> top > docs > PubMed:22572849 > annotations

PubMed:22572849 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 108-266 DRI_Approach denotes We investigated the impairment of ATP-sensitive K(+) (K(ATP)) channels in aortic smooth muscle cells (ASMCs) from isoproterenol-induced hypertrophied rabbits.
T2 267-421 DRI_Approach denotes The amplitude of K(ATP) channels induced by the K(ATP) channel opener pinacidil (10 μM) was greater in ASMCs from control than from hypertrophied animals.
T3 422-524 DRI_Background denotes In phenylephrine-preconstricted aortic rings, pinacidil induced relaxation in a dose-dependent manner.
T4 525-679 DRI_Outcome denotes The dose-dependent curve was shifted to the right in the hypertrophied (EC(50): 17.80 ± 3.28 μM) compared with the control model (EC(50): 6.69 ± 2.40 μM).
T5 680-881 DRI_Background denotes Although the level of Kir6.2 subtype expression did not differ between ASMCs from the control and hypertrophied models, those of the Kir6.1 and SUR2B subtypes were decreased in the hypertrophied model.
T6 882-1209 DRI_Approach denotes Application of the calcitonin-gene related peptide (100 nM) and adenylyl cyclase activator forskolin (10 μM), which activates protein kinase A (PKA) and consequently K(ATP) channels, induced a K(ATP) current in both control and hypertrophied animals; however, the K(ATP) current amplitude did not differ between the two groups.
T7 1210-1300 DRI_Outcome denotes Furthermore, PKA expression was not altered between the control and hypertrophied animals.
T8 1301-1378 DRI_Outcome denotes These results suggests that the decreased K(ATP) current amplitude and K(ATP)
T9 1410-1597 DRI_Outcome denotes in the hypertrophied animals were attributable to the reduction in K(ATP) channel expression but not to changes in the intracellular signaling mechanism that activates the K(ATP) current.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 108-110 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T2 500-501 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 597-603 CVCL_IR37|Cancer_cell_line|Homo sapiens denotes EC(50)
T4 597-599 CVCL_DG46|Spontaneously_immortalized_cell_line|Oncorhynchus tshawytscha denotes EC
T5 600-602 CVCL_ZC06|Finite_cell_line|Homo sapiens denotes 50
T6 655-661 CVCL_IR37|Cancer_cell_line|Homo sapiens denotes EC(50)
T7 655-657 CVCL_DG46|Spontaneously_immortalized_cell_line|Oncorhynchus tshawytscha denotes EC
T8 658-660 CVCL_ZC06|Finite_cell_line|Homo sapiens denotes 50
T9 963-972 CVCL_C410|Hybridoma|Mus musculus denotes activator
T10 998-1007 CVCL_C410|Hybridoma|Mus musculus denotes activates
T11 1023-1024 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T12 1073-1076 CVCL_1093|Cancer_cell_line|Homo sapiens denotes a K
T13 1073-1074 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 1514-1521 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T15 1568-1577 CVCL_C410|Hybridoma|Mus musculus denotes activates

GoldHamster

Id Subject Object Predicate Lexical cue
T2 14-17 318 denotes ATP
T1 14-17 D000255 denotes ATP
T3 14-17 CHEBI:30616 denotes ATP
T4 14-17 D000255 denotes ATP
T5 14-17 CHEBI:15422 denotes ATP
T7 43-49 813859 denotes rabbit
T6 43-49 D011817 denotes rabbit
T8 43-49 9986 denotes rabbit
T9 50-70 UBERON:0004178 denotes aortic smooth muscle
T14 78-106 D017379 denotes left ventricular hypertrophy
T15 78-106 D017379 denotes left ventricular hypertrophy
T19 142-145 318 denotes ATP
T18 142-145 D000255 denotes ATP
T20 142-145 CHEBI:30616 denotes ATP
T21 142-145 D000255 denotes ATP
T22 142-145 CHEBI:15422 denotes ATP
T24 164-167 318 denotes ATP
T23 164-167 D000255 denotes ATP
T25 164-167 CHEBI:30616 denotes ATP
T26 164-167 D000255 denotes ATP
T27 164-167 CHEBI:15422 denotes ATP
T28 182-202 UBERON:0004178 denotes aortic smooth muscle
T33 222-235 6054 denotes isoproterenol
T34 222-235 D007545 denotes isoproterenol
T35 222-235 D007545 denotes isoproterenol
T36 222-235 CHEBI:64317 denotes isoproterenol
T37 222-235 CHEBI:6257 denotes isoproterenol
T38 258-265 D011817 denotes rabbits
T39 258-265 9986 denotes rabbits
T41 286-289 318 denotes ATP
T40 286-289 D000255 denotes ATP
T42 286-289 CHEBI:30616 denotes ATP
T43 286-289 D000255 denotes ATP
T44 286-289 CHEBI:15422 denotes ATP
T46 317-320 318 denotes ATP
T45 317-320 D000255 denotes ATP
T47 317-320 CHEBI:30616 denotes ATP
T48 317-320 D000255 denotes ATP
T49 317-320 CHEBI:15422 denotes ATP
T50 337-346 D020110 denotes pinacidil
T51 337-346 CHEBI:34923 denotes pinacidil
T52 337-346 CHEBI:91706 denotes pinacidil
T53 337-346 D020110 denotes pinacidil
T60 425-438 8163 denotes phenylephrine
T58 425-438 D010656 denotes phenylephrine
T59 425-438 CHEBI:8093 denotes phenylephrine
T61 425-438 D010656 denotes phenylephrine
T62 468-477 D020110 denotes pinacidil
T63 468-477 CHEBI:34923 denotes pinacidil
T64 468-477 CHEBI:91706 denotes pinacidil
T65 468-477 D020110 denotes pinacidil
T66 597-602 CVCL_IR37 denotes EC(50
T71 655-660 CVCL_IR37 denotes EC(50
T76 702-705 PR:P55041 denotes Kir
T77 702-705 PR:000007932 denotes Kir
T78 702-705 PR:P55040 denotes Kir
T79 813-816 PR:P55041 denotes Kir
T80 813-816 PR:000007932 denotes Kir
T81 813-816 PR:P55040 denotes Kir
T89 824-828 PR:O43078 denotes SUR2
T90 824-828 PR:O94298 denotes SUR2
T91 824-828 PR:P38992 denotes SUR2
T92 824-828 PR:Q80YQ2 denotes SUR2
T93 824-828 PR:O60706 denotes SUR2
T94 824-828 PR:P70170 denotes SUR2
T95 824-828 PR:Q63563 denotes SUR2
T96 824-828 PR:O65782 denotes SUR2
T97 824-828 PR:000010295 denotes SUR2
T98 824-828 PR:Q10669 denotes SUR2
T99 824-828 PR:000003564 denotes SUR2
T100 824-828 PR:Q9ULK4 denotes SUR2
T117 901-932 P30881 denotes calcitonin-gene related peptide
T118 901-932 P30880 denotes calcitonin-gene related peptide
T119 901-932 P10286 denotes calcitonin-gene related peptide
T120 901-932 P31888 denotes calcitonin-gene related peptide
T115 901-932 D015740 denotes calcitonin-gene related peptide
T116 901-932 D015740 denotes calcitonin-gene related peptide
T121 912-916 SO:0000704 denotes gene
T122 925-932 SO:0001064 denotes peptide
T126 946-962 P40135 denotes adenylyl cyclase
T127 946-962 P9WQ34 denotes adenylyl cyclase
T128 946-962 Q99396 denotes adenylyl cyclase
T129 946-962 Q9WXC3 denotes adenylyl cyclase
T130 946-962 Q25263 denotes adenylyl cyclase
T131 946-962 P00936 denotes adenylyl cyclase
T132 946-962 Q59119 denotes adenylyl cyclase
T133 946-962 P30528 denotes adenylyl cyclase
T134 946-962 Q03101 denotes adenylyl cyclase
T135 946-962 P23466 denotes adenylyl cyclase
T137 946-962 Q03100 denotes adenylyl cyclase
T138 946-962 Q27675 denotes adenylyl cyclase
T139 946-962 P14605 denotes adenylyl cyclase
T140 946-962 P40127 denotes adenylyl cyclase
T141 946-962 P0A1A7 denotes adenylyl cyclase
T142 946-962 P40130 denotes adenylyl cyclase
T143 946-962 Q01513 denotes adenylyl cyclase
T144 946-962 P9WMU9 denotes adenylyl cyclase
T145 946-962 P9WMU8 denotes adenylyl cyclase
T146 946-962 P49606 denotes adenylyl cyclase
T147 946-962 P40136 denotes adenylyl cyclase
T148 946-962 Q01631 denotes adenylyl cyclase
T149 946-962 P26338 denotes adenylyl cyclase
T150 946-962 P0A1A8 denotes adenylyl cyclase
T151 946-962 Q26721 denotes adenylyl cyclase
T152 946-962 Q99280 denotes adenylyl cyclase
T153 946-962 PR:000022358 denotes adenylyl cyclase
T154 946-962 P9WQ35 denotes adenylyl cyclase
T155 946-962 Q55F68 denotes adenylyl cyclase
T156 946-962 P0A4Y1 denotes adenylyl cyclase
T157 946-962 Q26896 denotes adenylyl cyclase
T158 946-962 Q57692 denotes adenylyl cyclase
T159 946-962 P40134 denotes adenylyl cyclase
T160 946-962 Q8FBP0 denotes adenylyl cyclase
T161 946-962 P59739 denotes adenylyl cyclase
T162 946-962 O69199 denotes adenylyl cyclase
T163 946-962 P08678 denotes adenylyl cyclase
T164 946-962 Q05766 denotes adenylyl cyclase
T165 946-962 P43524 denotes adenylyl cyclase
T166 946-962 Q8XAP1 denotes adenylyl cyclase
T167 946-962 Q99279 denotes adenylyl cyclase
T168 946-962 Q59685 denotes adenylyl cyclase
T169 946-962 P27580 denotes adenylyl cyclase
T136 946-962 D000262 denotes adenylyl cyclase
T170 973-982 D005576 denotes forskolin
T171 973-982 CHEBI:42471 denotes forskolin
T172 973-982 D005576 denotes forskolin
T181 1008-1015 SO:0000104 denotes protein
T177 1008-1015 GO:0003675 denotes protein
T184 1008-1024 Q05608 denotes protein kinase A
T185 1008-1024 Q9RI12 denotes protein kinase A
T183 1008-1024 D017868 denotes protein kinase A
T187 1026-1029 PR:P76594 denotes PKA
T188 1026-1029 PR:000029188 denotes PKA
T189 1026-1029 GO:0005952 denotes PKA
T186 1026-1029 GO:0004691 denotes PKA
T191 1050-1053 318 denotes ATP
T190 1050-1053 D000255 denotes ATP
T192 1050-1053 CHEBI:30616 denotes ATP
T193 1050-1053 D000255 denotes ATP
T194 1050-1053 CHEBI:15422 denotes ATP
T196 1077-1080 318 denotes ATP
T195 1077-1080 D000255 denotes ATP
T197 1077-1080 CHEBI:30616 denotes ATP
T198 1077-1080 D000255 denotes ATP
T199 1077-1080 CHEBI:15422 denotes ATP
T201 1148-1151 318 denotes ATP
T200 1148-1151 D000255 denotes ATP
T202 1148-1151 CHEBI:30616 denotes ATP
T203 1148-1151 D000255 denotes ATP
T204 1148-1151 CHEBI:15422 denotes ATP
T206 1223-1226 PR:P76594 denotes PKA
T207 1223-1226 PR:000029188 denotes PKA
T208 1223-1226 GO:0005952 denotes PKA
T205 1223-1226 GO:0004691 denotes PKA
T210 1345-1348 318 denotes ATP
T209 1345-1348 D000255 denotes ATP
T211 1345-1348 CHEBI:30616 denotes ATP
T212 1345-1348 D000255 denotes ATP
T213 1345-1348 CHEBI:15422 denotes ATP
T215 1374-1377 318 denotes ATP
T214 1374-1377 D000255 denotes ATP
T216 1374-1377 CHEBI:30616 denotes ATP
T217 1374-1377 D000255 denotes ATP
T218 1374-1377 CHEBI:15422 denotes ATP
T219 1464-1473 MOP:0000569 denotes reduction
T221 1479-1482 318 denotes ATP
T220 1479-1482 D000255 denotes ATP
T222 1479-1482 CHEBI:30616 denotes ATP
T223 1479-1482 D000255 denotes ATP
T224 1479-1482 CHEBI:15422 denotes ATP
T225 1529-1542 GO:0005622 denotes intracellular
T226 1543-1552 GO:0023052 denotes signaling
T228 1584-1587 318 denotes ATP
T227 1584-1587 D000255 denotes ATP
T229 1584-1587 CHEBI:30616 denotes ATP
T230 1584-1587 D000255 denotes ATP
T231 1584-1587 CHEBI:15422 denotes ATP

Allie

Id Subject Object Predicate Lexical cue
SS1_22572849_1_0 182-208 expanded denotes aortic smooth muscle cells
SS2_22572849_1_0 210-215 abbr denotes ASMCs
SS1_22572849_2_0 271-285 expanded denotes amplitude of K
SS2_22572849_2_0 286-289 abbr denotes ATP
SS1_22572849_6_0 998-1049 expanded denotes activates protein kinase A (PKA) and consequently K
SS2_22572849_6_0 1050-1053 abbr denotes ATP
SS1_22572849_6_1 1008-1024 expanded denotes protein kinase A
SS2_22572849_6_1 1026-1029 abbr denotes PKA
SS1_22572849_8_0 1358-1373 expanded denotes amplitude and K
SS2_22572849_8_0 1374-1377 abbr denotes ATP
AE1_22572849_1_0 SS1_22572849_1_0 SS2_22572849_1_0 abbreviatedTo aortic smooth muscle cells,ASMCs
AE1_22572849_2_0 SS1_22572849_2_0 SS2_22572849_2_0 abbreviatedTo amplitude of K,ATP
AE1_22572849_6_0 SS1_22572849_6_0 SS2_22572849_6_0 abbreviatedTo activates protein kinase A (PKA) and consequently K,ATP
AE1_22572849_6_1 SS1_22572849_6_1 SS2_22572849_6_1 abbreviatedTo protein kinase A,PKA
AE1_22572849_8_0 SS1_22572849_8_0 SS2_22572849_8_0 abbreviatedTo amplitude and K,ATP