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PubMed:22797576 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 410-414 gene:596 denotes BCL2
T1 472-475 disease:C0005684 denotes BCa
T2 410-414 gene:596 denotes BCL2
T3 472-475 disease:C0699885 denotes BCa
T4 410-414 gene:596 denotes BCL2
T5 560-563 disease:C0005684 denotes BCa
T6 410-414 gene:596 denotes BCL2
T7 560-563 disease:C0699885 denotes BCa
T8 424-428 gene:331 denotes XIAP
T9 472-475 disease:C0005684 denotes BCa
T10 424-428 gene:331 denotes XIAP
T11 472-475 disease:C0699885 denotes BCa
T12 424-428 gene:331 denotes XIAP
T13 560-563 disease:C0005684 denotes BCa
T14 424-428 gene:331 denotes XIAP
T15 560-563 disease:C0699885 denotes BCa
R1 T0 T1 associated_with BCL2,BCa
R2 T2 T3 associated_with BCL2,BCa
R3 T4 T5 associated_with BCL2,BCa
R4 T6 T7 associated_with BCL2,BCa
R5 T8 T9 associated_with XIAP,BCa
R6 T10 T11 associated_with XIAP,BCa
R7 T12 T13 associated_with XIAP,BCa
R8 T14 T15 associated_with XIAP,BCa

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 112-126 HP_0009725 denotes Bladder cancer
T2 120-126 HP_0002664 denotes cancer
T3 366-372 HP_0002664 denotes cancer
T4 1406-1420 HP_0009725 denotes bladder cancer
T5 1414-1420 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_22797576_1_0 112-126 expanded denotes Bladder cancer
SS2_22797576_1_0 128-131 abbr denotes BCa
AE1_22797576_1_0 SS1_22797576_1_0 SS2_22797576_1_0 abbreviatedTo Bladder cancer,BCa

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22797576-0#69#73#gene331 69-73 gene331 denotes XIAP
22797576-0#90#104#diseaseC0005684 90-104 diseaseC0005684 denotes bladder cancer
22797576-0#90#104#diseaseC0005695 90-104 diseaseC0005695 denotes bladder cancer
22797576-0#90#104#diseaseC0699885 90-104 diseaseC0699885 denotes bladder cancer
22797576-9#51#55#gene596 1327-1331 gene596 denotes BCL2
22797576-9#130#144#diseaseC0005684 1406-1420 diseaseC0005684 denotes bladder cancer
22797576-9#130#144#diseaseC0005695 1406-1420 diseaseC0005695 denotes bladder cancer
22797576-9#130#144#diseaseC0699885 1406-1420 diseaseC0699885 denotes bladder cancer
69#73#gene33190#104#diseaseC0005684 22797576-0#69#73#gene331 22797576-0#90#104#diseaseC0005684 associated_with XIAP,bladder cancer
69#73#gene33190#104#diseaseC0005695 22797576-0#69#73#gene331 22797576-0#90#104#diseaseC0005695 associated_with XIAP,bladder cancer
69#73#gene33190#104#diseaseC0699885 22797576-0#69#73#gene331 22797576-0#90#104#diseaseC0699885 associated_with XIAP,bladder cancer
51#55#gene596130#144#diseaseC0005684 22797576-9#51#55#gene596 22797576-9#130#144#diseaseC0005684 associated_with BCL2,bladder cancer
51#55#gene596130#144#diseaseC0005695 22797576-9#51#55#gene596 22797576-9#130#144#diseaseC0005695 associated_with BCL2,bladder cancer
51#55#gene596130#144#diseaseC0699885 22797576-9#51#55#gene596 22797576-9#130#144#diseaseC0699885 associated_with BCL2,bladder cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1326 69-73 gene:331 denotes XIAP
T1327 90-104 disease:C0005684 denotes bladder cancer
T1328 1327-1331 gene:596 denotes BCL2
T1329 1406-1420 disease:C0005684 denotes bladder cancer
R1 T1326 T1327 associated_with XIAP,bladder cancer
R2 T1326 T1327 associated_with XIAP,bladder cancer
R3 T1326 T1327 associated_with XIAP,bladder cancer
R4 T1328 T1329 associated_with BCL2,bladder cancer
R5 T1328 T1329 associated_with BCL2,bladder cancer
R6 T1328 T1329 associated_with BCL2,bladder cancer

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells.
TextSentencer_T2 112-187 Sentence denotes Bladder cancer (BCa) represents the ninth most common malignancy worldwide.
TextSentencer_T3 188-317 Sentence denotes Despite intensive treatment with surgery and chemotherapy the prognosis for BCa patients particularly at advanced stages is poor.
TextSentencer_T4 318-379 Sentence denotes The ability to evade apoptosis is a hallmark of cancer cells.
TextSentencer_T5 380-612 Sentence denotes Since the antiapoptotic genes BCL2, Bcl-xL, XIAP and survivin are frequently upregulated in BCa tissues, their combined siRNA-mediated knockdown might be more potent in decreasing BCa growth than the single inhibition of one target.
TextSentencer_T6 613-766 Sentence denotes Against each target two siRNAs were selected that specifically reduced the mRNA and protein levels of their appropriate target in EJ28 and J82 BCa cells.
TextSentencer_T7 767-912 Sentence denotes Inhibition of survivin provoked the strongest antiproliferative effect of all single target treatments, for example cell counts decreased by 50%.
TextSentencer_T8 913-1119 Sentence denotes Simultaneous targeting of all four antiapoptotic genes downregulated expression levels of all targets and mediated significant reductions in cell viability and cell counts as well as induction of apoptosis.
TextSentencer_T9 1120-1275 Sentence denotes In EJ28 cells, combined knockdown of BCL2, Bcl-xL, XIAP and survivin caused a 2.5-fold enhancement in apoptosis rate and reduced cellular viability by 40%.
TextSentencer_T10 1276-1421 Sentence denotes Therefore, simultaneous knockdown of antiapoptotic BCL2, Bcl‑xL, XIAP and survivin may represent a promising treatment option for bladder cancer.
T1 0-111 Sentence denotes Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells.
T2 112-187 Sentence denotes Bladder cancer (BCa) represents the ninth most common malignancy worldwide.
T3 188-317 Sentence denotes Despite intensive treatment with surgery and chemotherapy the prognosis for BCa patients particularly at advanced stages is poor.
T4 318-379 Sentence denotes The ability to evade apoptosis is a hallmark of cancer cells.
T5 380-612 Sentence denotes Since the antiapoptotic genes BCL2, Bcl-xL, XIAP and survivin are frequently upregulated in BCa tissues, their combined siRNA-mediated knockdown might be more potent in decreasing BCa growth than the single inhibition of one target.
T6 613-766 Sentence denotes Against each target two siRNAs were selected that specifically reduced the mRNA and protein levels of their appropriate target in EJ28 and J82 BCa cells.
T7 767-912 Sentence denotes Inhibition of survivin provoked the strongest antiproliferative effect of all single target treatments, for example cell counts decreased by 50%.
T8 913-1119 Sentence denotes Simultaneous targeting of all four antiapoptotic genes downregulated expression levels of all targets and mediated significant reductions in cell viability and cell counts as well as induction of apoptosis.
T9 1120-1275 Sentence denotes In EJ28 cells, combined knockdown of BCL2, Bcl-xL, XIAP and survivin caused a 2.5-fold enhancement in apoptosis rate and reduced cellular viability by 40%.
T10 1276-1421 Sentence denotes Therefore, simultaneous knockdown of antiapoptotic BCL2, Bcl‑xL, XIAP and survivin may represent a promising treatment option for bladder cancer.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 476-483 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 476-483 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues