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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-82 Sentence denotes Subcellular localization of ERGIC-53 under endoplasmic reticulum stress condition.
TextSentencer_T2 83-237 Sentence denotes Newly synthesized glycoproteins destined for secretion are transported from the endoplasmic reticulum (ER), through the Golgi and toward the cell surface.
TextSentencer_T3 238-357 Sentence denotes In this secretion pathway, several intracellular ER- or Golgi-resident transmembrane proteins serve as cargo receptors.
TextSentencer_T4 358-570 Sentence denotes ER-Golgi intermediate compartment (ERGIC)-53, VIP36 and VIPL, which have an L-type lectin domain within the luminal portion, participate in the vectorial transport of glycoproteins via sugar-protein interactions.
TextSentencer_T5 571-753 Sentence denotes To understand the nature of these receptors, monoclonal antibodies were generated against human ERGIC-53, VIP36 and VIPL using 293T cells expressing these receptors on cell surfaces.
TextSentencer_T6 754-837 Sentence denotes These cells were used to immunize rats and for screening antibody-producing clones.
TextSentencer_T7 838-998 Sentence denotes Flow cytometric analysis and immunoprecipitation studies showed that the obtained monoclonal antibodies bound specifically to the corresponding cargo receptors.
TextSentencer_T8 999-1263 Sentence denotes Immunostaining of HeLa cells using the monoclonal antibodies showed that the localization of ERGIC-53 changed from relatively broad distribution in both the ER and the Golgi under normal conditions to a compact distribution in the Golgi under ER stress conditions.
TextSentencer_T9 1264-1391 Sentence denotes This redistribution was also observed by the overexpression of ERGIC-53 and abrogated by co-expression with VIPL but not VIP36.
TextSentencer_T10 1392-1581 Sentence denotes Real-time polymerase chain reaction revealed that ERGIC-53 along with several chaperone proteins was up-regulated after tunicamycin treatment; however, the expression of VIPL was unchanged.
TextSentencer_T11 1582-1765 Sentence denotes Furthermore, ERGIC-53 co-precipitated with VIPL but not VIP36, indicating that ERGIC-53 may interact with VIPL in the ER, which may regulate the localization of ERGIC-53 inside cells.
TextSentencer_T12 1766-1921 Sentence denotes Taken together, these observations provide new insights into the regulation of these cargo receptors and the quality control of glycoproteins within cells.
T1 0-82 Sentence denotes Subcellular localization of ERGIC-53 under endoplasmic reticulum stress condition.
T2 83-237 Sentence denotes Newly synthesized glycoproteins destined for secretion are transported from the endoplasmic reticulum (ER), through the Golgi and toward the cell surface.
T3 238-357 Sentence denotes In this secretion pathway, several intracellular ER- or Golgi-resident transmembrane proteins serve as cargo receptors.
T4 358-570 Sentence denotes ER-Golgi intermediate compartment (ERGIC)-53, VIP36 and VIPL, which have an L-type lectin domain within the luminal portion, participate in the vectorial transport of glycoproteins via sugar-protein interactions.
T5 571-753 Sentence denotes To understand the nature of these receptors, monoclonal antibodies were generated against human ERGIC-53, VIP36 and VIPL using 293T cells expressing these receptors on cell surfaces.
T6 754-837 Sentence denotes These cells were used to immunize rats and for screening antibody-producing clones.
T7 838-998 Sentence denotes Flow cytometric analysis and immunoprecipitation studies showed that the obtained monoclonal antibodies bound specifically to the corresponding cargo receptors.
T8 999-1263 Sentence denotes Immunostaining of HeLa cells using the monoclonal antibodies showed that the localization of ERGIC-53 changed from relatively broad distribution in both the ER and the Golgi under normal conditions to a compact distribution in the Golgi under ER stress conditions.
T9 1264-1391 Sentence denotes This redistribution was also observed by the overexpression of ERGIC-53 and abrogated by co-expression with VIPL but not VIP36.
T10 1392-1581 Sentence denotes Real-time polymerase chain reaction revealed that ERGIC-53 along with several chaperone proteins was up-regulated after tunicamycin treatment; however, the expression of VIPL was unchanged.
T11 1582-1765 Sentence denotes Furthermore, ERGIC-53 co-precipitated with VIPL but not VIP36, indicating that ERGIC-53 may interact with VIPL in the ER, which may regulate the localization of ERGIC-53 inside cells.
T12 1766-1921 Sentence denotes Taken together, these observations provide new insights into the regulation of these cargo receptors and the quality control of glycoproteins within cells.
T1 0-82 Sentence denotes Subcellular localization of ERGIC-53 under endoplasmic reticulum stress condition.
T2 83-237 Sentence denotes Newly synthesized glycoproteins destined for secretion are transported from the endoplasmic reticulum (ER), through the Golgi and toward the cell surface.
T3 238-357 Sentence denotes In this secretion pathway, several intracellular ER- or Golgi-resident transmembrane proteins serve as cargo receptors.
T4 358-570 Sentence denotes ER-Golgi intermediate compartment (ERGIC)-53, VIP36 and VIPL, which have an L-type lectin domain within the luminal portion, participate in the vectorial transport of glycoproteins via sugar-protein interactions.
T5 571-753 Sentence denotes To understand the nature of these receptors, monoclonal antibodies were generated against human ERGIC-53, VIP36 and VIPL using 293T cells expressing these receptors on cell surfaces.
T6 754-837 Sentence denotes These cells were used to immunize rats and for screening antibody-producing clones.
T7 838-998 Sentence denotes Flow cytometric analysis and immunoprecipitation studies showed that the obtained monoclonal antibodies bound specifically to the corresponding cargo receptors.
T8 999-1263 Sentence denotes Immunostaining of HeLa cells using the monoclonal antibodies showed that the localization of ERGIC-53 changed from relatively broad distribution in both the ER and the Golgi under normal conditions to a compact distribution in the Golgi under ER stress conditions.
T9 1264-1391 Sentence denotes This redistribution was also observed by the overexpression of ERGIC-53 and abrogated by co-expression with VIPL but not VIP36.
T10 1392-1581 Sentence denotes Real-time polymerase chain reaction revealed that ERGIC-53 along with several chaperone proteins was up-regulated after tunicamycin treatment; however, the expression of VIPL was unchanged.
T11 1582-1765 Sentence denotes Furthermore, ERGIC-53 co-precipitated with VIPL but not VIP36, indicating that ERGIC-53 may interact with VIPL in the ER, which may regulate the localization of ERGIC-53 inside cells.
T12 1766-1921 Sentence denotes Taken together, these observations provide new insights into the regulation of these cargo receptors and the quality control of glycoproteins within cells.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 43-54 FMAID:165003 denotes endoplasmic
_T2 43-54 FMAID:66856 denotes endoplasmic
_T3 43-64 FMAID:165027 denotes endoplasmic reticulum
_T4 43-64 FMAID:188464 denotes endoplasmic reticulum
_T5 43-64 FMAID:67434 denotes endoplasmic reticulum
_T6 43-64 FMAID:165144 denotes endoplasmic reticulum
_T7 43-64 FMAID:66897 denotes endoplasmic reticulum
_T8 43-64 FMAID:165026 denotes endoplasmic reticulum
_T9 43-64 FMAID:210694 denotes endoplasmic reticulum
_T10 43-64 FMAID:211269 denotes endoplasmic reticulum
_T11 43-64 FMAID:80351 denotes endoplasmic reticulum
_T12 43-64 FMAID:66898 denotes endoplasmic reticulum
_T13 43-64 FMAID:162308 denotes endoplasmic reticulum
_T14 43-64 FMAID:67438 denotes endoplasmic reticulum
_T15 43-64 FMAID:212510 denotes endoplasmic reticulum
_T16 43-64 FMAID:165141 denotes endoplasmic reticulum
_T17 43-64 FMAID:199093 denotes endoplasmic reticulum
_T18 43-64 FMAID:210679 denotes endoplasmic reticulum
_T19 43-64 FMAID:165250 denotes endoplasmic reticulum
_T20 43-64 FMAID:67429 denotes endoplasmic reticulum
_T21 43-64 FMAID:165142 denotes endoplasmic reticulum
_T22 43-64 FMAID:63842 denotes endoplasmic reticulum
_T23 55-64 FMAID:7646 denotes reticulum
_T24 55-64 FMAID:94520 denotes reticulum
_T25 101-114 FMAID:167256 denotes glycoproteins
_T26 101-114 FMAID:62925 denotes glycoproteins
_T27 163-174 FMAID:165003 denotes endoplasmic
_T28 163-174 FMAID:66856 denotes endoplasmic
_T29 163-184 FMAID:199093 denotes endoplasmic reticulum
_T30 163-184 FMAID:162308 denotes endoplasmic reticulum
_T31 163-184 FMAID:67434 denotes endoplasmic reticulum
_T32 163-184 FMAID:212510 denotes endoplasmic reticulum
_T33 163-184 FMAID:67438 denotes endoplasmic reticulum
_T34 163-184 FMAID:165142 denotes endoplasmic reticulum
_T35 163-184 FMAID:67429 denotes endoplasmic reticulum
_T36 163-184 FMAID:165250 denotes endoplasmic reticulum
_T37 163-184 FMAID:210679 denotes endoplasmic reticulum
_T38 163-184 FMAID:63842 denotes endoplasmic reticulum
_T39 163-184 FMAID:66898 denotes endoplasmic reticulum
_T40 163-184 FMAID:211269 denotes endoplasmic reticulum
_T41 163-184 FMAID:165027 denotes endoplasmic reticulum
_T42 163-184 FMAID:210694 denotes endoplasmic reticulum
_T43 163-184 FMAID:66897 denotes endoplasmic reticulum
_T44 163-184 FMAID:165144 denotes endoplasmic reticulum
_T45 163-184 FMAID:165026 denotes endoplasmic reticulum
_T46 163-184 FMAID:188464 denotes endoplasmic reticulum
_T47 163-184 FMAID:165141 denotes endoplasmic reticulum
_T48 163-184 FMAID:80351 denotes endoplasmic reticulum
_T49 175-184 FMAID:7646 denotes reticulum
_T50 175-184 FMAID:94520 denotes reticulum
_T51 224-236 FMAID:212684 denotes cell surface
_T52 224-236 FMAID:200942 denotes cell surface
_T53 229-236 FMAID:50594 denotes surface
_T54 229-236 FMAID:146300 denotes surface
_T55 309-331 FMAID:89997 denotes transmembrane proteins
_T56 309-331 FMAID:198530 denotes transmembrane proteins
_T57 309-331 FMAID:198531 denotes transmembrane proteins
_T58 309-331 FMAID:67858 denotes transmembrane proteins
_T59 323-331 FMAID:165447 denotes proteins
_T60 323-331 FMAID:67257 denotes proteins
_T61 367-379 FMAID:74531 denotes intermediate
_T62 367-379 FMAID:179268 denotes intermediate
_T63 367-391 FMAID:147014 denotes intermediate compartment
_T64 367-391 FMAID:51285 denotes intermediate compartment
_T65 380-391 FMAID:183399 denotes compartment
_T66 380-391 FMAID:183854 denotes compartment
_T67 380-391 FMAID:76700 denotes compartment
_T68 466-473 FMAID:179287 denotes luminal
_T69 466-473 FMAID:74550 denotes luminal
_T70 525-538 FMAID:62925 denotes glycoproteins
_T71 525-538 FMAID:167256 denotes glycoproteins
_T72 543-548 FMAID:196724 denotes sugar
_T73 549-556 FMAID:165447 denotes protein
_T74 549-556 FMAID:67257 denotes protein
_T75 627-637 FMAID:167180 denotes antibodies
_T76 703-708 FMAID:68646 denotes cells
_T77 703-708 FMAID:169002 denotes cells
_T78 739-752 FMAID:200942 denotes cell surfaces
_T79 739-752 FMAID:212684 denotes cell surfaces
_T80 744-752 FMAID:50594 denotes surfaces
_T81 744-752 FMAID:146300 denotes surfaces
_T82 760-765 FMAID:68646 denotes cells
_T83 760-765 FMAID:169002 denotes cells
_T84 811-819 FMAID:167180 denotes antibody
_T85 931-941 FMAID:167180 denotes antibodies
_T86 1022-1027 FMAID:68646 denotes cells
_T87 1022-1027 FMAID:169002 denotes cells
_T88 1049-1059 FMAID:167180 denotes antibodies
_T89 1480-1488 FMAID:67257 denotes proteins
_T90 1480-1488 FMAID:165447 denotes proteins
_T91 1759-1764 FMAID:68646 denotes cells
_T92 1759-1764 FMAID:169002 denotes cells
_T93 1894-1907 FMAID:62925 denotes glycoproteins
_T94 1894-1907 FMAID:167256 denotes glycoproteins
_T95 1915-1920 FMAID:68646 denotes cells
_T96 1915-1920 FMAID:169002 denotes cells

uniprot-human

Id Subject Object Predicate Lexical cue
T1 28-36 http://www.uniprot.org/uniprot/Q9UQG6 denotes ERGIC-53
T2 667-675 http://www.uniprot.org/uniprot/Q9UQG6 denotes ERGIC-53
T3 1092-1100 http://www.uniprot.org/uniprot/Q9UQG6 denotes ERGIC-53
T4 1327-1335 http://www.uniprot.org/uniprot/Q9UQG6 denotes ERGIC-53
T5 1442-1450 http://www.uniprot.org/uniprot/Q9UQG6 denotes ERGIC-53
T6 1595-1603 http://www.uniprot.org/uniprot/Q9UQG6 denotes ERGIC-53
T7 1661-1669 http://www.uniprot.org/uniprot/Q9UQG6 denotes ERGIC-53
T8 1743-1751 http://www.uniprot.org/uniprot/Q9UQG6 denotes ERGIC-53
T9 186-188 http://www.uniprot.org/uniprot/P03372 denotes ER
T10 287-289 http://www.uniprot.org/uniprot/P03372 denotes ER
T11 358-360 http://www.uniprot.org/uniprot/P03372 denotes ER
T12 1156-1158 http://www.uniprot.org/uniprot/P03372 denotes ER
T13 1242-1244 http://www.uniprot.org/uniprot/P03372 denotes ER
T14 1700-1702 http://www.uniprot.org/uniprot/P03372 denotes ER
T15 404-409 http://www.uniprot.org/uniprot/Q12907 denotes VIP36
T16 677-682 http://www.uniprot.org/uniprot/Q12907 denotes VIP36
T17 1385-1390 http://www.uniprot.org/uniprot/Q12907 denotes VIP36
T18 1638-1643 http://www.uniprot.org/uniprot/Q12907 denotes VIP36
T19 414-418 http://www.uniprot.org/uniprot/Q9H0V9 denotes VIPL
T20 687-691 http://www.uniprot.org/uniprot/Q9H0V9 denotes VIPL
T21 1372-1376 http://www.uniprot.org/uniprot/Q9H0V9 denotes VIPL
T22 1562-1566 http://www.uniprot.org/uniprot/Q9H0V9 denotes VIPL
T23 1625-1629 http://www.uniprot.org/uniprot/Q9H0V9 denotes VIPL
T24 1688-1692 http://www.uniprot.org/uniprot/Q9H0V9 denotes VIPL
T25 726-752 http://www.uniprot.org/uniprot/Q9UKJ1 denotes receptors on cell surfaces
T26 726-752 http://www.uniprot.org/uniprot/Q9UKJ0 denotes receptors on cell surfaces

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 28-36 http://www.uniprot.org/uniprot/Q9D0F3 denotes ERGIC-53
T2 667-675 http://www.uniprot.org/uniprot/Q9D0F3 denotes ERGIC-53
T3 1092-1100 http://www.uniprot.org/uniprot/Q9D0F3 denotes ERGIC-53
T4 1327-1335 http://www.uniprot.org/uniprot/Q9D0F3 denotes ERGIC-53
T5 1442-1450 http://www.uniprot.org/uniprot/Q9D0F3 denotes ERGIC-53
T6 1595-1603 http://www.uniprot.org/uniprot/Q9D0F3 denotes ERGIC-53
T7 1661-1669 http://www.uniprot.org/uniprot/Q9D0F3 denotes ERGIC-53
T8 1743-1751 http://www.uniprot.org/uniprot/Q9D0F3 denotes ERGIC-53
T9 186-188 http://www.uniprot.org/uniprot/P19785 denotes ER
T10 287-289 http://www.uniprot.org/uniprot/P19785 denotes ER
T11 358-360 http://www.uniprot.org/uniprot/P19785 denotes ER
T12 1156-1158 http://www.uniprot.org/uniprot/P19785 denotes ER
T13 1242-1244 http://www.uniprot.org/uniprot/P19785 denotes ER
T14 1700-1702 http://www.uniprot.org/uniprot/P19785 denotes ER
T15 404-409 http://www.uniprot.org/uniprot/Q9DBH5 denotes VIP36
T16 677-682 http://www.uniprot.org/uniprot/Q9DBH5 denotes VIP36
T17 1385-1390 http://www.uniprot.org/uniprot/Q9DBH5 denotes VIP36
T18 1638-1643 http://www.uniprot.org/uniprot/Q9DBH5 denotes VIP36

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 347-356 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T2 605-614 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T3 616-626 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T4 703-708 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 726-735 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T6 760-765 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 920-930 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T8 988-997 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T9 1022-1027 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 1038-1048 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T11 1353-1355 http://purl.bioontology.org/ontology/NCBITAXON/13893 denotes co
T12 1604-1606 http://purl.bioontology.org/ontology/NCBITAXON/13893 denotes co
T13 1759-1764 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T14 1857-1866 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T15 1915-1920 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 12-24 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T2 1076-1088 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T3 1727-1739 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T4 43-71 http://purl.obolibrary.org/obo/GO_0034976 denotes endoplasmic reticulum stress
T5 128-137 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T6 246-255 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T7 142-153 http://purl.obolibrary.org/obo/GO_0006810 denotes transported
T8 512-521 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T9 512-538 http://purl.obolibrary.org/obo/GO_0034436 denotes transport of glycoproteins
T10 1496-1505 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T11 1714-1722 http://purl.obolibrary.org/obo/GO_0065007 denotes regulate
T12 1831-1841 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T13 1714-1739 http://purl.obolibrary.org/obo/GO_0032879 denotes regulate the localization

GO-MF

Id Subject Object Predicate Lexical cue
T1 627-637 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T2 931-941 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T3 811-819 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody

GO-CC

Id Subject Object Predicate Lexical cue
T1 28-33 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T2 393-398 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T3 667-672 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T4 1092-1097 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T5 1327-1332 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T6 1442-1447 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T7 1595-1600 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T8 1661-1666 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T9 1743-1748 http://purl.obolibrary.org/obo/GO_0005793 denotes ERGIC
T10 43-64 http://purl.obolibrary.org/obo/GO_0005783 denotes endoplasmic reticulum
T11 163-184 http://purl.obolibrary.org/obo/GO_0005783 denotes endoplasmic reticulum
T12 186-188 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T13 287-289 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T14 358-360 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T15 1156-1158 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T16 1242-1244 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T17 1700-1702 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T18 203-208 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi
T19 294-299 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi
T20 361-366 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi
T21 1167-1172 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi
T22 1230-1235 http://purl.obolibrary.org/obo/GO_0005794 denotes Golgi
T23 224-228 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T24 703-708 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T25 760-765 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26 1022-1027 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T27 1759-1764 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28 1915-1920 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T29 224-236 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T30 744-765 http://purl.obolibrary.org/obo/GO_0009986 denotes surfaces. These cells
T31 273-286 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T32 309-322 http://purl.obolibrary.org/obo/GO_0016021 denotes transmembrane
T33 309-322 http://purl.obolibrary.org/obo/GO_0044214 denotes transmembrane

Allie

Id Subject Object Predicate Lexical cue
SS1_22821029_1_0 163-184 expanded denotes endoplasmic reticulum
SS2_22821029_1_0 186-188 abbr denotes ER
SS1_22821029_3_0 358-391 expanded denotes ER-Golgi intermediate compartment
SS2_22821029_3_0 393-398 abbr denotes ERGIC
AE1_22821029_1_0 SS1_22821029_1_0 SS2_22821029_1_0 abbreviatedTo endoplasmic reticulum,ER
AE1_22821029_3_0 SS1_22821029_3_0 SS2_22821029_3_0 abbreviatedTo ER-Golgi intermediate compartment,ERGIC

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 543-548 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugar
GlycanIUPAC_T2 543-548 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugar
GlycanIUPAC_T3 543-548 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugar

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes Subcellular localization of ERGIC-53 under endoplasmic reticulum stress condition.
T2 83-237 Sentence denotes Newly synthesized glycoproteins destined for secretion are transported from the endoplasmic reticulum (ER), through the Golgi and toward the cell surface.
T3 238-357 Sentence denotes In this secretion pathway, several intracellular ER- or Golgi-resident transmembrane proteins serve as cargo receptors.
T4 358-570 Sentence denotes ER-Golgi intermediate compartment (ERGIC)-53, VIP36 and VIPL, which have an L-type lectin domain within the luminal portion, participate in the vectorial transport of glycoproteins via sugar-protein interactions.
T5 571-753 Sentence denotes To understand the nature of these receptors, monoclonal antibodies were generated against human ERGIC-53, VIP36 and VIPL using 293T cells expressing these receptors on cell surfaces.
T6 754-837 Sentence denotes These cells were used to immunize rats and for screening antibody-producing clones.
T7 838-998 Sentence denotes Flow cytometric analysis and immunoprecipitation studies showed that the obtained monoclonal antibodies bound specifically to the corresponding cargo receptors.
T8 999-1263 Sentence denotes Immunostaining of HeLa cells using the monoclonal antibodies showed that the localization of ERGIC-53 changed from relatively broad distribution in both the ER and the Golgi under normal conditions to a compact distribution in the Golgi under ER stress conditions.
T9 1264-1391 Sentence denotes This redistribution was also observed by the overexpression of ERGIC-53 and abrogated by co-expression with VIPL but not VIP36.
T10 1392-1581 Sentence denotes Real-time polymerase chain reaction revealed that ERGIC-53 along with several chaperone proteins was up-regulated after tunicamycin treatment; however, the expression of VIPL was unchanged.
T11 1582-1765 Sentence denotes Furthermore, ERGIC-53 co-precipitated with VIPL but not VIP36, indicating that ERGIC-53 may interact with VIPL in the ER, which may regulate the localization of ERGIC-53 inside cells.
T12 1766-1921 Sentence denotes Taken together, these observations provide new insights into the regulation of these cargo receptors and the quality control of glycoproteins within cells.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 661-666 OrganismTaxon denotes human 9606
T2 788-792 OrganismTaxon denotes rats 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 55-64 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 175-184 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T3 203-208 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T4 273-286 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 294-299 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T6 309-322 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T7 361-366 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T8 726-743 Body_part denotes receptors on cell http://purl.obolibrary.org/obo/CL_0000197
T9 1167-1172 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T10 1230-1235 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 726-743 Cell denotes receptors on cell http://purl.obolibrary.org/obo/CL:0000197