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PubMed:22549772 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 494-510 Glycan_Motif denotes O-linked mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G59126YU
T2 532-553 Glycan_Motif denotes N-acetylgalactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB

sentences

Id Subject Object Predicate Lexical cue
T1 0-155 Sentence denotes Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases.
T2 156-608 Sentence denotes O-Linked glycosylation is a functionally and structurally diverse type of protein modification present in many tissues and across many species. α-Dystroglycan (α-DG), a protein linked to the extracellular matrix, whose glycosylation status is associated with human muscular dystrophies, displays two predominant types of O-glycosylation, O-linked mannose (O-Man) and O-linked N-acetylgalactosamine (O-GalNAc), in its highly conserved mucin-like domain.
T3 609-690 Sentence denotes The O-Man is installed by an enzyme complex present in the endoplasmic reticulum.
T4 691-849 Sentence denotes O-GalNAc modifications are initiated subsequently in the Golgi apparatus by the UDP-GalNAc polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T) enzymes.
T5 850-1021 Sentence denotes How the presence and position of O-Man influences the action of the ppGalNAc-Ts on α-DG and the distribution of the two forms of glycosylation in this domain is not known.
T6 1022-1230 Sentence denotes Here, we investigated the interplay between O-Man and the addition of O-GalNAc by examining the activity of the ppGalNAc-Ts on peptides and O-Man-containing glycopeptides mimicking those found in native α-DG.
T7 1231-1347 Sentence denotes These synthetic glycopeptides emulate intermediate structures, not otherwise readily available from natural sources.
T8 1348-1629 Sentence denotes Through enzymatic and mass spectrometric methods, we demonstrate that the presence and specific location of O-Man can impact either the regional exclusion or the site of O-GalNAc addition on α-DG, elucidating the factors contributing to the glycosylation patterns observed in vivo.
T9 1630-1950 Sentence denotes These results provide evidence that one form of glycosylation can influence another form of glycosylation in α-DG and suggest that in the absence of proper O-mannosylation, as is associated with certain forms of muscular dystrophy, aberrant O-GalNAc modifications may occur and could play a role in disease presentation.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 494-510 https://glytoucan.org/Structures/Glycans/G59126YU denotes O-linked mannose
T2 532-553 https://glytoucan.org/Structures/Glycans/G27025MB denotes N-acetylgalactosamine

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1739-1743 gene:1605 denotes α-DG
T1 1842-1860 disease:C0026850 denotes muscular dystrophy
R1 T0 T1 associated_with α-DG,muscular dystrophy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 421-441 HP_0003560 denotes muscular dystrophies
T2 1842-1860 HP_0003560 denotes muscular dystrophy

Allie

Id Subject Object Predicate Lexical cue
SS1_22549772_1_0 300-314 expanded denotes α-Dystroglycan
SS2_22549772_1_0 316-320 abbr denotes α-DG
SS1_22549772_1_1 494-510 expanded denotes O-linked mannose
SS2_22549772_1_1 512-517 abbr denotes O-Man
SS1_22549772_1_2 523-553 expanded denotes O-linked N-acetylgalactosamine
SS2_22549772_1_2 555-563 abbr denotes O-GalNAc
SS1_22549772_3_0 782-827 expanded denotes polypeptide N-acetylgalactosaminyltransferase
SS2_22549772_3_0 829-839 abbr denotes ppGalNAc-T
AE1_22549772_1_0 SS1_22549772_1_0 SS2_22549772_1_0 abbreviatedTo α-Dystroglycan,α-DG
AE1_22549772_1_1 SS1_22549772_1_1 SS2_22549772_1_1 abbreviatedTo O-linked mannose,O-Man
AE1_22549772_1_2 SS1_22549772_1_2 SS2_22549772_1_2 abbreviatedTo O-linked N-acetylgalactosamine,O-GalNAc
AE1_22549772_3_0 SS1_22549772_3_0 SS2_22549772_3_0 abbreviatedTo polypeptide N-acetylgalactosaminyltransferase,ppGalNAc-T

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22549772-9#109#113#gene1605 1739-1743 gene1605 denotes α-DG
22549772-9#212#230#diseaseC0026850 1842-1860 diseaseC0026850 denotes muscular dystrophy
109#113#gene1605212#230#diseaseC0026850 22549772-9#109#113#gene1605 22549772-9#212#230#diseaseC0026850 associated_with α-DG,muscular dystrophy

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 87-93 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 101-107 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 557-563 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 693-699 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T5 775-781 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T6 1094-1100 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 1520-1526 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T8 1873-1879 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 421-441 Disease denotes muscular dystrophies http://purl.obolibrary.org/obo/MONDO_0020121
T2 1842-1860 Disease denotes muscular dystrophy http://purl.obolibrary.org/obo/MONDO_0020121

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 421-441 Phenotype denotes muscular dystrophies HP:0003560
T2 1842-1860 Phenotype denotes muscular dystrophy HP:0003560

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 87-93 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 101-107 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 557-563 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 693-699 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T5 775-781 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T6 1094-1100 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 1520-1526 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T8 1873-1879 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 421-441 Phenotype denotes muscular dystrophies HP:0003560
T2 1842-1860 Phenotype denotes muscular dystrophy HP:0003560

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 421-441 Disease denotes muscular dystrophies MONDO:0020121
T2 1842-1860 Disease denotes muscular dystrophy MONDO:0020121

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 415-420 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-155 Sentence denotes Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases.
T2 156-608 Sentence denotes O-Linked glycosylation is a functionally and structurally diverse type of protein modification present in many tissues and across many species. α-Dystroglycan (α-DG), a protein linked to the extracellular matrix, whose glycosylation status is associated with human muscular dystrophies, displays two predominant types of O-glycosylation, O-linked mannose (O-Man) and O-linked N-acetylgalactosamine (O-GalNAc), in its highly conserved mucin-like domain.
T3 609-690 Sentence denotes The O-Man is installed by an enzyme complex present in the endoplasmic reticulum.
T4 691-849 Sentence denotes O-GalNAc modifications are initiated subsequently in the Golgi apparatus by the UDP-GalNAc polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T) enzymes.
T5 850-1021 Sentence denotes How the presence and position of O-Man influences the action of the ppGalNAc-Ts on α-DG and the distribution of the two forms of glycosylation in this domain is not known.
T6 1022-1230 Sentence denotes Here, we investigated the interplay between O-Man and the addition of O-GalNAc by examining the activity of the ppGalNAc-Ts on peptides and O-Man-containing glycopeptides mimicking those found in native α-DG.
T7 1231-1347 Sentence denotes These synthetic glycopeptides emulate intermediate structures, not otherwise readily available from natural sources.
T8 1348-1629 Sentence denotes Through enzymatic and mass spectrometric methods, we demonstrate that the presence and specific location of O-Man can impact either the regional exclusion or the site of O-GalNAc addition on α-DG, elucidating the factors contributing to the glycosylation patterns observed in vivo.
T9 1630-1950 Sentence denotes These results provide evidence that one form of glycosylation can influence another form of glycosylation in α-DG and suggest that in the absence of proper O-mannosylation, as is associated with certain forms of muscular dystrophy, aberrant O-GalNAc modifications may occur and could play a role in disease presentation.

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 347-367 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T2 680-689 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T3 748-763 Body_part denotes Golgi apparatus http://purl.obolibrary.org/obo/GO_0005794

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 267-274 Body_part denotes tissues FMA:9637
T2 347-367 Body_part denotes extracellular matrix FMA:9672
T3 668-689 Body_part denotes endoplasmic reticulum FMA:63842
T4 748-763 Body_part denotes Golgi apparatus FMA:63843

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 415-420 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 347-367 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T2 680-689 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T3 748-763 Body_part denotes Golgi apparatus http://purl.obolibrary.org/obo/GO_0005794