PubMed:22970411 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/22970411","sourcedb":"PubMed","sourceid":"22970411","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/22970411","text":"Parkinson's disease: leucine-rich repeat kinase 2 and autophagy, intimate enemies.\nParkinson's disease is the second common neurodegenerative disorder, after Alzheimer's disease. It is a clinical syndrome characterized by loss of dopamine-generating cells in the substancia nigra, a region of the midbrain. The etiology of Parkinson's disease has long been through to involve both genetic and environmental factors. Mutations in the leucine-rich repeat kinase 2 gene cause late-onset Parkinson's disease with a clinical appearance indistinguishable from Parkinson's disease idiopathic. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damage proteins and cytoplasmic organelles. This degradative process has been associated with cellular dysfunction in neurodegenerative processes including Parkinson's disease. We discuss the role of leucine-rich repeat kinase 2 in autophagy, and how the deregulations of this degradative mechanism in cells can be implicated in the Parkinson's disease etiology.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":83,"end":92},"obj":"HP_0001300"},{"id":"T2","span":{"begin":158,"end":177},"obj":"HP_0002511"},{"id":"T3","span":{"begin":323,"end":332},"obj":"HP_0001300"},{"id":"T4","span":{"begin":484,"end":493},"obj":"HP_0001300"},{"id":"T5","span":{"begin":554,"end":563},"obj":"HP_0001300"},{"id":"T6","span":{"begin":828,"end":837},"obj":"HP_0001300"},{"id":"T7","span":{"begin":1005,"end":1014},"obj":"HP_0001300"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93ecb1","default":true}]}]}}