PubMed:22730328
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 207-226 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
| T2 | 228-236 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T4 | 421-429 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T6 | 491-499 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-195 | Sentence | denotes | O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-β-D-glucosaminidase silencing on cell phenotype and transcriptome. |
| T2 | 196-376 | Sentence | denotes | O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation is a regulatory post-translational modification occurring on the serine or threonine residues of nucleocytoplasmic proteins. |
| T3 | 377-535 | Sentence | denotes | O-GlcNAcylation is dynamically regulated by O-GlcNAc transferase and O-GlcNAcase (OGA), which are responsible for O-GlcNAc addition and removal, respectively. |
| T4 | 536-762 | Sentence | denotes | Although O-GlcNAcylation was found to play a significant role in several pathologies such as type II diabetes and neurodegenerative diseases, the role of O-GlcNAcylation in the etiology and progression of cancer remains vague. |
| T5 | 763-952 | Sentence | denotes | Here, we followed O-GlcNAcylation and its catalytic machinery in metastatic clones of human colorectal cancer and the effect of OGA knockdown on cellular phenotype and on the transcriptome. |
| T6 | 953-1102 | Sentence | denotes | The colorectal cancer SW620 metastatic clone exhibited increased O-GlcNAcylation and decreased OGA expression compared with its primary clone, SW480. |
| T7 | 1103-1350 | Sentence | denotes | O-GlcNAcylation elevation in SW620 cells, through RNA interference of OGA, resulted in phenotypic alterations that included acquisition of a fibroblast-like morphology, which coincides with epithelial metastatic progression and growth retardation. |
| T8 | 1351-1561 | Sentence | denotes | Microarray analysis revealed that OGA silencing altered the expression of about 1300 genes, mostly involved in cell movement and growth, and specifically affected metabolic pathways of lipids and carbohydrates. |
| T9 | 1562-1756 | Sentence | denotes | These findings support the involvement of O-GlcNAcylation in various aspects of tumor cell physiology and suggest that this modification may serve as a link between metabolic changes and cancer. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 228-236 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 421-429 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 491-499 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 207-226 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
| T2 | 228-236 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T3 | 228-236 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T4 | 421-429 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T5 | 421-429 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T6 | 491-499 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T7 | 491-499 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 120-148 | gene:10724 | denotes | N-acetyl-β-D-glucosaminidase |
| T1 | 70-98 | disease:C0948380 | denotes | metastatic colorectal cancer |
| T2 | 891-894 | gene:10724 | denotes | OGA |
| T3 | 855-872 | disease:C1527249 | denotes | colorectal cancer |
| T4 | 891-894 | gene:10724 | denotes | OGA |
| T5 | 855-872 | disease:C0009402 | denotes | colorectal cancer |
| T6 | 1048-1051 | gene:10724 | denotes | OGA |
| T7 | 957-974 | disease:C1527249 | denotes | colorectal cancer |
| T8 | 1048-1051 | gene:10724 | denotes | OGA |
| T9 | 957-974 | disease:C0009402 | denotes | colorectal cancer |
| R1 | T0 | T1 | associated_with | N-acetyl-β-D-glucosaminidase,metastatic colorectal cancer |
| R2 | T2 | T3 | associated_with | OGA,colorectal cancer |
| R3 | T4 | T5 | associated_with | OGA,colorectal cancer |
| R4 | T6 | T7 | associated_with | OGA,colorectal cancer |
| R5 | T8 | T9 | associated_with | OGA,colorectal cancer |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22730328_0_0 | 0-36 | expanded | denotes | O-linked β-N-acetylglucosaminylation |
| SS2_22730328_0_0 | 38-53 | abbr | denotes | O-GlcNAcylation |
| SS1_22730328_1_0 | 196-226 | expanded | denotes | O-linked β-N-acetylglucosamine |
| SS2_22730328_1_0 | 228-236 | abbr | denotes | O-GlcNAc |
| SS1_22730328_2_0 | 446-457 | expanded | denotes | O-GlcNAcase |
| SS2_22730328_2_0 | 459-462 | abbr | denotes | OGA |
| AE1_22730328_0_0 | SS1_22730328_0_0 | SS2_22730328_0_0 | abbreviatedTo | O-linked β-N-acetylglucosaminylation,O-GlcNAcylation |
| AE1_22730328_1_0 | SS1_22730328_1_0 | SS2_22730328_1_0 | abbreviatedTo | O-linked β-N-acetylglucosamine,O-GlcNAc |
| AE1_22730328_2_0 | SS1_22730328_2_0 | SS2_22730328_2_0 | abbreviatedTo | O-GlcNAcase,OGA |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 741-747 | HP_0002664 | denotes | cancer |
| T2 | 866-872 | HP_0002664 | denotes | cancer |
| T3 | 968-974 | HP_0002664 | denotes | cancer |
| T4 | 1331-1349 | HP_0001510 | denotes | growth retardation |
| T5 | 1642-1647 | HP_0002664 | denotes | tumor |
| T6 | 1749-1755 | HP_0002664 | denotes | cancer |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 11-36 | chem:24139 | denotes | N-acetylglucosaminylation |
| PD-NGLY1-deficiency-B_T2 | 207-226 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T3 | 230-236 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T4 | 423-429 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T5 | 493-499 | chem:24139 | denotes | GlcNAc |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 22730328-0#120#148#gene10724 | 120-148 | gene10724 | denotes | N-acetyl-β-D-glucosaminidase |
| 22730328-0#70#98#diseaseC0948380 | 70-98 | diseaseC0948380 | denotes | metastatic colorectal cancer |
| 22730328-5#95#98#gene10724 | 1048-1051 | gene10724 | denotes | OGA |
| 22730328-5#4#21#diseaseC0009402 | 957-974 | diseaseC0009402 | denotes | colorectal cancer |
| 22730328-5#4#21#diseaseC1527249 | 957-974 | diseaseC1527249 | denotes | colorectal cancer |
| 120#148#gene1072470#98#diseaseC0948380 | 22730328-0#120#148#gene10724 | 22730328-0#70#98#diseaseC0948380 | associated_with | N-acetyl-β-D-glucosaminidase,metastatic colorectal cancer |
| 95#98#gene107244#21#diseaseC0009402 | 22730328-5#95#98#gene10724 | 22730328-5#4#21#diseaseC0009402 | associated_with | OGA,colorectal cancer |
| 95#98#gene107244#21#diseaseC1527249 | 22730328-5#95#98#gene10724 | 22730328-5#4#21#diseaseC1527249 | associated_with | OGA,colorectal cancer |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 228-236 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 421-429 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 491-499 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 81-98 | Phenotype | denotes | colorectal cancer | HP:0003003 |
| T2 | 629-645 | Phenotype | denotes | type II diabetes | HP:0005978 |
| T3 | 650-676 | Phenotype | denotes | neurodegenerative diseases | HP:0002180 |
| T4 | 741-747 | Phenotype | denotes | cancer | HP:0002664 |
| T5 | 855-872 | Phenotype | denotes | colorectal cancer | HP:0003003 |
| T6 | 957-974 | Phenotype | denotes | colorectal cancer | HP:0003003 |
| T7 | 1331-1349 | Phenotype | denotes | growth retardation | HP:0001510 |
| T8 | 1642-1647 | Phenotype | denotes | tumor | HP:0002664 |
| T9 | 1749-1755 | Phenotype | denotes | cancer | HP:0002664 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 81-98 | Disease | denotes | colorectal cancer | http://purl.obolibrary.org/obo/MONDO_0005575 |
| T2 | 629-645 | Disease | denotes | type II diabetes | http://purl.obolibrary.org/obo/MONDO_0005148 |
| T3 | 650-676 | Disease | denotes | neurodegenerative diseases | http://purl.obolibrary.org/obo/MONDO_0005559 |
| T4 | 741-747 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T5 | 855-872 | Disease | denotes | colorectal cancer | http://purl.obolibrary.org/obo/MONDO_0005575 |
| T6 | 957-974 | Disease | denotes | colorectal cancer | http://purl.obolibrary.org/obo/MONDO_0005575 |
| T7 | 1642-1647 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T8 | 1749-1755 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 228-236 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 421-429 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 491-499 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 228-236 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 421-429 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 491-499 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 81-98 | Phenotype | denotes | colorectal cancer | HP:0003003 |
| T2 | 629-645 | Phenotype | denotes | type II diabetes | HP:0005978 |
| T3 | 650-676 | Phenotype | denotes | neurodegenerative diseases | HP:0002180 |
| T4 | 741-747 | Phenotype | denotes | cancer | HP:0002664 |
| T5 | 855-872 | Phenotype | denotes | colorectal cancer | HP:0003003 |
| T6 | 957-974 | Phenotype | denotes | colorectal cancer | HP:0003003 |
| T7 | 1331-1349 | Phenotype | denotes | growth retardation | HP:0001510 |
| T8 | 1642-1647 | Phenotype | denotes | tumor | HP:0002664 |
| T9 | 1749-1755 | Phenotype | denotes | cancer | HP:0002664 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1244-1254 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |
| T2 | 1642-1652 | Cell | denotes | tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 349-366 | Body_part | denotes | nucleocytoplasmic | http://purl.obolibrary.org/obo/GO_0005622 |
| T2 | 1244-1254 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T5 | 741-747 | Disease | denotes | cancer | MONDO:0004992 |
| T6 | 855-872 | Disease | denotes | colorectal cancer | MONDO:0005575|MONDO:0024331 |
| T8 | 957-974 | Disease | denotes | colorectal cancer | MONDO:0005575|MONDO:0024331 |
| T10 | 1642-1647 | Disease | denotes | tumor | MONDO:0005070 |
| T11 | 1749-1755 | Disease | denotes | cancer | MONDO:0004992 |
| T1 | 81-98 | Disease | denotes | colorectal cancer | MONDO:0005575|MONDO:0024331 |
| T3 | 629-645 | Disease | denotes | type II diabetes | MONDO:0005148 |
| T4 | 650-676 | Disease | denotes | neurodegenerative diseases | MONDO:0005559 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 849-854 | Organism | denotes | human | 9606 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-195 | Sentence | denotes | O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-β-D-glucosaminidase silencing on cell phenotype and transcriptome. |
| T2 | 196-376 | Sentence | denotes | O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation is a regulatory post-translational modification occurring on the serine or threonine residues of nucleocytoplasmic proteins. |
| T3 | 377-535 | Sentence | denotes | O-GlcNAcylation is dynamically regulated by O-GlcNAc transferase and O-GlcNAcase (OGA), which are responsible for O-GlcNAc addition and removal, respectively. |
| T4 | 536-762 | Sentence | denotes | Although O-GlcNAcylation was found to play a significant role in several pathologies such as type II diabetes and neurodegenerative diseases, the role of O-GlcNAcylation in the etiology and progression of cancer remains vague. |
| T5 | 763-952 | Sentence | denotes | Here, we followed O-GlcNAcylation and its catalytic machinery in metastatic clones of human colorectal cancer and the effect of OGA knockdown on cellular phenotype and on the transcriptome. |
| T6 | 953-1102 | Sentence | denotes | The colorectal cancer SW620 metastatic clone exhibited increased O-GlcNAcylation and decreased OGA expression compared with its primary clone, SW480. |
| T7 | 1103-1350 | Sentence | denotes | O-GlcNAcylation elevation in SW620 cells, through RNA interference of OGA, resulted in phenotypic alterations that included acquisition of a fibroblast-like morphology, which coincides with epithelial metastatic progression and growth retardation. |
| T8 | 1351-1561 | Sentence | denotes | Microarray analysis revealed that OGA silencing altered the expression of about 1300 genes, mostly involved in cell movement and growth, and specifically affected metabolic pathways of lipids and carbohydrates. |
| T9 | 1562-1756 | Sentence | denotes | These findings support the involvement of O-GlcNAcylation in various aspects of tumor cell physiology and suggest that this modification may serve as a link between metabolic changes and cancer. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 228-236 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 421-429 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 491-499 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1244-1254 | Body_part | denotes | fibroblast | FMA:63877 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 849-854 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 349-366 | Body_part | denotes | nucleocytoplasmic | http://purl.obolibrary.org/obo/GO_0005622 |
| T2 | 1244-1254 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1244-1254 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |
| T2 | 1642-1652 | Cell | denotes | tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |