
PubMed:22539006
Annnotations
PubTator4TogoVar
Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
---|---|---|---|---|---|
22539006_0 | 1-7 | ProteinMutation | denotes | G2019S | rs34637584 |
22539006_1 | 129-135 | ProteinMutation | denotes | G2019S | rs34637584 |
22539006_2 | 311-317 | ProteinMutation | denotes | G2019S | rs34637584 |
22539006_3 | 639-645 | ProteinMutation | denotes | G2019S | rs34637584 |
22539006_4 | 847-853 | ProteinMutation | denotes | G2019S | rs34637584 |
22539006_5 | 1064-1070 | ProteinMutation | denotes | G2019S | rs34637584 |
22539006_6 | 1244-1250 | ProteinMutation | denotes | G2019S | rs34637584 |
22539006_7 | 1453-1459 | ProteinMutation | denotes | G2019S | rs34637584 |
22539006_8 | 1517-1523 | ProteinMutation | denotes | G2019S | rs34637584 |
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 9-14 | PR:Q5S006 | denotes | LRRK2 |
T2 | 9-14 | PR:000003033 | denotes | LRRK2 |
T3 | 9-14 | PR:Q5S007 | denotes | LRRK2 |
T5 | 25-29 | PR:000035964 | denotes | MKK4 |
T6 | 25-29 | PR:P45985 | denotes | MKK4 |
T7 | 25-29 | PR:Q20347 | denotes | MKK4 |
T8 | 25-29 | PR:P47809 | denotes | MKK4 |
T10 | 25-29 | PR:000003283 | denotes | MKK4 |
T11 | 25-29 | PR:O80397 | denotes | MKK4 |
T9 | 25-29 | GO:0004708 | denotes | MKK4 |
T12 | 30-33 | PR:P92208 | denotes | JNK |
T13 | 30-33 | GO:0004705 | denotes | JNK |
T14 | 34-41 | CHEBI:34922 | denotes | pathway |
T15 | 98-108 | SO:0000781 | denotes | transgenic |
T16 | 98-114 | D008822 | denotes | transgenic mouse |
T19 | 137-145 | SO:0000109 | denotes | mutation |
T21 | 149-156 | 6308 | denotes | leucine |
T22 | 149-156 | SO:0001437 | denotes | leucine |
T20 | 149-156 | CHEBI:15603 | denotes | leucine |
T23 | 149-156 | D007930 | denotes | leucine |
T24 | 149-156 | CHEBI:25017 | denotes | leucine |
T25 | 149-156 | D007930 | denotes | leucine |
T26 | 162-168 | SO:0001068 | denotes | repeat |
T27 | 179-184 | PR:Q5S006 | denotes | LRRK2 |
T28 | 179-184 | PR:000003033 | denotes | LRRK2 |
T29 | 179-184 | PR:Q5S007 | denotes | LRRK2 |
T34 | 249-268 | D010300 | denotes | Parkinson's disease |
T35 | 249-268 | D010300 | denotes | Parkinson's disease |
T38 | 319-324 | PR:Q5S006 | denotes | LRRK2 |
T39 | 319-324 | PR:000003033 | denotes | LRRK2 |
T40 | 319-324 | PR:Q5S007 | denotes | LRRK2 |
T41 | 325-335 | SO:0000781 | denotes | transgenic |
T42 | 325-340 | 10090 | denotes | transgenic mice |
T43 | 325-340 | D008822 | denotes | transgenic mice |
T44 | 336-340 | PR:000005054 | denotes | mice |
T46 | 336-340 | O89094 | denotes | mice |
T49 | 394-424 | UBERON:0001966 | denotes | substantia nigra pars compacta |
T50 | 394-424 | UBERON:0001965 | denotes | substantia nigra pars compacta |
T51 | 411-415 | PR:P07814 | denotes | pars |
T52 | 411-415 | PR:000007144 | denotes | pars |
T54 | 426-430 | PR:Q9U9R7 | denotes | SNpc |
T55 | 426-430 | UBERON:0001965 | denotes | SNpc |
T56 | 457-469 | D020734 | denotes | parkinsonism |
T57 | 457-469 | D020734 | denotes | parkinsonism |
T58 | 503-508 | PR:Q5S006 | denotes | LRRK2 |
T59 | 503-508 | PR:000003033 | denotes | LRRK2 |
T60 | 503-508 | PR:Q5S007 | denotes | LRRK2 |
T61 | 524-544 | O43283 | denotes | mixed lineage kinase |
T62 | 524-544 | Q63796 | denotes | mixed lineage kinase |
T63 | 524-544 | Q95UN8 | denotes | mixed lineage kinase |
T64 | 524-544 | PR:000010131 | denotes | mixed lineage kinase |
T65 | 524-544 | Q60700 | denotes | mixed lineage kinase |
T66 | 524-544 | PR:000010132 | denotes | mixed lineage kinase |
T67 | 524-544 | Q12852 | denotes | mixed lineage kinase |
T69 | 558-590 | PR:000000019 | denotes | mitogen-activated protein kinase |
T70 | 558-590 | Q00859 | denotes | mitogen-activated protein kinase |
T71 | 558-605 | D020930 | denotes | mitogen-activated protein kinase kinase kinases |
T72 | 576-583 | GO:0003675 | denotes | protein |
T76 | 576-583 | SO:0000104 | denotes | protein |
T78 | 607-614 | D020930 | denotes | MAPKKKs |
T79 | 647-655 | SO:0000109 | denotes | mutation |
T80 | 666-671 | PR:Q5S006 | denotes | LRRK2 |
T81 | 666-671 | PR:000003033 | denotes | LRRK2 |
T82 | 666-671 | PR:Q5S007 | denotes | LRRK2 |
T83 | 672-687 | GO:0016301 | denotes | kinase activity |
T84 | 723-733 | SO:0001633 | denotes | downstream |
T89 | 734-738 | GO:0004707 | denotes | MAPK |
T92 | 734-745 | P10506 | denotes | MAPK kinase |
T93 | 747-750 | GO:0004708 | denotes | MKK |
T94 | 798-804 | SO:0000725 | denotes | signal |
T95 | 798-804 | SO:0000418 | denotes | signal |
T96 | 805-812 | CHEBI:34922 | denotes | pathway |
T97 | 855-860 | PR:Q5S006 | denotes | LRRK2 |
T98 | 855-860 | PR:000003033 | denotes | LRRK2 |
T99 | 855-860 | PR:Q5S007 | denotes | LRRK2 |
T100 | 874-877 | PR:000007123 | denotes | HEK |
T102 | 874-877 | PR:P29320 | denotes | HEK |
T104 | 874-877 | P29320 | denotes | HEK |
T105 | 874-881 | CVCL_0045 | denotes | HEK 293 |
T106 | 911-926 | GO:0016301 | denotes | kinase activity |
T111 | 946-950 | GO:0004707 | denotes | MAPK |
T114 | 946-957 | P10506 | denotes | MAPK kinase |
T116 | 961-965 | PR:000035964 | denotes | MKK4 |
T117 | 961-965 | PR:P45985 | denotes | MKK4 |
T118 | 961-965 | PR:Q20347 | denotes | MKK4 |
T119 | 961-965 | PR:P47809 | denotes | MKK4 |
T121 | 961-965 | PR:000003283 | denotes | MKK4 |
T122 | 961-965 | PR:O80397 | denotes | MKK4 |
T120 | 961-965 | GO:0004708 | denotes | MKK4 |
T129 | 970-973 | SO:0001444 | denotes | Ser |
T123 | 970-973 | CHEBI:32838 | denotes | Ser |
T124 | 970-973 | CHEBI:32839 | denotes | Ser |
T126 | 970-973 | CHEBI:29999 | denotes | Ser |
T130 | 970-973 | CHEBI:17115 | denotes | Ser |
T127 | 970-973 | Q62230 | denotes | Ser |
T128 | 970-973 | PR:000001931 | denotes | Ser |
T131 | 970-973 | PR:P18168 | denotes | Ser |
T125 | 970-973 | GO:0005790 | denotes | Ser |
T136 | 984-991 | SO:0000104 | denotes | protein |
T133 | 984-991 | CHEBI:36080 | denotes | protein |
T134 | 984-991 | CHEBI:11122 | denotes | protein |
T135 | 984-991 | PR:000000001 | denotes | protein |
T132 | 984-991 | GO:0003675 | denotes | protein |
T137 | 1013-1020 | CHEBI:48108 | denotes | phospho |
T139 | 1021-1025 | PR:000035964 | denotes | MKK4 |
T140 | 1021-1025 | PR:P45985 | denotes | MKK4 |
T141 | 1021-1025 | PR:Q20347 | denotes | MKK4 |
T142 | 1021-1025 | PR:P47809 | denotes | MKK4 |
T144 | 1021-1025 | PR:000003283 | denotes | MKK4 |
T145 | 1021-1025 | PR:O80397 | denotes | MKK4 |
T143 | 1021-1025 | GO:0004708 | denotes | MKK4 |
T152 | 1026-1029 | SO:0001444 | denotes | Ser |
T146 | 1026-1029 | CHEBI:32838 | denotes | Ser |
T147 | 1026-1029 | CHEBI:32839 | denotes | Ser |
T149 | 1026-1029 | CHEBI:29999 | denotes | Ser |
T153 | 1026-1029 | CHEBI:17115 | denotes | Ser |
T150 | 1026-1029 | Q62230 | denotes | Ser |
T151 | 1026-1029 | PR:000001931 | denotes | Ser |
T154 | 1026-1029 | PR:P18168 | denotes | Ser |
T148 | 1026-1029 | GO:0005790 | denotes | Ser |
T155 | 1072-1077 | PR:Q5S006 | denotes | LRRK2 |
T156 | 1072-1077 | PR:000003033 | denotes | LRRK2 |
T157 | 1072-1077 | PR:Q5S007 | denotes | LRRK2 |
T158 | 1078-1088 | SO:0000781 | denotes | transgenic |
T159 | 1078-1093 | 10090 | denotes | transgenic mice |
T160 | 1078-1093 | D008822 | denotes | transgenic mice |
T161 | 1089-1093 | PR:000005054 | denotes | mice |
T163 | 1089-1093 | O89094 | denotes | mice |
T165 | 1095-1102 | CHEBI:16541 | denotes | Protein |
T166 | 1119-1126 | CHEBI:48108 | denotes | phospho |
T167 | 1127-1130 | PR:P92208 | denotes | JNK |
T168 | 1127-1130 | GO:0004705 | denotes | JNK |
T169 | 1131-1134 | SO:0001445 | denotes | Thr |
T174 | 1131-1134 | PR:P42286 | denotes | Thr |
T172 | 1131-1134 | CVCL_1M76 | denotes | Thr |
T170 | 1131-1134 | CHEBI:16857 | denotes | Thr |
T171 | 1131-1134 | CHEBI:32824 | denotes | Thr |
T173 | 1131-1134 | CHEBI:32823 | denotes | Thr |
T175 | 1131-1134 | CHEBI:30013 | denotes | Thr |
T182 | 1138-1141 | SO:0001446 | denotes | Tyr |
T176 | 1138-1141 | PR:P14679 | denotes | Tyr |
T177 | 1138-1141 | PR:P55024 | denotes | Tyr |
T179 | 1138-1141 | PR:000016877 | denotes | Tyr |
T183 | 1138-1141 | PR:P11344 | denotes | Tyr |
T187 | 1138-1141 | PR:P22270 | denotes | Tyr |
T178 | 1138-1141 | CHEBI:29977 | denotes | Tyr |
T180 | 1138-1141 | CHEBI:18186 | denotes | Tyr |
T181 | 1138-1141 | CHEBI:46857 | denotes | Tyr |
T184 | 1138-1141 | CHEBI:17895 | denotes | Tyr |
T185 | 1138-1141 | CHEBI:32766 | denotes | Tyr |
T186 | 1138-1141 | CHEBI:32764 | denotes | Tyr |
T188 | 1138-1141 | CHEBI:46858 | denotes | Tyr |
T189 | 1150-1157 | CHEBI:48108 | denotes | phospho |
T190 | 1160-1163 | PR:P17325 | denotes | Jun |
T191 | 1160-1163 | PR:P18870 | denotes | Jun |
T192 | 1160-1163 | PR:P05627 | denotes | Jun |
T193 | 1160-1163 | PR:P05412 | denotes | Jun |
T194 | 1160-1163 | PR:P18289 | denotes | Jun |
T195 | 1160-1163 | PR:000009232 | denotes | Jun |
T198 | 1164-1167 | GO:0005790 | denotes | Ser |
T202 | 1164-1167 | SO:0001444 | denotes | Ser |
T200 | 1164-1167 | Q62230 | denotes | Ser |
T201 | 1164-1167 | PR:000001931 | denotes | Ser |
T204 | 1164-1167 | PR:P18168 | denotes | Ser |
T196 | 1164-1167 | CHEBI:32838 | denotes | Ser |
T197 | 1164-1167 | CHEBI:32839 | denotes | Ser |
T199 | 1164-1167 | CHEBI:29999 | denotes | Ser |
T203 | 1164-1167 | CHEBI:17115 | denotes | Ser |
T205 | 1172-1182 | SO:0001633 | denotes | downstream |
T206 | 1194-1201 | CHEBI:48108 | denotes | phospho |
T208 | 1202-1206 | PR:000035964 | denotes | MKK4 |
T209 | 1202-1206 | PR:P45985 | denotes | MKK4 |
T210 | 1202-1206 | PR:Q20347 | denotes | MKK4 |
T211 | 1202-1206 | PR:P47809 | denotes | MKK4 |
T213 | 1202-1206 | PR:000003283 | denotes | MKK4 |
T214 | 1202-1206 | PR:O80397 | denotes | MKK4 |
T212 | 1202-1206 | GO:0004708 | denotes | MKK4 |
T217 | 1207-1210 | GO:0005790 | denotes | Ser |
T221 | 1207-1210 | SO:0001444 | denotes | Ser |
T219 | 1207-1210 | Q62230 | denotes | Ser |
T220 | 1207-1210 | PR:000001931 | denotes | Ser |
T223 | 1207-1210 | PR:P18168 | denotes | Ser |
T215 | 1207-1210 | CHEBI:32838 | denotes | Ser |
T216 | 1207-1210 | CHEBI:32839 | denotes | Ser |
T218 | 1207-1210 | CHEBI:29999 | denotes | Ser |
T222 | 1207-1210 | CHEBI:17115 | denotes | Ser |
T224 | 1252-1257 | PR:Q5S006 | denotes | LRRK2 |
T225 | 1252-1257 | PR:000003033 | denotes | LRRK2 |
T226 | 1252-1257 | PR:Q5S007 | denotes | LRRK2 |
T228 | 1258-1262 | D051379 | denotes | mice |
T230 | 1258-1262 | 10095 | denotes | mice |
T227 | 1258-1262 | PR:000005054 | denotes | mice |
T229 | 1258-1262 | O89094 | denotes | mice |
T233 | 1276-1280 | SO:0000234 | denotes | mRNA |
T231 | 1276-1280 | D012333 | denotes | mRNA |
T232 | 1276-1280 | CHEBI:33699 | denotes | mRNA |
T238 | 1295-1298 | SO:0001439 | denotes | pro |
T234 | 1295-1298 | CVCL_N817 | denotes | pro |
T235 | 1295-1298 | CHEBI:32871 | denotes | pro |
T236 | 1295-1298 | CHEBI:32865 | denotes | pro |
T237 | 1295-1298 | CHEBI:50342 | denotes | pro |
T239 | 1295-1298 | CHEBI:32866 | denotes | pro |
T240 | 1309-1312 | PR:O88498 | denotes | Bim |
T241 | 1309-1312 | PR:O43521 | denotes | Bim |
T242 | 1309-1312 | PR:000002187 | denotes | Bim |
T243 | 1309-1312 | PR:O54918 | denotes | Bim |
T244 | 1309-1312 | CHEBI:33173 | denotes | Bim |
T245 | 1317-1321 | P41047 | denotes | FasL |
T246 | 1317-1321 | Q9BDN1 | denotes | FasL |
T247 | 1317-1321 | P63306 | denotes | FasL |
T248 | 1317-1321 | Q9BEA8 | denotes | FasL |
T249 | 1317-1321 | P48023 | denotes | FasL |
T250 | 1317-1321 | PR:P48023 | denotes | FasL |
T251 | 1317-1321 | PR:P36940 | denotes | FasL |
T252 | 1317-1321 | P63308 | denotes | FasL |
T253 | 1317-1321 | P63307 | denotes | FasL |
T254 | 1317-1321 | P36940 | denotes | FasL |
T255 | 1317-1321 | Q861W5 | denotes | FasL |
T256 | 1317-1321 | PR:000000095 | denotes | FasL |
T257 | 1317-1321 | PR:P41047 | denotes | FasL |
T258 | 1339-1346 | CHEBI:48108 | denotes | phospho |
T259 | 1349-1352 | PR:P17325 | denotes | Jun |
T260 | 1349-1352 | PR:P18870 | denotes | Jun |
T261 | 1349-1352 | PR:P05627 | denotes | Jun |
T262 | 1349-1352 | PR:P05412 | denotes | Jun |
T263 | 1349-1352 | PR:P18289 | denotes | Jun |
T264 | 1349-1352 | PR:000009232 | denotes | Jun |
T271 | 1353-1356 | SO:0001444 | denotes | Ser |
T269 | 1353-1356 | Q62230 | denotes | Ser |
T270 | 1353-1356 | PR:000001931 | denotes | Ser |
T273 | 1353-1356 | PR:P18168 | denotes | Ser |
T265 | 1353-1356 | CHEBI:32838 | denotes | Ser |
T266 | 1353-1356 | CHEBI:32839 | denotes | Ser |
T268 | 1353-1356 | CHEBI:29999 | denotes | Ser |
T272 | 1353-1356 | CHEBI:17115 | denotes | Ser |
T267 | 1353-1356 | GO:0005790 | denotes | Ser |
T274 | 1365-1374 | GO:0009058 | denotes | formation |
T276 | 1385-1394 | PR:000002318 | denotes | caspase-9 |
T278 | 1385-1394 | Q8C3Q9 | denotes | caspase-9 |
T279 | 1385-1394 | P55211 | denotes | caspase-9 |
T277 | 1385-1394 | D053453 | denotes | caspase-9 |
T281 | 1396-1405 | O89110 | denotes | caspase-8 |
T283 | 1396-1405 | Q14790 | denotes | caspase-8 |
T284 | 1396-1405 | Q29IM7 | denotes | caspase-8 |
T285 | 1396-1405 | Q8IRY7 | denotes | caspase-8 |
T286 | 1396-1405 | Q9JHX4 | denotes | caspase-8 |
T287 | 1396-1405 | PR:000002317 | denotes | caspase-8 |
T282 | 1396-1405 | D053181 | denotes | caspase-8 |
T290 | 1410-1419 | P55866 | denotes | caspase-3 |
T291 | 1410-1419 | Q8MJC3 | denotes | caspase-3 |
T292 | 1410-1419 | Q2PFV2 | denotes | caspase-3 |
T293 | 1410-1419 | Q08DY9 | denotes | caspase-3 |
T294 | 1410-1419 | Q5IS54 | denotes | caspase-3 |
T295 | 1410-1419 | Q8MKI5 | denotes | caspase-3 |
T296 | 1410-1419 | PR:000002312 | denotes | caspase-3 |
T297 | 1410-1419 | Q8MJU1 | denotes | caspase-3 |
T298 | 1410-1419 | Q60431 | denotes | caspase-3 |
T299 | 1410-1419 | P42574 | denotes | caspase-3 |
T300 | 1410-1419 | Q5IS99 | denotes | caspase-3 |
T301 | 1410-1419 | Q95ND5 | denotes | caspase-3 |
T302 | 1410-1419 | P70677 | denotes | caspase-3 |
T303 | 1410-1419 | P55213 | denotes | caspase-3 |
T289 | 1410-1419 | D053148 | denotes | caspase-3 |
T304 | 1461-1466 | PR:Q5S006 | denotes | LRRK2 |
T305 | 1461-1466 | PR:000003033 | denotes | LRRK2 |
T306 | 1461-1466 | PR:Q5S007 | denotes | LRRK2 |
T307 | 1467-1477 | SO:0000781 | denotes | transgenic |
T308 | 1467-1482 | 10090 | denotes | transgenic mice |
T309 | 1467-1482 | D008822 | denotes | transgenic mice |
T310 | 1478-1482 | PR:000005054 | denotes | mice |
T312 | 1478-1482 | O89094 | denotes | mice |
T314 | 1525-1530 | PR:Q5S006 | denotes | LRRK2 |
T315 | 1525-1530 | PR:000003033 | denotes | LRRK2 |
T316 | 1525-1530 | PR:Q5S007 | denotes | LRRK2 |
T318 | 1541-1545 | PR:000035964 | denotes | MKK4 |
T319 | 1541-1545 | PR:P45985 | denotes | MKK4 |
T320 | 1541-1545 | PR:Q20347 | denotes | MKK4 |
T321 | 1541-1545 | PR:P47809 | denotes | MKK4 |
T323 | 1541-1545 | PR:000003283 | denotes | MKK4 |
T324 | 1541-1545 | PR:O80397 | denotes | MKK4 |
T322 | 1541-1545 | GO:0004708 | denotes | MKK4 |
T325 | 1546-1549 | PR:P92208 | denotes | JNK |
T326 | 1546-1549 | GO:0004705 | denotes | JNK |
T327 | 1552-1555 | PR:P17325 | denotes | Jun |
T328 | 1552-1555 | PR:P18870 | denotes | Jun |
T329 | 1552-1555 | PR:P05627 | denotes | Jun |
T330 | 1552-1555 | PR:P05412 | denotes | Jun |
T331 | 1552-1555 | PR:P18289 | denotes | Jun |
T332 | 1552-1555 | PR:000009232 | denotes | Jun |
T333 | 1556-1563 | CHEBI:34922 | denotes | pathway |
T334 | 1615-1619 | PR:Q9U9R7 | denotes | SNpc |
T335 | 1615-1619 | UBERON:0001965 | denotes | SNpc |
T336 | 1647-1657 | SO:0000781 | denotes | transgenic |
T337 | 1647-1662 | 10090 | denotes | transgenic mice |
T338 | 1647-1662 | D008822 | denotes | transgenic mice |
T339 | 1658-1662 | PR:000005054 | denotes | mice |
T341 | 1658-1662 | O89094 | denotes | mice |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 319-324 | gene:120892 | denotes | LRRK2 |
T1 | 457-469 | disease:C0242422 | denotes | parkinsonism |
R1 | T0 | T1 | associated_with | LRRK2,parkinsonism |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 249-258 | HP_0001300 | denotes | Parkinson |
T2 | 457-469 | HP_0001300 | denotes | parkinsonism |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_22539006_1_0 | 149-177 | expanded | denotes | leucine-rich repeat kinase 2 |
SS2_22539006_1_0 | 179-184 | abbr | denotes | LRRK2 |
SS1_22539006_1_1 | 249-268 | expanded | denotes | Parkinson's disease |
SS2_22539006_1_1 | 270-272 | abbr | denotes | PD |
SS1_22539006_2_0 | 394-424 | expanded | denotes | substantia nigra pars compacta |
SS2_22539006_2_0 | 426-430 | abbr | denotes | SNpc |
SS1_22539006_3_0 | 558-605 | expanded | denotes | mitogen-activated protein kinase kinase kinases |
SS2_22539006_3_0 | 607-614 | abbr | denotes | MAPKKKs |
SS1_22539006_4_0 | 734-745 | expanded | denotes | MAPK kinase |
SS2_22539006_4_0 | 747-750 | abbr | denotes | MKK |
SS1_22539006_5_0 | 946-959 | expanded | denotes | MAPK kinase 4 |
SS2_22539006_5_0 | 961-965 | abbr | denotes | MKK4 |
AE1_22539006_1_0 | SS1_22539006_1_0 | SS2_22539006_1_0 | abbreviatedTo | leucine-rich repeat kinase 2,LRRK2 |
AE1_22539006_1_1 | SS1_22539006_1_1 | SS2_22539006_1_1 | abbreviatedTo | Parkinson's disease,PD |
AE1_22539006_2_0 | SS1_22539006_2_0 | SS2_22539006_2_0 | abbreviatedTo | substantia nigra pars compacta,SNpc |
AE1_22539006_3_0 | SS1_22539006_3_0 | SS2_22539006_3_0 | abbreviatedTo | mitogen-activated protein kinase kinase kinases,MAPKKKs |
AE1_22539006_4_0 | SS1_22539006_4_0 | SS2_22539006_4_0 | abbreviatedTo | MAPK kinase,MKK |
AE1_22539006_5_0 | SS1_22539006_5_0 | SS2_22539006_5_0 | abbreviatedTo | MAPK kinase 4,MKK4 |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-127 | DRI_Challenge | denotes | (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. |
T2 | 128-280 | DRI_Background | denotes | (G2019S) mutation of leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause of both familial and sporadic Parkinson's disease (PD) cases. |
T3 | 281-502 | DRI_Background | denotes | Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive degeneration of substantia nigra pars compacta (SNpc) dopaminergic neurons and parkinsonism phenotypes of motor dysfunction. |
T4 | 503-616 | DRI_Background | denotes | LRRK2 is a member of mixed lineage kinase subfamily of mitogen-activated protein kinase kinase kinases (MAPKKKs). |
T5 | 617-813 | DRI_Challenge | denotes | We hypothesized that (G2019S) mutation augmented LRRK2 kinase activity, leading to overphosphorylation of downstream MAPK kinase (MKK) and resulting in activation of neuronal death signal pathway. |
T6 | 814-1094 | DRI_Outcome | denotes | Consistent with our hypothesis, (G2019S) LRRK2 expressed in HEK 293 cells exhibited an augmented kinase activity of phosphorylating MAPK kinase 4 (MKK4) at Ser(257), and protein expression of active phospho-MKK4(Ser257) was upregulated in the SN of (G2019S) LRRK2 transgenic mice. |
T7 | 1095-1263 | DRI_Background | denotes | Protein level of active phospho-JNK(Thr183/Tyr185) and phospho-c-Jun(Ser63), downstream targets of phospho-MKK4(Ser257), was increased in the SN of (G2019S) LRRK2 mice. |
T8 | 1264-1483 | DRI_Background | denotes | Upregulated mRNA expression of pro-apoptotic Bim and FasL, target genes of phospho-c-Jun(Ser63), and formation of active caspase-9, caspase-8 and caspase-3 were also observed in the SN of (G2019S) LRRK2 transgenic mice. |
T9 | 1484-1663 | DRI_Outcome | denotes | Our results suggest that mutant (G2019S) LRRK2 activates MKK4-JNK-c-Jun pathway in the SN and causes the resulting degeneration of SNpc dopaminergic neurons in PD transgenic mice. |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 128-280 | DRI_Background | denotes | (G2019S) mutation of leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause of both familial and sporadic Parkinson's disease (PD) cases. |
T2 | 281-502 | DRI_Background | denotes | Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive degeneration of substantia nigra pars compacta (SNpc) dopaminergic neurons and parkinsonism phenotypes of motor dysfunction. |
T3 | 503-616 | DRI_Background | denotes | LRRK2 is a member of mixed lineage kinase subfamily of mitogen-activated protein kinase kinase kinases (MAPKKKs). |
T4 | 617-813 | DRI_Challenge | denotes | We hypothesized that (G2019S) mutation augmented LRRK2 kinase activity, leading to overphosphorylation of downstream MAPK kinase (MKK) and resulting in activation of neuronal death signal pathway. |
T5 | 814-1094 | DRI_Outcome | denotes | Consistent with our hypothesis, (G2019S) LRRK2 expressed in HEK 293 cells exhibited an augmented kinase activity of phosphorylating MAPK kinase 4 (MKK4) at Ser(257), and protein expression of active phospho-MKK4(Ser257) was upregulated in the SN of (G2019S) LRRK2 transgenic mice. |
T6 | 1095-1263 | DRI_Background | denotes | Protein level of active phospho-JNK(Thr183/Tyr185) and phospho-c-Jun(Ser63), downstream targets of phospho-MKK4(Ser257), was increased in the SN of (G2019S) LRRK2 mice. |
T7 | 1264-1483 | DRI_Background | denotes | Upregulated mRNA expression of pro-apoptotic Bim and FasL, target genes of phospho-c-Jun(Ser63), and formation of active caspase-9, caspase-8 and caspase-3 were also observed in the SN of (G2019S) LRRK2 transgenic mice. |
T8 | 1484-1663 | DRI_Outcome | denotes | Our results suggest that mutant (G2019S) LRRK2 activates MKK4-JNK-c-Jun pathway in the SN and causes the resulting degeneration of SNpc dopaminergic neurons in PD transgenic mice. |
DisGeNET5_variant_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
22539006-2#30#36#geners34637584 | 311-317 | geners34637584 | denotes | G2019S |
22539006-2#176#188#diseaseC0242422 | 457-469 | diseaseC0242422 | denotes | parkinsonism |
22539006-2#209#220#diseaseC3887505 | 490-501 | diseaseC3887505 | denotes | dysfunction |
22539006-8#33#39#geners34637584 | 1517-1523 | geners34637584 | denotes | G2019S |
22539006-8#160#162#diseaseC0030567 | 1644-1646 | diseaseC0030567 | denotes | PD |
30#36#geners34637584176#188#diseaseC0242422 | 22539006-2#30#36#geners34637584 | 22539006-2#176#188#diseaseC0242422 | associated_with | G2019S,parkinsonism |
30#36#geners34637584209#220#diseaseC3887505 | 22539006-2#30#36#geners34637584 | 22539006-2#209#220#diseaseC3887505 | associated_with | G2019S,dysfunction |
33#39#geners34637584160#162#diseaseC0030567 | 22539006-8#33#39#geners34637584 | 22539006-8#160#162#diseaseC0030567 | associated_with | G2019S,PD |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
22539006-2#38#43#gene120892 | 319-324 | gene120892 | denotes | LRRK2 |
22539006-2#176#188#diseaseC0242422 | 457-469 | diseaseC0242422 | denotes | parkinsonism |
22539006-2#209#220#diseaseC3887505 | 490-501 | diseaseC3887505 | denotes | dysfunction |
22539006-8#41#46#gene120892 | 1525-1530 | gene120892 | denotes | LRRK2 |
22539006-8#57#61#gene6416 | 1541-1545 | gene6416 | denotes | MKK4 |
22539006-8#62#65#gene5599 | 1546-1549 | gene5599 | denotes | JNK |
22539006-8#160#162#diseaseC0030567 | 1644-1646 | diseaseC0030567 | denotes | PD |
38#43#gene120892176#188#diseaseC0242422 | 22539006-2#38#43#gene120892 | 22539006-2#176#188#diseaseC0242422 | associated_with | LRRK2,parkinsonism |
38#43#gene120892209#220#diseaseC3887505 | 22539006-2#38#43#gene120892 | 22539006-2#209#220#diseaseC3887505 | associated_with | LRRK2,dysfunction |
41#46#gene120892160#162#diseaseC0030567 | 22539006-8#41#46#gene120892 | 22539006-8#160#162#diseaseC0030567 | associated_with | LRRK2,PD |
57#61#gene6416160#162#diseaseC0030567 | 22539006-8#57#61#gene6416 | 22539006-8#160#162#diseaseC0030567 | associated_with | MKK4,PD |
62#65#gene5599160#162#diseaseC0030567 | 22539006-8#62#65#gene5599 | 22539006-8#160#162#diseaseC0030567 | associated_with | JNK,PD |