PubMed:22587010
Annnotations
GlyCosmos15-Species
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 24 | 908-913 | Species | denotes | human | 9606 |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 172-176 | gene:4582 | denotes | MUC1 |
| T1 | 133-150 | disease:C1368683 | denotes | epithelial tumors |
| R1 | T0 | T1 | associated_with | MUC1,epithelial tumors |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22587010_1_0 | 200-233 | expanded | denotes | variable number of tandem repeats |
| SS2_22587010_1_0 | 235-239 | abbr | denotes | VNTR |
| SS1_22587010_1_1 | 249-287 | expanded | denotes | tumor-associated carbohydrate antigens |
| SS2_22587010_1_1 | 289-294 | abbr | denotes | TACAs |
| AE1_22587010_1_0 | SS1_22587010_1_0 | SS2_22587010_1_0 | abbreviatedTo | variable number of tandem repeats,VNTR |
| AE1_22587010_1_1 | SS1_22587010_1_1 | SS2_22587010_1_1 | abbreviatedTo | tumor-associated carbohydrate antigens,TACAs |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 144-150 | HP_0002664 | denotes | tumors |
| T2 | 249-254 | HP_0002664 | denotes | tumor |
| T3 | 914-926 | HP_0003002 | denotes | breast tumor |
| T4 | 914-926 | HP_0100013 | denotes | breast tumor |
| T5 | 921-926 | HP_0002664 | denotes | tumor |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 22587010-1#74#78#gene4582 | 172-176 | gene4582 | denotes | MUC1 |
| 22587010-1#35#52#diseaseC1368683 | 133-150 | diseaseC1368683 | denotes | epithelial tumors |
| 74#78#gene458235#52#diseaseC1368683 | 22587010-1#74#78#gene4582 | 22587010-1#35#52#diseaseC1368683 | associated_with | MUC1,epithelial tumors |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 698-708 | Glycan | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 82-88 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 249-254 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 914-926 | Phenotype | denotes | breast tumor | HP:0100013 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 82-88 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T2 | 144-150 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 249-254 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 914-926 | Disease | denotes | breast tumor | http://purl.obolibrary.org/obo/MONDO_0007254|http://purl.obolibrary.org/obo/MONDO_0021100 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 698-708 | Glycan | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 698-708 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Tn antigen | http://www.glycoepitope.jp/epitopes/EP0021 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 82-88 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 249-254 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 914-926 | Phenotype | denotes | breast tumor | HP:0100013 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 642-648 | Cell | denotes | B-cell | http://purl.obolibrary.org/obo/CL:0000236 |
| T2 | 921-932 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
| T3 | 975-981 | Cell | denotes | T-cell | http://purl.obolibrary.org/obo/CL:0000084 |
| T4 | 1045-1062 | Cell | denotes | cytotoxic T cells | http://purl.obolibrary.org/obo/CL:0000794|http://purl.obolibrary.org/obo/CL:0000910 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 642-648 | Body_part | denotes | B-cell | http://purl.obolibrary.org/obo/CL_0000236 |
| T2 | 914-920 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T3 | 975-981 | Body_part | denotes | T-cell | http://purl.obolibrary.org/obo/CL_0000084 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 82-88 | Disease | denotes | cancer | MONDO:0004992 |
| T2 | 249-254 | Disease | denotes | tumor | MONDO:0005070 |
| T3 | 914-926 | Disease | denotes | breast tumor | MONDO:0007254|MONDO:0021100 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-97 | Sentence | denotes | A totally synthetic, self-assembling, adjuvant-free MUC1 glycopeptide vaccine for cancer therapy. |
| T2 | 98-316 | Sentence | denotes | In the development of vaccines for epithelial tumors, the key targets are MUC1 proteins, which have a variable number of tandem repeats (VNTR) bearing tumor-associated carbohydrate antigens (TACAs), such as Tn and STn. |
| T3 | 317-409 | Sentence | denotes | A major obstacle in vaccine development is the low immunogenicity of the short MUC1 peptide. |
| T4 | 410-566 | Sentence | denotes | To overcome this obstacle, we designed, synthesized, and evaluated several totally synthetic self-adjuvanting vaccine candidates with self-assembly domains. |
| T5 | 567-680 | Sentence | denotes | These vaccine candidates aggregated into fibrils and displayed multivalent B-cell epitopes under mild conditions. |
| T6 | 681-792 | Sentence | denotes | Glycosylation of Tn antigen on the Thr residue of PDTRP sequence in MUC1 VNTR led to effective immune response. |
| T7 | 793-933 | Sentence | denotes | These vaccines elicited a high level antibody response without any adjuvant and induced antibodies that recognized human breast tumor cells. |
| T8 | 934-1063 | Sentence | denotes | These vaccines appeared to act through a T-cell independent pathway and were associated with the activation of cytotoxic T cells. |
| T9 | 1064-1188 | Sentence | denotes | These fully synthetic, molecularly defined vaccine candidates had several features that hold promise for anticancer therapy. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 698-708 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Tn antigen | http://www.glycoepitope.jp/epitopes/EP0021 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 914-920 | Body_part | denotes | breast | FMA:9601 |
| T2 | 1045-1062 | Body_part | denotes | cytotoxic T cells | FMA:70573 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 908-913 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 642-648 | Body_part | denotes | B-cell | http://purl.obolibrary.org/obo/CL_0000236 |
| T2 | 914-920 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T3 | 975-981 | Body_part | denotes | T-cell | http://purl.obolibrary.org/obo/CL_0000084 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 642-648 | Cell | denotes | B-cell | http://purl.obolibrary.org/obo/CL:0000236 |
| T2 | 921-932 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
| T3 | 975-981 | Cell | denotes | T-cell | http://purl.obolibrary.org/obo/CL:0000084 |
| T4 | 1045-1062 | Cell | denotes | cytotoxic T cells | http://purl.obolibrary.org/obo/CL:0000794|http://purl.obolibrary.org/obo/CL:0000910 |