PubMed:22539006 / 1484-1663 JSONTXT

{"project":"c_corpus","denotations":[{"id":"T314","span":{"begin":41,"end":46},"obj":"PR:Q5S006"},{"id":"T315","span":{"begin":41,"end":46},"obj":"PR:000003033"},{"id":"T316","span":{"begin":41,"end":46},"obj":"PR:Q5S007"},{"id":"T318","span":{"begin":57,"end":61},"obj":"PR:000035964"},{"id":"T319","span":{"begin":57,"end":61},"obj":"PR:P45985"},{"id":"T320","span":{"begin":57,"end":61},"obj":"PR:Q20347"},{"id":"T321","span":{"begin":57,"end":61},"obj":"PR:P47809"},{"id":"T323","span":{"begin":57,"end":61},"obj":"PR:000003283"},{"id":"T324","span":{"begin":57,"end":61},"obj":"PR:O80397"},{"id":"T322","span":{"begin":57,"end":61},"obj":"GO:0004708"},{"id":"T325","span":{"begin":62,"end":65},"obj":"PR:P92208"},{"id":"T326","span":{"begin":62,"end":65},"obj":"GO:0004705"},{"id":"T327","span":{"begin":68,"end":71},"obj":"PR:P17325"},{"id":"T328","span":{"begin":68,"end":71},"obj":"PR:P18870"},{"id":"T329","span":{"begin":68,"end":71},"obj":"PR:P05627"},{"id":"T330","span":{"begin":68,"end":71},"obj":"PR:P05412"},{"id":"T331","span":{"begin":68,"end":71},"obj":"PR:P18289"},{"id":"T332","span":{"begin":68,"end":71},"obj":"PR:000009232"},{"id":"T333","span":{"begin":72,"end":79},"obj":"CHEBI:34922"},{"id":"T334","span":{"begin":131,"end":135},"obj":"PR:Q9U9R7"},{"id":"T335","span":{"begin":131,"end":135},"obj":"UBERON:0001965"},{"id":"T336","span":{"begin":163,"end":173},"obj":"SO:0000781"},{"id":"T337","span":{"begin":163,"end":178},"obj":"10090"},{"id":"T338","span":{"begin":163,"end":178},"obj":"D008822"},{"id":"T339","span":{"begin":174,"end":178},"obj":"PR:000005054"},{"id":"T341","span":{"begin":174,"end":178},"obj":"O89094"}],"text":"Our results suggest that mutant (G2019S) LRRK2 activates MKK4-JNK-c-Jun pathway in the SN and causes the resulting degeneration of SNpc dopaminergic neurons in PD transgenic mice."}

{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T9","span":{"begin":0,"end":179},"obj":"DRI_Outcome"}],"text":"Our results suggest that mutant (G2019S) LRRK2 activates MKK4-JNK-c-Jun pathway in the SN and causes the resulting degeneration of SNpc dopaminergic neurons in PD transgenic mice."}

{"project":"PubMed_ArguminSci","denotations":[{"id":"T8","span":{"begin":0,"end":179},"obj":"DRI_Outcome"}],"text":"Our results suggest that mutant (G2019S) LRRK2 activates MKK4-JNK-c-Jun pathway in the SN and causes the resulting degeneration of SNpc dopaminergic neurons in PD transgenic mice."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"22539006-8#33#39#geners34637584","span":{"begin":33,"end":39},"obj":"geners34637584"},{"id":"22539006-8#160#162#diseaseC0030567","span":{"begin":160,"end":162},"obj":"diseaseC0030567"}],"relations":[{"id":"33#39#geners34637584160#162#diseaseC0030567","pred":"associated_with","subj":"22539006-8#33#39#geners34637584","obj":"22539006-8#160#162#diseaseC0030567"}],"text":"Our results suggest that mutant (G2019S) LRRK2 activates MKK4-JNK-c-Jun pathway in the SN and causes the resulting degeneration of SNpc dopaminergic neurons in PD transgenic mice."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"22539006-8#41#46#gene120892","span":{"begin":41,"end":46},"obj":"gene120892"},{"id":"22539006-8#57#61#gene6416","span":{"begin":57,"end":61},"obj":"gene6416"},{"id":"22539006-8#62#65#gene5599","span":{"begin":62,"end":65},"obj":"gene5599"},{"id":"22539006-8#160#162#diseaseC0030567","span":{"begin":160,"end":162},"obj":"diseaseC0030567"}],"relations":[{"id":"41#46#gene120892160#162#diseaseC0030567","pred":"associated_with","subj":"22539006-8#41#46#gene120892","obj":"22539006-8#160#162#diseaseC0030567"},{"id":"57#61#gene6416160#162#diseaseC0030567","pred":"associated_with","subj":"22539006-8#57#61#gene6416","obj":"22539006-8#160#162#diseaseC0030567"},{"id":"62#65#gene5599160#162#diseaseC0030567","pred":"associated_with","subj":"22539006-8#62#65#gene5599","obj":"22539006-8#160#162#diseaseC0030567"}],"text":"Our results suggest that mutant (G2019S) LRRK2 activates MKK4-JNK-c-Jun pathway in the SN and causes the resulting degeneration of SNpc dopaminergic neurons in PD transgenic mice."}