PubMed:22752264 JSONTXT

{"project":"Allie","denotations":[{"id":"SS1_22752264_1_0","span":{"begin":129,"end":142},"obj":"expanded"},{"id":"SS2_22752264_1_0","span":{"begin":144,"end":146},"obj":"abbr"}],"relations":[{"id":"AE1_22752264_1_0","pred":"abbreviatedTo","subj":"SS1_22752264_1_0","obj":"SS2_22752264_1_0"}],"text":"Microbial production of itaconic acid: developing a stable platform for high product concentrations.\nBiotechnologically produced itaconic acid (IA) is a promising organic acid with a wide range of applications and the potential to open up new application fields in the area of polymer chemistry, pharmacy, and agriculture. In this study, a systematic process optimization was performed with an own isolated strain of Aspergillus terreus and transferred from a 250-mL to a 15-L scale. An IA concentration of 86.2 g/L was achieved within 7 days with an overall productivity of 0.51 g/(L h), a maximum productivity of 1.2 g/(L h), and a yield of 86 mol%. A cultivation of other well-known A. terreus strains with the developed process showed no significant differences. Based on this, a process is developed providing a high final IA concentration independent of the used strain combined with high reproducibility."}