> top > docs > PubMed:22647713 > annotations

PubMed:22647713 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q5S006 denotes LRRK2
T2 0-5 PR:000003033 denotes LRRK2
T3 0-5 PR:Q5S007 denotes LRRK2
T4 6-19 D018345 denotes knockout mice
T5 15-19 PR:000005054 denotes mice
T7 15-19 O89094 denotes mice
T9 35-54 UBERON:0027239 denotes dopaminergic system
T10 146-151 PR:Q5S006 denotes LRRK2
T11 146-151 PR:000003033 denotes LRRK2
T12 146-151 PR:Q5S007 denotes LRRK2
T13 152-156 SO:0000704 denotes gene
T18 194-213 D010300 denotes Parkinson's disease
T19 194-213 D010300 denotes Parkinson's disease
T22 272-277 PR:Q5S006 denotes LRRK2
T23 272-277 PR:000003033 denotes LRRK2
T24 272-277 PR:Q5S007 denotes LRRK2
T25 404-421 GO:0007268 denotes neurotransmission
T27 423-431 GO:0016020 denotes membrane
T26 423-431 UBERON:0000094 denotes membrane
T28 423-431 UBERON:0000158 denotes membrane
T33 462-469 SO:0000104 denotes protein
T32 462-469 PR:000000001 denotes protein
T29 462-469 GO:0003675 denotes protein
T30 462-469 CHEBI:36080 denotes protein
T31 462-469 CHEBI:11122 denotes protein
T34 462-481 GO:0030163 denotes protein degradation
T37 493-497 D051379 denotes mice
T39 493-497 10095 denotes mice
T36 493-497 PR:000005054 denotes mice
T38 493-497 O89094 denotes mice
T41 506-510 SO:0000147 denotes exon
T40 506-510 PR:P33696 denotes exon
T42 562-568 SO:0000417 denotes domain
T43 572-577 PR:Q5S006 denotes LRRK2
T44 572-577 PR:000003033 denotes LRRK2
T45 572-577 PR:Q5S007 denotes LRRK2
T46 631-635 PR:000005054 denotes mice
T48 631-635 O89094 denotes mice
T47 631-635 D051379 denotes mice
T49 631-635 10095 denotes mice
T54 684-692 3628 denotes dopamine
T50 684-692 CHEBI:59905 denotes dopamine
T51 684-692 CHEBI:18243 denotes dopamine
T52 684-692 D004298 denotes dopamine
T53 684-692 D004298 denotes dopamine
T55 693-700 GO:0051235 denotes storage
T56 711-717 GO:0098657 denotes uptake
T57 711-717 GO:0098739 denotes uptake
T58 722-731 GO:0009058 denotes synthesis
T59 753-768 GO:0043197 denotes dendritic spine
T61 763-768 UBERON:0004529 denotes spine
T62 763-768 UBERON:0013496 denotes spine
T63 763-768 UBERON:0001130 denotes spine
T64 763-768 UBERON:0008260 denotes spine
T65 773-786 UBERON:2000098 denotes proliferation
T66 787-799 GO:0022008 denotes neurogenesis
T67 835-854 UBERON:0027239 denotes dopaminergic system
T68 889-894 PR:Q5S006 denotes LRRK2
T69 889-894 PR:000003033 denotes LRRK2
T70 889-894 PR:Q5S007 denotes LRRK2
T71 895-908 D018345 denotes knockout mice
T72 904-908 PR:000005054 denotes mice
T74 904-908 O89094 denotes mice
T76 919-924 PR:Q5S006 denotes LRRK2
T77 919-924 PR:000003033 denotes LRRK2
T78 919-924 PR:Q5S007 denotes LRRK2
T79 925-938 D018345 denotes knockout mice
T80 934-938 PR:000005054 denotes mice
T82 934-938 O89094 denotes mice
T84 1013-1018 PR:Q5S006 denotes LRRK2
T85 1013-1018 PR:000003033 denotes LRRK2
T86 1013-1018 PR:Q5S007 denotes LRRK2
T87 1019-1032 D018345 denotes knockout mice
T88 1028-1032 PR:000005054 denotes mice
T90 1028-1032 O89094 denotes mice
T92 1058-1067 SO:0000817 denotes wild type
T93 1099-1102 PR:000009431 denotes rod
T94 1160-1165 PR:Q5S006 denotes LRRK2
T95 1160-1165 PR:000003033 denotes LRRK2
T96 1160-1165 PR:Q5S007 denotes LRRK2
T97 1193-1199 UBERON:0002113 denotes kidney

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 194-203 HP_0001300 denotes Parkinson

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-128 DRI_Background denotes LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
T2 129-214 DRI_Background denotes Mutations in the LRRK2 gene are the most common cause of genetic Parkinson's disease.
T3 215-578 DRI_Challenge denotes Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in regulating neuronal polarity, neurotransmission, membrane and cytoskeletal dynamics and protein degradation.We created mice lacking exon 41 that encodes the activation hinge of the kinase domain of LRRK2.
T4 579-772 DRI_Approach denotes We have performed a comprehensive analysis of these mice up to 20 months of age, including evaluation of dopamine storage, release, uptake and synthesis, behavioral testing, dendritic spine and
T5 773-812 Token_Label.OUTSIDE denotes proliferation/neurogenesis analysis.Our
T6 813-909 DRI_Approach denotes results show that the dopaminergic system was not functionally comprised in LRRK2 knockout mice.
T7 910-1002 DRI_Background denotes However, LRRK2 knockout mice displayed abnormal exploratory activity in the open-field test.
T8 1003-1126 DRI_Outcome denotes Moreover, LRRK2 knockout mice stayed longer than their wild type littermates on the accelerated rod during rotarod testing.
T9 1127-1352 DRI_Challenge denotes Finally, we confirm that loss of LRRK2 caused degeneration in the kidney, accompanied by a progressive enhancement of autophagic activity and accumulation of autofluorescent material, but without evidence of biphasic changes.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 129-214 DRI_Background denotes Mutations in the LRRK2 gene are the most common cause of genetic Parkinson's disease.
T2 215-578 DRI_Challenge denotes Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in regulating neuronal polarity, neurotransmission, membrane and cytoskeletal dynamics and protein degradation.We created mice lacking exon 41 that encodes the activation hinge of the kinase domain of LRRK2.
T3 579-772 DRI_Approach denotes We have performed a comprehensive analysis of these mice up to 20 months of age, including evaluation of dopamine storage, release, uptake and synthesis, behavioral testing, dendritic spine and
T4 813-909 DRI_Approach denotes results show that the dopaminergic system was not functionally comprised in LRRK2 knockout mice.
T5 910-1002 DRI_Background denotes However, LRRK2 knockout mice displayed abnormal exploratory activity in the open-field test.
T6 1003-1126 DRI_Outcome denotes Moreover, LRRK2 knockout mice stayed longer than their wild type littermates on the accelerated rod during rotarod testing.
T7 1127-1352 DRI_Challenge denotes Finally, we confirm that loss of LRRK2 caused degeneration in the kidney, accompanied by a progressive enhancement of autophagic activity and accumulation of autofluorescent material, but without evidence of biphasic changes.