PubMed:23035012
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 103-112 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T3 | 113-124 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T5 | 289-300 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T7 | 499-508 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T9 | 509-520 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T11 | 525-537 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T12 | 582-593 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T14 | 706-716 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T16 | 759-770 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T18 | 934-943 | Cell | denotes | monocytic | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T20 | 1032-1041 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T22 | 1042-1053 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T24 | 1058-1070 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T25 | 1925-1936 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 55-72 | https://glytoucan.org/Structures/Glycans/G08371CD | denotes | sialyl-Tn antigen |
| T2 | 55-72 | https://glytoucan.org/Structures/Glycans/G36123IU | denotes | sialyl-Tn antigen |
| T3 | 351-361 | https://glytoucan.org/Structures/Glycans/G58507AZ | denotes | antigen, a |
| T4 | 1311-1323 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acids |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 55-72 | Glycan_Motif | denotes | sialyl-Tn antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G36123IU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G08371CD |
| T3 | 62-72 | Glycan_Motif | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G57321FI |
| T4 | 351-361 | Glycan_Motif | denotes | antigen, a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G58507AZ |
| T5 | 1311-1323 | Glycan_Motif | denotes | sialic acids | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 976-980 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T2 | 1500-1506 | http://purl.obolibrary.org/obo/MAT_0000085 | denotes | spleen |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-155 | Sentence | denotes | The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. |
| TextSentencer_T2 | 156-396 | Sentence | denotes | We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure. |
| TextSentencer_T3 | 397-538 | Sentence | denotes | In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells. |
| TextSentencer_T4 | 539-632 | Sentence | denotes | Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues. |
| TextSentencer_T5 | 633-886 | Sentence | denotes | We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells. |
| TextSentencer_T6 | 887-1215 | Sentence | denotes | We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells. |
| TextSentencer_T7 | 1216-1324 | Sentence | denotes | The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids. |
| TextSentencer_T8 | 1325-1529 | Sentence | denotes | Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk). |
| TextSentencer_T9 | 1530-1751 | Sentence | denotes | The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12. |
| TextSentencer_T10 | 1752-2040 | Sentence | denotes | These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments. |
| T1 | 0-155 | Sentence | denotes | The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. |
| T2 | 156-396 | Sentence | denotes | We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure. |
| T3 | 397-538 | Sentence | denotes | In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells. |
| T4 | 539-632 | Sentence | denotes | Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues. |
| T5 | 633-886 | Sentence | denotes | We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells. |
| T6 | 887-1215 | Sentence | denotes | We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells. |
| T7 | 1216-1324 | Sentence | denotes | The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids. |
| T8 | 1325-1529 | Sentence | denotes | Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk). |
| T9 | 1530-1751 | Sentence | denotes | The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12. |
| T10 | 1752-2040 | Sentence | denotes | These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments. |
| T1 | 0-155 | Sentence | denotes | The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. |
| T2 | 156-396 | Sentence | denotes | We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure. |
| T3 | 397-538 | Sentence | denotes | In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells. |
| T4 | 539-632 | Sentence | denotes | Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues. |
| T5 | 633-886 | Sentence | denotes | We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells. |
| T6 | 887-1215 | Sentence | denotes | We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells. |
| T7 | 1216-1324 | Sentence | denotes | The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids. |
| T8 | 1325-1529 | Sentence | denotes | Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk). |
| T9 | 1530-1751 | Sentence | denotes | The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12. |
| T10 | 1752-2040 | Sentence | denotes | These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 55-72 | https://glytoucan.org/Structures/Glycans/G08371CD | denotes | sialyl-Tn antigen |
| T2 | 55-72 | https://glytoucan.org/Structures/Glycans/G36123IU | denotes | sialyl-Tn antigen |
| T3 | 62-72 | https://glytoucan.org/Structures/Glycans/G57321FI | denotes | Tn antigen |
| T4 | 351-361 | https://glytoucan.org/Structures/Glycans/G58507AZ | denotes | antigen, a |
| T5 | 1311-1323 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acids |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 55-72 | http://www.glycoepitope.jp/epitopes/EP0022 | denotes | sialyl-Tn antigen |
| T2 | 62-72 | http://www.glycoepitope.jp/epitopes/EP0021 | denotes | Tn antigen |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 103-112 | FMAID:167164 | denotes | monocytes |
| _T2 | 103-112 | FMAID:62864 | denotes | monocytes |
| _T3 | 113-124 | FMAID:167685 | denotes | macrophages |
| _T4 | 113-124 | FMAID:63261 | denotes | macrophages |
| _T5 | 251-259 | FMAID:165447 | denotes | proteins |
| _T6 | 251-259 | FMAID:67257 | denotes | proteins |
| _T7 | 289-300 | FMAID:63261 | denotes | macrophages |
| _T8 | 289-300 | FMAID:167685 | denotes | macrophages |
| _T9 | 499-508 | FMAID:167164 | denotes | monocytes |
| _T10 | 499-508 | FMAID:62864 | denotes | monocytes |
| _T11 | 509-520 | FMAID:167685 | denotes | macrophages |
| _T12 | 509-520 | FMAID:63261 | denotes | macrophages |
| _T13 | 532-537 | FMAID:68646 | denotes | cells |
| _T14 | 532-537 | FMAID:169002 | denotes | cells |
| _T15 | 582-593 | FMAID:63261 | denotes | macrophages |
| _T16 | 582-593 | FMAID:167685 | denotes | macrophages |
| _T17 | 624-631 | FMAID:256050 | denotes | tissues |
| _T18 | 680-693 | FMAID:188924 | denotes | substantially |
| _T19 | 706-716 | FMAID:63261 | denotes | macrophage |
| _T20 | 706-716 | FMAID:167685 | denotes | macrophage |
| _T21 | 759-770 | FMAID:63261 | denotes | macrophages |
| _T22 | 759-770 | FMAID:167685 | denotes | macrophages |
| _T23 | 857-862 | FMAID:169002 | denotes | cells |
| _T24 | 857-862 | FMAID:68646 | denotes | cells |
| _T25 | 880-885 | FMAID:169002 | denotes | cells |
| _T26 | 880-885 | FMAID:68646 | denotes | cells |
| _T27 | 934-943 | FMAID:167164 | denotes | monocytic |
| _T28 | 934-943 | FMAID:62864 | denotes | monocytic |
| _T29 | 954-959 | FMAID:169002 | denotes | cells |
| _T30 | 954-959 | FMAID:68646 | denotes | cells |
| _T31 | 976-980 | FMAID:7195 | denotes | lung |
| _T32 | 976-980 | FMAID:93670 | denotes | lung |
| _T33 | 976-980 | FMAID:169341 | denotes | lung |
| _T34 | 992-997 | FMAID:68646 | denotes | cells |
| _T35 | 992-997 | FMAID:169002 | denotes | cells |
| _T36 | 1032-1041 | FMAID:167164 | denotes | monocytes |
| _T37 | 1032-1041 | FMAID:62864 | denotes | monocytes |
| _T38 | 1042-1053 | FMAID:63261 | denotes | macrophages |
| _T39 | 1042-1053 | FMAID:167685 | denotes | macrophages |
| _T40 | 1065-1070 | FMAID:169002 | denotes | cells |
| _T41 | 1065-1070 | FMAID:68646 | denotes | cells |
| _T42 | 1150-1155 | FMAID:68646 | denotes | cells |
| _T43 | 1150-1155 | FMAID:169002 | denotes | cells |
| _T44 | 1209-1214 | FMAID:169002 | denotes | cells |
| _T45 | 1209-1214 | FMAID:68646 | denotes | cells |
| _T46 | 1359-1366 | FMAID:165447 | denotes | protein |
| _T47 | 1359-1366 | FMAID:67257 | denotes | protein |
| _T48 | 1383-1390 | FMAID:165447 | denotes | protein |
| _T49 | 1383-1390 | FMAID:67257 | denotes | protein |
| _T50 | 1500-1506 | FMAID:93671 | denotes | spleen |
| _T51 | 1500-1506 | FMAID:7196 | denotes | spleen |
| _T52 | 1500-1506 | FMAID:188495 | denotes | spleen |
| _T53 | 1507-1515 | FMAID:82768 | denotes | tyrosine |
| _T54 | 1507-1515 | FMAID:196757 | denotes | tyrosine |
| _T55 | 1624-1629 | FMAID:169002 | denotes | cells |
| _T56 | 1624-1629 | FMAID:68646 | denotes | cells |
| _T57 | 1869-1881 | FMAID:197657 | denotes | secretion in |
| _T58 | 1869-1881 | FMAID:83372 | denotes | secretion in |
| _T59 | 1925-1936 | FMAID:63261 | denotes | macrophages |
| _T60 | 1925-1936 | FMAID:167685 | denotes | macrophages |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 24-33 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T2 | 188-197 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T3 | 460-469 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T4 | 539-548 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T5 | 1123-1132 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T6 | 1325-1334 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T7 | 1656-1665 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T8 | 1781-1790 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T9 | 1912-1921 | http://www.uniprot.org/uniprot/Q6ZMC9 | denotes | Siglec-15 |
| T10 | 137-142 | http://www.uniprot.org/uniprot/O43914 | denotes | DAP12 |
| T11 | 1402-1407 | http://www.uniprot.org/uniprot/O43914 | denotes | DAP12 |
| T12 | 1745-1750 | http://www.uniprot.org/uniprot/O43914 | denotes | DAP12 |
| T13 | 351-378 | http://www.uniprot.org/uniprot/Q08380 | denotes | antigen, a tumor-associated |
| T14 | 351-378 | http://www.uniprot.org/uniprot/P30408 | denotes | antigen, a tumor-associated |
| T15 | 805-820 | http://www.uniprot.org/uniprot/P01138 | denotes | growth factor-β |
| T16 | 921-924 | http://www.uniprot.org/uniprot/P10070 | denotes | THP |
| T17 | 1144-1147 | http://www.uniprot.org/uniprot/P10070 | denotes | THP |
| T18 | 1618-1621 | http://www.uniprot.org/uniprot/P10070 | denotes | THP |
| T19 | 921-924 | http://www.uniprot.org/uniprot/P07911 | denotes | THP |
| T20 | 1144-1147 | http://www.uniprot.org/uniprot/P07911 | denotes | THP |
| T21 | 1618-1621 | http://www.uniprot.org/uniprot/P07911 | denotes | THP |
| T22 | 1500-1522 | http://www.uniprot.org/uniprot/P43405 | denotes | spleen tyrosine kinase |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 717-742 | http://www.uniprot.org/uniprot/P01587 | denotes | colony-stimulating factor |
| T2 | 921-924 | http://www.uniprot.org/uniprot/Q91X17 | denotes | THP |
| T3 | 1144-1147 | http://www.uniprot.org/uniprot/Q91X17 | denotes | THP |
| T4 | 1618-1621 | http://www.uniprot.org/uniprot/Q91X17 | denotes | THP |
| T5 | 1500-1522 | http://www.uniprot.org/uniprot/P48025 | denotes | spleen tyrosine kinase |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 525-531 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T2 | 532-537 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T3 | 624-631 | http://purl.bioontology.org/ontology/STY/T024 | denotes | tissues |
| T4 | 857-862 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T5 | 880-885 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T6 | 901-903 | http://purl.bioontology.org/ontology/NCBITAXON/13893 | denotes | co |
| T7 | 954-959 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T8 | 981-990 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinoma |
| T9 | 992-997 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T10 | 1058-1064 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T11 | 1065-1070 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T12 | 1150-1155 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T13 | 1209-1214 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T14 | 1624-1629 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T15 | 1758-1766 | http://purl.bioontology.org/ontology/STY/T033 | denotes | findings |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 55-61 | http://purl.obolibrary.org/obo/GO_0097503 | denotes | sialyl |
| T2 | 335-341 | http://purl.obolibrary.org/obo/GO_0097503 | denotes | sialyl |
| T3 | 88-97 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T4 | 1549-1558 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T5 | 1869-1878 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T6 | 805-811 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T7 | 1163-1171 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T8 | 1436-1439 | http://purl.obolibrary.org/obo/GO_0050065 | denotes | Lys |
| T9 | 1666-1669 | http://purl.obolibrary.org/obo/GO_0050065 | denotes | Lys |
| T10 | 1490-1496 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signal |
| T11 | 1843-1849 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signal |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1416-1423 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T2 | 1416-1423 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T3 | 1416-1423 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T4 | 1416-1423 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 532-537 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T2 | 857-862 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T3 | 880-885 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T4 | 954-959 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T5 | 992-997 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T6 | 1065-1070 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T7 | 1150-1155 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T8 | 1209-1214 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T9 | 1292-1296 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T10 | 1452-1465 | http://purl.obolibrary.org/obo/GO_0016021 | denotes | transmembrane |
| T11 | 1452-1465 | http://purl.obolibrary.org/obo/GO_0044214 | denotes | transmembrane |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 624-631 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| T2 | 976-980 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T3 | 1500-1506 | http://purl.obolibrary.org/obo/UBERON_0002106 | denotes | spleen |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_23035012_1_0 | 335-344 | expanded | denotes | sialyl-Tn |
| SS2_23035012_1_0 | 346-349 | abbr | denotes | sTn |
| SS1_23035012_3_0 | 565-593 | expanded | denotes | tumor-associated macrophages |
| SS2_23035012_3_0 | 595-599 | abbr | denotes | TAMs |
| SS1_23035012_4_0 | 792-820 | expanded | denotes | transforming growth factor-β |
| SS2_23035012_4_0 | 822-827 | abbr | denotes | TGF-β |
| SS1_23035012_7_0 | 1367-1400 | expanded | denotes | DNAX activation protein of 12 kDa |
| SS2_23035012_7_0 | 1402-1407 | abbr | denotes | DAP12 |
| SS1_23035012_7_1 | 1500-1522 | expanded | denotes | spleen tyrosine kinase |
| SS2_23035012_7_1 | 1524-1527 | abbr | denotes | Syk |
| AE1_23035012_1_0 | SS1_23035012_1_0 | SS2_23035012_1_0 | abbreviatedTo | sialyl-Tn,sTn |
| AE1_23035012_3_0 | SS1_23035012_3_0 | SS2_23035012_3_0 | abbreviatedTo | tumor-associated macrophages,TAMs |
| AE1_23035012_4_0 | SS1_23035012_4_0 | SS2_23035012_4_0 | abbreviatedTo | transforming growth factor-β,TGF-β |
| AE1_23035012_7_0 | SS1_23035012_7_0 | SS2_23035012_7_0 | abbreviatedTo | DNAX activation protein of 12 kDa,DAP12 |
| AE1_23035012_7_1 | SS1_23035012_7_1 | SS2_23035012_7_1 | abbreviatedTo | spleen tyrosine kinase,Syk |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 362-367 | HP_0002664 | denotes | tumor |
| T2 | 525-531 | HP_0002664 | denotes | cancer |
| T3 | 565-570 | HP_0002664 | denotes | tumor |
| T4 | 618-623 | HP_0002664 | denotes | tumor |
| T5 | 944-952 | HP_0001909 | denotes | leukemia |
| T6 | 1058-1064 | HP_0002664 | denotes | cancer |
| T7 | 1806-1813 | HP_0002664 | denotes | tumoral |
| T8 | 1955-1960 | HP_0002664 | denotes | tumor |
GlycoBiology-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 976-980 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T2 | 1500-1506 | http://purl.obolibrary.org/obo/MAT_0000085 | denotes | spleen |
Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| Lectin_T1 | 62-64 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T2 | 342-344 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
GlycoBiology-Epitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoEpitope-B_T1 | 62-72 | http://www.glycoepitope.jp/epitopes/EP0021 | denotes | Tn antigen |
| PD-GlycoEpitope-B_T2 | 55-72 | http://www.glycoepitope.jp/epitopes/EP0022 | denotes | sialyl-Tn antigen |
| PD-GlycoEpitope-B_T3 | 751-753 | http://www.glycoepitope.jp/epitopes/AN0542 | denotes | M2 |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 624-631 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T2 | 976-980 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| PD-UBERON-AE-B_T3 | 1500-1506 | http://purl.obolibrary.org/obo/UBERON_0002106 | denotes | spleen |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 38-43 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 362-367 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 525-531 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T4 | 565-570 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 618-623 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T6 | 934-952 | Disease | denotes | monocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0004600|http://purl.obolibrary.org/obo/MONDO_0007896 |
| T8 | 976-990 | Disease | denotes | lung carcinoma | http://purl.obolibrary.org/obo/MONDO_0005138 |
| T9 | 1058-1064 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T10 | 1955-1960 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 976-980 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T2 | 1500-1506 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/MAT_0000085 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 62-72 | Glycan | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 55-72 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Tn antigen | http://www.glycoepitope.jp/epitopes/EP0022 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 38-43 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 362-367 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 525-531 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 565-570 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 618-623 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 944-952 | Phenotype | denotes | leukemia | HP:0001909 |
| T7 | 981-990 | Phenotype | denotes | carcinoma | HP:0030731 |
| T8 | 1058-1064 | Phenotype | denotes | cancer | HP:0002664 |
| T9 | 1955-1960 | Phenotype | denotes | tumor | HP:0002664 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 103-112 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T3 | 113-124 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T5 | 289-300 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T7 | 499-508 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T9 | 509-520 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T11 | 525-537 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T12 | 582-593 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T14 | 706-716 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T16 | 759-770 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T18 | 934-943 | Cell | denotes | monocytic | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T20 | 1032-1041 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T22 | 1042-1053 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T24 | 1058-1070 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T25 | 1925-1936 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 103-112 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T3 | 113-124 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T4 | 289-300 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T5 | 499-508 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T7 | 509-520 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T8 | 582-593 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T9 | 706-716 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T10 | 759-770 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T11 | 976-980 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T12 | 1032-1041 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T14 | 1042-1053 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T15 | 1452-1465 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T16 | 1500-1506 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/UBERON_0002106 |
| T17 | 1925-1936 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-155 | Sentence | denotes | The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. |
| TextSentencer_T2 | 156-396 | Sentence | denotes | We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure. |
| TextSentencer_T3 | 397-538 | Sentence | denotes | In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells. |
| TextSentencer_T4 | 539-632 | Sentence | denotes | Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues. |
| TextSentencer_T5 | 633-886 | Sentence | denotes | We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells. |
| TextSentencer_T6 | 887-1215 | Sentence | denotes | We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells. |
| TextSentencer_T7 | 1216-1324 | Sentence | denotes | The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids. |
| TextSentencer_T8 | 1325-1529 | Sentence | denotes | Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk). |
| TextSentencer_T9 | 1530-1751 | Sentence | denotes | The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12. |
| TextSentencer_T10 | 1752-2040 | Sentence | denotes | These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments. |
| T1 | 0-155 | Sentence | denotes | The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. |
| T2 | 156-396 | Sentence | denotes | We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure. |
| T3 | 397-538 | Sentence | denotes | In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells. |
| T4 | 539-632 | Sentence | denotes | Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues. |
| T5 | 633-886 | Sentence | denotes | We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells. |
| T6 | 887-1215 | Sentence | denotes | We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells. |
| T7 | 1216-1324 | Sentence | denotes | The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids. |
| T8 | 1325-1529 | Sentence | denotes | Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk). |
| T9 | 1530-1751 | Sentence | denotes | The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12. |
| T10 | 1752-2040 | Sentence | denotes | These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments. |
| T1 | 0-155 | Sentence | denotes | The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. |
| T2 | 156-396 | Sentence | denotes | We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure. |
| T3 | 397-538 | Sentence | denotes | In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells. |
| T4 | 539-632 | Sentence | denotes | Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues. |
| T5 | 633-886 | Sentence | denotes | We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells. |
| T6 | 887-1215 | Sentence | denotes | We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells. |
| T7 | 1216-1324 | Sentence | denotes | The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids. |
| T8 | 1325-1529 | Sentence | denotes | Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk). |
| T9 | 1530-1751 | Sentence | denotes | The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12. |
| T10 | 1752-2040 | Sentence | denotes | These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-155 | Sentence | denotes | The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. |
| T2 | 156-396 | Sentence | denotes | We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure. |
| T3 | 397-538 | Sentence | denotes | In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells. |
| T4 | 539-632 | Sentence | denotes | Siglec-15 is expressed on tumor-associated macrophages (TAMs) in various human tumor tissues. |
| T5 | 633-886 | Sentence | denotes | We further demonstrated that its expression is substantially elevated in macrophage colony-stimulating factor-induced M2-like macrophages, which produced more transforming growth factor-β (TGF-β) in response to sTn-positive cells than to negative cells. |
| T6 | 887-1215 | Sentence | denotes | We designed a co-culture model of THP-1 (human monocytic leukemia) cells and H157 (human lung carcinoma) cells mimicking the interaction between monocytes/macrophages and cancer cells that recapitulated the enhanced TGF-β production in Siglec-15 expressing THP-1 cells by the cellular interaction with sTn expressing H157 cells. |
| T7 | 1216-1324 | Sentence | denotes | The enhanced TGF-β production required a direct interaction between the two cell lines through sialic acids. |
| T8 | 1325-1529 | Sentence | denotes | Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk). |
| T9 | 1530-1751 | Sentence | denotes | The enhanced TGF-β secretion was significantly attenuated by Syk inhibitor treatment of THP-1 cells or by substitution of the Siglec-15 Lys(274) to Ala, which disrupts the molecular interaction between Siglec15 and DAP12. |
| T10 | 1752-2040 | Sentence | denotes | These findings indicate that Siglec-15 recognizes the tumoral sTn antigen and transduces a signal for enhanced TGF-β secretion in TAMs and further suggest that Siglec-15 on macrophages may contribute to tumor progression by the TGF-β-mediated modulation of intratumoral microenvironments. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 55-72 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Tn antigen | http://www.glycoepitope.jp/epitopes/EP0022 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 55-72 | Glycan | denotes | sialyl-Tn antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G36123IU |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 38-43 | Disease | denotes | tumor | MONDO:0005070 |
| T2 | 362-367 | Disease | denotes | tumor | MONDO:0005070 |
| T3 | 525-531 | Disease | denotes | cancer | MONDO:0004992 |
| T4 | 565-570 | Disease | denotes | tumor | MONDO:0005070 |
| T5 | 618-623 | Disease | denotes | tumor | MONDO:0005070 |
| T6 | 934-952 | Disease | denotes | monocytic leukemia | MONDO:0004600|MONDO:0007896 |
| T8 | 976-990 | Disease | denotes | lung carcinoma | MONDO:0005138 |
| T9 | 1058-1064 | Disease | denotes | cancer | MONDO:0004992 |
| T10 | 1955-1960 | Disease | denotes | tumor | MONDO:0005070 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 612-617 | OrganismTaxon | denotes | human | 9606 |
| T2 | 928-933 | OrganismTaxon | denotes | human | 9606 |
| T3 | 970-975 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 103-112 | Body_part | denotes | monocytes | FMA:62864 |
| T2 | 113-124 | Body_part | denotes | macrophages | FMA:63261 |
| T3 | 289-300 | Body_part | denotes | macrophages | FMA:63261 |
| T4 | 499-508 | Body_part | denotes | monocytes | FMA:62864 |
| T5 | 509-520 | Body_part | denotes | macrophages | FMA:63261 |
| T6 | 582-593 | Body_part | denotes | macrophages | FMA:63261 |
| T7 | 624-631 | Body_part | denotes | tissues | FMA:9637 |
| T8 | 706-716 | Body_part | denotes | macrophage | FMA:63261 |
| T9 | 759-770 | Body_part | denotes | macrophages | FMA:63261 |
| T10 | 934-943 | Body_part | denotes | monocytic | FMA:62864 |
| T11 | 976-980 | Body_part | denotes | lung | FMA:7195 |
| T12 | 1032-1041 | Body_part | denotes | monocytes | FMA:62864 |
| T13 | 1042-1053 | Body_part | denotes | macrophages | FMA:63261 |
| T14 | 1500-1506 | Body_part | denotes | spleen | FMA:7196 |
| T15 | 1925-1936 | Body_part | denotes | macrophages | FMA:63261 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 976-980 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T2 | 1500-1506 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/MAT_0000085 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 612-617 | OrganismTaxon | denotes | human | 9606 |
| T2 | 928-933 | OrganismTaxon | denotes | human | 9606 |
| T3 | 970-975 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 103-112 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T3 | 113-124 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T4 | 289-300 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T5 | 499-508 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T7 | 509-520 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T8 | 582-593 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T9 | 706-716 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T10 | 759-770 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T11 | 976-980 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T12 | 1032-1041 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T14 | 1042-1053 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T15 | 1452-1465 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T16 | 1500-1506 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/UBERON_0002106 |
| T17 | 1925-1936 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 38-43 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 362-367 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 525-531 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 565-570 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 618-623 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 944-952 | Phenotype | denotes | leukemia | HP:0001909 |
| T7 | 981-990 | Phenotype | denotes | carcinoma | HP:0030731 |
| T8 | 1058-1064 | Phenotype | denotes | cancer | HP:0002664 |
| T9 | 1955-1960 | Phenotype | denotes | tumor | HP:0002664 |