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PubMed:22773839 JSONTXT

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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 543-549 http://purl.obolibrary.org/obo/MAT_0000153 denotes dermis

DisGeNET

Id Subject Object Predicate Lexical cue
T0 93-104 gene:3685 denotes integrin αv
T1 56-64 disease:C0025202 denotes melanoma
T2 35-38 gene:7157 denotes p53
T3 56-64 disease:C0025202 denotes melanoma
T4 0-17 gene:5578 denotes Protein kinase Cα
T5 56-64 disease:C0025202 denotes melanoma
T6 93-104 gene:3678 denotes integrin αv
T7 56-64 disease:C0025202 denotes melanoma
T8 148-166 gene:5578 denotes Protein kinase C α
T9 212-218 disease:C0006826 denotes cancer
T10 148-166 gene:5578 denotes Protein kinase C α
T11 212-218 disease:C1306459 denotes cancer
T12 233-237 gene:5578 denotes PKCα
T13 257-267 disease:C0027627 denotes metastasis
T14 233-237 gene:5578 denotes PKCα
T15 257-267 disease:C2939420 denotes metastasis
T16 233-237 gene:5578 denotes PKCα
T17 271-289 disease:C0025202 denotes malignant melanoma
T18 336-340 gene:5578 denotes PKCα
T19 388-396 disease:C0025202 denotes melanoma
T20 429-433 gene:5578 denotes PKCα
T21 437-445 disease:C0025202 denotes melanoma
T22 628-632 gene:5578 denotes PKCα
T23 707-715 disease:C0025202 denotes melanoma
T24 666-669 gene:7157 denotes p53
T25 707-715 disease:C0025202 denotes melanoma
T26 826-837 gene:3678 denotes integrin αv
T27 731-739 disease:C0025202 denotes Melanoma
T28 826-837 gene:3685 denotes integrin αv
T29 731-739 disease:C0025202 denotes Melanoma
R1 T0 T1 associated_with integrin αv,melanoma
R2 T2 T3 associated_with p53,melanoma
R3 T4 T5 associated_with Protein kinase Cα,melanoma
R4 T6 T7 associated_with integrin αv,melanoma
R5 T8 T9 associated_with Protein kinase C α,cancer
R6 T10 T11 associated_with Protein kinase C α,cancer
R7 T12 T13 associated_with PKCα,metastasis
R8 T14 T15 associated_with PKCα,metastasis
R9 T16 T17 associated_with PKCα,malignant melanoma
R10 T18 T19 associated_with PKCα,melanoma
R11 T20 T21 associated_with PKCα,melanoma
R12 T22 T23 associated_with PKCα,melanoma
R13 T24 T25 associated_with p53,melanoma
R14 T26 T27 associated_with integrin αv,Melanoma
R15 T28 T29 associated_with integrin αv,Melanoma

Allie

Id Subject Object Predicate Lexical cue
SS1_22773839_0_0 148-166 expanded denotes Protein kinase C α
SS2_22773839_0_0 168-172 abbr denotes PKCα
SS1_22773839_1_0 148-166 expanded denotes Protein kinase C α
SS2_22773839_1_0 168-172 abbr denotes PKCα
AE1_22773839_0_0 SS1_22773839_0_0 SS2_22773839_0_0 abbreviatedTo Protein kinase C α,PKCα
AE1_22773839_1_0 SS1_22773839_1_0 SS2_22773839_1_0 abbreviatedTo Protein kinase C α,PKCα

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 212-218 HP_0002664 denotes cancer
T2 271-289 HP_0002861 denotes malignant melanoma
T3 281-289 HP_0002861 denotes melanoma
T4 388-396 HP_0002861 denotes melanoma
T5 437-445 HP_0002861 denotes melanoma
T6 707-715 HP_0002861 denotes melanoma
T7 731-739 HP_0002861 denotes Melanoma
T8 1397-1402 HP_0002664 denotes tumor
T9 1543-1551 HP_0002861 denotes melanoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22773839-0#93#104#gene3678 1137-1245 gene3678 denotes in three-dimensional collagen as well as in vivo, whereas stable knockdown of PKCα inhibited the integrin αv
22773839-0#93#104#gene3685 1137-1245 gene3685 denotes in three-dimensional collagen as well as in vivo, whereas stable knockdown of PKCα inhibited the integrin αv
22773839-0#0#17#gene5578 148-166 gene5578 denotes Protein kinase C α
22773839-0#19#23#gene5578 168-172 gene5578 denotes PKCα
22773839-0#35#38#gene7157 520-669 gene7157 denotes pathophysiology of the dermis. A pathway was identified that involved integrin αv-mediated up-regulation of PKCα and PKCα-dependent regulation of p53
22773839-0#56#64#diseaseC0025202 707-715 diseaseC0025202 denotes melanoma
22773839-2#13#17#gene5578 233-237 gene5578 denotes PKCα
22773839-2#37#47#diseaseC0027627 257-267 diseaseC0027627 denotes metastasis
93#104#gene367856#64#diseaseC0025202 22773839-0#93#104#gene3678 22773839-0#56#64#diseaseC0025202 associated_with "in three-dimensional collagen as well as in vivo, whereas stable knockdown of PKCα inhibited the integrin αv",melanoma
93#104#gene368556#64#diseaseC0025202 22773839-0#93#104#gene3685 22773839-0#56#64#diseaseC0025202 associated_with "in three-dimensional collagen as well as in vivo, whereas stable knockdown of PKCα inhibited the integrin αv",melanoma
0#17#gene557856#64#diseaseC0025202 22773839-0#0#17#gene5578 22773839-0#56#64#diseaseC0025202 associated_with Protein kinase C α,melanoma
19#23#gene557856#64#diseaseC0025202 22773839-0#19#23#gene5578 22773839-0#56#64#diseaseC0025202 associated_with PKCα,melanoma
35#38#gene715756#64#diseaseC0025202 22773839-0#35#38#gene7157 22773839-0#56#64#diseaseC0025202 associated_with pathophysiology of the dermis. A pathway was identified that involved integrin αv-mediated up-regulation of PKCα and PKCα-dependent regulation of p53,melanoma
13#17#gene557837#47#diseaseC0027627 22773839-2#13#17#gene5578 22773839-2#37#47#diseaseC0027627 associated_with PKCα,metastasis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1573 233-237 gene:5578 denotes PKCα
T1574 257-267 disease:C0027627 denotes metastasis
R1 T1573 T1574 associated_with PKCα,metastasis

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-147 Sentence denotes Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo.
TextSentencer_T2 148-219 Sentence denotes Protein kinase C α (PKCα) is overexpressed in numerous types of cancer.
TextSentencer_T3 220-302 Sentence denotes Importantly, PKCα has been linked to metastasis of malignant melanoma in patients.
TextSentencer_T4 303-397 Sentence denotes However, it has been unclear how PKCα may be regulated and how it exerts its role in melanoma.
TextSentencer_T5 398-550 Sentence denotes Here, we identified a role for PKCα in melanoma cell survival in a three-dimensional collagen model mimicking the in vivo pathophysiology of the dermis.
TextSentencer_T6 551-730 Sentence denotes A pathway was identified that involved integrin αv-mediated up-regulation of PKCα and PKCα-dependent regulation of p53 localization, which was connected to melanoma cell survival.
TextSentencer_T7 731-875 Sentence denotes Melanoma survival and growth in three-dimensional microenvironments requires the expression of integrin αv, which acts to suppress p53 activity.
TextSentencer_T8 876-1019 Sentence denotes Interestingly, microarray analysis revealed that PKCα was up-regulated by integrin αv in a three-dimensional microenvironment-dependent manner.
TextSentencer_T9 1020-1277 Sentence denotes Integrin αv was observed to promote a relocalization of endogenous p53 from the nucleus to the cytoplasm upon growth in three-dimensional collagen as well as in vivo, whereas stable knockdown of PKCα inhibited the integrin αv-mediated relocalization of p53.
TextSentencer_T10 1278-1410 Sentence denotes Importantly, knockdown of PKCα also promoted apoptosis in three-dimensional collagen and in vivo, resulting in reduced tumor growth.
TextSentencer_T11 1411-1561 Sentence denotes This indicates that PKCα constitutes a crucial component of the integrin αv-mediated pathway(s) that promote p53 relocalization and melanoma survival.
T1 0-147 Sentence denotes Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo.
T2 148-219 Sentence denotes Protein kinase C α (PKCα) is overexpressed in numerous types of cancer.
T3 220-302 Sentence denotes Importantly, PKCα has been linked to metastasis of malignant melanoma in patients.
T4 303-397 Sentence denotes However, it has been unclear how PKCα may be regulated and how it exerts its role in melanoma.
T5 398-550 Sentence denotes Here, we identified a role for PKCα in melanoma cell survival in a three-dimensional collagen model mimicking the in vivo pathophysiology of the dermis.
T6 551-730 Sentence denotes A pathway was identified that involved integrin αv-mediated up-regulation of PKCα and PKCα-dependent regulation of p53 localization, which was connected to melanoma cell survival.
T7 731-875 Sentence denotes Melanoma survival and growth in three-dimensional microenvironments requires the expression of integrin αv, which acts to suppress p53 activity.
T8 876-1019 Sentence denotes Interestingly, microarray analysis revealed that PKCα was up-regulated by integrin αv in a three-dimensional microenvironment-dependent manner.
T9 1020-1277 Sentence denotes Integrin αv was observed to promote a relocalization of endogenous p53 from the nucleus to the cytoplasm upon growth in three-dimensional collagen as well as in vivo, whereas stable knockdown of PKCα inhibited the integrin αv-mediated relocalization of p53.
T10 1278-1410 Sentence denotes Importantly, knockdown of PKCα also promoted apoptosis in three-dimensional collagen and in vivo, resulting in reduced tumor growth.
T11 1411-1561 Sentence denotes This indicates that PKCα constitutes a crucial component of the integrin αv-mediated pathway(s) that promote p53 relocalization and melanoma survival.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 543-549 http://purl.obolibrary.org/obo/UBERON_0002067 denotes dermis

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 543-549 http://purl.obolibrary.org/obo/UBERON_0002067 denotes dermis

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 543-549 Body_part denotes dermis http://purl.obolibrary.org/obo/MAT_0000153

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 56-64 Phenotype denotes melanoma HP:0002861
T2 212-218 Phenotype denotes cancer HP:0002664
T3 271-289 Phenotype denotes malignant melanoma HP:0002861
T4 388-396 Phenotype denotes melanoma HP:0002861
T5 437-445 Phenotype denotes melanoma HP:0002861
T6 707-715 Phenotype denotes melanoma HP:0002861
T7 731-739 Phenotype denotes Melanoma HP:0002861
T8 1397-1402 Phenotype denotes tumor HP:0002664
T9 1543-1551 Phenotype denotes melanoma HP:0002861

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 56-64 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T2 212-218 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 271-289 Disease denotes malignant melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T4 388-396 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T5 437-445 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T6 707-715 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T7 731-739 Disease denotes Melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T8 1397-1402 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T9 1543-1551 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 543-549 Body_part denotes dermis http://purl.obolibrary.org/obo/UBERON_0002067
T2 1100-1107 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T4 1115-1124 Body_part denotes cytoplasm http://purl.obolibrary.org/obo/GO_0005737