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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-162 Sentence denotes Gender and the treatment of immune-mediated chronic inflammatory diseases: rheumatoid arthritis, inflammatory bowel disease and psoriasis: an observational study.
T2 163-174 Sentence denotes BACKGROUND:
T3 175-384 Sentence denotes Rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis are immune-mediated inflammatory diseases with similarities in pathophysiology, and all can be treated with similar biological agents.
T4 385-583 Sentence denotes Previous studies have shown that there are gender differences with regard to disease characteristics in RA and IBD, with women generally having worse scores on pain and quality of life measurements.
T5 584-629 Sentence denotes The relationship is less clear for psoriasis.
T6 630-852 Sentence denotes Because treatment differences between men and women could explain the dissimilarities, we investigated gender differences in the disease characteristics before treatment initiation and in the biologic treatment prescribed.
T7 853-861 Sentence denotes METHODS:
T8 862-994 Sentence denotes Data on patients with RA or IBD were collected from two registries in which patients treated with biologic medication were enrolled.
T9 995-1136 Sentence denotes Basic demographic data and disease activity parameters were collected from a time point just before the initiation of the biologic treatment.
T10 1137-1315 Sentence denotes For patients with psoriasis, the data were taken from the 2010 annual report of the Swedish Psoriasis Register for systemic treatment, which included also non-biologic treatment.
T11 1316-1429 Sentence denotes For all three diseases, the prescribed treatment and disease characteristics were compared between men and women.
T12 1430-1438 Sentence denotes RESULTS:
T13 1439-1550 Sentence denotes In total, 4493 adult patients were included in the study (1912 with RA, 131 with IBD, and 2450 with psoriasis).
T14 1551-1660 Sentence denotes Most of the treated patients with RA were women, whereas most of the patients with IBD or psoriasis were men.
T15 1661-1748 Sentence denotes There were no significant differences between men and women in the choice of biologics.
T16 1749-1934 Sentence denotes At treatment start, significant gender differences were seen in the subjective disease measurements for both RA and psoriasis, with women having higher (that is, worse) scores than men.
T17 1935-2092 Sentence denotes No differences in objective measurements were found for RA, but for psoriasis men had higher (that is, worse) scores for objective disease activity measures.
T18 2093-2131 Sentence denotes A similar trend to RA was seen in IBD.
T19 2132-2144 Sentence denotes CONCLUSIONS:
T20 2145-2308 Sentence denotes Women with RA or psoriasis scored significantly higher on subjective, but not on objective, disease activity measures than men, and the same trend was seen in IBD.
T21 2309-2403 Sentence denotes This indicates that at the same level of treatment, the disease has a greater effect in women.
T22 2404-2610 Sentence denotes These findings might suggest that in all three diseases, subjective measures are discounted to some extent in the therapeutic decision-making process, which could indicate undertreatment in female patients.
T1 0-162 Sentence denotes Gender and the treatment of immune-mediated chronic inflammatory diseases: rheumatoid arthritis, inflammatory bowel disease and psoriasis: an observational study.
T2 163-174 Sentence denotes BACKGROUND:
T3 175-384 Sentence denotes Rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis are immune-mediated inflammatory diseases with similarities in pathophysiology, and all can be treated with similar biological agents.
T4 385-583 Sentence denotes Previous studies have shown that there are gender differences with regard to disease characteristics in RA and IBD, with women generally having worse scores on pain and quality of life measurements.
T5 584-629 Sentence denotes The relationship is less clear for psoriasis.
T6 630-852 Sentence denotes Because treatment differences between men and women could explain the dissimilarities, we investigated gender differences in the disease characteristics before treatment initiation and in the biologic treatment prescribed.
T7 853-861 Sentence denotes METHODS:
T8 862-994 Sentence denotes Data on patients with RA or IBD were collected from two registries in which patients treated with biologic medication were enrolled.
T9 995-1136 Sentence denotes Basic demographic data and disease activity parameters were collected from a time point just before the initiation of the biologic treatment.
T10 1137-1315 Sentence denotes For patients with psoriasis, the data were taken from the 2010 annual report of the Swedish Psoriasis Register for systemic treatment, which included also non-biologic treatment.
T11 1316-1429 Sentence denotes For all three diseases, the prescribed treatment and disease characteristics were compared between men and women.
T12 1430-1438 Sentence denotes RESULTS:
T13 1439-1550 Sentence denotes In total, 4493 adult patients were included in the study (1912 with RA, 131 with IBD, and 2450 with psoriasis).
T14 1551-1660 Sentence denotes Most of the treated patients with RA were women, whereas most of the patients with IBD or psoriasis were men.
T15 1661-1748 Sentence denotes There were no significant differences between men and women in the choice of biologics.
T16 1749-1934 Sentence denotes At treatment start, significant gender differences were seen in the subjective disease measurements for both RA and psoriasis, with women having higher (that is, worse) scores than men.
T17 1935-2092 Sentence denotes No differences in objective measurements were found for RA, but for psoriasis men had higher (that is, worse) scores for objective disease activity measures.
T18 2093-2131 Sentence denotes A similar trend to RA was seen in IBD.
T19 2132-2144 Sentence denotes CONCLUSIONS:
T20 2145-2308 Sentence denotes Women with RA or psoriasis scored significantly higher on subjective, but not on objective, disease activity measures than men, and the same trend was seen in IBD.
T21 2309-2403 Sentence denotes This indicates that at the same level of treatment, the disease has a greater effect in women.
T22 2404-2610 Sentence denotes These findings might suggest that in all three diseases, subjective measures are discounted to some extent in the therapeutic decision-making process, which could indicate undertreatment in female patients.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 175-195 HP_0001370 denotes Rheumatoid arthritis
T2 186-195 HP_0001369 denotes arthritis
T3 240-249 HP_0003765 denotes psoriasis
T4 545-549 HP_0012531 denotes pain
T5 619-628 HP_0003765 denotes psoriasis

Allie

Id Subject Object Predicate Lexical cue
SS1_22853635_2_0 175-195 expanded denotes Rheumatoid arthritis
SS2_22853635_2_0 197-199 abbr denotes RA
SS1_22853635_2_1 202-228 expanded denotes inflammatory bowel disease
SS2_22853635_2_1 230-233 abbr denotes IBD
AE1_22853635_2_0 SS1_22853635_2_0 SS2_22853635_2_0 abbreviatedTo Rheumatoid arthritis,RA
AE1_22853635_2_1 SS1_22853635_2_1 SS2_22853635_2_1 abbreviatedTo inflammatory bowel disease,IBD