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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 171-352 DRI_Background denotes Concurrent supplement of estradiol and progesterone has been shown to reduce the cardiac sensitivity to class III antiarrhythmic agent-induced arrhythmias in ovariectomized rabbits.
T2 353-643 DRI_Background denotes To understand the underlying cardiac electrophysiological mechanisms of the hormones, present study explored the modulation of progesterone and estradiol on repolarization and its frequency dependence in papillary muscles of female rabbit right ventricles by glass microelectrode technique.
T3 644-890 DRI_Outcome denotes Results showed that progesterone shortened action potential duration for 90% repolarization (APD(90)) whereas estradiol prolonged APD(90) and those actions on APD(90) were concentration-dependent for both hormones at 1.0-30 μM (P<0.05 or P<0.01).
T4 891-1004 DRI_Approach denotes Further, the action of both hormones on APD(90) was found to be dependent on stimulation frequencies (0.2-3.3Hz).
T5 1005-1343 DRI_Outcome denotes The shortening of APD(90) by progesterone (10 μM) was enhanced with the increase in frequencies reaching a statistic significance at frequencies ≥1.0 Hz, whereas the prolongation of APD(90) by estradiol (3 μM) was weakened with the increase in frequencies and the significant change was observed at frequencies ≤2.0 Hz (P<0.05 or P<0.01).
T6 1344-1660 DRI_Outcome denotes More interestingly, the relative change of APD(90) and the incidence of early afterdepolarization induced after by dofetilide (0.1 μM), a class III antiarrhythmic agent, were significantly less or lower in the papillary muscles pretreated with progesterone than in those pretreated with estradiol (P<0.01 or P<0.05).
T7 1661-1768 DRI_Outcome denotes In conclusion, progesterone has a reverse modulating affect on cardiac repolarization to that of estradiol.
T8 1769-1897 DRI_Outcome denotes By acceleration of ventricular repolarization, progesterone may reduce the susceptibility of females to class III antiarrhythmic
T9 1927-1937 DRI_Outcome denotes affection.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 223-226 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T2 223-226 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T3 737-740 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APD
T4 774-777 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APD
T5 803-806 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APD
T6 865-867 CVCL_J925|Hybridoma|Mus musculus denotes 30
T7 931-934 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APD
T8 1023-1026 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APD
T9 1110-1111 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 1187-1190 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APD
T11 1281-1287 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T12 1377-1383 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T13 1387-1390 CVCL_E459|Transformed_cell_line|Homo sapiens denotes APD
T14 1480-1481 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T15 1689-1692 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T16 1689-1692 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T17 1693-1694 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T18 1829-1832 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

GoldHamster

Id Subject Object Predicate Lexical cue
T2 62-74 8727 denotes progesterone
T1 62-74 D011374 denotes progesterone
T3 62-74 CHEBI:17026 denotes progesterone
T4 62-74 D011374 denotes progesterone
T5 117-121 CHEBI:23888 denotes drug
T6 155-161 UBERON:0003100 denotes female
T7 162-169 D011817 denotes rabbits
T8 162-169 9986 denotes rabbits
T12 196-205 4083 denotes estradiol
T9 196-205 CHEBI:16469 denotes estradiol
T10 196-205 CHEBI:23965 denotes estradiol
T11 196-205 D004958 denotes estradiol
T13 196-205 D004958 denotes estradiol
T15 210-222 8727 denotes progesterone
T14 210-222 D011374 denotes progesterone
T16 210-222 CHEBI:17026 denotes progesterone
T17 210-222 D011374 denotes progesterone
T18 285-305 CHEBI:38070 denotes antiarrhythmic agent
T19 344-351 D011817 denotes rabbits
T20 344-351 9986 denotes rabbits
T21 429-437 D006728 denotes hormones
T22 429-437 D006728 denotes hormones
T23 429-437 CHEBI:24621 denotes hormones
T25 480-492 8727 denotes progesterone
T24 480-492 D011374 denotes progesterone
T26 480-492 CHEBI:17026 denotes progesterone
T27 480-492 D011374 denotes progesterone
T31 497-506 4083 denotes estradiol
T28 497-506 CHEBI:16469 denotes estradiol
T29 497-506 CHEBI:23965 denotes estradiol
T30 497-506 D004958 denotes estradiol
T32 497-506 D004958 denotes estradiol
T33 567-574 UBERON:0001015 denotes muscles
T34 578-584 UBERON:0003100 denotes female
T36 585-591 813859 denotes rabbit
T35 585-591 D011817 denotes rabbit
T37 585-591 9986 denotes rabbit
T38 612-617 CHEBI:131189 denotes glass
T40 664-676 8727 denotes progesterone
T39 664-676 D011374 denotes progesterone
T41 664-676 CHEBI:17026 denotes progesterone
T42 664-676 D011374 denotes progesterone
T43 687-703 GO:0001508 denotes action potential
T44 737-740 CVCL_E459 denotes APD
T48 754-763 4083 denotes estradiol
T45 754-763 CHEBI:16469 denotes estradiol
T46 754-763 CHEBI:23965 denotes estradiol
T47 754-763 D004958 denotes estradiol
T49 754-763 D004958 denotes estradiol
T50 774-777 CVCL_E459 denotes APD
T51 803-806 CVCL_E459 denotes APD
T52 849-857 D006728 denotes hormones
T53 849-857 D006728 denotes hormones
T54 849-857 CHEBI:24621 denotes hormones
T85 919-927 D006728 denotes hormones
T86 919-927 D006728 denotes hormones
T87 919-927 CHEBI:24621 denotes hormones
T88 931-934 CVCL_E459 denotes APD
T89 1023-1026 CVCL_E459 denotes APD
T91 1034-1046 8727 denotes progesterone
T90 1034-1046 D011374 denotes progesterone
T92 1034-1046 CHEBI:17026 denotes progesterone
T93 1034-1046 D011374 denotes progesterone
T98 1187-1190 CVCL_E459 denotes APD
T102 1198-1207 4083 denotes estradiol
T99 1198-1207 CHEBI:16469 denotes estradiol
T100 1198-1207 CHEBI:23965 denotes estradiol
T101 1198-1207 D004958 denotes estradiol
T103 1198-1207 D004958 denotes estradiol
T108 1387-1390 CVCL_E459 denotes APD
T110 1459-1469 49247 denotes dofetilide
T109 1459-1469 CHEBI:4681 denotes dofetilide
T111 1459-1469 C063533 denotes dofetilide
T112 1459-1469 C063533 denotes dofetilide
T117 1492-1512 CHEBI:38070 denotes antiarrhythmic agent
T118 1564-1571 UBERON:0001015 denotes muscles
T120 1588-1600 8727 denotes progesterone
T119 1588-1600 D011374 denotes progesterone
T121 1588-1600 CHEBI:17026 denotes progesterone
T122 1588-1600 D011374 denotes progesterone
T126 1631-1640 4083 denotes estradiol
T123 1631-1640 CHEBI:16469 denotes estradiol
T124 1631-1640 CHEBI:23965 denotes estradiol
T125 1631-1640 D004958 denotes estradiol
T127 1631-1640 D004958 denotes estradiol
T129 1676-1688 8727 denotes progesterone
T128 1676-1688 D011374 denotes progesterone
T130 1676-1688 CHEBI:17026 denotes progesterone
T131 1676-1688 D011374 denotes progesterone
T132 1695-1702 SO:0001031 denotes reverse
T136 1758-1767 4083 denotes estradiol
T133 1758-1767 CHEBI:16469 denotes estradiol
T134 1758-1767 CHEBI:23965 denotes estradiol
T135 1758-1767 D004958 denotes estradiol
T137 1758-1767 D004958 denotes estradiol
T138 1788-1814 GO:0060307 denotes ventricular repolarization
T139 1788-1814 GO:0098915 denotes ventricular repolarization
T141 1816-1828 8727 denotes progesterone
T140 1816-1828 D011374 denotes progesterone
T142 1816-1828 CHEBI:17026 denotes progesterone
T143 1816-1828 D011374 denotes progesterone
T144 1844-1858 D004198 denotes susceptibility
T145 1844-1858 D004198 denotes susceptibility

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 314-325 HP_0011675 denotes arrhythmias