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PubMed:22569271 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 134-158 HP_0001402 denotes Hepatocellular carcinoma
T2 262-267 HP_0002664 denotes tumor
T3 359-364 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22569271-0#76#81#gene11009 76-81 gene11009 denotes IL-24
22569271-0#96#120#diseaseC2239176 96-120 diseaseC2239176 denotes hepatocellular carcinoma
22569271-11#86#91#gene3439 1764-1769 gene3439 denotes IFN-α
22569271-11#86#91#gene3447 1764-1769 gene3447 denotes IFN-α
22569271-11#86#91#gene3439 1764-1769 gene3439 denotes IFN-α
22569271-11#86#91#gene3447 1764-1769 gene3447 denotes IFN-α
22569271-11#146#149#diseaseC2239176 1824-1827 diseaseC2239176 denotes HCC
22569271-11#243#246#diseaseC2239176 1921-1924 diseaseC2239176 denotes HCC
22569271-6#31#36#gene6772 914-919 gene6772 denotes STAT1
22569271-6#41#46#gene8651 924-929 gene8651 denotes SOCS1
22569271-6#155#159#gene7422 1038-1042 gene7422 denotes VEGF
22569271-6#184#189#gene6774 1067-1072 gene6774 denotes STAT3
22569271-6#193#196#diseaseC2239176 1076-1079 diseaseC2239176 denotes HCC
22569271-8#160#163#gene1131 1380-1383 gene1131 denotes PBS
22569271-8#160#163#gene706 1380-1383 gene706 denotes PBS
22569271-8#121#124#diseaseC2239176 1341-1344 diseaseC2239176 denotes HCC
76#81#gene1100996#120#diseaseC2239176 22569271-0#76#81#gene11009 22569271-0#96#120#diseaseC2239176 associated_with IL-24,hepatocellular carcinoma
86#91#gene3439146#149#diseaseC2239176 22569271-11#86#91#gene3439 22569271-11#146#149#diseaseC2239176 associated_with IFN-α,HCC
86#91#gene3439243#246#diseaseC2239176 22569271-11#86#91#gene3439 22569271-11#243#246#diseaseC2239176 associated_with IFN-α,HCC
86#91#gene3447146#149#diseaseC2239176 22569271-11#86#91#gene3447 22569271-11#146#149#diseaseC2239176 associated_with IFN-α,HCC
86#91#gene3447243#246#diseaseC2239176 22569271-11#86#91#gene3447 22569271-11#243#246#diseaseC2239176 associated_with IFN-α,HCC
86#91#gene3439146#149#diseaseC2239176 22569271-11#86#91#gene3439 22569271-11#146#149#diseaseC2239176 associated_with IFN-α,HCC
86#91#gene3439243#246#diseaseC2239176 22569271-11#86#91#gene3439 22569271-11#243#246#diseaseC2239176 associated_with IFN-α,HCC
86#91#gene3447146#149#diseaseC2239176 22569271-11#86#91#gene3447 22569271-11#146#149#diseaseC2239176 associated_with IFN-α,HCC
86#91#gene3447243#246#diseaseC2239176 22569271-11#86#91#gene3447 22569271-11#243#246#diseaseC2239176 associated_with IFN-α,HCC
31#36#gene6772193#196#diseaseC2239176 22569271-6#31#36#gene6772 22569271-6#193#196#diseaseC2239176 associated_with STAT1,HCC
41#46#gene8651193#196#diseaseC2239176 22569271-6#41#46#gene8651 22569271-6#193#196#diseaseC2239176 associated_with SOCS1,HCC
155#159#gene7422193#196#diseaseC2239176 22569271-6#155#159#gene7422 22569271-6#193#196#diseaseC2239176 associated_with VEGF,HCC
184#189#gene6774193#196#diseaseC2239176 22569271-6#184#189#gene6774 22569271-6#193#196#diseaseC2239176 associated_with STAT3,HCC
160#163#gene1131121#124#diseaseC2239176 22569271-8#160#163#gene1131 22569271-8#121#124#diseaseC2239176 associated_with PBS,HCC
160#163#gene706121#124#diseaseC2239176 22569271-8#160#163#gene706 22569271-8#121#124#diseaseC2239176 associated_with PBS,HCC

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T903 1764-1769 gene:3439 denotes IFN-α
T904 1824-1827 disease:C2239176 denotes HCC
T905 1921-1924 disease:C2239176 denotes HCC
R1 T903 T904 associated_with IFN-α,HCC
R2 T903 T904 associated_with IFN-α,HCC
R3 T903 T905 associated_with IFN-α,HCC
R4 T903 T905 associated_with IFN-α,HCC

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-121 Sentence denotes Interferon-α enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma.
TextSentencer_T2 122-133 Sentence denotes BACKGROUND:
TextSentencer_T3 134-241 Sentence denotes Hepatocellular carcinoma (HCC) has a dismal 5-year-survival rate of 10%, so novel strategies are warranted.
TextSentencer_T4 242-400 Sentence denotes IL-24 mediates anti-tumor activity reducing STAT3 expression, which suggests that interferon (IFN) alpha may augment tumor cell lysis and reduce angiogenesis.
TextSentencer_T5 401-563 Sentence denotes We investigated the antitumor activity of treatment with IFN-α, with the oncolytic adenovirus SG600-IL-24, or the combination of both in HCC in vitro and in vivo.
TextSentencer_T6 564-710 Sentence denotes RESULTS: RT-PCR, ELISA assay and Western-blot confirmed that the exogenous IL-24 gene was highly expressed in HCC cells infected with SG600-IL-24.
TextSentencer_T7 711-882 Sentence denotes Treatment with combined IFN-α and SG600-IL-24 suppressed growth and promoted apoptosis of the HepG2, MHCC97L, and HCCLM3 cell lines compared with the normal cell line L02.
TextSentencer_T8 883-1095 Sentence denotes The combined therapy increased STAT1 and SOCS1 and apoptosis, but decreased the expression of the metastatic and angiogenic proteins MMP-2, XIAP, OPN, and VEGF, which are regulated by STAT3 in HCC cells in vitro.
TextSentencer_T9 1096-1219 Sentence denotes To assess the effects in vivo, the HCC cell line HCCLM3 was transplanted subcutaneously into the right flanks of nude mice.
TextSentencer_T10 1220-1406 Sentence denotes Mice in the IFN-α group, the SG600-IL-24 group, or the combined therapy group had significantly suppressed growth of the HCC xenografted tumors compared to the PBS control group of mice.
TextSentencer_T11 1407-1553 Sentence denotes Among the mice treated with the combination of IFN-α and SG600-IL-24, three of those eight mice had long-term survival and no evidence of a tumor.
TextSentencer_T12 1554-1664 Sentence denotes These mice also had decreased expression of the metastatic and angiogenic proteins MMP-2, XIAP, OPN, and VEGF.
TextSentencer_T13 1665-1677 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1678-1945 Sentence denotes The present study demonstrated for the first time the potential antitumor activity of IFN-α combined with the oncolytic adenovirus SG600-IL-24 in HCC both in vitro and in vivo, and suggests its further development as a potential candidate for HCC cancer gene therapy.
T1 0-121 Sentence denotes Interferon-α enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma.
T2 122-133 Sentence denotes BACKGROUND:
T3 134-241 Sentence denotes Hepatocellular carcinoma (HCC) has a dismal 5-year-survival rate of 10%, so novel strategies are warranted.
T4 242-400 Sentence denotes IL-24 mediates anti-tumor activity reducing STAT3 expression, which suggests that interferon (IFN) alpha may augment tumor cell lysis and reduce angiogenesis.
T5 401-563 Sentence denotes We investigated the antitumor activity of treatment with IFN-α, with the oncolytic adenovirus SG600-IL-24, or the combination of both in HCC in vitro and in vivo.
T6 564-710 Sentence denotes RESULTS: RT-PCR, ELISA assay and Western-blot confirmed that the exogenous IL-24 gene was highly expressed in HCC cells infected with SG600-IL-24.
T7 711-882 Sentence denotes Treatment with combined IFN-α and SG600-IL-24 suppressed growth and promoted apoptosis of the HepG2, MHCC97L, and HCCLM3 cell lines compared with the normal cell line L02.
T8 883-1095 Sentence denotes The combined therapy increased STAT1 and SOCS1 and apoptosis, but decreased the expression of the metastatic and angiogenic proteins MMP-2, XIAP, OPN, and VEGF, which are regulated by STAT3 in HCC cells in vitro.
T9 1096-1219 Sentence denotes To assess the effects in vivo, the HCC cell line HCCLM3 was transplanted subcutaneously into the right flanks of nude mice.
T10 1220-1406 Sentence denotes Mice in the IFN-α group, the SG600-IL-24 group, or the combined therapy group had significantly suppressed growth of the HCC xenografted tumors compared to the PBS control group of mice.
T11 1407-1553 Sentence denotes Among the mice treated with the combination of IFN-α and SG600-IL-24, three of those eight mice had long-term survival and no evidence of a tumor.
T12 1554-1664 Sentence denotes These mice also had decreased expression of the metastatic and angiogenic proteins MMP-2, XIAP, OPN, and VEGF.
T13 1665-1677 Sentence denotes CONCLUSIONS:
T14 1678-1945 Sentence denotes The present study demonstrated for the first time the potential antitumor activity of IFN-α combined with the oncolytic adenovirus SG600-IL-24 in HCC both in vitro and in vivo, and suggests its further development as a potential candidate for HCC cancer gene therapy.