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PubMed:22645142 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Variants of Toll-like receptor 4 predict cardiac recovery in patients with dilated cardiomyopathy.
T2 99-221 Sentence denotes The clinical course of patients with dilated cardiomyopathy (DCM) varies from cardiac recovery to end stage heart failure.
T3 222-274 Sentence denotes The etiology of this variability is largely unknown.
T4 275-451 Sentence denotes In this study, we investigated the impact of coding polymorphisms of the innate immune protein Toll-like receptor 4 (TLR4) on left ventricular performance in patients with DCM.
T5 452-592 Sentence denotes Two variants of TLR4 (rs4986790, TLR4 c.1187A→G, p.299D→G and rs4986791,TLR4 c.1487C→T, p.T399I) were investigated in 158 patients with DCM.
T6 593-704 Sentence denotes Other reasons for heart failure were excluded by coronary angiography, myocardial biopsy, and echocardiography.
T7 705-777 Sentence denotes Risk factors, age, gender, or treatment did not differ among the groups.
T8 778-1133 Sentence denotes At the follow-up evaluation (median 4.0-5.4 months), patients carrying the TLR4 wild type gene displayed cardiac recovery under intense medical heart failure therapy indexed by reduced left ventricular dilation, improved left ventricular ejection fraction, and reduced NT-probrain natriuretic peptide blood level when compared with the initial evaluation.
T9 1134-1457 Sentence denotes In contrast, patients carrying both the rs4986790 and the rs4986791 variant showed significantly reduced improvement of left ventricular ejection fraction (p = 0.006) and left ventricular dilation (p = 0.015) at the follow-up evaluation when compared with carriers of the wild type gene under the same treatment conditions.
T10 1458-1629 Sentence denotes In addition, NT-probrain natriuretic peptide level in carriers of both TLR4 variants did not change significantly at the follow up when compared with the first evaluation.
T11 1630-1807 Sentence denotes Among patients with DCM, the presence of the TLR4 variants rs4986790 and rs4986791 predicts impaired cardiac recovery independently of medical treatment or cardiac risk factors.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 207-212 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T2 611-616 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T3 922-927 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T4 1079-1084 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T5 1079-1084 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

DisGeNET

Id Subject Object Predicate Lexical cue
T0 12-32 gene:7099 denotes Toll-like receptor 4
T1 75-97 disease:C0007193 denotes dilated cardiomyopathy
T2 392-396 gene:7099 denotes TLR4
T3 447-450 disease:C0007193 denotes DCM
T4 370-390 gene:7099 denotes Toll-like receptor 4
T5 447-450 disease:C0007193 denotes DCM
T6 524-528 gene:7099 denotes TLR4
T7 588-591 disease:C0007193 denotes DCM
T8 863-867 gene:6445 denotes type
T9 922-935 disease:C0018802 denotes heart failure
T10 863-867 gene:6445 denotes type
T11 922-935 disease:C0018801 denotes heart failure
T12 853-857 gene:7099 denotes TLR4
T13 922-935 disease:C0018802 denotes heart failure
T14 853-857 gene:7099 denotes TLR4
T15 922-935 disease:C0018801 denotes heart failure
R1 T0 T1 associated_with Toll-like receptor 4,dilated cardiomyopathy
R2 T2 T3 associated_with TLR4,DCM
R3 T4 T5 associated_with Toll-like receptor 4,DCM
R4 T6 T7 associated_with TLR4,DCM
R5 T8 T9 associated_with type,heart failure
R6 T10 T11 associated_with type,heart failure
R7 T12 T13 associated_with TLR4,heart failure
R8 T14 T15 associated_with TLR4,heart failure

Allie

Id Subject Object Predicate Lexical cue
SS1_22645142_1_0 136-158 expanded denotes dilated cardiomyopathy
SS2_22645142_1_0 160-163 abbr denotes DCM
SS1_22645142_3_0 370-390 expanded denotes Toll-like receptor 4
SS2_22645142_3_0 392-396 abbr denotes TLR4
AE1_22645142_1_0 SS1_22645142_1_0 SS2_22645142_1_0 abbreviatedTo dilated cardiomyopathy,DCM
AE1_22645142_3_0 SS1_22645142_3_0 SS2_22645142_3_0 abbreviatedTo Toll-like receptor 4,TLR4

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 136-158 HP_0001644 denotes dilated cardiomyopathy
T2 144-158 HP_0001638 denotes cardiomyopathy
T3 201-220 HP_0001635 denotes stage heart failure
T4 207-220 HP_0001635 denotes heart failure
T5 611-624 HP_0001635 denotes heart failure
T6 922-935 HP_0001635 denotes heart failure
T7 968-988 HP_0002119 denotes ventricular dilation
T8 1310-1330 HP_0002119 denotes ventricular dilation

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
22645142-4#88#95#geners4986791 540-547 geners4986791 denotes p.T399I
22645142-4#62#71#geners4986791 514-523 geners4986791 denotes rs4986791
22645142-4#136#139#diseaseC1449563 588-591 diseaseC1449563 denotes DCM
88#95#geners4986791136#139#diseaseC1449563 22645142-4#88#95#geners4986791 22645142-4#136#139#diseaseC1449563 associated_with p.T399I,DCM
62#71#geners4986791136#139#diseaseC1449563 22645142-4#62#71#geners4986791 22645142-4#136#139#diseaseC1449563 associated_with rs4986791,DCM

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22645142-0#12#32#gene7099 12-32 gene7099 denotes Toll-like receptor 4
22645142-0#75#97#diseaseC0007193 75-97 diseaseC0007193 denotes dilated cardiomyopathy
22645142-4#16#20#gene7099 468-472 gene7099 denotes TLR4
22645142-4#72#76#gene7099 524-528 gene7099 denotes TLR4
22645142-4#136#139#diseaseC1449563 588-591 diseaseC1449563 denotes DCM
22645142-7#85#89#gene6445 863-867 gene6445 denotes type
22645142-7#144#157#diseaseC0018801 922-935 diseaseC0018801 denotes heart failure
22645142-7#144#157#diseaseC0018802 922-935 diseaseC0018802 denotes heart failure
12#32#gene709975#97#diseaseC0007193 22645142-0#12#32#gene7099 22645142-0#75#97#diseaseC0007193 associated_with Toll-like receptor 4,dilated cardiomyopathy
16#20#gene7099136#139#diseaseC1449563 22645142-4#16#20#gene7099 22645142-4#136#139#diseaseC1449563 associated_with TLR4,DCM
72#76#gene7099136#139#diseaseC1449563 22645142-4#72#76#gene7099 22645142-4#136#139#diseaseC1449563 associated_with TLR4,DCM
85#89#gene6445144#157#diseaseC0018801 22645142-7#85#89#gene6445 22645142-7#144#157#diseaseC0018801 associated_with type,heart failure
85#89#gene6445144#157#diseaseC0018802 22645142-7#85#89#gene6445 22645142-7#144#157#diseaseC0018802 associated_with type,heart failure

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 75-97 Disease denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0005021
T2 136-158 Disease denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0005021
T3 160-163 Disease denotes DCM http://purl.obolibrary.org/obo/MONDO_0005021
T4 207-220 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T5 447-450 Disease denotes DCM http://purl.obolibrary.org/obo/MONDO_0005021
T6 588-591 Disease denotes DCM http://purl.obolibrary.org/obo/MONDO_0005021
T7 611-624 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T8 922-935 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T9 1650-1653 Disease denotes DCM http://purl.obolibrary.org/obo/MONDO_0005021

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 75-97 Phenotype denotes dilated cardiomyopathy HP:0001644
T2 136-158 Phenotype denotes dilated cardiomyopathy HP:0001644
T3 160-163 Phenotype denotes DCM HP:0001644
T4 207-220 Phenotype denotes heart failure HP:0001635
T5 447-450 Phenotype denotes DCM HP:0001644
T6 588-591 Phenotype denotes DCM HP:0001644
T7 611-624 Phenotype denotes heart failure HP:0001635
T8 922-935 Phenotype denotes heart failure HP:0001635
T9 963-988 Phenotype denotes left ventricular dilation HP:4000141
T10 1305-1330 Phenotype denotes left ventricular dilation HP:4000141
T11 1650-1653 Phenotype denotes DCM HP:0001644

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 207-212 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T5 611-616 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T9 922-927 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T13 1079-1084 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 207-212 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T2 611-616 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T3 922-927 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T4 1079-1084 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315