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PubMed:22547075 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 35-46 gene:406991 denotes microRNA-21
T1 74-87 disease:C0006142 denotes breast cancer
T2 35-46 gene:406991 denotes microRNA-21
T3 74-87 disease:C0678222 denotes breast cancer
T4 103-108 gene:4790 denotes NF-κB
T5 154-160 disease:C0006826 denotes cancer
T6 103-108 gene:4790 denotes NF-κB
T7 233-245 disease:C0006826 denotes malignancies
T8 103-108 gene:4790 denotes NF-κB
T9 154-160 disease:C1306459 denotes cancer
T10 540-545 gene:4790 denotes NF-κB
T11 566-579 disease:C0006142 denotes breast cancer
T12 540-545 gene:4790 denotes NF-κB
T13 566-579 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with microRNA-21,breast cancer
R2 T2 T3 associated_with microRNA-21,breast cancer
R3 T4 T5 associated_with NF-κB,cancer
R4 T6 T7 associated_with NF-κB,malignancies
R5 T8 T9 associated_with NF-κB,cancer
R6 T10 T11 associated_with NF-κB,breast cancer
R7 T12 T13 associated_with NF-κB,breast cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_22547075_6_0 773-784 expanded denotes microRNA-21
SS2_22547075_6_0 786-792 abbr denotes miR-21
SS1_22547075_6_1 897-947 expanded denotes signal transducer and activator of transcription 3
SS2_22547075_6_1 949-954 abbr denotes STAT3
AE1_22547075_6_0 SS1_22547075_6_0 SS2_22547075_6_0 abbreviatedTo microRNA-21,miR-21
AE1_22547075_6_1 SS1_22547075_6_1 SS2_22547075_6_1 abbreviatedTo signal transducer and activator of transcription 3,STAT3

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 154-160 HP_0002664 denotes cancer
T2 326-333 HP_0002664 denotes cancers
T3 345-358 HP_0003002 denotes breast cancer
T4 345-358 HP_0100013 denotes breast cancer
T5 352-358 HP_0002664 denotes cancer
T6 424-430 HP_0002664 denotes cancer
T7 566-579 HP_0003002 denotes breast cancer
T8 566-579 HP_0100013 denotes breast cancer
T9 573-579 HP_0002664 denotes cancer
T10 1305-1311 HP_0002664 denotes cancer
T11 1396-1409 HP_0003002 denotes breast cancer
T12 1396-1409 HP_0100013 denotes breast cancer
T13 1403-1409 HP_0002664 denotes cancer
T14 1550-1556 HP_0002664 denotes cancer
T15 1700-1713 HP_0003002 denotes breast cancer
T16 1700-1713 HP_0100013 denotes breast cancer
T17 1707-1713 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22547075-0#19#24#gene4790 19-24 gene4790 denotes NF-κB
22547075-0#35#46#gene406991 35-46 gene406991 denotes microRNA-21
22547075-0#74#87#diseaseC0006142 74-87 diseaseC0006142 denotes breast cancer
22547075-0#74#87#diseaseC0678222 74-87 diseaseC0678222 denotes breast cancer
22547075-0#74#87#diseaseC0006142 74-87 diseaseC0006142 denotes breast cancer
22547075-0#74#87#diseaseC0678222 74-87 diseaseC0678222 denotes breast cancer
22547075-10#55#60#gene4790 1520-1525 gene4790 denotes NF-κB
22547075-10#138#143#gene4790 1603-1608 gene4790 denotes NF-κB
22547075-10#154#160#gene406991 1619-1625 gene406991 denotes miR-21
22547075-10#221#231#diseaseC0027627 1686-1696 diseaseC0027627 denotes metastasis
22547075-9#175#179#gene5728 1449-1453 gene5728 denotes PTEN
22547075-9#184#189#gene27250 1458-1463 gene27250 denotes PDCD4
22547075-9#122#135#diseaseC0006142 1396-1409 diseaseC0006142 denotes breast cancer
22547075-9#122#135#diseaseC0678222 1396-1409 diseaseC0678222 denotes breast cancer
22547075-9#122#135#diseaseC0006142 1396-1409 diseaseC0006142 denotes breast cancer
22547075-9#122#135#diseaseC0678222 1396-1409 diseaseC0678222 denotes breast cancer
19#24#gene479074#87#diseaseC0006142 22547075-0#19#24#gene4790 22547075-0#74#87#diseaseC0006142 associated_with NF-κB,breast cancer
19#24#gene479074#87#diseaseC0678222 22547075-0#19#24#gene4790 22547075-0#74#87#diseaseC0678222 associated_with NF-κB,breast cancer
19#24#gene479074#87#diseaseC0006142 22547075-0#19#24#gene4790 22547075-0#74#87#diseaseC0006142 associated_with NF-κB,breast cancer
19#24#gene479074#87#diseaseC0678222 22547075-0#19#24#gene4790 22547075-0#74#87#diseaseC0678222 associated_with NF-κB,breast cancer
35#46#gene40699174#87#diseaseC0006142 22547075-0#35#46#gene406991 22547075-0#74#87#diseaseC0006142 associated_with microRNA-21,breast cancer
35#46#gene40699174#87#diseaseC0678222 22547075-0#35#46#gene406991 22547075-0#74#87#diseaseC0678222 associated_with microRNA-21,breast cancer
35#46#gene40699174#87#diseaseC0006142 22547075-0#35#46#gene406991 22547075-0#74#87#diseaseC0006142 associated_with microRNA-21,breast cancer
35#46#gene40699174#87#diseaseC0678222 22547075-0#35#46#gene406991 22547075-0#74#87#diseaseC0678222 associated_with microRNA-21,breast cancer
55#60#gene4790221#231#diseaseC0027627 22547075-10#55#60#gene4790 22547075-10#221#231#diseaseC0027627 associated_with NF-κB,metastasis
138#143#gene4790221#231#diseaseC0027627 22547075-10#138#143#gene4790 22547075-10#221#231#diseaseC0027627 associated_with NF-κB,metastasis
154#160#gene406991221#231#diseaseC0027627 22547075-10#154#160#gene406991 22547075-10#221#231#diseaseC0027627 associated_with miR-21,metastasis
175#179#gene5728122#135#diseaseC0006142 22547075-9#175#179#gene5728 22547075-9#122#135#diseaseC0006142 associated_with PTEN,breast cancer
175#179#gene5728122#135#diseaseC0678222 22547075-9#175#179#gene5728 22547075-9#122#135#diseaseC0678222 associated_with PTEN,breast cancer
175#179#gene5728122#135#diseaseC0006142 22547075-9#175#179#gene5728 22547075-9#122#135#diseaseC0006142 associated_with PTEN,breast cancer
175#179#gene5728122#135#diseaseC0678222 22547075-9#175#179#gene5728 22547075-9#122#135#diseaseC0678222 associated_with PTEN,breast cancer
184#189#gene27250122#135#diseaseC0006142 22547075-9#184#189#gene27250 22547075-9#122#135#diseaseC0006142 associated_with PDCD4,breast cancer
184#189#gene27250122#135#diseaseC0678222 22547075-9#184#189#gene27250 22547075-9#122#135#diseaseC0678222 associated_with PDCD4,breast cancer
184#189#gene27250122#135#diseaseC0006142 22547075-9#184#189#gene27250 22547075-9#122#135#diseaseC0006142 associated_with PDCD4,breast cancer
184#189#gene27250122#135#diseaseC0678222 22547075-9#184#189#gene27250 22547075-9#122#135#diseaseC0678222 associated_with PDCD4,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1196 1520-1525 gene:4790 denotes NF-κB
T1197 1686-1696 disease:C0027627 denotes metastasis
T1198 1603-1608 gene:4790 denotes NF-κB
T1199 1619-1625 gene:406991 denotes miR-21
R1 T1196 T1197 associated_with NF-κB,metastasis
R2 T1198 T1197 associated_with NF-κB,metastasis
R3 T1199 T1197 associated_with miR-21,metastasis

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-102 Sentence denotes DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion.
TextSentencer_T2 103-246 Sentence denotes NF-κB activation induced by genotoxic treatment in cancer cells has been associated with therapeutic resistance in multiple human malignancies.
TextSentencer_T3 247-359 Sentence denotes Therapeutic resistance also correlates with high metastatic potential in human cancers, including breast cancer.
TextSentencer_T4 360-490 Sentence denotes Whether genotoxic treatment-activated NF-κB also contributes to cancer metastasis following radiation and chemotherapy is unclear.
TextSentencer_T5 491-608 Sentence denotes Here, we show that chemotherapeutic drug-induced NF-κB activation promotes breast cancer cell migration and invasion.
TextSentencer_T6 609-714 Sentence denotes The increased metastatic potential is dependent on IL-6 induction mediated by genotoxic NF-κB activation.
TextSentencer_T7 715-989 Sentence denotes Moreover, genotoxic treatment also up-regulates oncogenic microRNA-21 (miR-21) expression through eliciting NF-κB recruitment to the miR-21 promoter region, where it cooperates with signal transducer and activator of transcription 3 (STAT3) to activate miR-21 transcription.
TextSentencer_T8 990-1140 Sentence denotes DNA damage-induced histone H3 phosphorylation via activated MSK1 creates an open chromatin structure for NF-κB/STAT3-driven transactivation of miR-21.
TextSentencer_T9 1141-1273 Sentence denotes NF-κB-dependent IL-6 up-regulation is responsible for STAT3 activation and recruitment to the miR-21 promoter upon genotoxic stress.
TextSentencer_T10 1274-1464 Sentence denotes Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4.
TextSentencer_T11 1465-1714 Sentence denotes Our data support a critical role of DNA damage-induced NF-κB activation in promoting cancer metastasis following genotoxic treatment, and NF-κB-dependent miR-21 induction may contribute to both therapeutic resistance and metastasis in breast cancer.
T1 0-102 Sentence denotes DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion.
T2 103-246 Sentence denotes NF-κB activation induced by genotoxic treatment in cancer cells has been associated with therapeutic resistance in multiple human malignancies.
T3 247-359 Sentence denotes Therapeutic resistance also correlates with high metastatic potential in human cancers, including breast cancer.
T4 360-490 Sentence denotes Whether genotoxic treatment-activated NF-κB also contributes to cancer metastasis following radiation and chemotherapy is unclear.
T5 491-608 Sentence denotes Here, we show that chemotherapeutic drug-induced NF-κB activation promotes breast cancer cell migration and invasion.
T6 609-714 Sentence denotes The increased metastatic potential is dependent on IL-6 induction mediated by genotoxic NF-κB activation.
T7 715-989 Sentence denotes Moreover, genotoxic treatment also up-regulates oncogenic microRNA-21 (miR-21) expression through eliciting NF-κB recruitment to the miR-21 promoter region, where it cooperates with signal transducer and activator of transcription 3 (STAT3) to activate miR-21 transcription.
T8 990-1140 Sentence denotes DNA damage-induced histone H3 phosphorylation via activated MSK1 creates an open chromatin structure for NF-κB/STAT3-driven transactivation of miR-21.
T9 1141-1273 Sentence denotes NF-κB-dependent IL-6 up-regulation is responsible for STAT3 activation and recruitment to the miR-21 promoter upon genotoxic stress.
T10 1274-1464 Sentence denotes Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4.
T11 1465-1714 Sentence denotes Our data support a critical role of DNA damage-induced NF-κB activation in promoting cancer metastasis following genotoxic treatment, and NF-κB-dependent miR-21 induction may contribute to both therapeutic resistance and metastasis in breast cancer.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 74-80 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 345-351 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 566-572 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 1396-1402 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1700-1706 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 74-80 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 345-351 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 566-572 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 1396-1402 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1700-1706 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 74-87 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 154-160 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 345-358 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T4 424-430 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T5 566-579 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T6 1305-1311 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T7 1396-1409 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T8 1550-1556 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T9 1700-1713 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 74-87 Phenotype denotes breast cancer HP:0003002
T2 154-160 Phenotype denotes cancer HP:0002664
T3 345-358 Phenotype denotes breast cancer HP:0003002
T4 424-430 Phenotype denotes cancer HP:0002664
T5 566-579 Phenotype denotes breast cancer HP:0003002
T6 1305-1311 Phenotype denotes cancer HP:0002664
T7 1396-1409 Phenotype denotes breast cancer HP:0003002
T8 1550-1556 Phenotype denotes cancer HP:0002664
T9 1700-1713 Phenotype denotes breast cancer HP:0003002

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 227-232 OrganismTaxon denotes human 9606
T2 320-325 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 74-80 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 345-351 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 566-572 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T4 1396-1402 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 1700-1706 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 81-92 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 154-166 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T3 573-584 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T4 1305-1317 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T5 1403-1415 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064