PubMed:22543584
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 138-300 | DRI_Background | denotes | The epithelial-mesenchymal transition (EMT) correlates with disruption of cell-cell adhesion, loss of cell polarity and development of epithelial cell malignancy. |
| T2 | 301-413 | DRI_Challenge | denotes | Identifying novel molecules that inhibit EMT has profound potential for developing mechanism-based therapeutics. |
| T3 | 414-614 | DRI_Outcome | denotes | We previously demonstrated that the endoplasmic reticulum protein 29 (ERp29) is a novel factor that can drive mesenchymal-epithelial transition (MET) and induce cell growth arrest in MDA-MB-231 cells. |
| T4 | 615-722 | DRI_Outcome | denotes | Here, we show that ERp29 is an important molecule in establishing epithelial cell integrity during the MET. |
| T5 | 723-798 | DRI_Approach | denotes | We demonstrate that ERp29 regulates MET in a cell context-dependent manner. |
| T6 | 799-1000 | DRI_Background | denotes | ERp29 overexpression induced a complete MET in mesenchymal MDA-MB-231 cells through downregulating the expression of transcriptional repressors (for example, Slug, Snai1, ZEB2 and Twist) of E-cadherin. |
| T7 | 1001-1063 | DRI_Background | denotes | In contrast, overexpression of ERp29 induces incomplete MET in |
| T8 | 1081-1262 | DRI_Background | denotes | cells in which the expression of EMT-related markers (for example, vimentin; cytokeratin 19 (CK19) and E-cadherin) and the transcriptional repressors of E-cadherin were not altered. |
| T9 | 1263-1430 | DRI_Background | denotes | However, ERp29 overexpression in both cell-types resulted in loss of filamentous stress fibers, formation of cortical actin and restoration of an epithelial phenotype. |
| T10 | 1431-1722 | DRI_Background | denotes | Mechanistic studies revealed that overexpression of ERp29 in both cell-types upregulated the expression of TJ proteins (zonula-occludens-1 (ZO-1) and occludin) and the core apical-basal polarity proteins (Par3 and Scribble) at the membrane to enhance cell-cell contact and cell polarization. |
| T11 | 1723-1864 | DRI_Challenge | denotes | Knockdown of ERp29 in the epithelial MCF-7 cells decreased the expression of these proteins, leading to the disruption of cell-cell adhesion. |
| T12 | 1865-1979 | DRI_Background | denotes | Taken together, ERp29 is a novel molecule that regulates MET and epithelial cell integrity in breast cancer cells. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 0-32 | gene:10961 | denotes | Endoplasmic reticulum protein 29 |
| T1 | 117-130 | disease:C0006142 | denotes | breast cancer |
| T2 | 0-32 | gene:10961 | denotes | Endoplasmic reticulum protein 29 |
| T3 | 117-130 | disease:C0678222 | denotes | breast cancer |
| R1 | T0 | T1 | associated_with | Endoplasmic reticulum protein 29,breast cancer |
| R2 | T2 | T3 | associated_with | Endoplasmic reticulum protein 29,breast cancer |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1959-1972 | HP_0003002 | denotes | breast cancer |
| T2 | 1959-1972 | HP_0100013 | denotes | breast cancer |
| T3 | 1966-1972 | HP_0002664 | denotes | cancer |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22543584_1_0 | 142-175 | expanded | denotes | epithelial-mesenchymal transition |
| SS2_22543584_1_0 | 177-180 | abbr | denotes | EMT |
| SS1_22543584_3_0 | 450-482 | expanded | denotes | endoplasmic reticulum protein 29 |
| SS2_22543584_3_0 | 484-489 | abbr | denotes | ERp29 |
| SS1_22543584_3_1 | 524-557 | expanded | denotes | mesenchymal-epithelial transition |
| SS2_22543584_3_1 | 559-562 | abbr | denotes | MET |
| SS1_22543584_7_0 | 1158-1172 | expanded | denotes | cytokeratin 19 |
| SS2_22543584_7_0 | 1174-1178 | abbr | denotes | CK19 |
| SS1_22543584_9_0 | 1551-1569 | expanded | denotes | zonula-occludens-1 |
| SS2_22543584_9_0 | 1571-1575 | abbr | denotes | ZO-1 |
| AE1_22543584_1_0 | SS1_22543584_1_0 | SS2_22543584_1_0 | abbreviatedTo | epithelial-mesenchymal transition,EMT |
| AE1_22543584_3_0 | SS1_22543584_3_0 | SS2_22543584_3_0 | abbreviatedTo | endoplasmic reticulum protein 29,ERp29 |
| AE1_22543584_3_1 | SS1_22543584_3_1 | SS2_22543584_3_1 | abbreviatedTo | mesenchymal-epithelial transition,MET |
| AE1_22543584_7_0 | SS1_22543584_7_0 | SS2_22543584_7_0 | abbreviatedTo | cytokeratin 19,CK19 |
| AE1_22543584_9_0 | SS1_22543584_9_0 | SS2_22543584_9_0 | abbreviatedTo | zonula-occludens-1,ZO-1 |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 22543584-0#0#32#gene10961 | 0-32 | gene10961 | denotes | Endoplasmic reticulum protein 29 |
| 22543584-0#117#130#diseaseC0006142 | 117-130 | diseaseC0006142 | denotes | breast cancer |
| 22543584-0#117#130#diseaseC0678222 | 117-130 | diseaseC0678222 | denotes | breast cancer |
| 0#32#gene10961117#130#diseaseC0006142 | 22543584-0#0#32#gene10961 | 22543584-0#117#130#diseaseC0006142 | associated_with | Endoplasmic reticulum protein 29,breast cancer |
| 0#32#gene10961117#130#diseaseC0678222 | 22543584-0#0#32#gene10961 | 22543584-0#117#130#diseaseC0678222 | associated_with | Endoplasmic reticulum protein 29,breast cancer |