PubMed:23030236 JSONTXT

{"project":"Allie","denotations":[{"id":"SS1_23030236_4_0","span":{"begin":318,"end":353},"obj":"expanded"},{"id":"SS2_23030236_4_0","span":{"begin":355,"end":359},"obj":"abbr"},{"id":"SS1_23030236_9_0","span":{"begin":630,"end":655},"obj":"expanded"},{"id":"SS2_23030236_9_0","span":{"begin":657,"end":663},"obj":"abbr"}],"relations":[{"id":"AE1_23030236_4_0","pred":"abbreviatedTo","subj":"SS1_23030236_4_0","obj":"SS2_23030236_4_0"},{"id":"AE1_23030236_9_0","pred":"abbreviatedTo","subj":"SS1_23030236_9_0","obj":"SS2_23030236_9_0"}],"text":"Short- and long-term changes in blood miRNA levels after nanogold injection in rats--potential biomarkers of nanoparticle exposure.\nCONTEXT: Increased use of engineered nanoparticles may result in exposure of workers and consumers, making them a health concern.\nOBJECTIVE: To identify potential blood miRNA biomarkers after intravenous gold nanoparticle (AuNP) exposure.\nMATERIALS AND METHODS: miRNA microarray analysis was carried out on blood of rats at 1 week and 2 months after injection.\nRESULTS: Many up- and downregulated miRNAs were detected. Of these, rno-miR-298 was confirmed to be increased at 1 week postinjection by reverse transcription-PCR (RT-PCR).\nDISCUSSION AND CONCLUSION: Blood miRNAs could be useful as biomarkers for exposure to nanoparticles. miR-298 regulates β-amyloid (Aβ) precursor protein-converting enzyme-1 (BACE1) in Alzheimer's disease."}