PubMed:22824559 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":95,"end":112},"obj":"HP_0001067"},{"id":"T2","span":{"begin":139,"end":160},"obj":"HP_0100634"},{"id":"T3","span":{"begin":154,"end":160},"obj":"HP_0002664"},{"id":"T4","span":{"begin":328,"end":345},"obj":"HP_0001410"},{"id":"T5","span":{"begin":481,"end":486},"obj":"HP_0002664"},{"id":"T6","span":{"begin":551,"end":556},"obj":"HP_0002664"},{"id":"T7","span":{"begin":642,"end":647},"obj":"HP_0002664"},{"id":"T8","span":{"begin":749,"end":765},"obj":"HP_0002894"},{"id":"T9","span":{"begin":760,"end":765},"obj":"HP_0002664"},{"id":"T10","span":{"begin":811,"end":816},"obj":"HP_0002664"},{"id":"T11","span":{"begin":907,"end":912},"obj":"HP_0002664"},{"id":"T12","span":{"begin":1059,"end":1064},"obj":"HP_0002664"},{"id":"T13","span":{"begin":1092,"end":1097},"obj":"HP_0002664"}],"text":"A case of pancreatic neuroendocrine tumor in a patient with neurofibromatosis-1.\nPatients with neurofibromatosis-1 (NF-1) sometime develop neuroendocrine tumors (NET). Although these NETs usually occur in the duodenum or peri-ampullary region, they occasionally grow in the pancreas (PNET). A 62-year-old man with NF-1 had mild liver dysfunction and was admitted to our hospital for further examination. An abdominal contrast-enhanced computed tomography scan demonstrated a 30-mm tumor in the head of the pancreas. The scan showed an invasion of the tumor into the duodenum, and biopsy under an endoscopic ultrasonography indicated that the tumor was a NET. A subtotal stomach-preserving pancreaticoduodenectomy was performed. Macroscopically, the pancreatic tumor was white and elastic hard. Microscopically, tumor cells were composed of ribbons, cords, and solid nests with an acinus-like structure. The tumor was diagnosed as NET G2 according to the WHO classification (2010). The product of the NF-1 gene, i.e., neurofibromin, was weakly positive in the tumor cells, suggesting that the tumor was induced by a mutation in the NF-1 gene. This is the seventh case of PNET arising in NF-1 patients worldwide."}

{"project":"Allie","denotations":[{"id":"SS1_22824559_1_0","span":{"begin":95,"end":114},"obj":"expanded"},{"id":"SS2_22824559_1_0","span":{"begin":116,"end":120},"obj":"abbr"},{"id":"SS1_22824559_1_1","span":{"begin":139,"end":160},"obj":"expanded"},{"id":"SS2_22824559_1_1","span":{"begin":162,"end":165},"obj":"abbr"}],"relations":[{"id":"AE1_22824559_1_0","pred":"abbreviatedTo","subj":"SS1_22824559_1_0","obj":"SS2_22824559_1_0"},{"id":"AE1_22824559_1_1","pred":"abbreviatedTo","subj":"SS1_22824559_1_1","obj":"SS2_22824559_1_1"}],"text":"A case of pancreatic neuroendocrine tumor in a patient with neurofibromatosis-1.\nPatients with neurofibromatosis-1 (NF-1) sometime develop neuroendocrine tumors (NET). Although these NETs usually occur in the duodenum or peri-ampullary region, they occasionally grow in the pancreas (PNET). A 62-year-old man with NF-1 had mild liver dysfunction and was admitted to our hospital for further examination. An abdominal contrast-enhanced computed tomography scan demonstrated a 30-mm tumor in the head of the pancreas. The scan showed an invasion of the tumor into the duodenum, and biopsy under an endoscopic ultrasonography indicated that the tumor was a NET. A subtotal stomach-preserving pancreaticoduodenectomy was performed. Macroscopically, the pancreatic tumor was white and elastic hard. Microscopically, tumor cells were composed of ribbons, cords, and solid nests with an acinus-like structure. The tumor was diagnosed as NET G2 according to the WHO classification (2010). The product of the NF-1 gene, i.e., neurofibromin, was weakly positive in the tumor cells, suggesting that the tumor was induced by a mutation in the NF-1 gene. This is the seventh case of PNET arising in NF-1 patients worldwide."}