PubMed:22798246 JSONTXT

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":536,"end":542},"obj":"gene:6711"},{"id":"T1","span":{"begin":568,"end":590},"obj":"disease:C0521170"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.\nTo investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P \u003c 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P \u003c 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures."}

{"project":"Allie","denotations":[{"id":"SS1_22798246_1_0","span":{"begin":187,"end":209},"obj":"expanded"},{"id":"SS2_22798246_1_0","span":{"begin":211,"end":215},"obj":"abbr"}],"relations":[{"id":"AE1_22798246_1_0","pred":"abbreviatedTo","subj":"SS1_22798246_1_0","obj":"SS2_22798246_1_0"}],"text":"The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.\nTo investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P \u003c 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P \u003c 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures."}

{"project":"PubTator4TogoVar","denotations":[{"id":"28","span":{"begin":522,"end":532},"obj":"SNP"},{"id":"32","span":{"begin":1074,"end":1084},"obj":"SNP"},{"id":"34","span":{"begin":1271,"end":1281},"obj":"SNP"}],"attributes":[{"id":"A28","pred":"resolved_to","subj":"28","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"},{"id":"A32","pred":"resolved_to","subj":"32","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"},{"id":"A34","pred":"resolved_to","subj":"34","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"}],"text":"The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.\nTo investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P \u003c 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P \u003c 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"28","span":{"begin":522,"end":532},"obj":"SNP"},{"id":"32","span":{"begin":1074,"end":1084},"obj":"SNP"},{"id":"34","span":{"begin":1271,"end":1281},"obj":"SNP"},{"id":"T1","span":{"begin":522,"end":532},"obj":"SNP"},{"id":"T2","span":{"begin":1074,"end":1084},"obj":"SNP"},{"id":"T3","span":{"begin":1271,"end":1281},"obj":"SNP"}],"attributes":[{"id":"A28","pred":"resolved_to","subj":"28","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"},{"id":"A32","pred":"resolved_to","subj":"32","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"},{"id":"A34","pred":"resolved_to","subj":"34","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"},{"id":"A3","pred":"resolved_to","subj":"T3","obj":"tmVar:rs11898505;VariantGroup:0;CorrespondingGene:6711;RS#:11898505;CorrespondingSpecies:9606"}],"text":"The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.\nTo investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P \u003c 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P \u003c 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures."}