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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-76 Sentence denotes Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2.
T2 77-189 Sentence denotes Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common genetic cause of PD (Parkinson's disease).
T3 190-336 Sentence denotes To investigate how mutations in LRRK2 cause PD, we generated LRRK2 mutant mice either lacking its expression or expressing the R1441C mutant form.
T4 337-720 Sentence denotes Homozygous R1441C knockin mice exhibit no dopaminergic neurodegeneration or alterations in steady-state levels of striatal dopamine, but they show impaired dopamine neurotransmission, as was evident from reductions in amphetamine-induced locomotor activity and stimulated catecholamine release in cultured chromaffin cells as well as impaired dopamine D2 receptor-mediated functions.
T5 721-1013 Sentence denotes Whereas LRRK2-/- brains are normal, LRRK2-/- kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy-lysosomal pathway, and increases in apoptotic cell death, inflammatory responses and oxidative damage.
T6 1014-1236 Sentence denotes Our further analysis of LRRK2-/- kidneys at multiple ages revealed unique age-dependent biphasic alterations of the autophagic activity, which is unchanged at 1 month of age, enhanced at 7 months, but reduced at 20 months.
T7 1237-1375 Sentence denotes Levels of α-synuclein and protein carbonyls, a general oxidative damage marker, are also decreased in LRRK2-/- kidneys at 7 months of age.
T8 1376-1565 Sentence denotes Interestingly, this biphasic alteration is associated with increased levels of lysosomal proteins and proteases as well as progressive accumulation of autolysosomes and lipofuscin granules.
T9 1566-1750 Sentence denotes We conclude that pathogenic mutations in LRRK2 impair the nigrostriatal dopaminergic pathway, and LRRK2 plays an essential role in the dynamic regulation of autophagy function in vivo.
T1 0-76 Sentence denotes Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2.
T2 77-189 Sentence denotes Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common genetic cause of PD (Parkinson's disease).
T3 190-336 Sentence denotes To investigate how mutations in LRRK2 cause PD, we generated LRRK2 mutant mice either lacking its expression or expressing the R1441C mutant form.
T4 337-720 Sentence denotes Homozygous R1441C knockin mice exhibit no dopaminergic neurodegeneration or alterations in steady-state levels of striatal dopamine, but they show impaired dopamine neurotransmission, as was evident from reductions in amphetamine-induced locomotor activity and stimulated catecholamine release in cultured chromaffin cells as well as impaired dopamine D2 receptor-mediated functions.
T5 721-1013 Sentence denotes Whereas LRRK2-/- brains are normal, LRRK2-/- kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy-lysosomal pathway, and increases in apoptotic cell death, inflammatory responses and oxidative damage.
T6 1014-1236 Sentence denotes Our further analysis of LRRK2-/- kidneys at multiple ages revealed unique age-dependent biphasic alterations of the autophagic activity, which is unchanged at 1 month of age, enhanced at 7 months, but reduced at 20 months.
T7 1237-1375 Sentence denotes Levels of α-synuclein and protein carbonyls, a general oxidative damage marker, are also decreased in LRRK2-/- kidneys at 7 months of age.
T8 1376-1565 Sentence denotes Interestingly, this biphasic alteration is associated with increased levels of lysosomal proteins and proteases as well as progressive accumulation of autolysosomes and lipofuscin granules.
T9 1566-1750 Sentence denotes We conclude that pathogenic mutations in LRRK2 impair the nigrostriatal dopaminergic pathway, and LRRK2 plays an essential role in the dynamic regulation of autophagy function in vivo.

c_corpus

Id Subject Object Predicate Lexical cue
T5 20-39 D010300 denotes Parkinson's disease
T6 20-39 D010300 denotes Parkinson's disease
T10 47-54 6308 denotes leucine
T11 47-54 SO:0001437 denotes leucine
T9 47-54 CHEBI:15603 denotes leucine
T12 47-54 D007930 denotes leucine
T13 47-54 CHEBI:25017 denotes leucine
T14 47-54 D007930 denotes leucine
T15 60-66 SO:0001068 denotes repeat
T16 90-95 PR:Q5S006 denotes LRRK2
T17 90-95 PR:000003033 denotes LRRK2
T18 90-95 PR:Q5S007 denotes LRRK2
T20 97-104 6308 denotes leucine
T21 97-104 SO:0001437 denotes leucine
T19 97-104 CHEBI:15603 denotes leucine
T22 97-104 D007930 denotes leucine
T23 97-104 CHEBI:25017 denotes leucine
T24 97-104 D007930 denotes leucine
T25 110-116 SO:0001068 denotes repeat
T30 168-187 D010300 denotes Parkinson's disease
T31 168-187 D010300 denotes Parkinson's disease
T34 222-227 PR:Q5S006 denotes LRRK2
T35 222-227 PR:000003033 denotes LRRK2
T36 222-227 PR:Q5S007 denotes LRRK2
T37 251-256 PR:Q5S006 denotes LRRK2
T38 251-256 PR:000003033 denotes LRRK2
T39 251-256 PR:Q5S007 denotes LRRK2
T40 264-268 PR:000005054 denotes mice
T42 264-268 O89094 denotes mice
T41 264-268 D051379 denotes mice
T43 264-268 10095 denotes mice
T44 363-367 PR:000005054 denotes mice
T46 363-367 O89094 denotes mice
T45 363-367 D051379 denotes mice
T47 363-367 10095 denotes mice
T52 460-468 3628 denotes dopamine
T48 460-468 CHEBI:59905 denotes dopamine
T49 460-468 CHEBI:18243 denotes dopamine
T50 460-468 D004298 denotes dopamine
T51 460-468 D004298 denotes dopamine
T57 493-501 3628 denotes dopamine
T53 493-501 CHEBI:59905 denotes dopamine
T54 493-501 CHEBI:18243 denotes dopamine
T55 493-501 D004298 denotes dopamine
T56 493-501 D004298 denotes dopamine
T58 502-519 GO:0007268 denotes neurotransmission
T64 555-566 725 denotes amphetamine
T59 555-566 D000661 denotes amphetamine
T60 555-566 CHEBI:42724 denotes amphetamine
T61 555-566 CHEBI:2679 denotes amphetamine
T62 555-566 D000661 denotes amphetamine
T63 555-566 CHEBI:4469 denotes amphetamine
T65 609-622 CHEBI:33567 denotes catecholamine
T66 643-659 UBERON:0001236 denotes chromaffin cells
T71 680-688 3628 denotes dopamine
T72 680-700 P20288 denotes dopamine D2 receptor
T73 680-700 P52702 denotes dopamine D2 receptor
T74 680-700 P14416 denotes dopamine D2 receptor
T75 680-700 P61169 denotes dopamine D2 receptor
T76 680-700 Q9GJU1 denotes dopamine D2 receptor
T77 680-700 PR:000001177 denotes dopamine D2 receptor
T78 680-700 P61168 denotes dopamine D2 receptor
T79 680-700 Q6TLI9 denotes dopamine D2 receptor
T81 680-700 O73810 denotes dopamine D2 receptor
T82 680-700 P60026 denotes dopamine D2 receptor
T80 680-700 D017448 denotes dopamine D2 receptor
T83 729-734 PR:Q5S006 denotes LRRK2
T84 729-734 PR:000003033 denotes LRRK2
T85 729-734 PR:Q5S007 denotes LRRK2
T86 757-762 PR:Q5S006 denotes LRRK2
T87 757-762 PR:000003033 denotes LRRK2
T88 757-762 PR:Q5S007 denotes LRRK2
T91 845-854 P37379 denotes synuclein
T90 845-854 D051843 denotes synuclein
T92 859-881 D057149 denotes ubiquitinated proteins
T94 901-910 GO:0016236 denotes autophagy
T95 901-910 GO:0006914 denotes autophagy
T96 921-928 CHEBI:34922 denotes pathway
T97 947-967 GO:0006915 denotes apoptotic cell death
T99 1038-1043 PR:Q5S006 denotes LRRK2
T100 1038-1043 PR:000003033 denotes LRRK2
T101 1038-1043 PR:Q5S007 denotes LRRK2
T132 1249-1258 P37379 denotes synuclein
T131 1249-1258 D051843 denotes synuclein
T136 1263-1270 PR:000000001 denotes protein
T133 1263-1270 GO:0003675 denotes protein
T137 1263-1270 SO:0000104 denotes protein
T134 1263-1270 CHEBI:36080 denotes protein
T135 1263-1270 CHEBI:11122 denotes protein
T138 1339-1344 PR:Q5S006 denotes LRRK2
T139 1339-1344 PR:000003033 denotes LRRK2
T140 1339-1344 PR:Q5S007 denotes LRRK2
T143 1455-1473 C018589 denotes lysosomal proteins
T145 1478-1487 D010447 denotes proteases
T146 1545-1555 D008062 denotes lipofuscin
T147 1545-1555 D008062 denotes lipofuscin
T148 1607-1612 PR:Q5S006 denotes LRRK2
T149 1607-1612 PR:000003033 denotes LRRK2
T150 1607-1612 PR:Q5S007 denotes LRRK2
T151 1651-1658 CHEBI:34922 denotes pathway
T152 1664-1669 PR:Q5S006 denotes LRRK2
T153 1664-1669 PR:000003033 denotes LRRK2
T154 1664-1669 PR:Q5S007 denotes LRRK2
T156 1709-1732 GO:0010506 denotes regulation of autophagy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 168-177 HP_0001300 denotes Parkinson
T2 392-409 HP_0002180 denotes neurodegeneration

Allie

Id Subject Object Predicate Lexical cue
SS1_22988862_1_0 97-125 expanded denotes leucine-rich repeat kinase 2
SS2_22988862_1_0 90-95 abbr denotes LRRK2
SS1_22988862_1_1 168-187 expanded denotes Parkinson's disease
SS2_22988862_1_1 164-166 abbr denotes PD
AE1_22988862_1_0 SS1_22988862_1_0 SS2_22988862_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_22988862_1_1 SS1_22988862_1_1 SS2_22988862_1_1 abbreviatedTo Parkinson's disease,PD

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-76 DRI_Unspecified denotes Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2.
T2 77-189 DRI_Approach denotes Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common genetic cause of PD (Parkinson's disease).
T3 190-336 DRI_Approach denotes To investigate how mutations in LRRK2 cause PD, we generated LRRK2 mutant mice either lacking its expression or expressing the R1441C mutant form.
T4 337-720 DRI_Background denotes Homozygous R1441C knockin mice exhibit no dopaminergic neurodegeneration or alterations in steady-state levels of striatal dopamine, but they show impaired dopamine neurotransmission, as was evident from reductions in amphetamine-induced locomotor activity and stimulated catecholamine release in cultured chromaffin cells as well as impaired dopamine D2 receptor-mediated functions.
T5 721-1013 DRI_Background denotes Whereas LRRK2-/- brains are normal, LRRK2-/- kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy-lysosomal pathway, and increases in apoptotic cell death, inflammatory responses and oxidative damage.
T6 1014-1236 DRI_Approach denotes Our further analysis of LRRK2-/- kidneys at multiple ages revealed unique age-dependent biphasic alterations of the autophagic activity, which is unchanged at 1 month of age, enhanced at 7 months, but reduced at 20 months.
T7 1237-1375 DRI_Background denotes Levels of α-synuclein and protein carbonyls, a general oxidative damage marker, are also decreased in LRRK2-/- kidneys at 7 months of age.
T8 1376-1565 DRI_Challenge denotes Interestingly, this biphasic alteration is associated with increased levels of lysosomal proteins and proteases as well as progressive accumulation of autolysosomes and lipofuscin granules.
T9 1566-1750 DRI_Outcome denotes We conclude that pathogenic mutations in LRRK2 impair the nigrostriatal dopaminergic pathway, and LRRK2 plays an essential role in the dynamic regulation of autophagy function in vivo.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 77-189 DRI_Approach denotes Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common genetic cause of PD (Parkinson's disease).
T2 190-336 DRI_Approach denotes To investigate how mutations in LRRK2 cause PD, we generated LRRK2 mutant mice either lacking its expression or expressing the R1441C mutant form.
T3 337-720 DRI_Background denotes Homozygous R1441C knockin mice exhibit no dopaminergic neurodegeneration or alterations in steady-state levels of striatal dopamine, but they show impaired dopamine neurotransmission, as was evident from reductions in amphetamine-induced locomotor activity and stimulated catecholamine release in cultured chromaffin cells as well as impaired dopamine D2 receptor-mediated functions.
T4 721-1013 DRI_Background denotes Whereas LRRK2-/- brains are normal, LRRK2-/- kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy-lysosomal pathway, and increases in apoptotic cell death, inflammatory responses and oxidative damage.
T5 1014-1236 DRI_Approach denotes Our further analysis of LRRK2-/- kidneys at multiple ages revealed unique age-dependent biphasic alterations of the autophagic activity, which is unchanged at 1 month of age, enhanced at 7 months, but reduced at 20 months.
T6 1237-1375 DRI_Background denotes Levels of α-synuclein and protein carbonyls, a general oxidative damage marker, are also decreased in LRRK2-/- kidneys at 7 months of age.
T7 1376-1565 DRI_Challenge denotes Interestingly, this biphasic alteration is associated with increased levels of lysosomal proteins and proteases as well as progressive accumulation of autolysosomes and lipofuscin granules.
T8 1566-1750 DRI_Outcome denotes We conclude that pathogenic mutations in LRRK2 impair the nigrostriatal dopaminergic pathway, and LRRK2 plays an essential role in the dynamic regulation of autophagy function in vivo.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22988862-0#47#75#gene120892 47-75 gene120892 denotes leucine-rich repeat kinase 2
22988862-0#20#39#diseaseC0030567 20-39 diseaseC0030567 denotes Parkinson's disease
47#75#gene12089220#39#diseaseC0030567 22988862-0#47#75#gene120892 22988862-0#20#39#diseaseC0030567 associated_with leucine-rich repeat kinase 2,Parkinson's disease

PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
22988862_0 350-356 ProteinMutation denotes 441C k rs33939927
22988862_1 319-325 ProteinMutation denotes 441C m rs33939927