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PubMed:22773119 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 4-9 PR:Q5S006 denotes LRRK2
T2 4-9 PR:000003033 denotes LRRK2
T3 4-9 PR:Q5S007 denotes LRRK2
T4 42-51 GO:0016236 denotes autophagy
T5 42-51 GO:0006914 denotes autophagy
T6 78-81 CHEBI:28398 denotes MEK
T7 82-85 PR:P29323 denotes ERK
T8 82-85 PR:000007130 denotes ERK
T9 82-85 GO:0004707 denotes ERK
T10 86-93 CHEBI:34922 denotes pathway
T12 108-115 6308 denotes leucine
T13 108-115 SO:0001437 denotes leucine
T11 108-115 CHEBI:15603 denotes leucine
T14 108-115 D007930 denotes leucine
T15 108-115 CHEBI:25017 denotes leucine
T16 108-115 D007930 denotes leucine
T17 121-127 SO:0001068 denotes repeat
T18 138-143 PR:Q5S006 denotes LRRK2
T19 138-143 PR:000003033 denotes LRRK2
T20 138-143 PR:Q5S007 denotes LRRK2
T21 175-187 D020734 denotes Parkinsonism
T22 175-187 D020734 denotes Parkinsonism
T23 204-212 SO:0000109 denotes mutation
T24 216-221 PR:Q5S006 denotes LRRK2
T25 216-221 PR:000003033 denotes LRRK2
T26 216-221 PR:Q5S007 denotes LRRK2
T27 293-302 UBERON:0004529 denotes processes
T28 306-311 UBERON:0001021 denotes nerve
T33 355-374 D010300 denotes Parkinson's disease
T34 355-374 D010300 denotes Parkinson's disease
T37 560-570 GO:0008219 denotes cell death
T38 630-639 GO:0097194 denotes apoptosis
T39 630-639 GO:0006915 denotes apoptosis
T40 677-682 PR:Q5S006 denotes LRRK2
T41 677-682 PR:000003033 denotes LRRK2
T42 677-682 PR:Q5S007 denotes LRRK2
T43 705-720 GO:0016310 denotes phosphorylation
T44 724-728 PR:P63086 denotes MAPK
T45 724-728 PR:P63085 denotes MAPK
T46 724-728 P27638 denotes MAPK
T47 724-728 PR:000000103 denotes MAPK
T49 724-728 PR:P40417 denotes MAPK
T50 724-728 PR:000000019 denotes MAPK
T48 724-728 GO:0004707 denotes MAPK
T51 724-740 D020929 denotes MAPK/ERK kinases
T52 729-732 PR:P29323 denotes ERK
T53 729-732 PR:000007130 denotes ERK
T54 729-732 GO:0004707 denotes ERK
T55 733-745 D020930 denotes kinases (MEK
T58 759-818 C113580 denotes 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
T59 759-818 C113580 denotes 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
T60 787-790 GO:0033815 denotes bis
T64 787-792 PR:Q8S307 denotes bis[2
T65 787-792 PR:000028348 denotes bis[2
T69 820-825 C113580 denotes U0126
T70 820-825 C113580 denotes U0126
T71 820-825 CHEBI:90693 denotes U0126
T72 847-856 CHEBI:35222 denotes inhibitor
T73 860-863 CHEBI:28398 denotes MEK
T74 860-864 PR:Q02750 denotes MEK1
T75 860-864 PR:Q21307 denotes MEK1
T76 860-864 PR:Q55CL6 denotes MEK1
T77 860-864 Q05116 denotes MEK1
T78 860-864 Q63980 denotes MEK1
T80 860-864 P31938 denotes MEK1
T81 860-864 P29678 denotes MEK1
T82 860-864 PR:000029222 denotes MEK1
T83 860-864 PR:Q01986 denotes MEK1
T84 860-864 PR:Q94A06 denotes MEK1
T85 860-864 Q9XT09 denotes MEK1
T86 860-864 Q02750 denotes MEK1
T87 860-864 PR:P29678 denotes MEK1
T88 860-864 Q91447 denotes MEK1
T89 860-864 PR:Q10292 denotes MEK1
T90 860-864 PR:P31938 denotes MEK1
T91 860-864 Q01986 denotes MEK1
T92 860-864 Q55CL6 denotes MEK1
T93 860-864 PR:P24719 denotes MEK1
T94 860-864 PR:000010125 denotes MEK1
T79 860-864 GO:0004708 denotes MEK1
T95 889-898 GO:0016236 denotes autophagy
T96 889-898 GO:0006914 denotes autophagy
T97 934-939 PR:Q5S006 denotes LRRK2
T98 934-939 PR:000003033 denotes LRRK2
T99 934-939 PR:Q5S007 denotes LRRK2
T100 940-948 SO:0000109 denotes mutation
T101 991-999 SO:0000109 denotes mutation
T102 1008-1017 GO:0016236 denotes autophagy
T103 1008-1017 GO:0006914 denotes autophagy
T104 1022-1025 CHEBI:28398 denotes MEK
T105 1026-1029 PR:P29323 denotes ERK
T106 1026-1029 PR:000007130 denotes ERK
T107 1026-1029 GO:0004707 denotes ERK
T108 1030-1037 CHEBI:34922 denotes pathway
T109 1082-1091 GO:0016236 denotes autophagy
T110 1082-1091 GO:0006914 denotes autophagy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 175-187 HP_0001300 denotes Parkinsonism
T2 355-364 HP_0001300 denotes Parkinson

Allie

Id Subject Object Predicate Lexical cue
SS1_22773119_1_0 108-136 expanded denotes leucine-rich repeat kinase 2
SS2_22773119_1_0 138-143 abbr denotes LRRK2
SS1_22773119_2_0 355-374 expanded denotes Parkinson's disease
SS2_22773119_2_0 376-378 abbr denotes PD
SS1_22773119_5_0 724-740 expanded denotes MAPK/ERK kinases
SS2_22773119_5_0 742-745 abbr denotes MEK
AE1_22773119_1_0 SS1_22773119_1_0 SS2_22773119_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_22773119_2_0 SS1_22773119_2_0 SS2_22773119_2_0 abbreviatedTo Parkinson's disease,PD
AE1_22773119_5_0 SS1_22773119_5_0 SS2_22773119_5_0 abbreviatedTo MAPK/ERK kinases,MEK

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-3 DRI_Outcome denotes The
T2 4-16 Token_Label.OUTSIDE denotes LRRK2 G2019S
T3 17-94 DRI_Outcome denotes mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.
T4 95-261 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are a major cause of familial Parkinsonism, and the G2019S mutation of LRRK2 is one of the most prevalent mutations.
T5 262-380 DRI_Challenge denotes The deregulation of autophagic processes in nerve cells is thought to be a possible cause of Parkinson's disease (PD).
T6 381-508 DRI_Outcome denotes In this study, we observed that G2019S mutant fibroblasts exhibited higher autophagic activity levels than control fibroblasts.
T7 509-676 DRI_Background denotes Elevated levels of autophagic activity can trigger cell death, and in our study, G2019S mutant cells exhibited increased apoptosis hallmarks compared to control cells.
T8 677-747 DRI_Background denotes LRRK2 is able to induce the phosphorylation of MAPK/ERK kinases (MEK).
T9 748-926 DRI_Background denotes The use of 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene (U0126), a highly selective inhibitor of MEK1/2, reduced the enhanced autophagy and sensibility observed in
T10 927-939 Token_Label.OUTSIDE denotes G2019S LRRK2
T11 940-955 DRI_Background denotes mutation cells.
T12 956-1148 DRI_Outcome denotes These data suggest that the G2019S mutation induces autophagy via MEK/ERK pathway and that the inhibition of this exacerbated autophagy reduces the sensitivity observed in G2019S mutant cells.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 95-261 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are a major cause of familial Parkinsonism, and the G2019S mutation of LRRK2 is one of the most prevalent mutations.
T2 262-380 DRI_Challenge denotes The deregulation of autophagic processes in nerve cells is thought to be a possible cause of Parkinson's disease (PD).
T3 381-508 DRI_Outcome denotes In this study, we observed that G2019S mutant fibroblasts exhibited higher autophagic activity levels than control fibroblasts.
T4 509-676 DRI_Background denotes Elevated levels of autophagic activity can trigger cell death, and in our study, G2019S mutant cells exhibited increased apoptosis hallmarks compared to control cells.
T5 677-747 DRI_Background denotes LRRK2 is able to induce the phosphorylation of MAPK/ERK kinases (MEK).
T6 748-926 DRI_Background denotes The use of 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene (U0126), a highly selective inhibitor of MEK1/2, reduced the enhanced autophagy and sensibility observed in
T7 940-955 DRI_Background denotes mutation cells.
T8 956-1148 DRI_Outcome denotes These data suggest that the G2019S mutation induces autophagy via MEK/ERK pathway and that the inhibition of this exacerbated autophagy reduces the sensitivity observed in G2019S mutant cells.