PubMed:22836123 JSONTXT

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    LitCoin-entities-OrganismTaxon-PD

    {"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":11,"end":22},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":91,"end":102},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:68787"},{"id":"A2","pred":"db_id","subj":"T1","obj":"NCBItxid:386268"},{"id":"A3","pred":"db_id","subj":"T3","obj":"NCBItxid:68787"},{"id":"A4","pred":"db_id","subj":"T3","obj":"NCBItxid:386268"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-sentences

    {"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"T2","span":{"begin":91,"end":258},"obj":"Sentence"},{"id":"T3","span":{"begin":259,"end":345},"obj":"Sentence"},{"id":"T4","span":{"begin":346,"end":463},"obj":"Sentence"},{"id":"T5","span":{"begin":464,"end":552},"obj":"Sentence"},{"id":"T6","span":{"begin":553,"end":646},"obj":"Sentence"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-entities

    {"project":"LitCoin-entities","denotations":[{"id":"9070","span":{"begin":11,"end":35},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9071","span":{"begin":47,"end":57},"obj":"ChemicalEntity"},{"id":"9072","span":{"begin":62,"end":74},"obj":"ChemicalEntity"},{"id":"9073","span":{"begin":91,"end":115},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9074","span":{"begin":117,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9075","span":{"begin":148,"end":166},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9076","span":{"begin":168,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9077","span":{"begin":281,"end":295},"obj":"ChemicalEntity"},{"id":"9078","span":{"begin":341,"end":344},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9079","span":{"begin":386,"end":412},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9080","span":{"begin":429,"end":441},"obj":"ChemicalEntity"},{"id":"9081","span":{"begin":445,"end":453},"obj":"OrganismTaxon"},{"id":"9082","span":{"begin":459,"end":462},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9083","span":{"begin":493,"end":500},"obj":"OrganismTaxon"},{"id":"9084","span":{"begin":506,"end":509},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9085","span":{"begin":521,"end":531},"obj":"ChemicalEntity"},{"id":"9086","span":{"begin":536,"end":551},"obj":"ChemicalEntity"},{"id":"9087","span":{"begin":610,"end":620},"obj":"ChemicalEntity"},{"id":"9088","span":{"begin":628,"end":636},"obj":"OrganismTaxon"},{"id":"9089","span":{"begin":642,"end":645},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"db_id","subj":"9070","obj":"MESH:D007674"},{"id":"A2","pred":"db_id","subj":"9071","obj":"MESH:D016559"},{"id":"A3","pred":"db_id","subj":"9072","obj":"MESH:D011239"},{"id":"A4","pred":"db_id","subj":"9073","obj":"MESH:D007674"},{"id":"A5","pred":"db_id","subj":"9074","obj":"MESH:D007674"},{"id":"A6","pred":"db_id","subj":"9075","obj":"MESH:D012595"},{"id":"A7","pred":"db_id","subj":"9076","obj":"MESH:D012595"},{"id":"A8","pred":"db_id","subj":"9077","obj":"MESH:D000305"},{"id":"A9","pred":"db_id","subj":"9078","obj":"MESH:D007674"},{"id":"A10","pred":"db_id","subj":"9079","obj":"MESH:D057049"},{"id":"A11","pred":"db_id","subj":"9080","obj":"MESH:D016572"},{"id":"A12","pred":"db_id","subj":"9081","obj":"NCBITaxon:9606"},{"id":"A13","pred":"db_id","subj":"9082","obj":"MESH:D012595"},{"id":"A14","pred":"db_id","subj":"9083","obj":"NCBITaxon:9606"},{"id":"A15","pred":"db_id","subj":"9084","obj":"MESH:D007674"},{"id":"A16","pred":"db_id","subj":"9085","obj":"MESH:D016559"},{"id":"A17","pred":"db_id","subj":"9086","obj":"MESH:D000305"},{"id":"A18","pred":"db_id","subj":"9087","obj":"MESH:D016559"},{"id":"A19","pred":"db_id","subj":"9088","obj":"NCBITaxon:9606"},{"id":"A20","pred":"db_id","subj":"9089","obj":"MESH:D012595"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin_Mondo

    {"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":11,"end":22},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":91,"end":102},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":127,"end":131},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":148,"end":166},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":386,"end":412},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0019340"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0019340"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0021136"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005100"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0019737"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-GeneOrGeneProduct-v0

    {"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":36,"end":43},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":78,"end":82},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":116,"end":126},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":127,"end":131},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":271,"end":275},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":319,"end":324},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":330,"end":336},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":510,"end":517},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":580,"end":584},"obj":"GeneOrGeneProduct"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-GeneOrGeneProduct-v2

    {"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":127,"end":131},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":271,"end":275},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":319,"end":324},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":330,"end":336},"obj":"GeneOrGeneProduct"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-Disease-MeSH

    {"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":148,"end":166},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":168,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":386,"end":412},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":459,"end":462},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":642,"end":645},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D012595"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D012595"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D057049"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D012595"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D012595"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin_Mondo_095

    {"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":11,"end":22},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":91,"end":102},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":148,"end":166},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":168,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":177,"end":180},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":386,"end":412},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":459,"end":462},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":642,"end":645},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005100"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0019737"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005100"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0005100"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0012833"},{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0019340"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0019340"},{"id":"A3","pred":"mondo_id","subj":"T2","obj":"0005100"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005100"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-MeSH-Disease-2

    {"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":11,"end":35},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":91,"end":115},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":117,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":148,"end":166},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":168,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":341,"end":344},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":386,"end":412},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":459,"end":462},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":506,"end":509},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":642,"end":645},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"ID:","subj":"T5","obj":"D012595"},{"id":"A3","pred":"ID:","subj":"T3","obj":"DISEASE"},{"id":"A1","pred":"ID:","subj":"T1","obj":"DISEASE"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D012595"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D012595"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D012595"},{"id":"A9","pred":"ID:","subj":"T9","obj":"DISEASE"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D057049"},{"id":"A2","pred":"ID:","subj":"T2","obj":"DISEASE"},{"id":"A6","pred":"ID:","subj":"T6","obj":"DISEASE"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-MONDO_bioort2019

    {"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":11,"end":35},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":91,"end":115},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":117,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":148,"end":166},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":168,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":341,"end":344},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":386,"end":412},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":459,"end":462},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":506,"end":509},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":642,"end":645},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"DISEASE"},{"id":"A6","pred":"#label","subj":"T6","obj":"DISEASE"},{"id":"A3","pred":"#label","subj":"T3","obj":"DISEASE"},{"id":"A8","pred":"#label","subj":"T8","obj":"D012595"},{"id":"A10","pred":"#label","subj":"T10","obj":"D012595"},{"id":"A5","pred":"#label","subj":"T5","obj":"D012595"},{"id":"A9","pred":"#label","subj":"T9","obj":"DISEASE"},{"id":"A2","pred":"#label","subj":"T2","obj":"DISEASE"},{"id":"A4","pred":"#label","subj":"T4","obj":"D012595"},{"id":"A7","pred":"#label","subj":"T7","obj":"D057049"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-Chemical-MeSH-CHEBI

    {"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":47,"end":57},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":62,"end":74},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":281,"end":295},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":429,"end":441},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":521,"end":531},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":536,"end":551},"obj":"ChemicalEntity"},{"id":"T14","span":{"begin":610,"end":620},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D016559"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_61057"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_61049"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D011239"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_8378"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D000305"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A8","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_4031"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D016559"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_61057"},{"id":"A11","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_61049"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D000305"},{"id":"A13","pred":"ID:","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D016559"},{"id":"A15","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_61057"},{"id":"A16","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_61049"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-NCBITaxon-2

    {"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":11,"end":22},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":91,"end":102},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":445,"end":453},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":493,"end":500},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":628,"end":636},"obj":"OrganismTaxon"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    LitCoin-training-merged

    {"project":"LitCoin-training-merged","denotations":[{"id":"T14","span":{"begin":610,"end":620},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":536,"end":551},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":521,"end":531},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":429,"end":441},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":281,"end":295},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":62,"end":74},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":47,"end":57},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":642,"end":645},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9746","span":{"begin":506,"end":509},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T20814","span":{"begin":459,"end":462},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":386,"end":412},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4561","span":{"begin":341,"end":344},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":168,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T83229","span":{"begin":148,"end":166},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":117,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":91,"end":115},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17304","span":{"begin":11,"end":35},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13329","span":{"begin":628,"end":636},"obj":"OrganismTaxon"},{"id":"T20158","span":{"begin":493,"end":500},"obj":"OrganismTaxon"},{"id":"T79533","span":{"begin":445,"end":453},"obj":"OrganismTaxon"},{"id":"T23171","span":{"begin":91,"end":102},"obj":"OrganismTaxon"},{"id":"T51670","span":{"begin":11,"end":22},"obj":"OrganismTaxon"}],"attributes":[{"id":"A16","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_61049"},{"id":"A15","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_61057"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D016559"},{"id":"A13","pred":"ID:","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D000305"},{"id":"A11","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_61049"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_61057"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D016559"},{"id":"A8","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_4031"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D000305"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_8378"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D011239"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_61049"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_61057"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D016559"},{"id":"A79605","pred":"#label","subj":"T10","obj":"D012595"},{"id":"A46831","pred":"#label","subj":"T9746","obj":"DISEASE"},{"id":"A84640","pred":"#label","subj":"T20814","obj":"D012595"},{"id":"A16372","pred":"#label","subj":"T7","obj":"D057049"},{"id":"A4510","pred":"#label","subj":"T4561","obj":"DISEASE"},{"id":"A73916","pred":"#label","subj":"T5","obj":"D012595"},{"id":"A44638","pred":"#label","subj":"T83229","obj":"D012595"},{"id":"A10431","pred":"#label","subj":"T3","obj":"DISEASE"},{"id":"A98569","pred":"#label","subj":"T2","obj":"DISEASE"},{"id":"A32993","pred":"#label","subj":"T17304","obj":"DISEASE"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    sentences

    {"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":91,"end":258},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":259,"end":345},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":346,"end":463},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":464,"end":552},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":553,"end":646},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"T2","span":{"begin":91,"end":258},"obj":"Sentence"},{"id":"T3","span":{"begin":259,"end":345},"obj":"Sentence"},{"id":"T4","span":{"begin":346,"end":463},"obj":"Sentence"},{"id":"T5","span":{"begin":464,"end":552},"obj":"Sentence"},{"id":"T6","span":{"begin":553,"end":646},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    PubmedHPO

    {"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":91,"end":102},"obj":"HP_0100324"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    PubCasesHPO

    {"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":91,"end":102},"obj":"HP:0100324"},{"id":"TI1","span":{"begin":11,"end":22},"obj":"HP:0100324"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}

    PubCasesORDO

    {"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":148,"end":166},"obj":"ORDO:90291"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"text":"Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.\nScleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc."}