PubMed:22801553
Annnotations
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 97-112 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T2 | 194-209 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T3 | 211-213 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T4 | 529-531 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T5 | 925-927 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T6 | 1309-1311 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T7 | 1491-1493 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T8 | 1696-1698 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T9 | 1805-1807 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 256-267 | http://purl.obolibrary.org/obo/MAT_0000373 | denotes | vertebrates |
| T2 | 272-285 | http://purl.obolibrary.org/obo/MAT_0000374 | denotes | invertebrates |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-147 | Sentence | denotes | Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage. |
| TextSentencer_T2 | 148-372 | Sentence | denotes | The membrane lipid-anchored glypicans (Gpcs) [heparan sulfate (HS) proteoglycans (PGs)] are present in both vertebrates and invertebrates and serve as important modulators of growth factors and morphogens during development. |
| TextSentencer_T3 | 373-565 | Sentence | denotes | Their core proteins are similar and consist of a large N-terminal domain comprising 14 evolutionary conserved cysteines and a C-terminal stalk carrying the HS side chains and the lipid anchor. |
| TextSentencer_T4 | 566-652 | Sentence | denotes | Cysteines in Gpc-1 can be S-nitrosylated but their positions have not been identified. |
| TextSentencer_T5 | 653-824 | Sentence | denotes | The recently determined crystal structure of the N-terminal domain of Gpc-1 has revealed that all the evolutionary conserved cysteines form intramolecular disulfide bonds. |
| TextSentencer_T6 | 825-945 | Sentence | denotes | However, Gpc-1 contains two more, non-conserved cysteines in the C-terminal stalk, located near the HS attachment sites. |
| TextSentencer_T7 | 946-1159 | Sentence | denotes | We show here that the non-conserved cysteines are free thiols as a Gpc-1 core protein containing the C-terminal stalk could be biotinylated by 1-biotinamido-4-(4'-[maleimidomethyl-cyclohexane]-carboxyamido)butane. |
| TextSentencer_T8 | 1160-1389 | Sentence | denotes | After S-nitrosylation by using a nitric oxide (NO) donor and copper ions, the Gpc-1 core protein was retained on an affinity matrix substituted with HS oligosaccharides containing N-unsubstituted glucosamines (GlcNH(2)/NH(3)(+)). |
| TextSentencer_T9 | 1390-1466 | Sentence | denotes | The protein was displaced with 0.2 M glucosamine but also by 2 mM ascorbate. |
| TextSentencer_T10 | 1467-1593 | Sentence | denotes | In the latter case, the HS of the affinity matrix was simultaneously cleaved into fragments containing anhydromannose (anMan). |
| TextSentencer_T11 | 1594-1727 | Sentence | denotes | We propose that the S-nitrosocysteine residues interact with closely located GlcNH(2)/NH(3)(+) in the HS side chains of the Gpc-1 PG. |
| TextSentencer_T12 | 1728-1892 | Sentence | denotes | Addition of ascorbate induces a series of reactions that eventually releases HS fragments with reducing terminal anMan, presumably without the formation of free NO. |
| T1 | 0-147 | Sentence | denotes | Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage. |
| T2 | 148-372 | Sentence | denotes | The membrane lipid-anchored glypicans (Gpcs) [heparan sulfate (HS) proteoglycans (PGs)] are present in both vertebrates and invertebrates and serve as important modulators of growth factors and morphogens during development. |
| T3 | 373-565 | Sentence | denotes | Their core proteins are similar and consist of a large N-terminal domain comprising 14 evolutionary conserved cysteines and a C-terminal stalk carrying the HS side chains and the lipid anchor. |
| T4 | 566-652 | Sentence | denotes | Cysteines in Gpc-1 can be S-nitrosylated but their positions have not been identified. |
| T5 | 653-824 | Sentence | denotes | The recently determined crystal structure of the N-terminal domain of Gpc-1 has revealed that all the evolutionary conserved cysteines form intramolecular disulfide bonds. |
| T6 | 825-945 | Sentence | denotes | However, Gpc-1 contains two more, non-conserved cysteines in the C-terminal stalk, located near the HS attachment sites. |
| T7 | 946-1159 | Sentence | denotes | We show here that the non-conserved cysteines are free thiols as a Gpc-1 core protein containing the C-terminal stalk could be biotinylated by 1-biotinamido-4-(4'-[maleimidomethyl-cyclohexane]-carboxyamido)butane. |
| T8 | 1160-1389 | Sentence | denotes | After S-nitrosylation by using a nitric oxide (NO) donor and copper ions, the Gpc-1 core protein was retained on an affinity matrix substituted with HS oligosaccharides containing N-unsubstituted glucosamines (GlcNH(2)/NH(3)(+)). |
| T9 | 1390-1466 | Sentence | denotes | The protein was displaced with 0.2 M glucosamine but also by 2 mM ascorbate. |
| T10 | 1467-1593 | Sentence | denotes | In the latter case, the HS of the affinity matrix was simultaneously cleaved into fragments containing anhydromannose (anMan). |
| T11 | 1594-1727 | Sentence | denotes | We propose that the S-nitrosocysteine residues interact with closely located GlcNH(2)/NH(3)(+) in the HS side chains of the Gpc-1 PG. |
| T12 | 1728-1892 | Sentence | denotes | Addition of ascorbate induces a series of reactions that eventually releases HS fragments with reducing terminal anMan, presumably without the formation of free NO. |
| T1 | 0-147 | Sentence | denotes | Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage. |
| T2 | 148-372 | Sentence | denotes | The membrane lipid-anchored glypicans (Gpcs) [heparan sulfate (HS) proteoglycans (PGs)] are present in both vertebrates and invertebrates and serve as important modulators of growth factors and morphogens during development. |
| T3 | 373-565 | Sentence | denotes | Their core proteins are similar and consist of a large N-terminal domain comprising 14 evolutionary conserved cysteines and a C-terminal stalk carrying the HS side chains and the lipid anchor. |
| T4 | 566-652 | Sentence | denotes | Cysteines in Gpc-1 can be S-nitrosylated but their positions have not been identified. |
| T5 | 653-824 | Sentence | denotes | The recently determined crystal structure of the N-terminal domain of Gpc-1 has revealed that all the evolutionary conserved cysteines form intramolecular disulfide bonds. |
| T6 | 825-945 | Sentence | denotes | However, Gpc-1 contains two more, non-conserved cysteines in the C-terminal stalk, located near the HS attachment sites. |
| T7 | 946-1159 | Sentence | denotes | We show here that the non-conserved cysteines are free thiols as a Gpc-1 core protein containing the C-terminal stalk could be biotinylated by 1-biotinamido-4-(4'-[maleimidomethyl-cyclohexane]-carboxyamido)butane. |
| T8 | 1160-1389 | Sentence | denotes | After S-nitrosylation by using a nitric oxide (NO) donor and copper ions, the Gpc-1 core protein was retained on an affinity matrix substituted with HS oligosaccharides containing N-unsubstituted glucosamines (GlcNH(2)/NH(3)(+)). |
| T9 | 1390-1466 | Sentence | denotes | The protein was displaced with 0.2 M glucosamine but also by 2 mM ascorbate. |
| T10 | 1467-1593 | Sentence | denotes | In the latter case, the HS of the affinity matrix was simultaneously cleaved into fragments containing anhydromannose (anMan). |
| T11 | 1594-1727 | Sentence | denotes | We propose that the S-nitrosocysteine residues interact with closely located GlcNH(2)/NH(3)(+) in the HS side chains of the Gpc-1 PG. |
| T12 | 1728-1892 | Sentence | denotes | Addition of ascorbate induces a series of reactions that eventually releases HS fragments with reducing terminal anMan, presumably without the formation of free NO. |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 30-39 | FMAID:196740 | denotes | cysteines |
| _T2 | 30-39 | FMAID:82751 | denotes | cysteines |
| _T3 | 81-93 | FMAID:82797 | denotes | glucosamines |
| _T4 | 81-93 | FMAID:196792 | denotes | glucosamines |
| _T5 | 97-104 | FMAID:165191 | denotes | heparan |
| _T6 | 97-104 | FMAID:67110 | denotes | heparan |
| _T7 | 97-112 | FMAID:63023 | denotes | heparan sulfate |
| _T8 | 97-112 | FMAID:167405 | denotes | heparan sulfate |
| _T9 | 161-166 | FMAID:165448 | denotes | lipid |
| _T10 | 161-166 | FMAID:67264 | denotes | lipid |
| _T11 | 194-201 | FMAID:165191 | denotes | heparan |
| _T12 | 194-201 | FMAID:67110 | denotes | heparan |
| _T13 | 194-209 | FMAID:63023 | denotes | heparan sulfate |
| _T14 | 194-209 | FMAID:167405 | denotes | heparan sulfate |
| _T15 | 194-228 | FMAID:82834 | denotes | heparan sulfate (HS) proteoglycans |
| _T16 | 194-228 | FMAID:196834 | denotes | heparan sulfate (HS) proteoglycans |
| _T17 | 215-228 | FMAID:167397 | denotes | proteoglycans |
| _T18 | 215-228 | FMAID:63015 | denotes | proteoglycans |
| _T19 | 256-285 | FMAID:100641 | denotes | vertebrates and invertebrates |
| _T20 | 256-285 | FMAID:11946 | denotes | vertebrates and invertebrates |
| _T21 | 256-285 | FMAID:103073 | denotes | vertebrates and invertebrates |
| _T22 | 384-392 | FMAID:67257 | denotes | proteins |
| _T23 | 384-392 | FMAID:165447 | denotes | proteins |
| _T24 | 483-492 | FMAID:82751 | denotes | cysteines |
| _T25 | 483-492 | FMAID:196740 | denotes | cysteines |
| _T26 | 552-557 | FMAID:165448 | denotes | lipid |
| _T27 | 552-557 | FMAID:67264 | denotes | lipid |
| _T28 | 566-575 | FMAID:82751 | denotes | Cysteines |
| _T29 | 566-575 | FMAID:196740 | denotes | Cysteines |
| _T30 | 778-787 | FMAID:82751 | denotes | cysteines |
| _T31 | 778-787 | FMAID:196740 | denotes | cysteines |
| _T32 | 873-882 | FMAID:196740 | denotes | cysteines |
| _T33 | 873-882 | FMAID:82751 | denotes | cysteines |
| _T34 | 982-991 | FMAID:196740 | denotes | cysteines |
| _T35 | 982-991 | FMAID:82751 | denotes | cysteines |
| _T36 | 1024-1031 | FMAID:67257 | denotes | protein |
| _T37 | 1024-1031 | FMAID:165447 | denotes | protein |
| _T38 | 1249-1256 | FMAID:67257 | denotes | protein |
| _T39 | 1249-1256 | FMAID:165447 | denotes | protein |
| _T40 | 1312-1328 | FMAID:82742 | denotes | oligosaccharides |
| _T41 | 1312-1328 | FMAID:196731 | denotes | oligosaccharides |
| _T42 | 1356-1368 | FMAID:196792 | denotes | glucosamines |
| _T43 | 1356-1368 | FMAID:82797 | denotes | glucosamines |
| _T44 | 1394-1401 | FMAID:67257 | denotes | protein |
| _T45 | 1394-1401 | FMAID:165447 | denotes | protein |
| _T46 | 1427-1438 | FMAID:82797 | denotes | glucosamine |
| _T47 | 1427-1438 | FMAID:196792 | denotes | glucosamine |
| _T48 | 1474-1480 | FMAID:171168 | denotes | latter |
| _T49 | 1474-1480 | FMAID:30332 | denotes | latter |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 43-53 | http://www.uniprot.org/uniprot/P35052 | denotes | glypican-1 |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 43-53 | http://www.uniprot.org/uniprot/Q9QZF2 | denotes | glypican-1 |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-3 | http://purl.bioontology.org/ontology/NCBITAXON/604139 | denotes | Non |
| T2 | 256-267 | http://purl.bioontology.org/ontology/STY/T010 | denotes | vertebrates |
| T3 | 859-862 | http://purl.bioontology.org/ontology/NCBITAXON/604139 | denotes | non |
| T4 | 968-971 | http://purl.bioontology.org/ontology/NCBITAXON/604139 | denotes | non |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-29 | http://purl.obolibrary.org/obo/GO_0018119 | denotes | S-nitrosylated |
| T2 | 592-606 | http://purl.obolibrary.org/obo/GO_0018119 | denotes | S-nitrosylated |
| T3 | 1166-1181 | http://purl.obolibrary.org/obo/GO_0018119 | denotes | S-nitrosylation |
| T4 | 15-39 | http://purl.obolibrary.org/obo/GO_0018119 | denotes | S-nitrosylated cysteines |
| T5 | 105-112 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T6 | 202-209 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T7 | 323-329 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T8 | 360-371 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
| T9 | 1871-1880 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 167-175 | http://purl.obolibrary.org/obo/GO_0043495 | denotes | anchored |
| T2 | 558-564 | http://purl.obolibrary.org/obo/GO_0043495 | denotes | anchor |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 152-160 | http://purl.obolibrary.org/obo/GO_0016020 | denotes | membrane |
| T2 | 379-383 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
| T3 | 1019-1023 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
| T4 | 1244-1248 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
| T5 | 1724-1726 | http://purl.obolibrary.org/obo/GO_0010287 | denotes | PG |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 256-267 | http://purl.obolibrary.org/obo/UBERON_3010224 | denotes | vertebrates |
| T2 | 928-944 | http://purl.obolibrary.org/obo/UBERON_4200047 | denotes | attachment sites |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22801553_1_0 | 176-185 | expanded | denotes | glypicans |
| SS2_22801553_1_0 | 187-191 | abbr | denotes | Gpcs |
| SS1_22801553_1_1 | 194-209 | expanded | denotes | heparan sulfate |
| SS2_22801553_1_1 | 211-213 | abbr | denotes | HS |
| SS1_22801553_1_2 | 215-228 | expanded | denotes | proteoglycans |
| SS2_22801553_1_2 | 230-233 | abbr | denotes | PGs |
| SS1_22801553_7_0 | 1193-1205 | expanded | denotes | nitric oxide |
| SS2_22801553_7_0 | 1207-1209 | abbr | denotes | NO |
| SS1_22801553_9_0 | 1570-1584 | expanded | denotes | anhydromannose |
| SS2_22801553_9_0 | 1586-1591 | abbr | denotes | anMan |
| AE1_22801553_1_0 | SS1_22801553_1_0 | SS2_22801553_1_0 | abbreviatedTo | glypicans,Gpcs |
| AE1_22801553_1_1 | SS1_22801553_1_1 | SS2_22801553_1_1 | abbreviatedTo | heparan sulfate,HS |
| AE1_22801553_1_2 | SS1_22801553_1_2 | SS2_22801553_1_2 | abbreviatedTo | proteoglycans,PGs |
| AE1_22801553_7_0 | SS1_22801553_7_0 | SS2_22801553_7_0 | abbreviatedTo | nitric oxide,NO |
| AE1_22801553_9_0 | SS1_22801553_9_0 | SS2_22801553_9_0 | abbreviatedTo | anhydromannose,anMan |
GlyTouCan-IUPAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| GlycanIUPAC_T1 | 0-3 | "http://rdf.glycoinfo.org/glycan/G02780QX" | denotes | Non |
| GlycanIUPAC_T2 | 859-862 | "http://rdf.glycoinfo.org/glycan/G02780QX" | denotes | non |
| GlycanIUPAC_T3 | 968-971 | "http://rdf.glycoinfo.org/glycan/G02780QX" | denotes | non |
| GlycanIUPAC_T4 | 0-3 | "http://rdf.glycoinfo.org/glycan/G18425DX" | denotes | Non |
| GlycanIUPAC_T5 | 859-862 | "http://rdf.glycoinfo.org/glycan/G18425DX" | denotes | non |
| GlycanIUPAC_T6 | 968-971 | "http://rdf.glycoinfo.org/glycan/G18425DX" | denotes | non |
| GlycanIUPAC_T7 | 0-3 | "http://rdf.glycoinfo.org/glycan/G18630JE" | denotes | Non |
| GlycanIUPAC_T8 | 859-862 | "http://rdf.glycoinfo.org/glycan/G18630JE" | denotes | non |
| GlycanIUPAC_T9 | 968-971 | "http://rdf.glycoinfo.org/glycan/G18630JE" | denotes | non |
| GlycanIUPAC_T10 | 0-3 | "http://rdf.glycoinfo.org/glycan/G01004IT" | denotes | Non |
| GlycanIUPAC_T11 | 859-862 | "http://rdf.glycoinfo.org/glycan/G01004IT" | denotes | non |
| GlycanIUPAC_T12 | 968-971 | "http://rdf.glycoinfo.org/glycan/G01004IT" | denotes | non |
| GlycanIUPAC_T13 | 0-3 | "http://rdf.glycoinfo.org/glycan/G87301QZ" | denotes | Non |
| GlycanIUPAC_T14 | 859-862 | "http://rdf.glycoinfo.org/glycan/G87301QZ" | denotes | non |
| GlycanIUPAC_T15 | 968-971 | "http://rdf.glycoinfo.org/glycan/G87301QZ" | denotes | non |
| GlycanIUPAC_T16 | 0-3 | "http://rdf.glycoinfo.org/glycan/G39790GW" | denotes | Non |
| GlycanIUPAC_T17 | 859-862 | "http://rdf.glycoinfo.org/glycan/G39790GW" | denotes | non |
| GlycanIUPAC_T18 | 968-971 | "http://rdf.glycoinfo.org/glycan/G39790GW" | denotes | non |
| GlycanIUPAC_T19 | 0-3 | "http://rdf.glycoinfo.org/glycan/G42928BB" | denotes | Non |
| GlycanIUPAC_T20 | 859-862 | "http://rdf.glycoinfo.org/glycan/G42928BB" | denotes | non |
| GlycanIUPAC_T21 | 968-971 | "http://rdf.glycoinfo.org/glycan/G42928BB" | denotes | non |
| GlycanIUPAC_T22 | 0-3 | "http://rdf.glycoinfo.org/glycan/G51134HC" | denotes | Non |
| GlycanIUPAC_T23 | 859-862 | "http://rdf.glycoinfo.org/glycan/G51134HC" | denotes | non |
| GlycanIUPAC_T24 | 968-971 | "http://rdf.glycoinfo.org/glycan/G51134HC" | denotes | non |
| GlycanIUPAC_T25 | 0-3 | "http://rdf.glycoinfo.org/glycan/G68183GR" | denotes | Non |
| GlycanIUPAC_T26 | 859-862 | "http://rdf.glycoinfo.org/glycan/G68183GR" | denotes | non |
| GlycanIUPAC_T27 | 968-971 | "http://rdf.glycoinfo.org/glycan/G68183GR" | denotes | non |
| GlycanIUPAC_T28 | 0-3 | "http://rdf.glycoinfo.org/glycan/G46883FA" | denotes | Non |
| GlycanIUPAC_T29 | 859-862 | "http://rdf.glycoinfo.org/glycan/G46883FA" | denotes | non |
| GlycanIUPAC_T30 | 968-971 | "http://rdf.glycoinfo.org/glycan/G46883FA" | denotes | non |
| GlycanIUPAC_T31 | 0-3 | "http://rdf.glycoinfo.org/glycan/G54702VY" | denotes | Non |
| GlycanIUPAC_T32 | 859-862 | "http://rdf.glycoinfo.org/glycan/G54702VY" | denotes | non |
| GlycanIUPAC_T33 | 968-971 | "http://rdf.glycoinfo.org/glycan/G54702VY" | denotes | non |
| GlycanIUPAC_T34 | 747-750 | "http://rdf.glycoinfo.org/glycan/G41652MJ" | denotes | all |
| GlycanIUPAC_T35 | 747-750 | "http://rdf.glycoinfo.org/glycan/G20761YC" | denotes | all |
| GlycanIUPAC_T36 | 747-750 | "http://rdf.glycoinfo.org/glycan/G19807HM" | denotes | all |
| GlycanIUPAC_T37 | 747-750 | "http://rdf.glycoinfo.org/glycan/G20351TE" | denotes | all |
| GlycanIUPAC_T38 | 747-750 | "http://rdf.glycoinfo.org/glycan/G71957MR" | denotes | all |
| GlycanIUPAC_T39 | 747-750 | "http://rdf.glycoinfo.org/glycan/G59040AE" | denotes | all |
| GlycanIUPAC_T40 | 747-750 | "http://rdf.glycoinfo.org/glycan/G14987PW" | denotes | all |
| GlycanIUPAC_T41 | 747-750 | "http://rdf.glycoinfo.org/glycan/G95064PC" | denotes | all |
| GlycanIUPAC_T42 | 747-750 | "http://rdf.glycoinfo.org/glycan/G39143AQ" | denotes | all |
| GlycanIUPAC_T43 | 747-750 | "http://rdf.glycoinfo.org/glycan/G65149OO" | denotes | all |
| GlycanIUPAC_T44 | 747-750 | "http://rdf.glycoinfo.org/glycan/G02766SY" | denotes | all |
| GlycanIUPAC_T45 | 747-750 | "http://rdf.glycoinfo.org/glycan/G26019KJ" | denotes | all |
| GlycanIUPAC_T46 | 747-750 | "http://rdf.glycoinfo.org/glycan/G36429CZ" | denotes | all |
| GlycanIUPAC_T47 | 747-750 | "http://rdf.glycoinfo.org/glycan/G89633TP" | denotes | all |
| GlycanIUPAC_T48 | 747-750 | "http://rdf.glycoinfo.org/glycan/G28494FO" | denotes | all |
| GlycanIUPAC_T49 | 747-750 | "http://rdf.glycoinfo.org/glycan/G06219CP" | denotes | all |
| GlycanIUPAC_T50 | 747-750 | "http://rdf.glycoinfo.org/glycan/G44237SM" | denotes | all |
| GlycanIUPAC_T51 | 747-750 | "http://rdf.glycoinfo.org/glycan/G57948RL" | denotes | all |
| GlycanIUPAC_T52 | 747-750 | "http://rdf.glycoinfo.org/glycan/G64016DN" | denotes | all |
| GlycanIUPAC_T53 | 747-750 | "http://rdf.glycoinfo.org/glycan/G14536PC" | denotes | all |
| GlycanIUPAC_T54 | 747-750 | "http://rdf.glycoinfo.org/glycan/G14356FW" | denotes | all |
| GlycanIUPAC_T55 | 747-750 | "http://rdf.glycoinfo.org/glycan/G34565UO" | denotes | all |
| GlycanIUPAC_T56 | 747-750 | "http://rdf.glycoinfo.org/glycan/G67124MW" | denotes | all |
| GlycanIUPAC_T57 | 747-750 | "http://rdf.glycoinfo.org/glycan/G71457ZU" | denotes | all |
| GlycanIUPAC_T58 | 747-750 | "http://rdf.glycoinfo.org/glycan/G55228VZ" | denotes | all |
| GlycanIUPAC_T59 | 747-750 | "http://rdf.glycoinfo.org/glycan/G31034MJ" | denotes | all |
| GlycanIUPAC_T60 | 747-750 | "http://rdf.glycoinfo.org/glycan/G25776IP" | denotes | all |
| GlycanIUPAC_T61 | 747-750 | "http://rdf.glycoinfo.org/glycan/G64442BV" | denotes | all |
| GlycanIUPAC_T62 | 747-750 | "http://rdf.glycoinfo.org/glycan/G57018LE" | denotes | all |
| GlycanIUPAC_T63 | 747-750 | "http://rdf.glycoinfo.org/glycan/G61761GX" | denotes | all |
| GlycanIUPAC_T64 | 747-750 | "http://rdf.glycoinfo.org/glycan/G76318UX" | denotes | all |
| GlycanIUPAC_T65 | 747-750 | "http://rdf.glycoinfo.org/glycan/G61906ER" | denotes | all |
| GlycanIUPAC_T66 | 747-750 | "http://rdf.glycoinfo.org/glycan/G68723GR" | denotes | all |
| GlycanIUPAC_T67 | 747-750 | "http://rdf.glycoinfo.org/glycan/G19540LE" | denotes | all |
| GlycanIUPAC_T68 | 747-750 | "http://rdf.glycoinfo.org/glycan/G74944PO" | denotes | all |
| GlycanIUPAC_T69 | 747-750 | "http://rdf.glycoinfo.org/glycan/G89489ZJ" | denotes | all |
| GlycanIUPAC_T70 | 747-750 | "http://rdf.glycoinfo.org/glycan/G04434YU" | denotes | all |
| GlycanIUPAC_T71 | 747-750 | "http://rdf.glycoinfo.org/glycan/G21450PB" | denotes | all |
| GlycanIUPAC_T72 | 747-750 | "http://rdf.glycoinfo.org/glycan/G93629QY" | denotes | all |
| GlycanIUPAC_T73 | 747-750 | "http://rdf.glycoinfo.org/glycan/G02603TR" | denotes | all |
| GlycanIUPAC_T74 | 747-750 | "http://rdf.glycoinfo.org/glycan/G40280JP" | denotes | all |
| GlycanIUPAC_T75 | 747-750 | "http://rdf.glycoinfo.org/glycan/G95259IC" | denotes | all |
| GlycanIUPAC_T76 | 747-750 | "http://rdf.glycoinfo.org/glycan/G26900FE" | denotes | all |
| GlycanIUPAC_T77 | 747-750 | "http://rdf.glycoinfo.org/glycan/G21346KK" | denotes | all |
| GlycanIUPAC_T78 | 747-750 | "http://rdf.glycoinfo.org/glycan/G62509FF" | denotes | all |
| GlycanIUPAC_T79 | 747-750 | "http://rdf.glycoinfo.org/glycan/G83932AK" | denotes | all |
| GlycanIUPAC_T80 | 747-750 | "http://rdf.glycoinfo.org/glycan/G96978IB" | denotes | all |
| GlycanIUPAC_T81 | 747-750 | "http://rdf.glycoinfo.org/glycan/G34275DN" | denotes | all |
| GlycanIUPAC_T82 | 747-750 | "http://rdf.glycoinfo.org/glycan/G07071JF" | denotes | all |
| GlycanIUPAC_T83 | 747-750 | "http://rdf.glycoinfo.org/glycan/G80639QD" | denotes | all |
| GlycanIUPAC_T84 | 747-750 | "http://rdf.glycoinfo.org/glycan/G99460PJ" | denotes | all |
| GlycanIUPAC_T85 | 747-750 | "http://rdf.glycoinfo.org/glycan/G22024BZ" | denotes | all |
| GlycanIUPAC_T86 | 747-750 | "http://rdf.glycoinfo.org/glycan/G74097ZY" | denotes | all |
| GlycanIUPAC_T87 | 747-750 | "http://rdf.glycoinfo.org/glycan/G84439YP" | denotes | all |
| GlycanIUPAC_T88 | 747-750 | "http://rdf.glycoinfo.org/glycan/G52207WQ" | denotes | all |
| GlycanIUPAC_T89 | 747-750 | "http://rdf.glycoinfo.org/glycan/G90695MS" | denotes | all |
| GlycanIUPAC_T90 | 747-750 | "http://rdf.glycoinfo.org/glycan/G50398QX" | denotes | all |
| GlycanIUPAC_T91 | 747-750 | "http://rdf.glycoinfo.org/glycan/G12166ZT" | denotes | all |
| GlycanIUPAC_T92 | 747-750 | "http://rdf.glycoinfo.org/glycan/G48368BR" | denotes | all |
| GlycanIUPAC_T93 | 747-750 | "http://rdf.glycoinfo.org/glycan/G57407RW" | denotes | all |
| GlycanIUPAC_T94 | 747-750 | "http://rdf.glycoinfo.org/glycan/G00386TY" | denotes | all |
| GlycanIUPAC_T95 | 747-750 | "http://rdf.glycoinfo.org/glycan/G18723JK" | denotes | all |
| GlycanIUPAC_T96 | 747-750 | "http://rdf.glycoinfo.org/glycan/G93757OR" | denotes | all |
| GlycanIUPAC_T97 | 747-750 | "http://rdf.glycoinfo.org/glycan/G29006SI" | denotes | all |
| GlycanIUPAC_T98 | 747-750 | "http://rdf.glycoinfo.org/glycan/G03099OQ" | denotes | all |
| GlycanIUPAC_T99 | 747-750 | "http://rdf.glycoinfo.org/glycan/G53739OW" | denotes | all |
| GlycanIUPAC_T100 | 747-750 | "http://rdf.glycoinfo.org/glycan/G70440ZO" | denotes | all |
| GlycanIUPAC_T101 | 747-750 | "http://rdf.glycoinfo.org/glycan/G29951RR" | denotes | all |
| GlycanIUPAC_T102 | 747-750 | "http://rdf.glycoinfo.org/glycan/G58402TI" | denotes | all |
| GlycanIUPAC_T103 | 747-750 | "http://rdf.glycoinfo.org/glycan/G39875TP" | denotes | all |
| GlycanIUPAC_T104 | 747-750 | "http://rdf.glycoinfo.org/glycan/G83439QV" | denotes | all |
| GlycanIUPAC_T105 | 747-750 | "http://rdf.glycoinfo.org/glycan/G41762RC" | denotes | all |
| GlycanIUPAC_T106 | 747-750 | "http://rdf.glycoinfo.org/glycan/G91604UI" | denotes | all |
| GlycanIUPAC_T107 | 747-750 | "http://rdf.glycoinfo.org/glycan/G88447WE" | denotes | all |
| GlycanIUPAC_T108 | 747-750 | "http://rdf.glycoinfo.org/glycan/G93634BS" | denotes | all |
| GlycanIUPAC_T109 | 747-750 | "http://rdf.glycoinfo.org/glycan/G02587BH" | denotes | all |
| GlycanIUPAC_T110 | 747-750 | "http://rdf.glycoinfo.org/glycan/G43511MX" | denotes | all |
| GlycanIUPAC_T111 | 747-750 | "http://rdf.glycoinfo.org/glycan/G64958DH" | denotes | all |
| GlycanIUPAC_T112 | 747-750 | "http://rdf.glycoinfo.org/glycan/G30384TR" | denotes | all |
| GlycanIUPAC_T113 | 747-750 | "http://rdf.glycoinfo.org/glycan/G15624EX" | denotes | all |
| GlycanIUPAC_T114 | 747-750 | "http://rdf.glycoinfo.org/glycan/G22706ST" | denotes | all |
| GlycanIUPAC_T115 | 747-750 | "http://rdf.glycoinfo.org/glycan/G57408PI" | denotes | all |
| GlycanIUPAC_T116 | 747-750 | "http://rdf.glycoinfo.org/glycan/G86403XX" | denotes | all |
| GlycanIUPAC_T117 | 747-750 | "http://rdf.glycoinfo.org/glycan/G78043YB" | denotes | all |
| GlycanIUPAC_T118 | 747-750 | "http://rdf.glycoinfo.org/glycan/G18952JK" | denotes | all |
| GlycanIUPAC_T119 | 747-750 | "http://rdf.glycoinfo.org/glycan/G49020ND" | denotes | all |
| GlycanIUPAC_T120 | 747-750 | "http://rdf.glycoinfo.org/glycan/G63590YW" | denotes | all |
| GlycanIUPAC_T121 | 747-750 | "http://rdf.glycoinfo.org/glycan/G22793KS" | denotes | all |
| GlycanIUPAC_T122 | 747-750 | "http://rdf.glycoinfo.org/glycan/G64134SS" | denotes | all |
| GlycanIUPAC_T123 | 747-750 | "http://rdf.glycoinfo.org/glycan/G17338HY" | denotes | all |
| GlycanIUPAC_T124 | 747-750 | "http://rdf.glycoinfo.org/glycan/G99745XF" | denotes | all |
| GlycanIUPAC_T125 | 747-750 | "http://rdf.glycoinfo.org/glycan/G27782HN" | denotes | all |
| GlycanIUPAC_T126 | 747-750 | "http://rdf.glycoinfo.org/glycan/G57496DC" | denotes | all |
| GlycanIUPAC_T127 | 747-750 | "http://rdf.glycoinfo.org/glycan/G93169WB" | denotes | all |
| GlycanIUPAC_T128 | 747-750 | "http://rdf.glycoinfo.org/glycan/G05518TD" | denotes | all |
| GlycanIUPAC_T129 | 747-750 | "http://rdf.glycoinfo.org/glycan/G62603DN" | denotes | all |
| GlycanIUPAC_T130 | 747-750 | "http://rdf.glycoinfo.org/glycan/G59574FS" | denotes | all |
| GlycanIUPAC_T131 | 747-750 | "http://rdf.glycoinfo.org/glycan/G47567WC" | denotes | all |
GlycoBiology-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 256-267 | http://purl.obolibrary.org/obo/MAT_0000373 | denotes | vertebrates |
| T2 | 272-285 | http://purl.obolibrary.org/obo/MAT_0000374 | denotes | invertebrates |
| T3 | 1474-1480 | http://purl.obolibrary.org/obo/MAT_0000488 | denotes | latter |
GlycoBiology-Epitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoEpitope-B_T1 | 97-112 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| PD-GlycoEpitope-B_T2 | 194-209 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 256-267 | http://purl.obolibrary.org/obo/UBERON_3010224 | denotes | vertebrates |
| PD-UBERON-AE-B_T2 | 928-944 | http://purl.obolibrary.org/obo/UBERON_4200047 | denotes | attachment sites |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-147 | Sentence | denotes | Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage. |
| T2 | 148-372 | Sentence | denotes | The membrane lipid-anchored glypicans (Gpcs) [heparan sulfate (HS) proteoglycans (PGs)] are present in both vertebrates and invertebrates and serve as important modulators of growth factors and morphogens during development. |
| T3 | 373-565 | Sentence | denotes | Their core proteins are similar and consist of a large N-terminal domain comprising 14 evolutionary conserved cysteines and a C-terminal stalk carrying the HS side chains and the lipid anchor. |
| T4 | 566-652 | Sentence | denotes | Cysteines in Gpc-1 can be S-nitrosylated but their positions have not been identified. |
| T5 | 653-824 | Sentence | denotes | The recently determined crystal structure of the N-terminal domain of Gpc-1 has revealed that all the evolutionary conserved cysteines form intramolecular disulfide bonds. |
| T6 | 825-945 | Sentence | denotes | However, Gpc-1 contains two more, non-conserved cysteines in the C-terminal stalk, located near the HS attachment sites. |
| T7 | 946-1159 | Sentence | denotes | We show here that the non-conserved cysteines are free thiols as a Gpc-1 core protein containing the C-terminal stalk could be biotinylated by 1-biotinamido-4-(4'-[maleimidomethyl-cyclohexane]-carboxyamido)butane. |
| T8 | 1160-1389 | Sentence | denotes | After S-nitrosylation by using a nitric oxide (NO) donor and copper ions, the Gpc-1 core protein was retained on an affinity matrix substituted with HS oligosaccharides containing N-unsubstituted glucosamines (GlcNH(2)/NH(3)(+)). |
| T9 | 1390-1466 | Sentence | denotes | The protein was displaced with 0.2 M glucosamine but also by 2 mM ascorbate. |
| T10 | 1467-1593 | Sentence | denotes | In the latter case, the HS of the affinity matrix was simultaneously cleaved into fragments containing anhydromannose (anMan). |
| T11 | 1594-1727 | Sentence | denotes | We propose that the S-nitrosocysteine residues interact with closely located GlcNH(2)/NH(3)(+) in the HS side chains of the Gpc-1 PG. |
| T12 | 1728-1892 | Sentence | denotes | Addition of ascorbate induces a series of reactions that eventually releases HS fragments with reducing terminal anMan, presumably without the formation of free NO. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 97-112 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 194-209 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 211-213 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 529-531 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T5 | 925-927 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T6 | 1309-1311 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T7 | 1491-1493 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T8 | 1696-1698 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
| T9 | 1805-1807 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 152-160 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/UBERON_0000094 |
| T2 | 928-944 | Body_part | denotes | attachment sites | http://purl.obolibrary.org/obo/UBERON_4200047 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 256-267 | Body_part | denotes | vertebrates | http://purl.obolibrary.org/obo/MAT_0000373 |
| T2 | 272-285 | Body_part | denotes | invertebrates | http://purl.obolibrary.org/obo/MAT_0000374 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 256-267 | Body_part | denotes | vertebrates | http://purl.obolibrary.org/obo/MAT_0000373 |
| T2 | 272-285 | Body_part | denotes | invertebrates | http://purl.obolibrary.org/obo/MAT_0000374 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 152-160 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 928-944 | Body_part | denotes | attachment sites | http://purl.obolibrary.org/obo/UBERON_4200047 |