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PubMed:22751464 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T3 61-85 D002285 denotes ductal carcinoma in situ
T4 61-85 D002285 denotes ductal carcinoma in situ
T9 98-104 UBERON:0000310 denotes breast
T10 98-111 D001943 denotes breast cancer
T11 98-111 D001943 denotes breast cancer
T14 163-187 D002285 denotes ductal carcinoma in situ
T15 163-187 D002285 denotes ductal carcinoma in situ
T21 189-193 CVCL_5552 denotes DCIS
T20 189-193 D002285 denotes DCIS
T22 189-193 D002285 denotes DCIS
T23 207-213 UBERON:0000310 denotes breast
T24 207-220 D001943 denotes breast cancer
T25 207-220 D001943 denotes breast cancer
T26 236-243 32644 denotes unknown
T27 253-257 SO:0000704 denotes gene
T28 253-268 GO:0010467 denotes gene expression
T29 282-287 D006801 denotes human
T31 288-292 CVCL_5552 denotes DCIS
T30 288-292 D002285 denotes DCIS
T32 288-292 D002285 denotes DCIS
T33 315-321 UBERON:0000310 denotes breast
T34 315-328 D001943 denotes breast cancer
T35 315-328 D001943 denotes breast cancer
T36 467-471 PR:000022679 denotes fold
T37 467-471 PR:Q2FZJ6 denotes fold
T38 467-471 PR:A5I112 denotes fold
T39 467-471 PR:P24186 denotes fold
T40 525-534 GO:0009058 denotes synthesis
T42 555-575 GO:0031012 denotes extracellular matrix
T43 569-575 UBERON:0027368 denotes matrix
T44 610-620 UBERON:0000483 denotes epithelium
T45 633-639 UBERON:0000310 denotes breast
T46 633-646 D001943 denotes breast cancer
T47 633-646 D001943 denotes breast cancer
T48 856-860 SO:0000704 denotes gene
T49 920-924 SO:0000704 denotes gene
T51 1067-1071 CVCL_5552 denotes DCIS
T50 1067-1071 D002285 denotes DCIS
T52 1067-1071 D002285 denotes DCIS
T53 1084-1090 UBERON:0000310 denotes breast
T54 1084-1097 D001943 denotes breast cancer
T55 1084-1097 D001943 denotes breast cancer
T56 1121-1126 D006801 denotes human
T58 1127-1131 CVCL_5552 denotes DCIS
T57 1127-1131 D002285 denotes DCIS
T59 1127-1131 D002285 denotes DCIS
T60 1143-1153 SO:0000783 denotes engineered
T62 1208-1212 CVCL_5552 denotes DCIS
T61 1208-1212 D002285 denotes DCIS
T63 1208-1212 D002285 denotes DCIS
T64 1231-1242 D018450 denotes Progression
T65 1231-1242 D018450 denotes Progression
T66 1269-1275 UBERON:0000310 denotes breast
T67 1269-1282 D001943 denotes breast cancer
T68 1269-1282 D001943 denotes breast cancer
T70 1386-1390 CVCL_5552 denotes DCIS
T69 1386-1390 D002285 denotes DCIS
T71 1386-1390 D002285 denotes DCIS
T111 1404-1422 P0DM47 denotes protease inhibitor
T113 1404-1422 P84885 denotes protease inhibitor
T115 1404-1422 P61153 denotes protease inhibitor
T117 1404-1422 P43131 denotes protease inhibitor
T118 1404-1422 P26228 denotes protease inhibitor
T112 1404-1422 CHEBI:60258 denotes protease inhibitor
T114 1404-1422 D011480 denotes protease inhibitor
T116 1404-1422 D011480 denotes protease inhibitor
T119 1404-1422 CHEBI:37670 denotes protease inhibitor
T121 1424-1428 PR:P56567 denotes CSTA
T122 1424-1428 PR:000022346 denotes CSTA
T123 1424-1428 PR:000005973 denotes CSTA
T124 1424-1428 PR:P01039 denotes CSTA
T125 1424-1428 PR:P15078 denotes CSTA
T126 1424-1428 PR:P01040 denotes CSTA
T127 1452-1465 GO:0007155 denotes cell adhesion
T128 1470-1479 GO:0023052 denotes signaling
T133 1481-1485 PR:000007350 denotes FAT1
T134 1481-1485 PR:Q14517 denotes FAT1
T135 1481-1485 PR:P38225 denotes FAT1
T136 1481-1485 PR:O13735 denotes FAT1
T137 1481-1485 PR:Q9NEQ0 denotes FAT1
T138 1487-1490 PR:Q91ZU6 denotes DST
T139 1487-1490 PR:Q03001 denotes DST
T140 1487-1490 P07631 denotes DST
T142 1487-1490 PR:000031275 denotes DST
T141 1487-1490 CHEBI:38291 denotes DST
T143 1496-1503 PR:000029808 denotes TMEM45A
T144 1496-1503 PR:Q9NWC5 denotes TMEM45A
T145 1496-1503 PR:Q60774 denotes TMEM45A
T146 1617-1621 SO:0000704 denotes gene
T147 1617-1632 GO:0010467 denotes gene expression
T148 1645-1650 D006801 denotes human
T150 1651-1655 CVCL_5552 denotes DCIS
T149 1651-1655 D002285 denotes DCIS
T151 1651-1655 D002285 denotes DCIS
T152 1669-1675 UBERON:0000310 denotes breast
T153 1669-1682 D001943 denotes breast cancer
T154 1669-1682 D001943 denotes breast cancer
T155 1721-1726 D009369 denotes tumor
T156 1721-1726 D009369 denotes tumor
T158 1823-1827 CVCL_5552 denotes DCIS
T157 1823-1827 D002285 denotes DCIS
T159 1823-1827 D002285 denotes DCIS

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1424-1428 gene:1475 denotes CSTA
T1 1260-1282 disease:C0853879 denotes invasive breast cancer
T2 1481-1485 gene:2195 denotes FAT1
T3 1260-1282 disease:C0853879 denotes invasive breast cancer
T4 1481-1485 gene:2195 denotes FAT1
T5 1386-1390 disease:C0007124 denotes DCIS
T6 1487-1490 gene:667 denotes DST
T7 1260-1282 disease:C0853879 denotes invasive breast cancer
T8 1496-1503 gene:55076 denotes TMEM45A
T9 1260-1282 disease:C0853879 denotes invasive breast cancer
T10 1496-1503 gene:55076 denotes TMEM45A
T11 1386-1390 disease:C0007124 denotes DCIS
R1 T0 T1 associated_with CSTA,invasive breast cancer
R2 T2 T3 associated_with FAT1,invasive breast cancer
R3 T4 T5 associated_with FAT1,DCIS
R4 T6 T7 associated_with DST,invasive breast cancer
R5 T8 T9 associated_with TMEM45A,invasive breast cancer
R6 T10 T11 associated_with TMEM45A,DCIS

Allie

Id Subject Object Predicate Lexical cue
SS1_22751464_1_0 163-187 expanded denotes ductal carcinoma in situ
SS2_22751464_1_0 189-193 abbr denotes DCIS
SS1_22751464_8_0 1366-1422 expanded denotes clinical samples of DCIS, including a protease inhibitor
SS2_22751464_8_0 1424-1428 abbr denotes CSTA
AE1_22751464_1_0 SS1_22751464_1_0 SS2_22751464_1_0 abbreviatedTo ductal carcinoma in situ,DCIS
AE1_22751464_8_0 SS1_22751464_8_0 SS2_22751464_8_0 abbreviatedTo "clinical samples of DCIS, including a protease inhibitor",CSTA

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 113-244 DRI_Background denotes Molecular mechanisms mediating the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer remain largely unknown.
T2 245-410 DRI_Approach denotes We used gene expression profiling of human DCIS (n = 53) and invasive breast cancer (n = 51) to discover uniquely expressed genes that may also regulate progression.
T3 411-483 DRI_Approach denotes There were 470 total differentially expressed genes (≥2-fold; P < 0.05).
T4 484-647 DRI_Background denotes Elevated expression of genes involved in synthesis and organization of extracellular matrix was particularly prominent in the epithelium of invasive breast cancer.
T5 648-881 DRI_Approach denotes The degree of overlap of the genes with nine similar studies in the literature was determined to help prioritize their potential importance, resulting in 74 showing overlap in ≥2 studies (average 3.6 studies/gene; range 2-8 studies).
T6 882-1038 DRI_Approach denotes Using hierarchical clustering, the 74-gene profile correctly categorized 96% of samples in this study and 94% of samples from 3 similar independent studies.
T7 1039-1230 DRI_Background denotes To study the progression of DCIS to invasive breast cancer in vivo, we introduced human DCIS cell lines engineered to express specific genes into a "mammary intraductal DCIS" xenograft model.
T8 1231-1578 DRI_Background denotes Progression of xenografts to invasive breast cancer was dramatically increased by suppressing four genes that were usually elevated in clinical samples of DCIS, including a protease inhibitor (CSTA) and genes involved in cell adhesion and signaling (FAT1, DST, and TMEM45A), strongly suggesting that they normally function to suppress progression.
T9 1579-1739 DRI_Outcome denotes In summary, we have identified unique gene expression profiles of human DCIS and invasive breast cancer, which include novel genes regulating tumor progression.
T10 1740-1828 DRI_Background denotes Targeting some of these genes may improve the detection, diagnosis, and therapy of DCIS.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 207-220 HP_0003002 denotes breast cancer
T2 207-220 HP_0100013 denotes breast cancer
T3 214-220 HP_0002664 denotes cancer
T4 315-328 HP_0003002 denotes breast cancer
T5 315-328 HP_0100013 denotes breast cancer
T6 322-328 HP_0002664 denotes cancer
T7 633-646 HP_0003002 denotes breast cancer
T8 633-646 HP_0100013 denotes breast cancer
T9 640-646 HP_0002664 denotes cancer
T10 1084-1097 HP_0003002 denotes breast cancer
T11 1084-1097 HP_0100013 denotes breast cancer
T12 1091-1097 HP_0002664 denotes cancer
T13 1269-1282 HP_0003002 denotes breast cancer
T14 1269-1282 HP_0100013 denotes breast cancer
T15 1276-1282 HP_0002664 denotes cancer
T16 1669-1682 HP_0003002 denotes breast cancer
T17 1669-1682 HP_0100013 denotes breast cancer
T18 1676-1682 HP_0002664 denotes cancer
T19 1721-1726 HP_0002664 denotes tumor