> top > docs > PubMed:22808010 > annotations
TextAE configuration unavailable!

PubMed:22808010 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 1315-1321 OrganismTaxon denotes anemia NCBItxid:12939

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation.
T2 150-240 Sentence denotes Certain concepts concerning EPO/EPOR action modes have been challenged by in vivo studies:
T3 241-482 Sentence denotes Bcl-x levels are elevated in maturing erythroblasts, but not in their progenitors; truncated EPOR alleles that lack a major p85/PI3K recruitment site nonetheless promote polycythemia; and Erk1 disruption unexpectedly bolsters erythropoiesis.
T4 483-662 Sentence denotes To discover novel EPO/EPOR action routes, global transcriptome analyses presently are applied to interrogate EPO/EPOR effects on primary bone marrow-derived CFUe-like progenitors.
T5 663-748 Sentence denotes Overall, 160 EPO/EPOR target transcripts were significantly modulated 2-to 21.8-fold.
T6 749-855 Sentence denotes A unique set of EPO-regulated survival factors included Lyl1, Gas5, Pim3, Pim1, Bim, Trib3 and Serpina 3g.
T7 856-968 Sentence denotes EPO/EPOR-modulated cell cycle mediators included Cdc25a, Btg3, Cyclin-d2, p27-kip1, Cyclin-g2 and CyclinB1-IP-1.
T8 969-1046 Sentence denotes EPO regulation of signal transduction factors was also interestingly complex.
T9 1047-1168 Sentence denotes For example, not only Socs3 plus Socs2 but also Spred2, Spred1 and Eaf1 were EPO-induced as negative-feedback components.
T10 1169-1323 Sentence denotes Socs2, plus five additional targets, further proved to comprise new EPOR/Jak2/Stat5 response genes (which are important for erythropoiesis during anemia).
T11 1324-1409 Sentence denotes Among receptors, an atypical TNF-receptor Tnfr-sf13c was up-modulated >5-fold by EPO.
T12 1410-1542 Sentence denotes Functionally, Tnfr-sf13c ligation proved to both promote proerythroblast survival, and substantially enhance erythroblast formation.
T13 1543-1712 Sentence denotes The EPOR therefore engages a sophisticated set of transcriptome response circuits, with Tnfr-sf13c deployed as one novel positive regulator of proerythroblast formation.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9020 12-16 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9021 77-87 GeneOrGeneProduct denotes Tnfr-sf13c NCBIGene:72049
9022 111-114 GeneOrGeneProduct denotes EPO NCBIGene:13856
9023 178-181 GeneOrGeneProduct denotes EPO NCBIGene:13856
9024 182-186 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9025 241-246 GeneOrGeneProduct denotes Bcl-x NCBIGene:12048
9026 334-338 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9027 365-373 GeneOrGeneProduct denotes p85/PI3K NCBIGene:18708
9028 411-423 DiseaseOrPhenotypicFeature denotes polycythemia MESH:D011086
9029 429-433 GeneOrGeneProduct denotes Erk1 NCBIGene:26417
9030 501-504 GeneOrGeneProduct denotes EPO NCBIGene:13856
9031 505-509 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9032 592-595 GeneOrGeneProduct denotes EPO NCBIGene:13856
9033 596-600 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9034 676-679 GeneOrGeneProduct denotes EPO NCBIGene:13856
9035 680-684 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9036 765-768 GeneOrGeneProduct denotes EPO NCBIGene:13856
9037 805-809 GeneOrGeneProduct denotes Lyl1 NCBIGene:17095
9038 811-815 GeneOrGeneProduct denotes Gas5 NCBIGene:14455
9039 817-821 GeneOrGeneProduct denotes Pim3 NCBIGene:223775
9040 823-827 GeneOrGeneProduct denotes Pim1 NCBIGene:18712
9041 829-832 GeneOrGeneProduct denotes Bim NCBIGene:12125
9042 834-839 GeneOrGeneProduct denotes Trib3 NCBIGene:228775
9043 844-854 GeneOrGeneProduct denotes Serpina 3g NCBIGene:20715
9044 856-859 GeneOrGeneProduct denotes EPO NCBIGene:13856
9045 860-864 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9046 905-911 GeneOrGeneProduct denotes Cdc25a NCBIGene:12530
9047 913-917 GeneOrGeneProduct denotes Btg3 NCBIGene:12228
9048 919-928 GeneOrGeneProduct denotes Cyclin-d2 NCBIGene:12444
9049 930-938 GeneOrGeneProduct denotes p27-kip1 NCBIGene:12576
9050 940-949 GeneOrGeneProduct denotes Cyclin-g2 NCBIGene:12452
9051 954-967 GeneOrGeneProduct denotes CyclinB1-IP-1 NCBIGene:239083
9052 969-972 GeneOrGeneProduct denotes EPO NCBIGene:13856
9053 1069-1074 GeneOrGeneProduct denotes Socs3 NCBIGene:12702
9054 1080-1085 GeneOrGeneProduct denotes Socs2 NCBIGene:216233
9055 1095-1101 GeneOrGeneProduct denotes Spred2 NCBIGene:114716
9056 1103-1109 GeneOrGeneProduct denotes Spred1 NCBIGene:114715
9057 1114-1118 GeneOrGeneProduct denotes Eaf1 NCBIGene:74427
9058 1124-1127 GeneOrGeneProduct denotes EPO NCBIGene:13856
9059 1169-1174 GeneOrGeneProduct denotes Socs2 NCBIGene:216233
9060 1237-1241 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9061 1242-1246 GeneOrGeneProduct denotes Jak2 NCBIGene:16452
9062 1247-1252 GeneOrGeneProduct denotes Stat5 NCBIGene:20850
9063 1315-1321 DiseaseOrPhenotypicFeature denotes anemia MESH:D000740
9064 1353-1365 GeneOrGeneProduct denotes TNF-receptor NCBIGene:72049
9065 1366-1376 GeneOrGeneProduct denotes Tnfr-sf13c NCBIGene:72049
9066 1405-1408 GeneOrGeneProduct denotes EPO NCBIGene:13856
9067 1424-1434 GeneOrGeneProduct denotes Tnfr-sf13c NCBIGene:72049
9068 1547-1551 GeneOrGeneProduct denotes EPOR NCBIGene:13857
9069 1631-1641 GeneOrGeneProduct denotes Tnfr-sf13c NCBIGene:72049

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 411-423 DiseaseOrPhenotypicFeature denotes polycythemia 0005571
T2 1315-1321 DiseaseOrPhenotypicFeature denotes anemia 0002280

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 12-16 GeneOrGeneProduct denotes EPOR
T2 18-27 GeneOrGeneProduct denotes regulated
T3 77-87 GeneOrGeneProduct denotes Tnfr-sf13c
T4 93-98 GeneOrGeneProduct denotes novel
T5 99-107 GeneOrGeneProduct denotes mediator
T6 139-148 GeneOrGeneProduct denotes formation
T7 158-166 GeneOrGeneProduct denotes concepts
T8 182-186 GeneOrGeneProduct denotes EPOR
T9 194-199 GeneOrGeneProduct denotes modes
T10 241-246 GeneOrGeneProduct denotes Bcl-x
T11 267-278 GeneOrGeneProduct denotes in maturing
T12 324-333 GeneOrGeneProduct denotes truncated
T13 334-338 GeneOrGeneProduct denotes EPOR
T14 352-356 GeneOrGeneProduct denotes lack
T15 359-364 GeneOrGeneProduct denotes major
T16 369-373 GeneOrGeneProduct denotes PI3K
T17 429-433 GeneOrGeneProduct denotes Erk1
T18 434-444 GeneOrGeneProduct denotes disruption
T19 495-500 GeneOrGeneProduct denotes novel
T20 505-509 GeneOrGeneProduct denotes EPOR
T21 596-600 GeneOrGeneProduct denotes EPOR
T22 620-624 GeneOrGeneProduct denotes bone
T23 645-649 GeneOrGeneProduct denotes like
T24 680-684 GeneOrGeneProduct denotes EPOR
T25 692-703 GeneOrGeneProduct denotes transcripts
T26 743-747 GeneOrGeneProduct denotes fold
T27 769-778 GeneOrGeneProduct denotes regulated
T28 779-795 GeneOrGeneProduct denotes survival factors
T29 805-809 GeneOrGeneProduct denotes Lyl1
T30 811-815 GeneOrGeneProduct denotes Gas5
T31 817-821 GeneOrGeneProduct denotes Pim3
T32 823-827 GeneOrGeneProduct denotes Pim1
T33 834-839 GeneOrGeneProduct denotes Trib3
T34 844-854 GeneOrGeneProduct denotes Serpina 3g
T35 860-864 GeneOrGeneProduct denotes EPOR
T36 875-885 GeneOrGeneProduct denotes cell cycle
T37 886-895 GeneOrGeneProduct denotes mediators
T38 905-911 GeneOrGeneProduct denotes Cdc25a
T39 913-917 GeneOrGeneProduct denotes Btg3
T40 919-925 GeneOrGeneProduct denotes Cyclin
T41 926-928 GeneOrGeneProduct denotes d2
T42 934-938 GeneOrGeneProduct denotes kip1
T43 940-946 GeneOrGeneProduct denotes Cyclin
T44 954-962 GeneOrGeneProduct denotes CyclinB1
T45 963-967 GeneOrGeneProduct denotes IP-1
T46 973-983 GeneOrGeneProduct denotes regulation
T47 987-1006 GeneOrGeneProduct denotes signal transduction
T48 1007-1014 GeneOrGeneProduct denotes factors
T49 1069-1074 GeneOrGeneProduct denotes Socs3
T50 1080-1085 GeneOrGeneProduct denotes Socs2
T51 1095-1101 GeneOrGeneProduct denotes Spred2
T52 1103-1109 GeneOrGeneProduct denotes Spred1
T53 1114-1118 GeneOrGeneProduct denotes Eaf1
T54 1128-1135 GeneOrGeneProduct denotes induced
T55 1169-1174 GeneOrGeneProduct denotes Socs2
T56 1237-1241 GeneOrGeneProduct denotes EPOR
T57 1242-1246 GeneOrGeneProduct denotes Jak2
T58 1247-1252 GeneOrGeneProduct denotes Stat5
T59 1330-1339 GeneOrGeneProduct denotes receptors
T60 1344-1352 GeneOrGeneProduct denotes atypical
T61 1357-1365 GeneOrGeneProduct denotes receptor
T62 1366-1376 GeneOrGeneProduct denotes Tnfr-sf13c
T63 1397-1401 GeneOrGeneProduct denotes fold
T64 1424-1434 GeneOrGeneProduct denotes Tnfr-sf13c
T65 1532-1541 GeneOrGeneProduct denotes formation
T66 1547-1551 GeneOrGeneProduct denotes EPOR
T67 1631-1641 GeneOrGeneProduct denotes Tnfr-sf13c
T68 1658-1663 GeneOrGeneProduct denotes novel
T69 1673-1682 GeneOrGeneProduct denotes regulator
T70 1702-1711 GeneOrGeneProduct denotes formation

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 12-16 GeneOrGeneProduct denotes EPOR
T2 77-87 GeneOrGeneProduct denotes Tnfr-sf13c
T3 93-98 GeneOrGeneProduct denotes novel
T4 99-107 GeneOrGeneProduct denotes mediator
T5 182-186 GeneOrGeneProduct denotes EPOR
T6 241-246 GeneOrGeneProduct denotes Bcl-x
T7 324-333 GeneOrGeneProduct denotes truncated
T8 334-338 GeneOrGeneProduct denotes EPOR
T9 352-356 GeneOrGeneProduct denotes lack
T10 359-364 GeneOrGeneProduct denotes major
T11 369-373 GeneOrGeneProduct denotes PI3K
T12 429-433 GeneOrGeneProduct denotes Erk1
T13 495-500 GeneOrGeneProduct denotes novel
T14 505-509 GeneOrGeneProduct denotes EPOR
T15 596-600 GeneOrGeneProduct denotes EPOR
T16 645-649 GeneOrGeneProduct denotes like
T17 680-684 GeneOrGeneProduct denotes EPOR
T18 743-747 GeneOrGeneProduct denotes fold
T19 779-795 GeneOrGeneProduct denotes survival factors
T20 805-809 GeneOrGeneProduct denotes Lyl1
T21 811-815 GeneOrGeneProduct denotes Gas5
T22 817-821 GeneOrGeneProduct denotes Pim3
T23 823-827 GeneOrGeneProduct denotes Pim1
T24 834-839 GeneOrGeneProduct denotes Trib3
T25 844-854 GeneOrGeneProduct denotes Serpina 3g
T26 860-864 GeneOrGeneProduct denotes EPOR
T27 875-885 GeneOrGeneProduct denotes cell cycle
T28 905-911 GeneOrGeneProduct denotes Cdc25a
T29 913-917 GeneOrGeneProduct denotes Btg3
T30 919-925 GeneOrGeneProduct denotes Cyclin
T31 934-938 GeneOrGeneProduct denotes kip1
T32 940-946 GeneOrGeneProduct denotes Cyclin
T33 954-962 GeneOrGeneProduct denotes CyclinB1
T34 987-1006 GeneOrGeneProduct denotes signal transduction
T35 1069-1074 GeneOrGeneProduct denotes Socs3
T36 1080-1085 GeneOrGeneProduct denotes Socs2
T37 1095-1101 GeneOrGeneProduct denotes Spred2
T38 1103-1109 GeneOrGeneProduct denotes Spred1
T39 1114-1118 GeneOrGeneProduct denotes Eaf1
T40 1169-1174 GeneOrGeneProduct denotes Socs2
T41 1237-1241 GeneOrGeneProduct denotes EPOR
T42 1242-1246 GeneOrGeneProduct denotes Jak2
T43 1247-1252 GeneOrGeneProduct denotes Stat5
T44 1344-1352 GeneOrGeneProduct denotes atypical
T45 1357-1365 GeneOrGeneProduct denotes receptor
T46 1366-1376 GeneOrGeneProduct denotes Tnfr-sf13c
T47 1397-1401 GeneOrGeneProduct denotes fold
T48 1424-1434 GeneOrGeneProduct denotes Tnfr-sf13c
T49 1547-1551 GeneOrGeneProduct denotes EPOR
T50 1631-1641 GeneOrGeneProduct denotes Tnfr-sf13c
T51 1658-1663 GeneOrGeneProduct denotes novel
T52 1673-1682 GeneOrGeneProduct denotes regulator

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 411-423 DiseaseOrPhenotypicFeature denotes polycythemia D011086
T2 1315-1321 DiseaseOrPhenotypicFeature denotes anemia D000740

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 12-16 GeneOrGeneProduct denotes EPOR
T2 77-87 GeneOrGeneProduct denotes Tnfr-sf13c
T3 182-186 GeneOrGeneProduct denotes EPOR
T4 241-246 GeneOrGeneProduct denotes Bcl-x
T5 334-338 GeneOrGeneProduct denotes EPOR
T6 369-373 GeneOrGeneProduct denotes PI3K
T7 429-433 GeneOrGeneProduct denotes Erk1
T8 505-509 GeneOrGeneProduct denotes EPOR
T9 596-600 GeneOrGeneProduct denotes EPOR
T10 680-684 GeneOrGeneProduct denotes EPOR
T11 779-795 GeneOrGeneProduct denotes survival factors
T12 805-809 GeneOrGeneProduct denotes Lyl1
T13 811-815 GeneOrGeneProduct denotes Gas5
T14 817-821 GeneOrGeneProduct denotes Pim3
T15 823-827 GeneOrGeneProduct denotes Pim1
T16 834-839 GeneOrGeneProduct denotes Trib3
T17 844-854 GeneOrGeneProduct denotes Serpina 3g
T18 860-864 GeneOrGeneProduct denotes EPOR
T19 905-911 GeneOrGeneProduct denotes Cdc25a
T20 913-917 GeneOrGeneProduct denotes Btg3
T21 919-925 GeneOrGeneProduct denotes Cyclin
T22 934-938 GeneOrGeneProduct denotes kip1
T23 940-946 GeneOrGeneProduct denotes Cyclin
T24 954-962 GeneOrGeneProduct denotes CyclinB1
T25 1069-1074 GeneOrGeneProduct denotes Socs3
T26 1080-1085 GeneOrGeneProduct denotes Socs2
T27 1095-1101 GeneOrGeneProduct denotes Spred2
T28 1103-1109 GeneOrGeneProduct denotes Spred1
T29 1114-1118 GeneOrGeneProduct denotes Eaf1
T30 1169-1174 GeneOrGeneProduct denotes Socs2
T31 1237-1241 GeneOrGeneProduct denotes EPOR
T32 1242-1246 GeneOrGeneProduct denotes Jak2
T33 1247-1252 GeneOrGeneProduct denotes Stat5
T34 1353-1365 GeneOrGeneProduct denotes TNF-receptor
T35 1366-1376 GeneOrGeneProduct denotes Tnfr-sf13c
T36 1424-1434 GeneOrGeneProduct denotes Tnfr-sf13c
T37 1547-1551 GeneOrGeneProduct denotes EPOR
T38 1631-1641 GeneOrGeneProduct denotes Tnfr-sf13c

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 411-423 DiseaseOrPhenotypicFeature denotes polycythemia 0005571
T2 963-965 DiseaseOrPhenotypicFeature denotes IP 0010631
T3 1315-1321 DiseaseOrPhenotypicFeature denotes anemia 0002280

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 411-423 DiseaseOrPhenotypicFeature denotes polycythemia D011086
T2 1315-1321 DiseaseOrPhenotypicFeature denotes anemia D000740

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 411-423 DiseaseOrPhenotypicFeature denotes polycythemia D011086
T2 1315-1321 DiseaseOrPhenotypicFeature denotes anemia D000740

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 111-114 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T2 178-181 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T3 501-504 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T4 592-595 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T5 676-679 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T6 765-768 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T7 856-859 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T8 969-972 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T9 1124-1127 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T10 1405-1408 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T10 1405-1408 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T9 1124-1127 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T8 969-972 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T7 856-859 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T6 765-768 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T5 676-679 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T4 592-595 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T3 501-504 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T2 178-181 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T1 111-114 ChemicalEntity denotes EPO http://purl.obolibrary.org/obo/CHEBI_81579
T38 1631-1641 GeneOrGeneProduct denotes Tnfr-sf13c
T37 1547-1551 GeneOrGeneProduct denotes EPOR
T36 1424-1434 GeneOrGeneProduct denotes Tnfr-sf13c
T35 1366-1376 GeneOrGeneProduct denotes Tnfr-sf13c
T34 1353-1365 GeneOrGeneProduct denotes TNF-receptor
T33 1247-1252 GeneOrGeneProduct denotes Stat5
T32 1242-1246 GeneOrGeneProduct denotes Jak2
T31 1237-1241 GeneOrGeneProduct denotes EPOR
T30 1169-1174 GeneOrGeneProduct denotes Socs2
T29 1114-1118 GeneOrGeneProduct denotes Eaf1
T28 1103-1109 GeneOrGeneProduct denotes Spred1
T27 1095-1101 GeneOrGeneProduct denotes Spred2
T26 1080-1085 GeneOrGeneProduct denotes Socs2
T25 1069-1074 GeneOrGeneProduct denotes Socs3
T24 954-962 GeneOrGeneProduct denotes CyclinB1
T23 940-946 GeneOrGeneProduct denotes Cyclin
T22 934-938 GeneOrGeneProduct denotes kip1
T21 919-925 GeneOrGeneProduct denotes Cyclin
T20 913-917 GeneOrGeneProduct denotes Btg3
T19 905-911 GeneOrGeneProduct denotes Cdc25a
T18 860-864 GeneOrGeneProduct denotes EPOR
T17 844-854 GeneOrGeneProduct denotes Serpina 3g
T16 834-839 GeneOrGeneProduct denotes Trib3
T15 823-827 GeneOrGeneProduct denotes Pim1
T14 817-821 GeneOrGeneProduct denotes Pim3
T13 811-815 GeneOrGeneProduct denotes Gas5
T12 805-809 GeneOrGeneProduct denotes Lyl1
T11 779-795 GeneOrGeneProduct denotes survival factors
T97064 680-684 GeneOrGeneProduct denotes EPOR
T54613 596-600 GeneOrGeneProduct denotes EPOR
T65866 505-509 GeneOrGeneProduct denotes EPOR
T28563 429-433 GeneOrGeneProduct denotes Erk1
T27717 369-373 GeneOrGeneProduct denotes PI3K
T38822 334-338 GeneOrGeneProduct denotes EPOR
T8192 241-246 GeneOrGeneProduct denotes Bcl-x
T21007 182-186 GeneOrGeneProduct denotes EPOR
T36952 77-87 GeneOrGeneProduct denotes Tnfr-sf13c
T44540 12-16 GeneOrGeneProduct denotes EPOR
T86264 1315-1321 DiseaseOrPhenotypicFeature denotes anemia D000740
T91349 411-423 DiseaseOrPhenotypicFeature denotes polycythemia D011086

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 411-423 HP_0001901 denotes polycythemia
T2 1315-1321 HP_0001903 denotes anemia