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PubMed:22987071 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 544-549 gene:55170 denotes PRMT6
T1 801-807 disease:C1306459 denotes cancer
T2 544-549 gene:55170 denotes PRMT6
T3 801-807 disease:C0006826 denotes cancer
T4 544-549 gene:55170 denotes PRMT6
T5 778-782 disease:C0085110 denotes SCID
T6 544-549 gene:55170 denotes PRMT6
T7 744-776 disease:C0085110 denotes severe combined immunodeficiency
T8 544-549 gene:55170 denotes PRMT6
T9 599-612 disease:C0006142 denotes breast cancer
T10 544-549 gene:55170 denotes PRMT6
T11 599-612 disease:C0678222 denotes breast cancer
T12 988-993 gene:55170 denotes PRMT6
T13 1117-1123 disease:C1306459 denotes cancer
T14 988-993 gene:55170 denotes PRMT6
T15 1117-1123 disease:C0006826 denotes cancer
T16 988-993 gene:55170 denotes PRMT6
T17 1017-1030 disease:C0678222 denotes breast cancer
T18 988-993 gene:55170 denotes PRMT6
T19 1017-1030 disease:C0006142 denotes breast cancer
R1 T0 T1 associated_with PRMT6,cancer
R2 T2 T3 associated_with PRMT6,cancer
R3 T4 T5 associated_with PRMT6,SCID
R4 T6 T7 associated_with PRMT6,severe combined immunodeficiency
R5 T8 T9 associated_with PRMT6,breast cancer
R6 T10 T11 associated_with PRMT6,breast cancer
R7 T12 T13 associated_with PRMT6,cancer
R8 T14 T15 associated_with PRMT6,cancer
R9 T16 T17 associated_with PRMT6,breast cancer
R10 T18 T19 associated_with PRMT6,breast cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 271-277 HP_0002664 denotes tumour
T2 348-355 HP_0002664 denotes tumours
T3 367-380 HP_0003002 denotes breast cancer
T4 367-380 HP_0100013 denotes breast cancer
T5 374-380 HP_0002664 denotes cancer
T6 599-612 HP_0003002 denotes breast cancer
T7 599-612 HP_0100013 denotes breast cancer
T8 606-612 HP_0002664 denotes cancer
T9 744-776 HP_0004430 denotes severe combined immunodeficiency
T10 751-776 HP_0005387 denotes combined immunodeficiency
T11 760-776 HP_0002721 denotes immunodeficiency
T12 801-807 HP_0002664 denotes cancer
T13 1017-1030 HP_0003002 denotes breast cancer
T14 1017-1030 HP_0100013 denotes breast cancer
T15 1024-1030 HP_0002664 denotes cancer
T16 1117-1123 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_22987071_3_0 403-439 expanded denotes protein arginine methyltransferase 6
SS2_22987071_3_0 441-446 abbr denotes PRMT6
SS1_22987071_4_0 550-560 expanded denotes knock-down
SS2_22987071_4_0 562-564 abbr denotes KD
SS1_22987071_4_1 744-776 expanded denotes severe combined immunodeficiency
SS2_22987071_4_1 778-782 abbr denotes SCID
AE1_22987071_3_0 SS1_22987071_3_0 SS2_22987071_3_0 abbreviatedTo protein arginine methyltransferase 6,PRMT6
AE1_22987071_4_0 SS1_22987071_4_0 SS2_22987071_4_0 abbreviatedTo knock-down,KD
AE1_22987071_4_1 SS1_22987071_4_1 SS2_22987071_4_1 abbreviatedTo severe combined immunodeficiency,SCID

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22987071-4#0#5#gene55170 544-549 gene55170 denotes PRMT6
22987071-4#200#232#diseaseC0085110 744-776 diseaseC0085110 denotes severe combined immunodeficiency
22987071-4#234#238#diseaseC0085110 778-782 diseaseC0085110 denotes SCID
22987071-6#17#22#gene55170 988-993 gene55170 denotes PRMT6
22987071-6#46#59#diseaseC0006142 1017-1030 diseaseC0006142 denotes breast cancer
22987071-6#46#59#diseaseC0678222 1017-1030 diseaseC0678222 denotes breast cancer
0#5#gene55170200#232#diseaseC0085110 22987071-4#0#5#gene55170 22987071-4#200#232#diseaseC0085110 associated_with PRMT6,severe combined immunodeficiency
0#5#gene55170234#238#diseaseC0085110 22987071-4#0#5#gene55170 22987071-4#234#238#diseaseC0085110 associated_with PRMT6,SCID
17#22#gene5517046#59#diseaseC0006142 22987071-6#17#22#gene55170 22987071-6#46#59#diseaseC0006142 associated_with PRMT6,breast cancer
17#22#gene5517046#59#diseaseC0678222 22987071-6#17#22#gene55170 22987071-6#46#59#diseaseC0678222 associated_with PRMT6,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2509 988-993 gene:55170 denotes PRMT6
T2510 1017-1030 disease:C0006142 denotes breast cancer
R1 T2509 T2510 associated_with PRMT6,breast cancer
R2 T2509 T2510 associated_with PRMT6,breast cancer

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-78 Sentence denotes p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
TextSentencer_T2 79-205 Sentence denotes p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence.
TextSentencer_T3 206-381 Sentence denotes Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulated in the majority of tumours, including breast cancer.
TextSentencer_T4 382-543 Sentence denotes Here, we report that protein arginine methyltransferase 6 (PRMT6), a type I PRMT known to act as a transcriptional cofactor, directly represses the p21 promoter.
TextSentencer_T5 544-823 Sentence denotes PRMT6 knock-down (KD) results in a p21 derepression in breast cancer cells, which is p53-independent, and leads to cell cycle arrest, cellular senescence and reduced growth in soft agar assays and in severe combined immunodeficiency (SCID) mice for all the cancer lines examined.
TextSentencer_T6 824-970 Sentence denotes We finally show that bypassing the p21-mediated arrest rescues PRMT6 KD cells from senescence, and it restores their ability to grow on soft agar.
TextSentencer_T7 971-1132 Sentence denotes We conclude that PRMT6 acts as an oncogene in breast cancer cells, promoting growth and preventing senescence, making it an attractive target for cancer therapy.
T1 0-78 Sentence denotes p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
T2 79-205 Sentence denotes p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence.
T3 206-381 Sentence denotes Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulated in the majority of tumours, including breast cancer.
T4 382-543 Sentence denotes Here, we report that protein arginine methyltransferase 6 (PRMT6), a type I PRMT known to act as a transcriptional cofactor, directly represses the p21 promoter.
T5 544-823 Sentence denotes PRMT6 knock-down (KD) results in a p21 derepression in breast cancer cells, which is p53-independent, and leads to cell cycle arrest, cellular senescence and reduced growth in soft agar assays and in severe combined immunodeficiency (SCID) mice for all the cancer lines examined.
T6 824-970 Sentence denotes We finally show that bypassing the p21-mediated arrest rescues PRMT6 KD cells from senescence, and it restores their ability to grow on soft agar.
T7 971-1132 Sentence denotes We conclude that PRMT6 acts as an oncogene in breast cancer cells, promoting growth and preventing senescence, making it an attractive target for cancer therapy.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 367-373 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 599-605 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 1017-1023 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 367-373 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 599-605 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 1017-1023 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast