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PubMed:22577142 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes.
T2 131-356 Sentence denotes The N-end rule pathway is a proteolytic system in which destabilizing N-terminal amino acids of short lived proteins are recognized by recognition components (N-recognins) as an essential element of degrons, called N-degrons.
T3 357-569 Sentence denotes In eukaryotes, the major way to generate N-degrons is through arginylation by ATE1 arginyl-tRNA-protein transferases, which transfer Arg from aminoacyl-tRNA to N-terminal Asp and Glu (and Cys as well in mammals).
T4 570-694 Sentence denotes We have shown previously that ATE1-deficient mice die during embryogenesis with defects in cardiac and vascular development.
T5 695-782 Sentence denotes Here, we characterized the arginylation-dependent N-end rule pathway in cardiomyocytes.
T6 783-919 Sentence denotes Our results suggest that the cardiac and vascular defects in ATE1-deficient embryos are independent from each other and cell-autonomous.
T7 920-1246 Sentence denotes ATE1-deficient myocardium and cardiomyocytes therein, but not non-cardiomyocytes, showed reduced DNA synthesis and mitotic activity ~24 h before the onset of cardiac and vascular defects at embryonic day 12.5 associated with the impairment in the phospholipase C/PKC-MEK1-ERK axis of Gα(q)-mediated cardiac signaling pathways.
T8 1247-1453 Sentence denotes Cardiac overexpression of Gα(q) rescued ATE1-deficient embryos from thin myocardium and ventricular septal defect but not from vascular defects, genetically dissecting vascular defects from cardiac defects.
T9 1454-1621 Sentence denotes The misregulation in cardiovascular signaling can be attributed in part to the failure in hypoxia-sensitive degradation of RGS4, a GTPase-activating protein for Gα(q).
T10 1622-1882 Sentence denotes This study is the first to characterize the N-end rule pathway in cardiomyocytes and reveals the role of its arginylation branch in Gα(q)-mediated signaling of cardiomyocytes in part through N-degron-based, oxygen-sensitive proteolysis of G-protein regulators.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 859-866 http://purl.obolibrary.org/obo/MAT_0000226 denotes embryos
T2 935-945 http://purl.obolibrary.org/obo/MAT_0000453 denotes myocardium
T3 1302-1309 http://purl.obolibrary.org/obo/MAT_0000226 denotes embryos
T4 1320-1330 http://purl.obolibrary.org/obo/MAT_0000453 denotes myocardium

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 650-681 HP_0002597 denotes defects in cardiac and vascular
T2 650-668 HP_0001627 denotes defects in cardiac
T3 812-840 HP_0001627 denotes cardiac and vascular defects
T4 824-840 HP_0002597 denotes vascular defects
T5 1078-1106 HP_0001627 denotes cardiac and vascular defects
T6 1090-1106 HP_0002597 denotes vascular defects
T7 1335-1360 HP_0001629 denotes ventricular septal defect
T8 1347-1360 HP_0001671 denotes septal defect
T9 1374-1390 HP_0002597 denotes vascular defects
T10 1415-1431 HP_0002597 denotes vascular defects
T11 1424-1444 HP_0001627 denotes defects from cardiac
T12 1437-1452 HP_0001627 denotes cardiac defects

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1335-1360 Disease denotes ventricular septal defect http://purl.obolibrary.org/obo/MONDO_0002070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1335-1360 Phenotype denotes ventricular septal defect HP:0001629
T2 1544-1551 Phenotype denotes hypoxia HP:0012418

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 360-370 OrganismTaxon denotes eukaryotes 2759
T2 615-619 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 115-129 Body_part denotes cardiomyocytes http://purl.obolibrary.org/obo/CL_0000746
T2 767-781 Body_part denotes cardiomyocytes http://purl.obolibrary.org/obo/CL_0000746
T3 935-945 Body_part denotes myocardium http://purl.obolibrary.org/obo/UBERON_0002349
T4 950-964 Body_part denotes cardiomyocytes http://purl.obolibrary.org/obo/CL_0000746
T5 986-1000 Body_part denotes cardiomyocytes http://purl.obolibrary.org/obo/CL_0000746
T6 1196-1200 Body_part denotes axis http://purl.obolibrary.org/obo/UBERON_0001093
T7 1320-1330 Body_part denotes myocardium http://purl.obolibrary.org/obo/UBERON_0002349
T8 1688-1702 Body_part denotes cardiomyocytes http://purl.obolibrary.org/obo/CL_0000746
T9 1782-1796 Body_part denotes cardiomyocytes http://purl.obolibrary.org/obo/CL_0000746

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 859-866 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226
T2 935-945 Body_part denotes myocardium http://purl.obolibrary.org/obo/MAT_0000453
T3 1302-1309 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226
T4 1320-1330 Body_part denotes myocardium http://purl.obolibrary.org/obo/MAT_0000453

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 115-129 Cell denotes cardiomyocytes http://purl.obolibrary.org/obo/CL:0000746
T2 767-781 Cell denotes cardiomyocytes http://purl.obolibrary.org/obo/CL:0000746
T3 950-964 Cell denotes cardiomyocytes http://purl.obolibrary.org/obo/CL:0000746
T4 986-1000 Cell denotes cardiomyocytes http://purl.obolibrary.org/obo/CL:0000746
T5 1688-1702 Cell denotes cardiomyocytes http://purl.obolibrary.org/obo/CL:0000746
T6 1782-1796 Cell denotes cardiomyocytes http://purl.obolibrary.org/obo/CL:0000746