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PubMed:22649237 JSONTXT

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Allie

Id Subject Object Predicate Lexical cue
SS1_22649237_1_0 150-169 expanded denotes Parkinson's disease
SS2_22649237_1_0 171-173 abbr denotes PD
SS1_22649237_1_1 241-252 expanded denotes α-synuclein
SS2_22649237_1_1 254-259 abbr denotes α-syn
SS1_22649237_1_2 309-317 expanded denotes dopamine
SS2_22649237_1_2 319-321 abbr denotes DA
AE1_22649237_1_0 SS1_22649237_1_0 SS2_22649237_1_0 abbreviatedTo Parkinson's disease,PD
AE1_22649237_1_1 SS1_22649237_1_1 SS2_22649237_1_1 abbreviatedTo α-synuclein,α-syn
AE1_22649237_1_2 SS1_22649237_1_2 SS2_22649237_1_2 abbreviatedTo dopamine,DA

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-149 DRI_Background denotes Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain.
T2 150-374 DRI_Background denotes Parkinson's disease (PD) is characterized pathologically by the formation of ubiquitin and α-synuclein (α-syn)-containing inclusions (Lewy bodies), dystrophic dopamine (DA) terminals, and degeneration of midbrain DA neurons.
T3 375-462 DRI_Challenge denotes The precise molecular mechanisms underlying these pathological features remain elusive.
T4 463-660 DRI_Challenge denotes Accumulating evidence has implicated dysfunctional autophagy, the cell self-digestion and neuroprotective pathway, as one of the pathogenic systems contributing to the development of idiopathic PD.
T5 661-832 DRI_Outcome denotes Here we characterize autophagy-deficient mouse models and provide in vivo evidence for the potential role that impaired autophagy plays in pathogenesis associated with PD.
T6 833-991 DRI_Challenge denotes Cell-specific deletion of essential autophagy gene Atg7 in midbrain DA neurons causes delayed neurodegeneration, accompanied by late-onset locomotor deficits.
T7 992-1210 DRI_Background denotes In contrast, Atg7-deficient DA neurons in the midbrain exhibit early dendritic and axonal dystrophy, reduced striatal dopamine content, and the formation of somatic and dendritic ubiquitinated inclusions in DA neurons.
T8 1211-1394 DRI_Background denotes Furthermore, whole-brain-specific loss of Atg7 leads to presynaptic accumulation of α-syn and LRRK2 proteins, which are encoded by two autosomal dominantly inherited PD-related genes.
T9 1395-1526 DRI_Outcome denotes Our results suggest that disrupted autophagy may be associated with enhanced levels of endogenous α-syn and LRRK2 proteins in vivo.
T10 1527-1662 DRI_Challenge denotes Our findings implicate dysfunctional autophagy as one of the failing cellular mechanisms involved in the pathogenesis of idiopathic PD.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 150-159 HP_0001300 denotes Parkinson
T2 284-295 HP_0100315 denotes Lewy bodies
T3 927-944 HP_0002180 denotes neurodegeneration
T4 1346-1366 HP_0000006 denotes autosomal dominantly
T5 1346-1376 HP_0000006 denotes autosomal dominantly inherited