PubMed:23002246
Annnotations
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1045-1051 | https://glytoucan.org/Structures/Glycans/G32254QI | denotes | SSEA-4 |
| T2 | 1045-1051 | https://glytoucan.org/Structures/Glycans/G84263XI | denotes | SSEA-4 |
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 105-205 | DRI_Background | denotes | Human embryonic stem (hES) cell production of heparan sulfate influences cell fate and pluripotency. |
| T2 | 206-408 | DRI_Outcome | denotes | Human ES cells remain pluripotent in vitro through the action of growth factors signaling, and the activity of these factors depends on interaction with specific receptors and also with heparan sulfate. |
| T3 | 409-598 | DRI_Approach | denotes | Here, we tested the hypothesis that matrix-associated heparan sulfate is enough to maintain hES cells under low fibroblast growth factor-2 concentration in the absence of live feeder cells. |
| T4 | 599-754 | DRI_Background | denotes | To pursue this goal, we compared hES cells cultured either on coated plates containing live murine embryonic fibroblasts (MEFs) or on a matrix derived from |
| T5 | 773-774 | DRI_Background | denotes | . |
| T6 | 775-882 | DRI_Approach | denotes | hES cells were analyzed for the expression of pluripotency markers and the ability to form embryoid bodies. |
| T7 | 883-1084 | DRI_Background | denotes | hES cells cultured either on live mouse fibroblasts or onto a matrix derived from fixed fibroblasts expressed similar levels of Oct-4, SOX-2, Nanog, TRA-1-60 and SSEA-4, and they were also able to form |
| T8 | 1104-1111 | DRI_Background | denotes | bodies. |
| T9 | 1112-1339 | DRI_Approach | denotes | Heparan sulfate-depleted matrix lost the ability to support the adherence and growth of hES cells, confirming that this glycosaminoglycan, bound to the extracellular matrix, is enough for the growth and attachment of hES cells. |
| T10 | 1340-1501 | DRI_Approach | denotes | Finally, we observed that the ethanol-fixed matrix decreases by 30% the levels of Neu5Gc in hES cells, indicating that this procedure reduces xeno-contamination. |
| T11 | 1502-1618 | DRI_Outcome | denotes | Our data suggest that matrix-bound heparan sulfate is required for the growth and pluripotency of hES cells and that |
| T12 | 1638-1697 | DRI_Outcome | denotes | may be used as a "live cell"-free substrate for stem cells. |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1045-1051 | Glycan_Motif | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84263XI|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G32254QI |
| T3 | 1045-1049 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 93-103 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T2 | 93-97 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T3 | 121-125 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T4 | 1686-1696 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T5 | 1686-1690 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-104 | Sentence | denotes | Matrix-bound heparan sulfate is essential for the growth and pluripotency of human embryonic stem cells. |
| TextSentencer_T2 | 105-205 | Sentence | denotes | Human embryonic stem (hES) cell production of heparan sulfate influences cell fate and pluripotency. |
| TextSentencer_T3 | 206-408 | Sentence | denotes | Human ES cells remain pluripotent in vitro through the action of growth factors signaling, and the activity of these factors depends on interaction with specific receptors and also with heparan sulfate. |
| TextSentencer_T4 | 409-598 | Sentence | denotes | Here, we tested the hypothesis that matrix-associated heparan sulfate is enough to maintain hES cells under low fibroblast growth factor-2 concentration in the absence of live feeder cells. |
| TextSentencer_T5 | 599-1111 | Sentence | denotes | To pursue this goal, we compared hES cells cultured either on coated plates containing live murine embryonic fibroblasts (MEFs) or on a matrix derived from ethanol-fixed MEFs. hES cells were analyzed for the expression of pluripotency markers and the ability to form embryoid bodies. hES cells cultured either on live mouse fibroblasts or onto a matrix derived from fixed fibroblasts expressed similar levels of Oct-4, SOX-2, Nanog, TRA-1-60 and SSEA-4, and they were also able to form cavitated embryoid bodies. |
| TextSentencer_T6 | 1112-1339 | Sentence | denotes | Heparan sulfate-depleted matrix lost the ability to support the adherence and growth of hES cells, confirming that this glycosaminoglycan, bound to the extracellular matrix, is enough for the growth and attachment of hES cells. |
| TextSentencer_T7 | 1340-1501 | Sentence | denotes | Finally, we observed that the ethanol-fixed matrix decreases by 30% the levels of Neu5Gc in hES cells, indicating that this procedure reduces xeno-contamination. |
| TextSentencer_T8 | 1502-1697 | Sentence | denotes | Our data suggest that matrix-bound heparan sulfate is required for the growth and pluripotency of hES cells and that ethanol-fixed MEFs may be used as a "live cell"-free substrate for stem cells. |
| T1 | 0-104 | Sentence | denotes | Matrix-bound heparan sulfate is essential for the growth and pluripotency of human embryonic stem cells. |
| T2 | 105-205 | Sentence | denotes | Human embryonic stem (hES) cell production of heparan sulfate influences cell fate and pluripotency. |
| T3 | 206-408 | Sentence | denotes | Human ES cells remain pluripotent in vitro through the action of growth factors signaling, and the activity of these factors depends on interaction with specific receptors and also with heparan sulfate. |
| T4 | 409-598 | Sentence | denotes | Here, we tested the hypothesis that matrix-associated heparan sulfate is enough to maintain hES cells under low fibroblast growth factor-2 concentration in the absence of live feeder cells. |
| T5 | 599-1111 | Sentence | denotes | To pursue this goal, we compared hES cells cultured either on coated plates containing live murine embryonic fibroblasts (MEFs) or on a matrix derived from ethanol-fixed MEFs. hES cells were analyzed for the expression of pluripotency markers and the ability to form embryoid bodies. hES cells cultured either on live mouse fibroblasts or onto a matrix derived from fixed fibroblasts expressed similar levels of Oct-4, SOX-2, Nanog, TRA-1-60 and SSEA-4, and they were also able to form cavitated embryoid bodies. |
| T6 | 1112-1339 | Sentence | denotes | Heparan sulfate-depleted matrix lost the ability to support the adherence and growth of hES cells, confirming that this glycosaminoglycan, bound to the extracellular matrix, is enough for the growth and attachment of hES cells. |
| T7 | 1340-1501 | Sentence | denotes | Finally, we observed that the ethanol-fixed matrix decreases by 30% the levels of Neu5Gc in hES cells, indicating that this procedure reduces xeno-contamination. |
| T8 | 1502-1697 | Sentence | denotes | Our data suggest that matrix-bound heparan sulfate is required for the growth and pluripotency of hES cells and that ethanol-fixed MEFs may be used as a "live cell"-free substrate for stem cells. |
| T1 | 0-104 | Sentence | denotes | Matrix-bound heparan sulfate is essential for the growth and pluripotency of human embryonic stem cells. |
| T2 | 105-205 | Sentence | denotes | Human embryonic stem (hES) cell production of heparan sulfate influences cell fate and pluripotency. |
| T3 | 206-408 | Sentence | denotes | Human ES cells remain pluripotent in vitro through the action of growth factors signaling, and the activity of these factors depends on interaction with specific receptors and also with heparan sulfate. |
| T4 | 409-598 | Sentence | denotes | Here, we tested the hypothesis that matrix-associated heparan sulfate is enough to maintain hES cells under low fibroblast growth factor-2 concentration in the absence of live feeder cells. |
| T5 | 599-1111 | Sentence | denotes | To pursue this goal, we compared hES cells cultured either on coated plates containing live murine embryonic fibroblasts (MEFs) or on a matrix derived from ethanol-fixed MEFs. hES cells were analyzed for the expression of pluripotency markers and the ability to form embryoid bodies. hES cells cultured either on live mouse fibroblasts or onto a matrix derived from fixed fibroblasts expressed similar levels of Oct-4, SOX-2, Nanog, TRA-1-60 and SSEA-4, and they were also able to form cavitated embryoid bodies. |
| T6 | 1112-1339 | Sentence | denotes | Heparan sulfate-depleted matrix lost the ability to support the adherence and growth of hES cells, confirming that this glycosaminoglycan, bound to the extracellular matrix, is enough for the growth and attachment of hES cells. |
| T7 | 1340-1501 | Sentence | denotes | Finally, we observed that the ethanol-fixed matrix decreases by 30% the levels of Neu5Gc in hES cells, indicating that this procedure reduces xeno-contamination. |
| T8 | 1502-1697 | Sentence | denotes | Our data suggest that matrix-bound heparan sulfate is required for the growth and pluripotency of hES cells and that ethanol-fixed MEFs may be used as a "live cell"-free substrate for stem cells. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1045-1051 | https://glytoucan.org/Structures/Glycans/G32254QI | denotes | SSEA-4 |
| T2 | 1045-1051 | https://glytoucan.org/Structures/Glycans/G84263XI | denotes | SSEA-4 |
| T3 | 1045-1049 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T4 | 1045-1049 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 13-28 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T2 | 151-166 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T3 | 392-407 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T4 | 463-478 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T5 | 1032-1040 | http://www.glycoepitope.jp/epitopes/AN0727 | denotes | TRA-1-60 |
| T6 | 1045-1051 | http://www.glycoepitope.jp/epitopes/EP0044 | denotes | SSEA-4 |
| T7 | 1112-1127 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | Heparan sulfate |
| T8 | 1537-1552 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 13-20 | FMAID:165191 | denotes | heparan |
| _T2 | 13-20 | FMAID:67110 | denotes | heparan |
| _T3 | 13-28 | FMAID:63023 | denotes | heparan sulfate |
| _T4 | 13-28 | FMAID:167405 | denotes | heparan sulfate |
| _T5 | 83-103 | FMAID:196840 | denotes | embryonic stem cells |
| _T6 | 83-103 | FMAID:82841 | denotes | embryonic stem cells |
| _T7 | 93-103 | FMAID:63368 | denotes | stem cells |
| _T8 | 93-103 | FMAID:167693 | denotes | stem cells |
| _T9 | 98-103 | FMAID:169002 | denotes | cells |
| _T10 | 98-103 | FMAID:68646 | denotes | cells |
| _T11 | 151-158 | FMAID:67110 | denotes | heparan |
| _T12 | 151-158 | FMAID:165191 | denotes | heparan |
| _T13 | 151-166 | FMAID:63023 | denotes | heparan sulfate |
| _T14 | 151-166 | FMAID:167405 | denotes | heparan sulfate |
| _T15 | 215-220 | FMAID:169002 | denotes | cells |
| _T16 | 215-220 | FMAID:68646 | denotes | cells |
| _T17 | 392-399 | FMAID:67110 | denotes | heparan |
| _T18 | 392-399 | FMAID:165191 | denotes | heparan |
| _T19 | 392-407 | FMAID:167405 | denotes | heparan sulfate |
| _T20 | 392-407 | FMAID:63023 | denotes | heparan sulfate |
| _T21 | 418-424 | FMAID:178661 | denotes | tested |
| _T22 | 463-470 | FMAID:67110 | denotes | heparan |
| _T23 | 463-470 | FMAID:165191 | denotes | heparan |
| _T24 | 463-478 | FMAID:63023 | denotes | heparan sulfate |
| _T25 | 463-478 | FMAID:167405 | denotes | heparan sulfate |
| _T26 | 492-500 | FMAID:214734 | denotes | maintain |
| _T27 | 505-510 | FMAID:169002 | denotes | cells |
| _T28 | 505-510 | FMAID:68646 | denotes | cells |
| _T29 | 521-531 | FMAID:63877 | denotes | fibroblast |
| _T30 | 521-531 | FMAID:162340 | denotes | fibroblast |
| _T31 | 592-597 | FMAID:68646 | denotes | cells |
| _T32 | 592-597 | FMAID:169002 | denotes | cells |
| _T33 | 636-641 | FMAID:68646 | denotes | cells |
| _T34 | 636-641 | FMAID:169002 | denotes | cells |
| _T35 | 708-719 | FMAID:162340 | denotes | fibroblasts |
| _T36 | 708-719 | FMAID:63877 | denotes | fibroblasts |
| _T37 | 779-784 | FMAID:68646 | denotes | cells |
| _T38 | 779-784 | FMAID:169002 | denotes | cells |
| _T39 | 875-881 | FMAID:256135 | denotes | bodies |
| _T40 | 875-881 | FMAID:256134 | denotes | bodies |
| _T41 | 887-892 | FMAID:68646 | denotes | cells |
| _T42 | 887-892 | FMAID:169002 | denotes | cells |
| _T43 | 923-934 | FMAID:162340 | denotes | fibroblasts |
| _T44 | 923-934 | FMAID:63877 | denotes | fibroblasts |
| _T45 | 971-982 | FMAID:162340 | denotes | fibroblasts |
| _T46 | 971-982 | FMAID:63877 | denotes | fibroblasts |
| _T47 | 1104-1110 | FMAID:256134 | denotes | bodies |
| _T48 | 1104-1110 | FMAID:256135 | denotes | bodies |
| _T49 | 1112-1119 | FMAID:165191 | denotes | Heparan |
| _T50 | 1112-1119 | FMAID:67110 | denotes | Heparan |
| _T51 | 1112-1127 | FMAID:63023 | denotes | Heparan sulfate |
| _T52 | 1112-1127 | FMAID:167405 | denotes | Heparan sulfate |
| _T53 | 1204-1209 | FMAID:169002 | denotes | cells |
| _T54 | 1204-1209 | FMAID:68646 | denotes | cells |
| _T55 | 1232-1249 | FMAID:63011 | denotes | glycosaminoglycan |
| _T56 | 1232-1249 | FMAID:167395 | denotes | glycosaminoglycan |
| _T57 | 1264-1284 | FMAID:165194 | denotes | extracellular matrix |
| _T58 | 1264-1284 | FMAID:265717 | denotes | extracellular matrix |
| _T59 | 1333-1338 | FMAID:68646 | denotes | cells |
| _T60 | 1333-1338 | FMAID:169002 | denotes | cells |
| _T61 | 1436-1441 | FMAID:169002 | denotes | cells |
| _T62 | 1436-1441 | FMAID:68646 | denotes | cells |
| _T63 | 1537-1544 | FMAID:67110 | denotes | heparan |
| _T64 | 1537-1544 | FMAID:165191 | denotes | heparan |
| _T65 | 1537-1552 | FMAID:167405 | denotes | heparan sulfate |
| _T66 | 1537-1552 | FMAID:63023 | denotes | heparan sulfate |
| _T67 | 1604-1609 | FMAID:169002 | denotes | cells |
| _T68 | 1604-1609 | FMAID:68646 | denotes | cells |
| _T69 | 1656-1665 | FMAID:63179 | denotes | live cell |
| _T70 | 1656-1665 | FMAID:167570 | denotes | live cell |
| _T71 | 1686-1696 | FMAID:167693 | denotes | stem cells |
| _T72 | 1686-1696 | FMAID:63368 | denotes | stem cells |
| _T73 | 1691-1696 | FMAID:68646 | denotes | cells |
| _T74 | 1691-1696 | FMAID:169002 | denotes | cells |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 532-547 | http://www.uniprot.org/uniprot/Q9UC54 | denotes | growth factor-2 |
| T2 | 532-547 | http://www.uniprot.org/uniprot/P20783 | denotes | growth factor-2 |
| T3 | 532-547 | http://www.uniprot.org/uniprot/Q9UK05 | denotes | growth factor-2 |
| T4 | 532-547 | http://www.uniprot.org/uniprot/O15520 | denotes | growth factor-2 |
| T5 | 1011-1016 | http://www.uniprot.org/uniprot/Q5STF3 | denotes | Oct-4 |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1011-1016 | http://www.uniprot.org/uniprot/P20263 | denotes | Oct-4 |
| T2 | 1025-1030 | http://www.uniprot.org/uniprot/Q80Z64 | denotes | Nanog |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 98-103 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T2 | 215-220 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T3 | 368-377 | http://purl.bioontology.org/ontology/STY/T192 | denotes | receptors |
| T4 | 505-510 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T5 | 592-597 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T6 | 636-641 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T7 | 779-784 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T8 | 887-892 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T9 | 1204-1209 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T10 | 1333-1338 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T11 | 1436-1441 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T12 | 1482-1486 | http://purl.bioontology.org/ontology/NCBITAXON/32435 | denotes | xeno |
| T13 | 1604-1609 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T14 | 1691-1696 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-28 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T2 | 159-166 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T3 | 400-407 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T4 | 471-478 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T5 | 1120-1127 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T6 | 1545-1552 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T7 | 50-56 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T8 | 271-277 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T9 | 532-538 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T10 | 1190-1196 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T11 | 1304-1310 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T12 | 1573-1579 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T13 | 286-295 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 98-103 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T2 | 215-220 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T3 | 505-510 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T4 | 592-597 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T5 | 636-641 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T6 | 779-784 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T7 | 887-892 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T8 | 1204-1209 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T9 | 1333-1338 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T10 | 1436-1441 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T11 | 1604-1609 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T12 | 132-136 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T13 | 178-182 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T14 | 1661-1665 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T15 | 1264-1277 | http://purl.obolibrary.org/obo/GO_0005576 | denotes | extracellular |
| T16 | 1264-1284 | http://purl.obolibrary.org/obo/GO_0031012 | denotes | extracellular matrix |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 866-881 | http://purl.obolibrary.org/obo/UBERON_0014374 | denotes | embryoid bodies |
| T2 | 1095-1110 | http://purl.obolibrary.org/obo/UBERON_0014374 | denotes | embryoid bodies |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_23002246_1_0 | 105-125 | expanded | denotes | Human embryonic stem |
| SS2_23002246_1_0 | 127-130 | abbr | denotes | hES |
| SS1_23002246_4_0 | 691-719 | expanded | denotes | murine embryonic fibroblasts |
| SS2_23002246_4_0 | 721-725 | abbr | denotes | MEFs |
| AE1_23002246_1_0 | SS1_23002246_1_0 | SS2_23002246_1_0 | abbreviatedTo | Human embryonic stem,hES |
| AE1_23002246_4_0 | SS1_23002246_4_0 | SS2_23002246_4_0 | abbreviatedTo | murine embryonic fibroblasts,MEFs |
GlycoBiology-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 93-97 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T2 | 93-103 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T3 | 121-125 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T4 | 1686-1690 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T5 | 1686-1696 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
GlycoBiology-Epitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoEpitope-B_T1 | 13-28 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| PD-GlycoEpitope-B_T2 | 151-166 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| PD-GlycoEpitope-B_T3 | 392-407 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| PD-GlycoEpitope-B_T4 | 463-478 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| PD-GlycoEpitope-B_T5 | 1112-1127 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | Heparan sulfate |
| PD-GlycoEpitope-B_T6 | 1537-1552 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| PD-GlycoEpitope-B_T7 | 1032-1040 | http://www.glycoepitope.jp/epitopes/AN0727 | denotes | TRA-1-60 |
| PD-GlycoEpitope-B_T8 | 1045-1051 | http://www.glycoepitope.jp/epitopes/EP0044 | denotes | SSEA-4 |
GlyTouCan-IUPAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| GlycanIUPAC_T1 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G52626JU" | denotes | Oct |
| GlycanIUPAC_T2 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G44803MF" | denotes | Oct |
| GlycanIUPAC_T3 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G75769XJ" | denotes | Oct |
| GlycanIUPAC_T4 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G32075UV" | denotes | Oct |
| GlycanIUPAC_T5 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G19871KB" | denotes | Oct |
| GlycanIUPAC_T6 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G02297CB" | denotes | Oct |
| GlycanIUPAC_T7 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G86711IL" | denotes | Oct |
| GlycanIUPAC_T8 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G29641QF" | denotes | Oct |
| GlycanIUPAC_T9 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G81991PU" | denotes | Oct |
| GlycanIUPAC_T10 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G50843NR" | denotes | Oct |
| GlycanIUPAC_T11 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G72982UM" | denotes | Oct |
| GlycanIUPAC_T12 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G99079GA" | denotes | Oct |
| GlycanIUPAC_T13 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G45378TF" | denotes | Oct |
| GlycanIUPAC_T14 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G57506TF" | denotes | Oct |
| GlycanIUPAC_T15 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G07340KF" | denotes | Oct |
| GlycanIUPAC_T16 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G64568HT" | denotes | Oct |
| GlycanIUPAC_T17 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G46846LC" | denotes | Oct |
| GlycanIUPAC_T18 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G77011RU" | denotes | Oct |
| GlycanIUPAC_T19 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G31033PX" | denotes | Oct |
| GlycanIUPAC_T20 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G16221YF" | denotes | Oct |
| GlycanIUPAC_T21 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G61143JT" | denotes | Oct |
| GlycanIUPAC_T22 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G51234LG" | denotes | Oct |
| GlycanIUPAC_T23 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G61307AH" | denotes | Oct |
| GlycanIUPAC_T24 | 1011-1014 | "http://rdf.glycoinfo.org/glycan/G57624ZE" | denotes | Oct |
| GlycanIUPAC_T25 | 1422-1428 | "http://rdf.glycoinfo.org/glycan/G37754MA" | denotes | Neu5Gc |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 866-881 | http://purl.obolibrary.org/obo/UBERON_0014374 | denotes | embryoid bodies |
| PD-UBERON-AE-B_T2 | 1095-1110 | http://purl.obolibrary.org/obo/UBERON_0014374 | denotes | embryoid bodies |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1045-1051 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T2 | 13-28 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T3 | 151-166 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T4 | 392-407 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T5 | 463-478 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T7 | 1112-1127 | Glycan | denotes | Heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T8 | 1537-1552 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 93-103 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T2 | 121-125 | Body_part | denotes | stem | http://purl.obolibrary.org/obo/MAT_0000239 |
| T3 | 1686-1696 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1045-1051 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
| T3 | 13-28 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T2 | 151-166 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T4 | 392-407 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T5 | 463-478 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T7 | 1112-1127 | Glycan | denotes | Heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T8 | 1537-1552 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 13-28 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 151-166 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 392-407 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 463-478 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T5 | 1032-1040 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | TRA-1-60 | http://www.glycoepitope.jp/epitopes/AN0727 |
| T6 | 1045-1051 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T7 | 1112-1127 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T8 | 1537-1552 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 83-103 | Cell | denotes | embryonic stem cells | http://purl.obolibrary.org/obo/CL:0002322 |
| T2 | 521-531 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |
| T3 | 698-719 | Cell | denotes | embryonic fibroblasts | http://purl.obolibrary.org/obo/CL:2000042 |
| T4 | 923-934 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
| T5 | 971-982 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
| T6 | 1686-1696 | Cell | denotes | stem cells | http://purl.obolibrary.org/obo/CL:0000034 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 93-103 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T2 | 521-531 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
| T3 | 698-719 | Body_part | denotes | embryonic fibroblasts | http://purl.obolibrary.org/obo/CL_2000042 |
| T4 | 866-881 | Body_part | denotes | embryoid bodies | http://purl.obolibrary.org/obo/UBERON_0014374 |
| T5 | 923-934 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T6 | 971-982 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T7 | 1095-1110 | Body_part | denotes | embryoid bodies | http://purl.obolibrary.org/obo/UBERON_0014374 |
| T8 | 1264-1284 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T9 | 1686-1696 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 77-82 | Organism | denotes | human | 9606 |
| T2 | 105-110 | Organism | denotes | Human | 9606 |
| T3 | 206-211 | Organism | denotes | Human | 9606 |
| T4 | 917-922 | Organism | denotes | mouse | 10088|10090 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 13-28 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 151-166 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 392-407 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 463-478 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T5 | 1032-1040 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | TRA-1-60 | http://www.glycoepitope.jp/epitopes/AN0727 |
| T6 | 1045-1051 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
| T7 | 1112-1127 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T8 | 1537-1552 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-104 | Sentence | denotes | Matrix-bound heparan sulfate is essential for the growth and pluripotency of human embryonic stem cells. |
| T2 | 105-205 | Sentence | denotes | Human embryonic stem (hES) cell production of heparan sulfate influences cell fate and pluripotency. |
| T3 | 206-408 | Sentence | denotes | Human ES cells remain pluripotent in vitro through the action of growth factors signaling, and the activity of these factors depends on interaction with specific receptors and also with heparan sulfate. |
| T4 | 409-598 | Sentence | denotes | Here, we tested the hypothesis that matrix-associated heparan sulfate is enough to maintain hES cells under low fibroblast growth factor-2 concentration in the absence of live feeder cells. |
| T5 | 599-1111 | Sentence | denotes | To pursue this goal, we compared hES cells cultured either on coated plates containing live murine embryonic fibroblasts (MEFs) or on a matrix derived from ethanol-fixed MEFs. hES cells were analyzed for the expression of pluripotency markers and the ability to form embryoid bodies. hES cells cultured either on live mouse fibroblasts or onto a matrix derived from fixed fibroblasts expressed similar levels of Oct-4, SOX-2, Nanog, TRA-1-60 and SSEA-4, and they were also able to form cavitated embryoid bodies. |
| T6 | 1112-1339 | Sentence | denotes | Heparan sulfate-depleted matrix lost the ability to support the adherence and growth of hES cells, confirming that this glycosaminoglycan, bound to the extracellular matrix, is enough for the growth and attachment of hES cells. |
| T7 | 1340-1501 | Sentence | denotes | Finally, we observed that the ethanol-fixed matrix decreases by 30% the levels of Neu5Gc in hES cells, indicating that this procedure reduces xeno-contamination. |
| T8 | 1502-1697 | Sentence | denotes | Our data suggest that matrix-bound heparan sulfate is required for the growth and pluripotency of hES cells and that ethanol-fixed MEFs may be used as a "live cell"-free substrate for stem cells. |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 83-103 | Body_part | denotes | embryonic stem cells | FMA:82841 |
| T2 | 521-531 | Body_part | denotes | fibroblast | FMA:63877 |
| T3 | 708-719 | Body_part | denotes | fibroblasts | FMA:63877 |
| T4 | 923-934 | Body_part | denotes | fibroblasts | FMA:63877 |
| T5 | 971-982 | Body_part | denotes | fibroblasts | FMA:63877 |
| T6 | 1264-1284 | Body_part | denotes | extracellular matrix | FMA:9672 |
| T7 | 1686-1696 | Body_part | denotes | stem cells | FMA:63368 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 93-103 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T2 | 121-125 | Body_part | denotes | stem | http://purl.obolibrary.org/obo/MAT_0000239 |
| T3 | 1686-1696 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 77-82 | OrganismTaxon | denotes | human | 9606 |
| T2 | 105-110 | OrganismTaxon | denotes | Human | 9606 |
| T3 | 206-211 | OrganismTaxon | denotes | Human | 9606 |
| T4 | 917-922 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 93-103 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T2 | 521-531 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
| T3 | 698-719 | Body_part | denotes | embryonic fibroblasts | http://purl.obolibrary.org/obo/CL_2000042 |
| T4 | 866-881 | Body_part | denotes | embryoid bodies | http://purl.obolibrary.org/obo/UBERON_0014374 |
| T5 | 923-934 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T6 | 971-982 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T7 | 1095-1110 | Body_part | denotes | embryoid bodies | http://purl.obolibrary.org/obo/UBERON_0014374 |
| T8 | 1264-1284 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T9 | 1686-1696 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 83-103 | Cell | denotes | embryonic stem cells | http://purl.obolibrary.org/obo/CL:0002322 |
| T2 | 521-531 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |
| T3 | 698-719 | Cell | denotes | embryonic fibroblasts | http://purl.obolibrary.org/obo/CL:2000042 |
| T4 | 923-934 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
| T5 | 971-982 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
| T6 | 1686-1696 | Cell | denotes | stem cells | http://purl.obolibrary.org/obo/CL:0000034 |