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PubMed:22997241 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 54-61 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 54-61 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 767-774 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 767-774 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 843-850 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 843-850 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 1182-1189 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 1182-1189 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 1276-1283 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 1276-1283 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 1288-1295 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1288-1295 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 1349-1356 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 1349-1356 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 74-262 DRI_Challenge denotes Toxoplasma gondii is the causative agent of toxoplasmosis, one of the most widespread infections in humans and animals, and is a major opportunistic pathogen in immunocompromised patients.
T2 263-392 DRI_Outcome denotes Toxoplasma gondii is unique as it can invade virtually any nucleated cell, although the mechanisms are not completely understood.
T3 393-556 DRI_Challenge denotes Parasite attachment to the host cell is a prerequisite for reorientation and penetration and likely requires the recognition of molecules at the host cell surface.
T4 557-760 DRI_Outcome denotes It has been reported that the affinity of tachyzoites, the invasive form of T. gondii, for host cells can be inhibited by a variety of soluble-sulfated glycosaminoglycans (GAGs), such as heparan sulfate.
T5 761-935 DRI_Approach denotes Using heparin-functionalized zeolites in the absence of host cells, we visualized heparin-binding sites on the surface of tachyzoites by confocal and atomic force microscopy.
T6 936-1044 DRI_Outcome denotes Furthermore, we report that protein components of the parasite rhoptry, dense granule and surface bind GAGs.
T7 1045-1190 DRI_Background denotes In particular, the proteins ROP2 and ROP4 from the rhoptry, GRA2 from the dense granules and the surface protein SAG1 were found to bind heparin.
T8 1191-1415 DRI_Outcome denotes The binding specificities and affinities of individual parasite proteins for natural heparin and heparin oligosaccharides were determined by a combination of heparin oligosaccharide microarrays and surface plasmon resonance.
T9 1416-1792 DRI_Outcome denotes Our results suggest that interactions between sulfated GAGs and parasite surface antigens contribute to T. gondii attachment to host cell surfaces as well as initiating the invasion process, while rhoptries and dense granule organelles may play an important role during the establishment of the infection and during the life of the parasite inside the parasitophorous vacuole.

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 54-61 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 767-774 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T5 843-850 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T7 1182-1189 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T9 1276-1283 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T11 1288-1295 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T13 1349-1356 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-73 Sentence denotes Toxoplasma gondii secretory proteins bind to sulfated heparin structures.
TextSentencer_T2 74-262 Sentence denotes Toxoplasma gondii is the causative agent of toxoplasmosis, one of the most widespread infections in humans and animals, and is a major opportunistic pathogen in immunocompromised patients.
TextSentencer_T3 263-392 Sentence denotes Toxoplasma gondii is unique as it can invade virtually any nucleated cell, although the mechanisms are not completely understood.
TextSentencer_T4 393-556 Sentence denotes Parasite attachment to the host cell is a prerequisite for reorientation and penetration and likely requires the recognition of molecules at the host cell surface.
TextSentencer_T5 557-760 Sentence denotes It has been reported that the affinity of tachyzoites, the invasive form of T. gondii, for host cells can be inhibited by a variety of soluble-sulfated glycosaminoglycans (GAGs), such as heparan sulfate.
TextSentencer_T6 761-935 Sentence denotes Using heparin-functionalized zeolites in the absence of host cells, we visualized heparin-binding sites on the surface of tachyzoites by confocal and atomic force microscopy.
TextSentencer_T7 936-1044 Sentence denotes Furthermore, we report that protein components of the parasite rhoptry, dense granule and surface bind GAGs.
TextSentencer_T8 1045-1190 Sentence denotes In particular, the proteins ROP2 and ROP4 from the rhoptry, GRA2 from the dense granules and the surface protein SAG1 were found to bind heparin.
TextSentencer_T9 1191-1415 Sentence denotes The binding specificities and affinities of individual parasite proteins for natural heparin and heparin oligosaccharides were determined by a combination of heparin oligosaccharide microarrays and surface plasmon resonance.
TextSentencer_T10 1416-1792 Sentence denotes Our results suggest that interactions between sulfated GAGs and parasite surface antigens contribute to T. gondii attachment to host cell surfaces as well as initiating the invasion process, while rhoptries and dense granule organelles may play an important role during the establishment of the infection and during the life of the parasite inside the parasitophorous vacuole.
T1 0-73 Sentence denotes Toxoplasma gondii secretory proteins bind to sulfated heparin structures.
T2 74-262 Sentence denotes Toxoplasma gondii is the causative agent of toxoplasmosis, one of the most widespread infections in humans and animals, and is a major opportunistic pathogen in immunocompromised patients.
T3 263-392 Sentence denotes Toxoplasma gondii is unique as it can invade virtually any nucleated cell, although the mechanisms are not completely understood.
T4 393-556 Sentence denotes Parasite attachment to the host cell is a prerequisite for reorientation and penetration and likely requires the recognition of molecules at the host cell surface.
T5 557-760 Sentence denotes It has been reported that the affinity of tachyzoites, the invasive form of T. gondii, for host cells can be inhibited by a variety of soluble-sulfated glycosaminoglycans (GAGs), such as heparan sulfate.
T6 761-935 Sentence denotes Using heparin-functionalized zeolites in the absence of host cells, we visualized heparin-binding sites on the surface of tachyzoites by confocal and atomic force microscopy.
T7 936-1044 Sentence denotes Furthermore, we report that protein components of the parasite rhoptry, dense granule and surface bind GAGs.
T8 1045-1190 Sentence denotes In particular, the proteins ROP2 and ROP4 from the rhoptry, GRA2 from the dense granules and the surface protein SAG1 were found to bind heparin.
T9 1191-1415 Sentence denotes The binding specificities and affinities of individual parasite proteins for natural heparin and heparin oligosaccharides were determined by a combination of heparin oligosaccharide microarrays and surface plasmon resonance.
T10 1416-1792 Sentence denotes Our results suggest that interactions between sulfated GAGs and parasite surface antigens contribute to T. gondii attachment to host cell surfaces as well as initiating the invasion process, while rhoptries and dense granule organelles may play an important role during the establishment of the infection and during the life of the parasite inside the parasitophorous vacuole.
T1 0-73 Sentence denotes Toxoplasma gondii secretory proteins bind to sulfated heparin structures.
T2 74-262 Sentence denotes Toxoplasma gondii is the causative agent of toxoplasmosis, one of the most widespread infections in humans and animals, and is a major opportunistic pathogen in immunocompromised patients.
T3 263-392 Sentence denotes Toxoplasma gondii is unique as it can invade virtually any nucleated cell, although the mechanisms are not completely understood.
T4 393-556 Sentence denotes Parasite attachment to the host cell is a prerequisite for reorientation and penetration and likely requires the recognition of molecules at the host cell surface.
T5 557-760 Sentence denotes It has been reported that the affinity of tachyzoites, the invasive form of T. gondii, for host cells can be inhibited by a variety of soluble-sulfated glycosaminoglycans (GAGs), such as heparan sulfate.
T6 761-935 Sentence denotes Using heparin-functionalized zeolites in the absence of host cells, we visualized heparin-binding sites on the surface of tachyzoites by confocal and atomic force microscopy.
T7 936-1044 Sentence denotes Furthermore, we report that protein components of the parasite rhoptry, dense granule and surface bind GAGs.
T8 1045-1190 Sentence denotes In particular, the proteins ROP2 and ROP4 from the rhoptry, GRA2 from the dense granules and the surface protein SAG1 were found to bind heparin.
T9 1191-1415 Sentence denotes The binding specificities and affinities of individual parasite proteins for natural heparin and heparin oligosaccharides were determined by a combination of heparin oligosaccharide microarrays and surface plasmon resonance.
T10 1416-1792 Sentence denotes Our results suggest that interactions between sulfated GAGs and parasite surface antigens contribute to T. gondii attachment to host cell surfaces as well as initiating the invasion process, while rhoptries and dense granule organelles may play an important role during the establishment of the infection and during the life of the parasite inside the parasitophorous vacuole.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 54-61 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 54-61 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 767-774 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 767-774 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 843-850 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 843-850 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 1182-1189 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 1182-1189 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 1276-1283 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 1276-1283 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 1288-1295 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1288-1295 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 1349-1356 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 1349-1356 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 744-759 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1008-1013 HP_0011088 denotes dense
T2 1119-1124 HP_0011088 denotes dense
T3 1627-1632 HP_0011088 denotes dense

ICD10

Id Subject Object Predicate Lexical cue
T1 118-131 http://purl.bioontology.org/ontology/ICD10/B58.9 denotes toxoplasmosis
T2 118-131 http://purl.bioontology.org/ontology/ICD10/B58 denotes toxoplasmosis

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 28-36 FMAID:165447 denotes proteins
_T2 28-36 FMAID:67257 denotes proteins
_T3 54-61 FMAID:82839 denotes heparin
_T4 54-61 FMAID:167420 denotes heparin
_T5 318-336 FMAID:169004 denotes any nucleated cell
_T6 322-336 FMAID:68647 denotes nucleated cell
_T7 322-336 FMAID:169003 denotes nucleated cell
_T8 322-336 FMAID:67513 denotes nucleated cell
_T9 322-336 FMAID:166084 denotes nucleated cell
_T10 543-555 FMAID:212684 denotes cell surface
_T11 543-555 FMAID:200942 denotes cell surface
_T12 548-555 FMAID:146300 denotes surface
_T13 548-555 FMAID:50594 denotes surface
_T14 653-658 FMAID:68646 denotes cells
_T15 653-658 FMAID:169002 denotes cells
_T16 709-727 FMAID:63011 denotes glycosaminoglycans
_T17 709-727 FMAID:167395 denotes glycosaminoglycans
_T18 729-733 FMAID:167404 denotes GAGs
_T19 744-751 FMAID:67110 denotes heparan
_T20 744-751 FMAID:165191 denotes heparan
_T21 744-759 FMAID:63023 denotes heparan sulfate
_T22 744-759 FMAID:167405 denotes heparan sulfate
_T23 767-774 FMAID:82839 denotes heparin
_T24 767-774 FMAID:167420 denotes heparin
_T25 822-827 FMAID:169002 denotes cells
_T26 822-827 FMAID:68646 denotes cells
_T27 843-850 FMAID:82839 denotes heparin
_T28 843-850 FMAID:167420 denotes heparin
_T29 872-879 FMAID:50594 denotes surface
_T30 872-879 FMAID:146300 denotes surface
_T31 964-971 FMAID:165447 denotes protein
_T32 964-971 FMAID:67257 denotes protein
_T33 964-982 FMAID:210763 denotes protein components
_T34 1022-1033 FMAID:212744 denotes and surface
_T35 1026-1033 FMAID:146300 denotes surface
_T36 1026-1033 FMAID:50594 denotes surface
_T37 1039-1043 FMAID:167404 denotes GAGs
_T38 1064-1072 FMAID:165447 denotes proteins
_T39 1064-1072 FMAID:67257 denotes proteins
_T40 1142-1149 FMAID:146300 denotes surface
_T41 1142-1149 FMAID:50594 denotes surface
_T42 1150-1157 FMAID:165447 denotes protein
_T43 1150-1157 FMAID:67257 denotes protein
_T44 1182-1189 FMAID:82839 denotes heparin
_T45 1182-1189 FMAID:167420 denotes heparin
_T46 1255-1263 FMAID:67257 denotes proteins
_T47 1255-1263 FMAID:165447 denotes proteins
_T48 1276-1283 FMAID:167420 denotes heparin
_T49 1276-1283 FMAID:82839 denotes heparin
_T50 1288-1295 FMAID:82839 denotes heparin
_T51 1288-1295 FMAID:167420 denotes heparin
_T52 1296-1312 FMAID:196731 denotes oligosaccharides
_T53 1296-1312 FMAID:82742 denotes oligosaccharides
_T54 1349-1356 FMAID:82839 denotes heparin
_T55 1349-1356 FMAID:167420 denotes heparin
_T56 1357-1372 FMAID:196731 denotes oligosaccharide
_T57 1357-1372 FMAID:82742 denotes oligosaccharide
_T58 1385-1396 FMAID:212744 denotes and surface
_T59 1389-1396 FMAID:50594 denotes surface
_T60 1389-1396 FMAID:146300 denotes surface
_T61 1471-1475 FMAID:167404 denotes GAGs
_T62 1489-1496 FMAID:146300 denotes surface
_T63 1489-1496 FMAID:50594 denotes surface
_T64 1549-1562 FMAID:212684 denotes cell surfaces
_T65 1549-1562 FMAID:200942 denotes cell surfaces
_T66 1554-1562 FMAID:50594 denotes surfaces
_T67 1554-1562 FMAID:146300 denotes surfaces
_T68 1641-1651 FMAID:162296 denotes organelles
_T69 1641-1651 FMAID:63832 denotes organelles
_T70 1641-1651 FMAID:226763 denotes organelles

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 0-10 http://purl.bioontology.org/ontology/NCBITAXON/241603 denotes Toxoplasma
T2 0-10 http://purl.bioontology.org/ontology/NCBITAXON/5810 denotes Toxoplasma
T3 0-10 http://purl.bioontology.org/ontology/NCBITAXON/152250 denotes Toxoplasma
T4 0-17 http://purl.bioontology.org/ontology/NCBITAXON/5811 denotes Toxoplasma gondii
T5 74-84 http://purl.bioontology.org/ontology/NCBITAXON/152250 denotes Toxoplasma
T6 74-84 http://purl.bioontology.org/ontology/NCBITAXON/241603 denotes Toxoplasma
T7 74-84 http://purl.bioontology.org/ontology/NCBITAXON/5810 denotes Toxoplasma
T8 74-91 http://purl.bioontology.org/ontology/NCBITAXON/5811 denotes Toxoplasma gondii
T9 263-273 http://purl.bioontology.org/ontology/NCBITAXON/152250 denotes Toxoplasma
T10 263-273 http://purl.bioontology.org/ontology/NCBITAXON/241603 denotes Toxoplasma
T11 263-273 http://purl.bioontology.org/ontology/NCBITAXON/5810 denotes Toxoplasma
T12 263-280 http://purl.bioontology.org/ontology/NCBITAXON/5811 denotes Toxoplasma gondii
T13 351-361 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms
T14 393-401 http://purl.bioontology.org/ontology/NCBITAXON/600794 denotes Parasite
T15 653-658 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T16 822-827 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T17 990-998 http://purl.bioontology.org/ontology/NCBITAXON/600794 denotes parasite
T18 1246-1254 http://purl.bioontology.org/ontology/NCBITAXON/600794 denotes parasite
T19 1480-1488 http://purl.bioontology.org/ontology/NCBITAXON/600794 denotes parasite
T20 1748-1756 http://purl.bioontology.org/ontology/NCBITAXON/600794 denotes parasite

GO-BP

Id Subject Object Predicate Lexical cue
T1 45-53 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T2 700-708 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T3 752-759 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T4 393-401 http://purl.obolibrary.org/obo/GO_0072519 denotes Parasite
T5 990-998 http://purl.obolibrary.org/obo/GO_0072519 denotes parasite
T6 1246-1254 http://purl.obolibrary.org/obo/GO_0072519 denotes parasite
T7 1480-1488 http://purl.obolibrary.org/obo/GO_0072519 denotes parasite
T8 1748-1756 http://purl.obolibrary.org/obo/GO_0072519 denotes parasite

GO-MF

Id Subject Object Predicate Lexical cue
T1 28-41 http://purl.obolibrary.org/obo/GO_0005515 denotes proteins bind
T2 37-41 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T3 1034-1038 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T4 851-858 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 1195-1202 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 37-41 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T7 1034-1038 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T8 851-858 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 1195-1202 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T10 37-41 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T11 1034-1038 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T12 851-858 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T13 1195-1202 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T14 37-41 http://purl.obolibrary.org/obo/GO_0005488 denotes bind
T15 1034-1038 http://purl.obolibrary.org/obo/GO_0005488 denotes bind
T16 851-858 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T17 1195-1202 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18 37-53 http://purl.obolibrary.org/obo/GO_0043199 denotes bind to sulfated
T19 538-555 http://purl.obolibrary.org/obo/GO_0046812 denotes host cell surface
T20 1544-1562 http://purl.obolibrary.org/obo/GO_0046812 denotes host cell surfaces
T21 843-858 http://purl.obolibrary.org/obo/GO_0008201 denotes heparin-binding
T22 1182-1202 http://purl.obolibrary.org/obo/GO_0008201 denotes heparin. The binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 332-336 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 425-429 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 543-547 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 653-658 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 822-827 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 420-424 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T7 538-542 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T8 648-652 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T9 817-821 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T10 1544-1548 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T11 420-429 http://purl.obolibrary.org/obo/GO_0043657 denotes host cell
T12 538-547 http://purl.obolibrary.org/obo/GO_0043657 denotes host cell
T13 648-658 http://purl.obolibrary.org/obo/GO_0043657 denotes host cells
T14 817-827 http://purl.obolibrary.org/obo/GO_0043657 denotes host cells
T15 538-555 http://purl.obolibrary.org/obo/GO_0044228 denotes host cell surface
T16 1544-1562 http://purl.obolibrary.org/obo/GO_0044228 denotes host cell surfaces
T17 543-555 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T18 1549-1562 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surfaces
T19 1641-1651 http://purl.obolibrary.org/obo/GO_0043226 denotes organelles
T20 1768-1791 http://purl.obolibrary.org/obo/GO_0020003 denotes parasitophorous vacuole
T21 1784-1791 http://purl.obolibrary.org/obo/GO_0005773 denotes vacuole

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 28-36 http://edamontology.org/topic_0078 denotes proteins
T2 174-180 http://edamontology.org/topic_2815 denotes humans
T3 223-231 http://edamontology.org/topic_0783 denotes pathogen
T4 521-530 http://edamontology.org/topic_2839 denotes molecules
T5 924-934 http://edamontology.org/topic_3382 denotes microscopy
T6 964-971 http://edamontology.org/topic_0078 denotes protein
T7 1064-1072 http://edamontology.org/topic_0078 denotes proteins
T8 1150-1157 http://edamontology.org/topic_0078 denotes protein
T9 1255-1263 http://edamontology.org/topic_0078 denotes proteins
T10 1373-1384 http://edamontology.org/topic_0200 denotes microarrays
T11 1373-1384 http://edamontology.org/topic_3518 denotes microarrays
T12 1441-1453 http://edamontology.org/topic_0602 denotes interactions
T13 1497-1505 http://edamontology.org/topic_2830 denotes antigens
T14 1641-1651 http://edamontology.org/topic_0616 denotes organelles

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 28-36 http://edamontology.org/data_1467 denotes proteins
T2 28-36 http://edamontology.org/format_1208 denotes proteins
T3 62-72 http://edamontology.org/data_0883 denotes structures
T4 223-231 http://edamontology.org/data_3718 denotes pathogen
T5 506-517 http://edamontology.org/operation_2423 denotes recognition
T6 569-577 http://edamontology.org/data_2048 denotes reported
T7 775-789 http://edamontology.org/operation_0004 denotes functionalized
T8 832-842 http://edamontology.org/operation_0337 denotes visualized
T9 952-958 http://edamontology.org/data_2048 denotes report
T10 964-971 http://edamontology.org/data_1467 denotes protein
T11 964-971 http://edamontology.org/format_1208 denotes protein
T12 964-982 http://edamontology.org/operation_2997 denotes protein components
T13 1064-1072 http://edamontology.org/data_1467 denotes proteins
T14 1064-1072 http://edamontology.org/format_1208 denotes proteins
T15 1150-1157 http://edamontology.org/data_1467 denotes protein
T16 1150-1157 http://edamontology.org/format_1208 denotes protein
T17 1255-1263 http://edamontology.org/data_1467 denotes proteins
T18 1255-1263 http://edamontology.org/format_1208 denotes proteins
T19 1598-1605 http://edamontology.org/operation_2409 denotes process
T20 1598-1605 http://edamontology.org/operation_0004 denotes process

Allie

Id Subject Object Predicate Lexical cue
SS1_22997241_4_0 709-727 expanded denotes glycosaminoglycans
SS2_22997241_4_0 729-733 abbr denotes GAGs
AE1_22997241_4_0 SS1_22997241_4_0 SS2_22997241_4_0 abbreviatedTo glycosaminoglycans,GAGs

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 54-61 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T2 767-774 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T3 843-850 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T4 1182-1189 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T5 1276-1283 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T6 1288-1295 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T7 1349-1356 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 744-759 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 118-131 Disease denotes toxoplasmosis http://purl.obolibrary.org/obo/MONDO_0005989
T2 160-173 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T3 1711-1720 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Toxoplasma gondii secretory proteins bind to sulfated heparin structures.
T2 74-262 Sentence denotes Toxoplasma gondii is the causative agent of toxoplasmosis, one of the most widespread infections in humans and animals, and is a major opportunistic pathogen in immunocompromised patients.
T3 263-392 Sentence denotes Toxoplasma gondii is unique as it can invade virtually any nucleated cell, although the mechanisms are not completely understood.
T4 393-556 Sentence denotes Parasite attachment to the host cell is a prerequisite for reorientation and penetration and likely requires the recognition of molecules at the host cell surface.
T5 557-760 Sentence denotes It has been reported that the affinity of tachyzoites, the invasive form of T. gondii, for host cells can be inhibited by a variety of soluble-sulfated glycosaminoglycans (GAGs), such as heparan sulfate.
T6 761-935 Sentence denotes Using heparin-functionalized zeolites in the absence of host cells, we visualized heparin-binding sites on the surface of tachyzoites by confocal and atomic force microscopy.
T7 936-1044 Sentence denotes Furthermore, we report that protein components of the parasite rhoptry, dense granule and surface bind GAGs.
T8 1045-1190 Sentence denotes In particular, the proteins ROP2 and ROP4 from the rhoptry, GRA2 from the dense granules and the surface protein SAG1 were found to bind heparin.
T9 1191-1415 Sentence denotes The binding specificities and affinities of individual parasite proteins for natural heparin and heparin oligosaccharides were determined by a combination of heparin oligosaccharide microarrays and surface plasmon resonance.
T10 1416-1792 Sentence denotes Our results suggest that interactions between sulfated GAGs and parasite surface antigens contribute to T. gondii attachment to host cell surfaces as well as initiating the invasion process, while rhoptries and dense granule organelles may play an important role during the establishment of the infection and during the life of the parasite inside the parasitophorous vacuole.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 118-131 Disease denotes toxoplasmosis MONDO:0005989
T2 160-173 Disease denotes infections in MONDO:0005550
T3 1711-1720 Disease denotes infection MONDO:0005550

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 0-17 Organism denotes Toxoplasma gondii 5811
T2 74-91 Organism denotes Toxoplasma gondii 5811
T3 253-261 Organism denotes patients 9606
T4 263-280 Organism denotes Toxoplasma gondii 5811

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 744-759 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 322-336 Body_part denotes nucleated cell http://purl.obolibrary.org/obo/CL_0002242
T2 1641-1651 Body_part denotes organelles http://purl.obolibrary.org/obo/GO_0043226
T3 1784-1791 Body_part denotes vacuole http://purl.obolibrary.org/obo/GO_0005773

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 322-336 Body_part denotes nucleated cell FMA:67513
T2 543-555 Body_part denotes cell surface FMA:67653
T3 1549-1562 Body_part denotes cell surfaces FMA:67653
T4 1641-1651 Body_part denotes organelles FMA:63832
T5 1784-1791 Body_part denotes vacuole FMA:0326886

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-17 OrganismTaxon denotes Toxoplasma gondii 5811
T2 74-91 OrganismTaxon denotes Toxoplasma gondii 5811
T3 263-280 OrganismTaxon denotes Toxoplasma gondii 5811

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 322-336 Body_part denotes nucleated cell http://purl.obolibrary.org/obo/CL_0002242
T2 1641-1651 Body_part denotes organelles http://purl.obolibrary.org/obo/GO_0043226
T3 1784-1791 Body_part denotes vacuole http://purl.obolibrary.org/obo/GO_0005773

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 322-336 Cell denotes nucleated cell http://purl.obolibrary.org/obo/CL:0002242