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PubMed:22584709 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 702-732 gene:5979 denotes rearranged during transfection
T1 822-849 disease:C0238462 denotes medullary thyroid carcinoma
T2 905-935 gene:5979 denotes rearranged during transfection
T3 1027-1062 disease:C0025268 denotes multiple endocrine neoplasia type 2
T4 905-935 gene:5979 denotes rearranged during transfection
T5 1068-1103 disease:C0025268 denotes multiple endocrine neoplasia type 2
R1 T0 T1 associated_with rearranged during transfection,medullary thyroid carcinoma
R2 T2 T3 associated_with rearranged during transfection,multiple endocrine neoplasia type 2
R3 T4 T5 associated_with rearranged during transfection,multiple endocrine neoplasia type 2

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 80-99 HP_0100568 denotes endocrine neoplasia
T2 90-99 HP_0002664 denotes neoplasia
T3 113-131 HP_0000006 denotes autosomal-dominant
T4 143-149 HP_0002664 denotes cancer
T5 351-379 HP_0002865 denotes medullary thyroid carcinomas
T6 361-379 HP_0002890 denotes thyroid carcinomas
T7 417-433 HP_0002666 denotes pheochromocytoma
T8 438-465 HP_0008200 denotes primary hyperparathyroidism
T9 446-465 HP_0000843 denotes hyperparathyroidism
T10 476-495 HP_0100568 denotes endocrine neoplasia
T11 486-495 HP_0002664 denotes neoplasia
T12 580-599 HP_0100568 denotes endocrine neoplasia
T13 590-599 HP_0002664 denotes neoplasia
T14 618-637 HP_0100568 denotes endocrine neoplasia
T15 628-637 HP_0002664 denotes neoplasia
T16 660-687 HP_0002865 denotes medullary thyroid carcinoma
T17 670-687 HP_0002890 denotes thyroid carcinoma
T18 822-849 HP_0002865 denotes medullary thyroid carcinoma
T19 832-849 HP_0002890 denotes thyroid carcinoma
T20 1036-1055 HP_0100568 denotes endocrine neoplasia
T21 1046-1055 HP_0002664 denotes neoplasia
T22 1077-1096 HP_0100568 denotes endocrine neoplasia
T23 1087-1096 HP_0002664 denotes neoplasia
T24 1464-1491 HP_0002865 denotes medullary thyroid carcinoma
T25 1474-1491 HP_0002890 denotes thyroid carcinoma
T26 1534-1539 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22584709-4#13#43#gene5979 702-732 gene5979 denotes rearranged during transfection
22584709-4#133#160#diseaseC0238462 822-849 diseaseC0238462 denotes medullary thyroid carcinoma
22584709-5#9#39#gene5979 905-935 gene5979 denotes rearranged during transfection
22584709-5#131#166#diseaseC0025268 1027-1062 diseaseC0025268 denotes multiple endocrine neoplasia type 2
22584709-5#172#207#diseaseC0025268 1068-1103 diseaseC0025268 denotes multiple endocrine neoplasia type 2
13#43#gene5979133#160#diseaseC0238462 22584709-4#13#43#gene5979 22584709-4#133#160#diseaseC0238462 associated_with rearranged during transfection,medullary thyroid carcinoma
9#39#gene5979131#166#diseaseC0025268 22584709-5#9#39#gene5979 22584709-5#131#166#diseaseC0025268 associated_with rearranged during transfection,multiple endocrine neoplasia type 2
9#39#gene5979172#207#diseaseC0025268 22584709-5#9#39#gene5979 22584709-5#172#207#diseaseC0025268 associated_with rearranged during transfection,multiple endocrine neoplasia type 2

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1004 905-935 gene:5979 denotes rearranged during transfection
T1005 1027-1062 disease:C0025268 denotes multiple endocrine neoplasia type 2
T1006 1068-1103 disease:C0025268 denotes multiple endocrine neoplasia type 2
R1 T1004 T1005 associated_with rearranged during transfection,multiple endocrine neoplasia type 2
R2 T1004 T1006 associated_with rearranged during transfection,multiple endocrine neoplasia type 2

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-70 Sentence denotes Genotype-phenotype correlation in multiple endocrine neoplasia type 2.
TextSentencer_T2 71-320 Sentence denotes Multiple endocrine neoplasia type 2 is an autosomal-dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the rearranged during transfection proto-oncogene, which encodes the receptor tyrosine kinase, on chromosome 10.
TextSentencer_T3 321-466 Sentence denotes It has a strong penetrance of medullary thyroid carcinomas and can be associated with bilateral pheochromocytoma and primary hyperparathyroidism.
TextSentencer_T4 467-688 Sentence denotes Multiple endocrine neoplasia type 2 is divided into three varieties depending on its clinical features: multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma.
TextSentencer_T5 689-895 Sentence denotes The specific rearranged during transfection mutation may suggest a predilection toward a particular phenotype and clinical course of medullary thyroid carcinoma, with strong genotype-phenotype correlations.
TextSentencer_T6 896-1191 Sentence denotes Offering rearranged during transfection testing is the best practice for the clinical management of patients at risk of developing multiple endocrine neoplasia type 2, and multiple endocrine neoplasia type 2 has become a classic model for the integration of molecular medicine into patient care.
TextSentencer_T7 1192-1412 Sentence denotes Recommendations on the timing of prophylactic thyroidectomy and extent of surgery are based on the classification of rearranged during transfection mutations into risk levels according to genotype-phenotype correlations.
TextSentencer_T8 1413-1643 Sentence denotes Earlier identification of patients with hereditary medullary thyroid carcinoma can change the presentation from clinical tumor to preclinical disease, resulting in a high cure rate of affected patients and a much better prognoses.
T1 0-70 Sentence denotes Genotype-phenotype correlation in multiple endocrine neoplasia type 2.
T2 71-320 Sentence denotes Multiple endocrine neoplasia type 2 is an autosomal-dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the rearranged during transfection proto-oncogene, which encodes the receptor tyrosine kinase, on chromosome 10.
T3 321-466 Sentence denotes It has a strong penetrance of medullary thyroid carcinomas and can be associated with bilateral pheochromocytoma and primary hyperparathyroidism.
T4 467-688 Sentence denotes Multiple endocrine neoplasia type 2 is divided into three varieties depending on its clinical features: multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma.
T5 689-895 Sentence denotes The specific rearranged during transfection mutation may suggest a predilection toward a particular phenotype and clinical course of medullary thyroid carcinoma, with strong genotype-phenotype correlations.
T6 896-1191 Sentence denotes Offering rearranged during transfection testing is the best practice for the clinical management of patients at risk of developing multiple endocrine neoplasia type 2, and multiple endocrine neoplasia type 2 has become a classic model for the integration of molecular medicine into patient care.
T7 1192-1412 Sentence denotes Recommendations on the timing of prophylactic thyroidectomy and extent of surgery are based on the classification of rearranged during transfection mutations into risk levels according to genotype-phenotype correlations.
T8 1413-1643 Sentence denotes Earlier identification of patients with hereditary medullary thyroid carcinoma can change the presentation from clinical tumor to preclinical disease, resulting in a high cure rate of affected patients and a much better prognoses.