PubMed:22729903 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/22729903","sourcedb":"PubMed","sourceid":"22729903","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/22729903","text":"Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population.\nThe STAT4 has been found to be a susceptible gene in the development of systemic lupus erythematosus (SLE) in various populations. There are evident population differences in the context of clinical manifestations of SLE, therefore we investigated the prevalence of the STAT4 G \u003e C (rs7582694) polymorphism in patients with SLE (n = 253) and controls (n = 521) in a sample of the Polish population. We found that patients with the STAT4 C/G and CC genotypes exhibited a 1.583-fold increased risk of SLE incidence (95 % CI = 1.168-2.145, p = 0.003), with OR for the C/C versus C/G and G/G genotypes was 1.967 (95 % CI = 1.152-3.358, p = 0.0119). The OR for the STAT4 C allele frequency showed a 1.539-fold increased risk of SLE (95 % CI = 1.209-1.959, p = 0.0004). We also observed an increased frequency of STAT4 C/C and C/G genotypes in SLE patients with renal symptoms OR = 2.259 (1.365-3.738, p = 0.0014), (p (corr) = 0.0238) and in SLE patients with neurologic manifestations OR = 2.867 (1.467-5.604, p = 0.0016), (p (corr) = 0.0272). Moreover, we found a contribution of STAT4 C/C and C/G genotypes to the presence of the anti-snRNP Ab OR = 3.237 (1.667-6.288, p = 0.0003), (p (corr) = 0.0051) and the presence of the anti-Scl-70 Ab OR = 2.665 (1.380-5.147, p = 0.0028), (p (corr) = 0.0476). Our studies confirmed an association of the STAT4 C (rs7582694) variant with the development of SLE and occurrence of some clinical manifestations of the disease.","tracks":[{"project":"TEST-DiseaseOrPhenotypicFeature","denotations":[{"id":"T1","span":{"begin":61,"end":89},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":188,"end":216},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":218,"end":221},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":333,"end":336},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":440,"end":443},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":615,"end":618},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":839,"end":842},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":954,"end":957},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1052,"end":1055},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1070,"end":1095},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1509,"end":1512},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"#label","subj":"T5","obj":"D008180"},{"id":"A8","pred":"#label","subj":"T8","obj":"D008180"},{"id":"A10","pred":"#label","subj":"T10","obj":"D009461"},{"id":"A9","pred":"#label","subj":"T9","obj":"D008180"},{"id":"A6","pred":"#label","subj":"T6","obj":"D008180"},{"id":"A7","pred":"#label","subj":"T7","obj":"D008180"},{"id":"A4","pred":"#label","subj":"T4","obj":"D008180"},{"id":"A2","pred":"#label","subj":"T2","obj":"D008180"},{"id":"A1","pred":"#label","subj":"T1","obj":"D008180"},{"id":"A11","pred":"#label","subj":"T11","obj":"D008180"},{"id":"A3","pred":"#label","subj":"T3","obj":"D008180"},{"subj":"T1","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T2","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T3","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T4","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T5","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T6","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T7","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T8","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T9","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T10","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T11","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"}]},{"project":"TEST-OrganismTaxon","denotations":[{"id":"T1","span":{"begin":426,"end":434},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":529,"end":537},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":958,"end":966},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":1056,"end":1064},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T2","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T3","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T4","pred":"source","obj":"TEST-OrganismTaxon"}]},{"project":"Test-SequenceVariant","denotations":[{"id":"T1","span":{"begin":399,"end":408},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":1466,"end":1475},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"Test-SequenceVariant"},{"subj":"T2","pred":"source","obj":"Test-SequenceVariant"}]},{"project":"Test-GeneOrGeneProduct","denotations":[{"id":"T1","span":{"begin":16,"end":21},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":120,"end":125},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":386,"end":391},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":547,"end":552},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":776,"end":781},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":923,"end":928},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1029,"end":1033},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1138,"end":1142},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1192,"end":1197},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1248,"end":1253},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1299,"end":1303},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1396,"end":1400},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1457,"end":1462},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T2","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T3","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T4","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T5","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T6","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T7","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T8","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T9","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T10","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T11","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T12","pred":"source","obj":"Test-GeneOrGeneProduct"},{"subj":"T13","pred":"source","obj":"Test-GeneOrGeneProduct"}]},{"project":"Test-merged","denotations":[{"id":"T11","span":{"begin":1509,"end":1512},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1070,"end":1095},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1052,"end":1055},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":954,"end":957},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":839,"end":842},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":615,"end":618},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":440,"end":443},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":333,"end":336},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":218,"end":221},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":188,"end":216},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T1","span":{"begin":61,"end":89},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T89665","span":{"begin":1056,"end":1064},"obj":"OrganismTaxon"},{"id":"T23052","span":{"begin":958,"end":966},"obj":"OrganismTaxon"},{"id":"T35087","span":{"begin":529,"end":537},"obj":"OrganismTaxon"},{"id":"T61112","span":{"begin":426,"end":434},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":1457,"end":1462},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1396,"end":1400},"obj":"GeneOrGeneProduct"},{"id":"T59937","span":{"begin":1299,"end":1303},"obj":"GeneOrGeneProduct"},{"id":"T35667","span":{"begin":1248,"end":1253},"obj":"GeneOrGeneProduct"},{"id":"T47719","span":{"begin":1192,"end":1197},"obj":"GeneOrGeneProduct"},{"id":"T14748","span":{"begin":1138,"end":1142},"obj":"GeneOrGeneProduct"},{"id":"T53521","span":{"begin":1029,"end":1033},"obj":"GeneOrGeneProduct"},{"id":"T25753","span":{"begin":923,"end":928},"obj":"GeneOrGeneProduct"},{"id":"T42236","span":{"begin":776,"end":781},"obj":"GeneOrGeneProduct"},{"id":"T69800","span":{"begin":547,"end":552},"obj":"GeneOrGeneProduct"},{"id":"T14314","span":{"begin":386,"end":391},"obj":"GeneOrGeneProduct"},{"id":"T55508","span":{"begin":120,"end":125},"obj":"GeneOrGeneProduct"},{"id":"T4507","span":{"begin":16,"end":21},"obj":"GeneOrGeneProduct"},{"id":"T35261","span":{"begin":1466,"end":1475},"obj":"SequenceVariant"},{"id":"T26383","span":{"begin":399,"end":408},"obj":"SequenceVariant"}],"attributes":[{"id":"A9","pred":"#label","subj":"T9","obj":"D008180"},{"id":"A6","pred":"#label","subj":"T6","obj":"D008180"},{"id":"A7","pred":"#label","subj":"T7","obj":"D008180"},{"id":"A2","pred":"#label","subj":"T2","obj":"D008180"},{"id":"A11","pred":"#label","subj":"T11","obj":"D008180"},{"id":"A8","pred":"#label","subj":"T8","obj":"D008180"},{"id":"A10","pred":"#label","subj":"T10","obj":"D009461"},{"id":"A1","pred":"#label","subj":"T1","obj":"D008180"},{"id":"A4","pred":"#label","subj":"T4","obj":"D008180"},{"id":"A3","pred":"#label","subj":"T3","obj":"D008180"},{"id":"A5","pred":"#label","subj":"T5","obj":"D008180"},{"subj":"T11","pred":"source","obj":"Test-merged"},{"subj":"T10","pred":"source","obj":"Test-merged"},{"subj":"T9","pred":"source","obj":"Test-merged"},{"subj":"T8","pred":"source","obj":"Test-merged"},{"subj":"T7","pred":"source","obj":"Test-merged"},{"subj":"T6","pred":"source","obj":"Test-merged"},{"subj":"T5","pred":"source","obj":"Test-merged"},{"subj":"T4","pred":"source","obj":"Test-merged"},{"subj":"T3","pred":"source","obj":"Test-merged"},{"subj":"T2","pred":"source","obj":"Test-merged"},{"subj":"T1","pred":"source","obj":"Test-merged"},{"subj":"T89665","pred":"source","obj":"Test-merged"},{"subj":"T23052","pred":"source","obj":"Test-merged"},{"subj":"T35087","pred":"source","obj":"Test-merged"},{"subj":"T61112","pred":"source","obj":"Test-merged"},{"subj":"T13","pred":"source","obj":"Test-merged"},{"subj":"T12","pred":"source","obj":"Test-merged"},{"subj":"T59937","pred":"source","obj":"Test-merged"},{"subj":"T35667","pred":"source","obj":"Test-merged"},{"subj":"T47719","pred":"source","obj":"Test-merged"},{"subj":"T14748","pred":"source","obj":"Test-merged"},{"subj":"T53521","pred":"source","obj":"Test-merged"},{"subj":"T25753","pred":"source","obj":"Test-merged"},{"subj":"T42236","pred":"source","obj":"Test-merged"},{"subj":"T69800","pred":"source","obj":"Test-merged"},{"subj":"T14314","pred":"source","obj":"Test-merged"},{"subj":"T55508","pred":"source","obj":"Test-merged"},{"subj":"T4507","pred":"source","obj":"Test-merged"},{"subj":"T35261","pred":"source","obj":"Test-merged"},{"subj":"T26383","pred":"source","obj":"Test-merged"}]},{"project":"Test-merged-2","denotations":[{"id":"T26383","span":{"begin":399,"end":408},"obj":"SequenceVariant"},{"id":"T35261","span":{"begin":1466,"end":1475},"obj":"SequenceVariant"},{"id":"T4507","span":{"begin":16,"end":21},"obj":"GeneOrGeneProduct"},{"id":"T55508","span":{"begin":120,"end":125},"obj":"GeneOrGeneProduct"},{"id":"T14314","span":{"begin":386,"end":391},"obj":"GeneOrGeneProduct"},{"id":"T69800","span":{"begin":547,"end":552},"obj":"GeneOrGeneProduct"},{"id":"T42236","span":{"begin":776,"end":781},"obj":"GeneOrGeneProduct"},{"id":"T25753","span":{"begin":923,"end":928},"obj":"GeneOrGeneProduct"},{"id":"T53521","span":{"begin":1029,"end":1033},"obj":"GeneOrGeneProduct"},{"id":"T14748","span":{"begin":1138,"end":1142},"obj":"GeneOrGeneProduct"},{"id":"T47719","span":{"begin":1192,"end":1197},"obj":"GeneOrGeneProduct"},{"id":"T35667","span":{"begin":1248,"end":1253},"obj":"GeneOrGeneProduct"},{"id":"T59937","span":{"begin":1299,"end":1303},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1396,"end":1400},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1457,"end":1462},"obj":"GeneOrGeneProduct"},{"id":"T61112","span":{"begin":426,"end":434},"obj":"OrganismTaxon"},{"id":"T35087","span":{"begin":529,"end":537},"obj":"OrganismTaxon"},{"id":"T23052","span":{"begin":958,"end":966},"obj":"OrganismTaxon"},{"id":"T89665","span":{"begin":1056,"end":1064},"obj":"OrganismTaxon"},{"id":"T1","span":{"begin":61,"end":89},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":188,"end":216},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":218,"end":221},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":333,"end":336},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":440,"end":443},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":615,"end":618},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":839,"end":842},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":954,"end":957},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1052,"end":1055},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1070,"end":1095},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1509,"end":1512},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A8","pred":"#label","subj":"T8","obj":"D008180"},{"id":"A2","pred":"#label","subj":"T2","obj":"D008180"},{"id":"A11","pred":"#label","subj":"T11","obj":"D008180"},{"id":"A4","pred":"#label","subj":"T4","obj":"D008180"},{"id":"A10","pred":"#label","subj":"T10","obj":"D009461"},{"id":"A5","pred":"#label","subj":"T5","obj":"D008180"},{"id":"A1","pred":"#label","subj":"T1","obj":"D008180"},{"id":"A3","pred":"#label","subj":"T3","obj":"D008180"},{"id":"A9","pred":"#label","subj":"T9","obj":"D008180"},{"id":"A6","pred":"#label","subj":"T6","obj":"D008180"},{"id":"A7","pred":"#label","subj":"T7","obj":"D008180"},{"subj":"T26383","pred":"source","obj":"Test-merged-2"},{"subj":"T35261","pred":"source","obj":"Test-merged-2"},{"subj":"T4507","pred":"source","obj":"Test-merged-2"},{"subj":"T55508","pred":"source","obj":"Test-merged-2"},{"subj":"T14314","pred":"source","obj":"Test-merged-2"},{"subj":"T69800","pred":"source","obj":"Test-merged-2"},{"subj":"T42236","pred":"source","obj":"Test-merged-2"},{"subj":"T25753","pred":"source","obj":"Test-merged-2"},{"subj":"T53521","pred":"source","obj":"Test-merged-2"},{"subj":"T14748","pred":"source","obj":"Test-merged-2"},{"subj":"T47719","pred":"source","obj":"Test-merged-2"},{"subj":"T35667","pred":"source","obj":"Test-merged-2"},{"subj":"T59937","pred":"source","obj":"Test-merged-2"},{"subj":"T12","pred":"source","obj":"Test-merged-2"},{"subj":"T13","pred":"source","obj":"Test-merged-2"},{"subj":"T61112","pred":"source","obj":"Test-merged-2"},{"subj":"T35087","pred":"source","obj":"Test-merged-2"},{"subj":"T23052","pred":"source","obj":"Test-merged-2"},{"subj":"T89665","pred":"source","obj":"Test-merged-2"},{"subj":"T1","pred":"source","obj":"Test-merged-2"},{"subj":"T2","pred":"source","obj":"Test-merged-2"},{"subj":"T3","pred":"source","obj":"Test-merged-2"},{"subj":"T4","pred":"source","obj":"Test-merged-2"},{"subj":"T5","pred":"source","obj":"Test-merged-2"},{"subj":"T6","pred":"source","obj":"Test-merged-2"},{"subj":"T7","pred":"source","obj":"Test-merged-2"},{"subj":"T8","pred":"source","obj":"Test-merged-2"},{"subj":"T9","pred":"source","obj":"Test-merged-2"},{"subj":"T10","pred":"source","obj":"Test-merged-2"},{"subj":"T11","pred":"source","obj":"Test-merged-2"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":16,"end":21},"obj":"gene:6775"},{"id":"T1","span":{"begin":61,"end":89},"obj":"disease:C0024141"},{"id":"T2","span":{"begin":1457,"end":1462},"obj":"gene:6775"},{"id":"T3","span":{"begin":1509,"end":1512},"obj":"disease:C0024141"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":188,"end":216},"obj":"HP_0002725"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"Allie","denotations":[{"id":"SS1_22729903_1_0","span":{"begin":188,"end":216},"obj":"expanded"},{"id":"SS2_22729903_1_0","span":{"begin":218,"end":221},"obj":"abbr"}],"relations":[{"id":"AE1_22729903_1_0","pred":"abbreviatedTo","subj":"SS1_22729903_1_0","obj":"SS2_22729903_1_0"}],"attributes":[{"subj":"SS1_22729903_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_22729903_1_0","pred":"source","obj":"Allie"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"22729903-7#53#62#geners7582694","span":{"begin":1466,"end":1475},"obj":"geners7582694"},{"id":"22729903-7#96#99#diseaseC0024141","span":{"begin":1509,"end":1512},"obj":"diseaseC0024141"}],"relations":[{"id":"53#62#geners758269496#99#diseaseC0024141","pred":"associated_with","subj":"22729903-7#53#62#geners7582694","obj":"22729903-7#96#99#diseaseC0024141"}],"attributes":[{"subj":"22729903-7#53#62#geners7582694","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"22729903-7#96#99#diseaseC0024141","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"22729903-0#16#21#gene6775","span":{"begin":16,"end":21},"obj":"gene6775"},{"id":"22729903-0#61#89#diseaseC0024141","span":{"begin":61,"end":89},"obj":"diseaseC0024141"}],"relations":[{"id":"16#21#gene677561#89#diseaseC0024141","pred":"associated_with","subj":"22729903-0#16#21#gene6775","obj":"22729903-0#61#89#diseaseC0024141"}],"attributes":[{"subj":"22729903-0#16#21#gene6775","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22729903-0#61#89#diseaseC0024141","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST-DiseaseOrPhenotypicFeature","color":"#e6ec93","default":true},{"id":"TEST-OrganismTaxon","color":"#d793ec"},{"id":"Test-SequenceVariant","color":"#93ecbd"},{"id":"Test-GeneOrGeneProduct","color":"#eca393"},{"id":"Test-merged","color":"#939cec"},{"id":"Test-merged-2","color":"#b6ec93"},{"id":"DisGeNET","color":"#ec93d0"},{"id":"PubmedHPO","color":"#93eaec"},{"id":"Allie","color":"#ecd393"},{"id":"DisGeNET5_variant_disease","color":"#b993ec"},{"id":"DisGeNET5_gene_disease","color":"#93ec9f"}]}]}}