred":"associated_with","subj":"23049543-7#82#85#gene1401","obj":"23049543-7#19#41#diseaseC1956346"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T732","span":{"begin":1153,"end":1156},"obj":"gene:1401"},{"id":"T733","span":{"begin":1090,"end":1112},"obj":"disease:C0010054"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T732","obj":"T733"},{"id":"R2","pred":"associated_with","subj":"T732","obj":"T733"},{"id":"R3","pred":"associated_with","subj":"T732","obj":"T733"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":517,"end":522},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":340,"end":345},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":675,"end":680},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":1099,"end":1104},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":340,"end":345},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":675,"end":680},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1099,"end":1104},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"}],"text":"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.\nOBJECTIVE: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.\nMETHODS: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology.\nRESULTS: The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (β = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (β = 0.2; 95%CI: 0.1, 0.3; P \u003c 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype.\nCONCLUSIONS: The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico."}