PubMed:22868358 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/22868358","sourcedb":"PubMed","sourceid":"22868358","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/22868358","text":"Posthepatectomy HBV reactivation in hepatitis B-related hepatocellular carcinoma influences postoperative survival in patients with preoperative low HBV-DNA levels.\nOBJECTIVE: This study aimed to clarify the incidence of hepatitis B virus (HBV) reactivation and its significance on long-term survival after partial hepatectomy in patients with HBV-related hepatocellular carcinoma (HCC), who had preoperative low HBV-DNA level of less than 2000 IU/mL.\nBACKGROUND: HBV reactivation is a frequent complication of systemic chemotherapy in hepatitis B surface antigen-positive patients. Surgery and anesthesia result in a generalized state of immunosuppression in the immediate postoperative period. Data on HBV reactivation and its significance after partial hepatectomy are unclear.\nPATIENTS AND METHODS: Consecutive patients from January 2006 to December 2007 were retrospectively studied.\nRESULTS: HBV reactivation happened in 19.1% of patients in 1 year. There were 28 patients whose HBV reactivation was detected after the diagnosis of HCC recurrence. On multivariate analysis, hepatitis B e antigen (HBeAg) positivity, preoperative HBV-DNA above the lower limit of quantification (≥200 IU/mL), Ishak inflammation score of greater than 3, preoperative transarterial chemoembolization (TACE), operation time of more than 180 minutes, blood transfusion, and without prophylactic antiviral therapy were significantly associated with an increased risk of HBV reactivation. HBV reactivation negatively influenced postoperative hepatic functions. The posthepatectomy liver failure rate in patients with HBV reactivation was significantly higher than in those without reactivation (11.8% vs 6.4%; P = 0.002). The 3-year disease-free survival (DFS) rate and overall survival (OS) rates after resection in patients with HBV reactivation were significantly lower than those without reactivation (34.1% vs 46.0%; P = 0.009, and 51.6% vs 67.2%; P \u003c 0.001, respectively). HBeAg positivity, detectable preoperative HBV-DNA level, high Ishak inflammation score, preoperative TACE, long operation time, and blood transfusion were independent risk factors for HBV reactivation, whereas prophylactic antiviral therapy was a protective factor. HBV reactivation, HBeAg positivity, HBV-DNA level of 200 IU/mL or more, tumor diameter greater than 5 cm, presence of satellite nodules, presence of portal vein tumor thrombus, blood transfusion, and resection margin less than 1.0 cm were independent risk factors for DFS. A HBV-DNA level of 200 IU/mL or more, an Ishak fibrosis score of 4 or greater, a tumor diameter greater than 5 cm, the presence of satellite nodules, the presence of portal vein tumor thrombus, a resection margin less than 1.0 cm, no prophylactic antiviral therapy, and HBV reactivation were independent risk factors for OS.\nCONCLUSIONS: HBV reactivation was common after partial hepatectomy for HBV-related HCC with a preoperative low HBV-DNA level of less than 2000 IU/mL. Routine prophylactic antiviral treatment should be given before partial hepatectomy.","tracks":[{"project":"LitCoin-PubTator-for-Tuning","denotations":[{"id":"5","span":{"begin":16,"end":19},"obj":"OrganismTaxon"},{"id":"6","span":{"begin":36,"end":45},"obj":"OrganismTaxon"},{"id":"7","span":{"begin":56,"end":80},"obj":"DiseaseOrPhenotypicFeature"},{"id":"8","span":{"begin":118,"end":126},"obj":"OrganismTaxon"},{"id":"9","span":{"begin":149,"end":152},"obj":"OrganismTaxon"},{"id":"51","span":{"begin":221,"end":238},"obj":"OrganismTaxon"},{"id":"52","span":{"begin":240,"end":243},"obj":"OrganismTaxon"},{"id":"53","span":{"begin":330,"end":338},"obj":"OrganismTaxon"},{"id":"54","span":{"begin":344,"end":347},"obj":"OrganismTaxon"},{"id":"55","span":{"begin":356,"end":380},"obj":"DiseaseOrPhenotypicFeature"},{"id":"56","span":{"begin":413,"end":416},"obj":"OrganismTaxon"},{"id":"57","span":{"begin":464,"end":467},"obj":"OrganismTaxon"},{"id":"58","span":{"begin":536,"end":545},"obj":"OrganismTaxon"},{"id":"59","span":{"begin":573,"end":581},"obj":"OrganismTaxon"},{"id":"60","span":{"begin":704,"end":707},"obj":"OrganismTaxon"},{"id":"61","span":{"begin":781,"end":789},"obj":"OrganismTaxon"},{"id":"62","span":{"begin":815,"end":823},"obj":"OrganismTaxon"},{"id":"63","span":{"begin":898,"end":901},"obj":"OrganismTaxon"},{"id":"64","span":{"begin":936,"end":944},"obj":"OrganismTaxon"},{"id":"65","span":{"begin":970,"end":978},"obj":"OrganismTaxon"},{"id":"66","span":{"begin":985,"end":988},"obj":"OrganismTaxon"},{"id":"67","span":{"begin":1080,"end":1109},"obj":"GeneOrGeneProduct"},{"id":"68","span":{"begin":1135,"end":1138},"obj":"OrganismTaxon"},{"id":"69","span":{"begin":1203,"end":1215},"obj":"DiseaseOrPhenotypicFeature"},{"id":"70","span":{"begin":1453,"end":1456},"obj":"OrganismTaxon"},{"id":"71","span":{"begin":1471,"end":1474},"obj":"OrganismTaxon"},{"id":"72","span":{"begin":1563,"end":1576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"73","span":{"begin":1585,"end":1593},"obj":"OrganismTaxon"},{"id":"74","span":{"begin":1599,"end":1602},"obj":"OrganismTaxon"},{"id":"75","span":{"begin":1799,"end":1807},"obj":"OrganismTaxon"},{"id":"76","span":{"begin":1813,"end":1816},"obj":"OrganismTaxon"},{"id":"77","span":{"begin":2003,"end":2006},"obj":"OrganismTaxon"},{"id":"78","span":{"begin":2029,"end":2041},"obj":"DiseaseOrPhenotypicFeature"},{"id":"79","span":{"begin":2145,"end":2148},"obj":"OrganismTaxon"},{"id":"80","span":{"begin":2227,"end":2230},"obj":"OrganismTaxon"},{"id":"81","span":{"begin":2263,"end":2266},"obj":"OrganismTaxon"},{"id":"82","span":{"begin":2299,"end":2304},"obj":"DiseaseOrPhenotypicFeature"},{"id":"83","span":{"begin":2383,"end":2402},"obj":"DiseaseOrPhenotypicFeature"},{"id":"84","span":{"begin":2502,"end":2505},"obj":"OrganismTaxon"},{"id":"85","span":{"begin":2547,"end":2555},"obj":"DiseaseOrPhenotypicFeature"},{"id":"86","span":{"begin":2581,"end":2586},"obj":"DiseaseOrPhenotypicFeature"},{"id":"87","span":{"begin":2673,"end":2692},"obj":"DiseaseOrPhenotypicFeature"},{"id":"88","span":{"begin":2770,"end":2773},"obj":"OrganismTaxon"},{"id":"89","span":{"begin":2838,"end":2841},"obj":"OrganismTaxon"},{"id":"90","span":{"begin":2896,"end":2899},"obj":"OrganismTaxon"},{"id":"91","span":{"begin":2936,"end":2939},"obj":"OrganismTaxon"}],"attributes":[{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"MESH:D007249"},{"id":"A83","pred":"tao:has_database_id","subj":"83","obj":"MESH:D013927"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"MESH:D013927"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"Tax:10407"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"Tax:10407"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"Tax:10407"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"Tax:10407"},{"id":"A9","pred":"tao:has_database_id","subj":"9","obj":"Tax:10407"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Tax:9606"},{"id":"A8","pred":"tao:has_database_id","subj":"8","obj":"Tax:9606"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:10407"},{"id":"A7","pred":"tao:has_database_id","subj":"7","obj":"MESH:D006528"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"Tax:10407"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:9606"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"Tax:10407"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Tax:10407"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Tax:10407"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"Tax:9606"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"Tax:10407"},{"id":"A6","pred":"tao:has_database_id","subj":"6","obj":"Tax:10407"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"Tax:9606"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"Tax:10407"},{"id":"A86","pred":"tao:has_database_id","subj":"86","obj":"MESH:D009369"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"Tax:10407"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:10407"},{"id":"A76","pred":"tao:has_database_id","subj":"76","obj":"Tax:10407"},{"id":"A85","pred":"tao:has_database_id","subj":"85","obj":"MESH:D005355"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"Gene:944568"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"Tax:9606"},{"id":"A79","pred":"tao:has_database_id","subj":"79","obj":"Tax:10407"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:10407"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"Tax:9606"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"MESH:D006528"},{"id":"A84","pred":"tao:has_database_id","subj":"84","obj":"Tax:10407"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"Tax:10407"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Tax:9606"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"Tax:9606"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Tax:10407"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"Tax:10407"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:D017093"},{"id":"A78","pred":"tao:has_database_id","subj":"78","obj":"MESH:D007249"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"MESH:D009369"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Tax:10407"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Tax:10407"},{"id":"A77","pred":"tao:has_database_id","subj":"77","obj":"Tax:10407"},{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"Tax:10407"},{"subj":"5","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"6","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"7","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"8","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"9","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"51","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"52","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"53","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"54","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"55","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"56","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"57","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"58","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"59","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"60","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"61","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"62","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"63","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"64","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"65","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"66","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"67","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"68","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"69","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"70","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"71","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"72","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"73","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"74","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"75","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"76","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"77","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"78","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"79","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"80","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"81","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"82","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"83","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"84","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"85","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"86","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"87","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"88","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"89","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"90","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"91","pred":"source","obj":"LitCoin-PubTator-for-Tuning"}]},{"project":"LitCoin-Disease-Tuning-1","denotations":[{"id":"T1","span":{"begin":36,"end":47},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":56,"end":80},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":221,"end":232},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":356,"end":380},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":382,"end":385},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":536,"end":547},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1038,"end":1041},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1042,"end":1052},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1080,"end":1091},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1203,"end":1215},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1563,"end":1576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1715,"end":1722},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":2029,"end":2041},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T18","span":{"begin":2299,"end":2304},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19","span":{"begin":2388,"end":2393},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T20","span":{"begin":2394,"end":2402},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21","span":{"begin":2427,"end":2443},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22","span":{"begin":2547,"end":2555},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T23","span":{"begin":2581,"end":2586},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T24","span":{"begin":2678,"end":2683},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T25","span":{"begin":2684,"end":2692},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T26","span":{"begin":2696,"end":2712},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T27","span":{"begin":2908,"end":2911},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"ID:","subj":"T4","obj":"D006528"},{"id":"A24","pred":"ID:","subj":"T24","obj":"D009369"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D006509"},{"id":"A5","pred":"ID:","subj":"T5","obj":"DISEASE"},{"id":"A6","pred":"ID:","subj":"T5","obj":"D006528"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D004194"},{"id":"A26","pred":"ID:","subj":"T26","obj":"D000072662"},{"id":"A27","pred":"ID:","subj":"T27","obj":"DISEASE"},{"id":"A28","pred":"ID:","subj":"T27","obj":"D006528"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D012008"},{"id":"A8","pred":"ID:","subj":"T8","obj":"DISEASE"},{"id":"A9","pred":"ID:","subj":"T8","obj":"D006528"},{"id":"A12","pred":"ID:","subj":"T12","obj":"DISEASE"},{"id":"A13","pred":"ID:","subj":"T12","obj":"D007249"},{"id":"A19","pred":"ID:","subj":"T19","obj":"D009369"},{"id":"A16","pred":"ID:","subj":"T16","obj":"DISEASE"},{"id":"A17","pred":"ID:","subj":"T16","obj":"D007249"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D006509"},{"id":"A20","pred":"ID:","subj":"T20","obj":"D013927"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D017093"},{"id":"A23","pred":"ID:","subj":"T23","obj":"D009369"},{"id":"A18","pred":"ID:","subj":"T18","obj":"D009369"},{"id":"A25","pred":"ID:","subj":"T25","obj":"D013927"},{"id":"A22","pred":"ID:","subj":"T22","obj":"D005355"},{"id":"A21","pred":"ID:","subj":"T21","obj":"D000072662"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D006509"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D006509"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D006528"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T10","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T11","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T12","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T14","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T15","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T16","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T18","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T19","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T20","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T21","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T22","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T23","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T24","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T25","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T26","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T27","pred":"source","obj":"LitCoin-Disease-Tuning-1"}]},{"project":"LitEisuke","denotations":[{"id":"T1","span":{"begin":36,"end":47},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":56,"end":80},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":221,"end":232},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":356,"end":380},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":382,"end":385},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":536,"end":547},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1038,"end":1041},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1080,"end":1091},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1203,"end":1215},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1563,"end":1576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":2029,"end":2041},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":2299,"end":2304},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":2388,"end":2393},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":2394,"end":2402},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":2427,"end":2443},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T18","span":{"begin":2547,"end":2555},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19","span":{"begin":2581,"end":2586},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T20","span":{"begin":2678,"end":2683},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21","span":{"begin":2684,"end":2692},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22","span":{"begin":2696,"end":2712},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T23","span":{"begin":2908,"end":2911},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D006509"},{"id":"A2","pred":"#label","subj":"T2","obj":"D006528"},{"id":"A3","pred":"#label","subj":"T3","obj":"D006509"},{"id":"A4","pred":"#label","subj":"T4","obj":"D006528"},{"id":"A5","pred":"#label","subj":"T5","obj":"DISEASE"},{"id":"A6","pred":"#label","subj":"T5","obj":"D006528"},{"id":"A7","pred":"#label","subj":"T7","obj":"D006509"},{"id":"A8","pred":"#label","subj":"T8","obj":"DISEASE"},{"id":"A9","pred":"#label","subj":"T8","obj":"D006528"},{"id":"A10","pred":"#label","subj":"T10","obj":"D006509"},{"id":"A11","pred":"#label","subj":"T11","obj":"D007249"},{"id":"A12","pred":"#label","subj":"T12","obj":"D017093"},{"id":"A13","pred":"#label","subj":"T13","obj":"D007249"},{"id":"A14","pred":"#label","subj":"T14","obj":"D009369"},{"id":"A15","pred":"#label","subj":"T15","obj":"D009369"},{"id":"A16","pred":"#label","subj":"T16","obj":"D013927"},{"id":"A17","pred":"#label","subj":"T17","obj":"D000072662"},{"id":"A18","pred":"#label","subj":"T18","obj":"D005355"},{"id":"A19","pred":"#label","subj":"T19","obj":"D009369"},{"id":"A20","pred":"#label","subj":"T20","obj":"D009369"},{"id":"A21","pred":"#label","subj":"T21","obj":"D013927"},{"id":"A22","pred":"#label","subj":"T22","obj":"D000072662"},{"id":"A23","pred":"#label","subj":"T23","obj":"DISEASE"},{"id":"A24","pred":"#label","subj":"T23","obj":"D006528"},{"subj":"T1","pred":"source","obj":"LitEisuke"},{"subj":"T2","pred":"source","obj":"LitEisuke"},{"subj":"T3","pred":"source","obj":"LitEisuke"},{"subj":"T4","pred":"source","obj":"LitEisuke"},{"subj":"T5","pred":"source","obj":"LitEisuke"},{"subj":"T7","pred":"source","obj":"LitEisuke"},{"subj":"T8","pred":"source","obj":"LitEisuke"},{"subj":"T10","pred":"source","obj":"LitEisuke"},{"subj":"T11","pred":"source","obj":"LitEisuke"},{"subj":"T12","pred":"source","obj":"LitEisuke"},{"subj":"T13","pred":"source","obj":"LitEisuke"},{"subj":"T14","pred":"source","obj":"LitEisuke"},{"subj":"T15","pred":"source","obj":"LitEisuke"},{"subj":"T16","pred":"source","obj":"LitEisuke"},{"subj":"T17","pred":"source","obj":"LitEisuke"},{"subj":"T18","pred":"source","obj":"LitEisuke"},{"subj":"T19","pred":"source","obj":"LitEisuke"},{"subj":"T20","pred":"source","obj":"LitEisuke"},{"subj":"T21","pred":"source","obj":"LitEisuke"},{"subj":"T22","pred":"source","obj":"LitEisuke"},{"subj":"T23","pred":"source","obj":"LitEisuke"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":164},"obj":"Sentence"},{"id":"T2","span":{"begin":165,"end":175},"obj":"Sentence"},{"id":"T3","span":{"begin":176,"end":451},"obj":"Sentence"},{"id":"T4","span":{"begin":452,"end":582},"obj":"Sentence"},{"id":"T5","span":{"begin":583,"end":695},"obj":"Sentence"},{"id":"T6","span":{"begin":696,"end":780},"obj":"Sentence"},{"id":"T7","span":{"begin":781,"end":802},"obj":"Sentence"},{"id":"T8","span":{"begin":803,"end":888},"obj":"Sentence"},{"id":"T9","span":{"begin":889,"end":955},"obj":"Sentence"},{"id":"T10","span":{"begin":956,"end":1053},"obj":"Sentence"},{"id":"T11","span":{"begin":1054,"end":1470},"obj":"Sentence"},{"id":"T12","span":{"begin":1471,"end":1542},"obj":"Sentence"},{"id":"T13","span":{"begin":1543,"end":1703},"obj":"Sentence"},{"id":"T14","span":{"begin":1704,"end":1960},"obj":"Sentence"},{"id":"T15","span":{"begin":1961,"end":2226},"obj":"Sentence"},{"id":"T16","span":{"begin":2227,"end":2499},"obj":"Sentence"},{"id":"T17","span":{"begin":2500,"end":2824},"obj":"Sentence"},{"id":"T18","span":{"begin":2825,"end":2974},"obj":"Sentence"},{"id":"T19","span":{"begin":2975,"end":3059},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":164},"obj":"Sentence"},{"id":"T2","span":{"begin":165,"end":175},"obj":"Sentence"},{"id":"T3","span":{"begin":176,"end":451},"obj":"Sentence"},{"id":"T4","span":{"begin":452,"end":582},"obj":"Sentence"},{"id":"T5","span":{"begin":583,"end":695},"obj":"Sentence"},{"id":"T6","span":{"begin":696,"end":780},"obj":"Sentence"},{"id":"T7","span":{"begin":781,"end":802},"obj":"Sentence"},{"id":"T8","span":{"begin":803,"end":888},"obj":"Sentence"},{"id":"T9","span":{"begin":889,"end":955},"obj":"Sentence"},{"id":"T10","span":{"begin":956,"end":1053},"obj":"Sentence"},{"id":"T11","span":{"begin":1054,"end":1470},"obj":"Sentence"},{"id":"T12","span":{"begin":1471,"end":1542},"obj":"Sentence"},{"id":"T13","span":{"begin":1543,"end":1703},"obj":"Sentence"},{"id":"T14","span":{"begin":1704,"end":1960},"obj":"Sentence"},{"id":"T15","span":{"begin":1961,"end":2226},"obj":"Sentence"},{"id":"T16","span":{"begin":2227,"end":2499},"obj":"Sentence"},{"id":"T17","span":{"begin":2500,"end":2824},"obj":"Sentence"},{"id":"T18","span":{"begin":2825,"end":2974},"obj":"Sentence"},{"id":"T19","span":{"begin":2975,"end":3059},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T16","pred":"source","obj":"Inflammaging"},{"subj":"T17","pred":"source","obj":"Inflammaging"},{"subj":"T18","pred":"source","obj":"Inflammaging"},{"subj":"T19","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T16","pred":"source","obj":"Inflammaging"},{"subj":"T17","pred":"source","obj":"Inflammaging"},{"subj":"T18","pred":"source","obj":"Inflammaging"},{"subj":"T19","pred":"source","obj":"Inflammaging"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":356,"end":380},"obj":"HP_0001402"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"Allie","denotations":[{"id":"SS1_22868358_2_0","span":{"begin":221,"end":238},"obj":"expanded"},{"id":"SS2_22868358_2_0","span":{"begin":240,"end":243},"obj":"abbr"},{"id":"SS1_22868358_2_1","span":{"begin":356,"end":380},"obj":"expanded"},{"id":"SS2_22868358_2_1","span":{"begin":382,"end":385},"obj":"abbr"},{"id":"SS1_22868358_12_0","span":{"begin":1080,"end":1101},"obj":"expanded"},{"id":"SS2_22868358_12_0","span":{"begin":1103,"end":1108},"obj":"abbr"},{"id":"SS1_22868358_12_1","span":{"begin":1254,"end":1285},"obj":"expanded"},{"id":"SS2_22868358_12_1","span":{"begin":1287,"end":1291},"obj":"abbr"},{"id":"SS1_22868358_15_0","span":{"begin":1715,"end":1736},"obj":"expanded"},{"id":"SS2_22868358_15_0","span":{"begin":1738,"end":1741},"obj":"abbr"},{"id":"SS1_22868358_15_1","span":{"begin":1752,"end":1768},"obj":"expanded"},{"id":"SS2_22868358_15_1","span":{"begin":1770,"end":1772},"obj":"abbr"}],"relations":[{"id":"AE1_22868358_2_0","pred":"abbreviatedTo","subj":"SS1_22868358_2_0","obj":"SS2_22868358_2_0"},{"id":"AE1_22868358_2_1","pred":"abbreviatedTo","subj":"SS1_22868358_2_1","obj":"SS2_22868358_2_1"},{"id":"AE1_22868358_12_0","pred":"abbreviatedTo","subj":"SS1_22868358_12_0","obj":"SS2_22868358_12_0"},{"id":"AE1_22868358_12_1","pred":"abbreviatedTo","subj":"SS1_22868358_12_1","obj":"SS2_22868358_12_1"},{"id":"AE1_22868358_15_0","pred":"abbreviatedTo","subj":"SS1_22868358_15_0","obj":"SS2_22868358_15_0"},{"id":"AE1_22868358_15_1","pred":"abbreviatedTo","subj":"SS1_22868358_15_1","obj":"SS2_22868358_15_1"}],"attributes":[{"subj":"SS1_22868358_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_22868358_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_22868358_2_1","pred":"source","obj":"Allie"},{"subj":"SS2_22868358_2_1","pred":"source","obj":"Allie"},{"subj":"SS1_22868358_12_0","pred":"source","obj":"Allie"},{"subj":"SS2_22868358_12_0","pred":"source","obj":"Allie"},{"subj":"SS1_22868358_12_1","pred":"source","obj":"Allie"},{"subj":"SS2_22868358_12_1","pred":"source","obj":"Allie"},{"subj":"SS1_22868358_15_0","pred":"source","obj":"Allie"},{"subj":"SS2_22868358_15_0","pred":"source","obj":"Allie"},{"subj":"SS1_22868358_15_1","pred":"source","obj":"Allie"},{"subj":"SS2_22868358_15_1","pred":"source","obj":"Allie"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-PubTator-for-Tuning","color":"#da93ec","default":true},{"id":"LitCoin-Disease-Tuning-1","color":"#93ecc0"},{"id":"LitEisuke","color":"#eca693"},{"id":"Inflammaging","color":"#9399ec"},{"id":"PubmedHPO","color":"#b3ec93"},{"id":"Allie","color":"#ec93cd"}]}]}}