PubMed:22534569
Annnotations
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 226-235 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
| T2 | 389-398 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
| T3 | 694-699 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Le(X) |
| T4 | 762-771 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
| T5 | 801-806 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Le(X) |
| T6 | 947-953 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T7 | 1565-1574 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 77-83 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T2 | 226-235 | Glycan_Motif | denotes | T antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T3 | 389-398 | Glycan_Motif | denotes | T antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T4 | 694-699 | Glycan_Motif | denotes | Le(X) | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC |
| T5 | 762-771 | Glycan_Motif | denotes | T antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T6 | 801-806 | Glycan_Motif | denotes | Le(X) | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC |
| T7 | 947-953 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T8 | 982-988 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T9 | 1565-1574 | Glycan_Motif | denotes | T antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 226-235 | http://www.glycoepitope.jp/epitopes/EP0020 | denotes | T antigen |
| T2 | 389-398 | http://www.glycoepitope.jp/epitopes/EP0020 | denotes | T antigen |
| T3 | 762-771 | http://www.glycoepitope.jp/epitopes/EP0020 | denotes | T antigen |
| T4 | 1565-1574 | http://www.glycoepitope.jp/epitopes/EP0020 | denotes | T antigen |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 226-235 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
| T2 | 389-398 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
| T3 | 694-699 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Le(X) |
| T4 | 762-771 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
| T5 | 801-806 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Le(X) |
| T6 | 947-953 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T7 | 1565-1574 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 0-4 | gene:4582 | denotes | MUC1 |
| T1 | 25-42 | disease:C0678222 | denotes | mammary carcinoma |
| T2 | 216-220 | gene:4582 | denotes | MUC1 |
| T3 | 249-262 | disease:C0006142 | denotes | breast cancer |
| T4 | 216-220 | gene:4582 | denotes | MUC1 |
| T5 | 249-262 | disease:C0678222 | denotes | breast cancer |
| T6 | 216-220 | gene:4582 | denotes | MUC1 |
| T7 | 274-287 | disease:C0678222 | denotes | breast cancer |
| T8 | 216-220 | gene:4582 | denotes | MUC1 |
| T9 | 274-287 | disease:C0006142 | denotes | breast cancer |
| T10 | 538-542 | gene:4582 | denotes | MUC1 |
| T11 | 500-517 | disease:C0678222 | denotes | mammary carcinoma |
| R1 | T0 | T1 | associated_with | MUC1,mammary carcinoma |
| R2 | T2 | T3 | associated_with | MUC1,breast cancer |
| R3 | T4 | T5 | associated_with | MUC1,breast cancer |
| R4 | T6 | T7 | associated_with | MUC1,breast cancer |
| R5 | T8 | T9 | associated_with | MUC1,breast cancer |
| R6 | T10 | T11 | associated_with | MUC1,mammary carcinoma |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 249-262 | HP_0003002 | denotes | breast cancer |
| T2 | 249-262 | HP_0100013 | denotes | breast cancer |
| T3 | 256-262 | HP_0002664 | denotes | cancer |
| T4 | 263-269 | HP_0002664 | denotes | tumors |
| T5 | 274-287 | HP_0003002 | denotes | breast cancer |
| T6 | 274-287 | HP_0100013 | denotes | breast cancer |
| T7 | 281-287 | HP_0002664 | denotes | cancer |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T18 | 1210-1215 | FMAID:169002 | denotes | cells |
| _T1 | 43-48 | FMAID:169002 | denotes | cells |
| _T2 | 43-48 | FMAID:68646 | denotes | cells |
| _T3 | 249-255 | FMAID:97486 | denotes | breast |
| _T4 | 249-255 | FMAID:9601 | denotes | breast |
| _T5 | 274-280 | FMAID:97486 | denotes | breast |
| _T6 | 274-280 | FMAID:9601 | denotes | breast |
| _T7 | 479-484 | FMAID:68646 | denotes | cells |
| _T8 | 479-484 | FMAID:169002 | denotes | cells |
| _T9 | 518-523 | FMAID:68646 | denotes | cells |
| _T10 | 518-523 | FMAID:169002 | denotes | cells |
| _T11 | 604-608 | FMAID:198663 | denotes | gene |
| _T12 | 617-622 | FMAID:169002 | denotes | cells |
| _T13 | 617-622 | FMAID:68646 | denotes | cells |
| _T14 | 663-668 | FMAID:68646 | denotes | cells |
| _T15 | 663-668 | FMAID:169002 | denotes | cells |
| _T16 | 1188-1193 | FMAID:68646 | denotes | cells |
| _T17 | 1188-1193 | FMAID:169002 | denotes | cells |
| _T19 | 1210-1215 | FMAID:68646 | denotes | cells |
| _T20 | 1384-1389 | FMAID:68646 | denotes | cells |
| _T21 | 1384-1389 | FMAID:169002 | denotes | cells |
| _T22 | 1412-1417 | FMAID:169002 | denotes | cells |
| _T23 | 1412-1417 | FMAID:68646 | denotes | cells |
| _T24 | 1516-1532 | FMAID:82742 | denotes | oligosaccharides |
| _T25 | 1516-1532 | FMAID:196731 | denotes | oligosaccharides |
| _T26 | 1749-1754 | FMAID:68646 | denotes | cells |
| _T27 | 1749-1754 | FMAID:169002 | denotes | cells |
| _T28 | 1809-1814 | FMAID:68646 | denotes | cells |
| _T29 | 1809-1814 | FMAID:169002 | denotes | cells |
| _T30 | 1832-1842 | FMAID:62932 | denotes | E-selectin |
| _T31 | 1832-1842 | FMAID:167265 | denotes | E-selectin |
| _T32 | 1832-1842 | FMAID:62933 | denotes | E-selectin |
| _T33 | 1832-1842 | FMAID:167267 | denotes | E-selectin |
| _T34 | 1832-1842 | FMAID:167268 | denotes | E-selectin |
| _T35 | 1832-1842 | FMAID:62931 | denotes | E-selectin |
| _T36 | 1834-1842 | FMAID:61795 | denotes | selectin |
| _T37 | 1834-1842 | FMAID:165243 | denotes | selectin |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T2 | 216-220 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T3 | 425-429 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T4 | 538-542 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T5 | 599-603 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T6 | 727-731 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T7 | 1152-1156 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T8 | 1259-1263 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T9 | 1349-1353 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T10 | 1448-1452 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T11 | 1615-1619 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T12 | 1737-1741 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T13 | 1793-1797 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T14 | 89-120 | http://www.uniprot.org/uniprot/Q06430 | denotes | N-acetylglucosaminyltransferase |
| T15 | 994-1025 | http://www.uniprot.org/uniprot/Q06430 | denotes | N-acetylglucosaminyltransferase |
| T16 | 89-120 | http://www.uniprot.org/uniprot/Q8N0V5 | denotes | N-acetylglucosaminyltransferase |
| T17 | 994-1025 | http://www.uniprot.org/uniprot/Q8N0V5 | denotes | N-acetylglucosaminyltransferase |
| T18 | 89-120 | http://www.uniprot.org/uniprot/Q8NFS9 | denotes | N-acetylglucosaminyltransferase |
| T19 | 994-1025 | http://www.uniprot.org/uniprot/Q8NFS9 | denotes | N-acetylglucosaminyltransferase |
| T20 | 274-292 | http://www.uniprot.org/uniprot/Q8IZY5 | denotes | breast cancer cell |
| T21 | 472-474 | http://www.uniprot.org/uniprot/P02144 | denotes | MB |
| T22 | 1173-1175 | http://www.uniprot.org/uniprot/P02144 | denotes | MB |
| T23 | 1369-1371 | http://www.uniprot.org/uniprot/P02144 | denotes | MB |
| T24 | 697-707 | http://www.uniprot.org/uniprot/Q16222 | denotes | X) antigen |
| T25 | 1077-1085 | http://www.uniprot.org/uniprot/Q11201 | denotes | ST3Gal I |
| T26 | 1317-1325 | http://www.uniprot.org/uniprot/Q11201 | denotes | ST3Gal I |
| T27 | 1685-1693 | http://www.uniprot.org/uniprot/Q11201 | denotes | ST3Gal I |
| T28 | 1832-1842 | http://www.uniprot.org/uniprot/P16581 | denotes | E-selectin |
| T29 | 1853-1863 | http://www.uniprot.org/uniprot/P17931 | denotes | galectin-3 |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 89-120 | http://www.uniprot.org/uniprot/P97402 | denotes | N-acetylglucosaminyltransferase |
| T2 | 994-1025 | http://www.uniprot.org/uniprot/P97402 | denotes | N-acetylglucosaminyltransferase |
| T3 | 959-980 | http://www.uniprot.org/uniprot/P23336 | denotes | galactosyltransferase |
| T4 | 1077-1085 | http://www.uniprot.org/uniprot/P54751 | denotes | ST3Gal I |
| T5 | 1317-1325 | http://www.uniprot.org/uniprot/P54751 | denotes | ST3Gal I |
| T6 | 1685-1693 | http://www.uniprot.org/uniprot/P54751 | denotes | ST3Gal I |
| T7 | 1832-1842 | http://www.uniprot.org/uniprot/Q00690 | denotes | E-selectin |
| T8 | 1853-1863 | http://www.uniprot.org/uniprot/P16110 | denotes | galectin-3 |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 33-42 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinoma |
| T2 | 43-48 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T3 | 256-262 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T4 | 281-287 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T5 | 479-484 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T6 | 508-517 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinoma |
| T7 | 518-523 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T8 | 617-622 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T9 | 663-668 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T10 | 1188-1193 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T11 | 1210-1215 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T12 | 1384-1389 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T13 | 1412-1417 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T14 | 1749-1754 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T15 | 1809-1814 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 556-560 | http://purl.obolibrary.org/obo/GO_0016246 | denotes | RNAi |
| T2 | 687-693 | http://purl.obolibrary.org/obo/GO_0097503 | denotes | sialyl |
| T3 | 794-800 | http://purl.obolibrary.org/obo/GO_0097503 | denotes | sialyl |
| T4 | 854-863 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T5 | 1646-1655 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulates |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1834-1842 | http://purl.obolibrary.org/obo/GO_0030246 | denotes | selectin |
| T2 | 1848-1852 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | bind |
| T3 | 1848-1852 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | bind |
| T4 | 1848-1852 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | bind |
| T5 | 1848-1852 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | bind |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 43-48 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T2 | 479-484 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T3 | 518-523 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T4 | 617-622 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T5 | 663-668 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T6 | 1188-1193 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T7 | 1210-1215 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T8 | 1384-1389 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T9 | 1412-1417 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T10 | 1749-1754 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T11 | 288-292 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T12 | 77-81 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
| T13 | 947-951 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
| T14 | 982-986 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 249-255 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T2 | 274-280 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22534569_1_0 | 208-214 | expanded | denotes | mucin1 |
| SS2_22534569_1_0 | 216-220 | abbr | denotes | MUC1 |
| SS1_22534569_4_0 | 982-1025 | expanded | denotes | core 2 β1,6-N-acetylglucosaminyltransferase |
| SS2_22534569_4_0 | 1027-1033 | abbr | denotes | C2GnT1 |
| AE1_22534569_1_0 | SS1_22534569_1_0 | SS2_22534569_1_0 | abbreviatedTo | mucin1,MUC1 |
| AE1_22534569_4_0 | SS1_22534569_4_0 | SS2_22534569_4_0 | abbreviatedTo | "core 2 β1,6-N-acetylglucosaminyltransferase",C2GnT1 |
EDAM-topics
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 8-13 | http://edamontology.org/topic_2815 | denotes | human |
| T2 | 228-235 | http://edamontology.org/topic_2830 | denotes | antigen |
| T3 | 256-262 | http://edamontology.org/topic_2640 | denotes | cancer |
| T4 | 281-287 | http://edamontology.org/topic_2640 | denotes | cancer |
| T5 | 391-398 | http://edamontology.org/topic_2830 | denotes | antigen |
| T6 | 529-533 | http://edamontology.org/topic_3512 | denotes | cDNA |
| T7 | 700-707 | http://edamontology.org/topic_2830 | denotes | antigen |
| T8 | 764-771 | http://edamontology.org/topic_2830 | denotes | antigen |
| T9 | 1091-1098 | http://edamontology.org/topic_3678 | denotes | studied |
| T10 | 1250-1258 | http://edamontology.org/topic_0154 | denotes | targeted |
| T11 | 1567-1574 | http://edamontology.org/topic_2830 | denotes | antigen |
EDAM-DFO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 170-181 | http://edamontology.org/operation_3465 | denotes | correlation |
| T2 | 807-816 | http://edamontology.org/data_0883 | denotes | structure |
| T3 | 1494-1503 | http://edamontology.org/data_0883 | denotes | structure |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 22534569-0#0#4#gene4582 | 216-220 | gene4582 | denotes | MUC1 |
| 22534569-0#25#42#diseaseC0678222 | 500-517 | diseaseC0678222 | denotes | mammary carcinoma |
| 22534569-1#53#57#gene4582 | 216-220 | gene4582 | denotes | MUC1 |
| 22534569-1#86#99#diseaseC0006142 | 249-262 | diseaseC0006142 | denotes | breast cancer |
| 22534569-1#111#124#diseaseC0006142 | 274-287 | diseaseC0006142 | denotes | breast cancer |
| 0#4#gene458225#42#diseaseC0678222 | 22534569-0#0#4#gene4582 | 22534569-0#25#42#diseaseC0678222 | associated_with | MUC1,mammary carcinoma |
| 53#57#gene458286#99#diseaseC0006142 | 22534569-1#53#57#gene4582 | 22534569-1#86#99#diseaseC0006142 | associated_with | MUC1,breast cancer |
| 53#57#gene4582111#124#diseaseC0006142 | 22534569-1#53#57#gene4582 | 22534569-1#111#124#diseaseC0006142 | associated_with | MUC1,breast cancer |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-162 | Sentence | denotes | MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. |
| TextSentencer_T2 | 163-346 | Sentence | denotes | A good correlation between the expression of mucin1 (MUC1) and T antigen was found in breast cancer tumors and breast cancer cell lines, especially after treatment with neuraminidase. |
| TextSentencer_T3 | 347-623 | Sentence | denotes | The association between the appearance of T antigen and the overexpression of MUC1 was further confirmed by transfecting MDA-MB-231 cells and murine 4T1 mammary carcinoma cells with cDNA for MUC1 and using an RNAi approach to inhibit the expression of MUC1 gene in T47D cells. |
| TextSentencer_T4 | 624-817 | Sentence | denotes | Furthermore, we discovered that in 4T1 cells which express the sialyl Le(X) antigen, overexpression of MUC1 caused not only appearance of T antigen, but also loss of the sialyl Le(X) structure. |
| TextSentencer_T5 | 818-1269 | Sentence | denotes | As the observed changes in O-glycan synthesis can be associated with changes in the expression of specific glycosyltransferases, core 1 β1,3-galactosyltransferase, core 2 β1,6-N-acetylglucosaminyltransferase (C2GnT1) and β-galactoside α2,3-sialyltransferase (ST3Gal I), we studied their expression in parental, vector-transfected and MUC1-transfected MDA-MB-231 and 4T1 cells as well as T47D cells transduced with small hairpin RNA targeted MUC1 mRNA. |
| TextSentencer_T6 | 1270-1453 | Sentence | denotes | It was found that the expression of C2GnT1 and ST3Gal I is highly decreased in MUC1-expressing MDA-MB-231 and 4T1 cells and increased in T47D cells with suppressed expression of MUC1. |
| TextSentencer_T7 | 1454-1694 | Sentence | denotes | Therefore, we found that changes in the structure of O-linked oligosaccharides, resulting in the occurrence of T antigen, are at least partially associated with MUC1 overexpression which down-regulates the expression of C2GnT1 and ST3Gal I. |
| TextSentencer_T8 | 1695-1864 | Sentence | denotes | We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. |
| T1 | 0-162 | Sentence | denotes | MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. |
| T2 | 163-346 | Sentence | denotes | A good correlation between the expression of mucin1 (MUC1) and T antigen was found in breast cancer tumors and breast cancer cell lines, especially after treatment with neuraminidase. |
| T3 | 347-623 | Sentence | denotes | The association between the appearance of T antigen and the overexpression of MUC1 was further confirmed by transfecting MDA-MB-231 cells and murine 4T1 mammary carcinoma cells with cDNA for MUC1 and using an RNAi approach to inhibit the expression of MUC1 gene in T47D cells. |
| T4 | 624-817 | Sentence | denotes | Furthermore, we discovered that in 4T1 cells which express the sialyl Le(X) antigen, overexpression of MUC1 caused not only appearance of T antigen, but also loss of the sialyl Le(X) structure. |
| T5 | 818-1269 | Sentence | denotes | As the observed changes in O-glycan synthesis can be associated with changes in the expression of specific glycosyltransferases, core 1 β1,3-galactosyltransferase, core 2 β1,6-N-acetylglucosaminyltransferase (C2GnT1) and β-galactoside α2,3-sialyltransferase (ST3Gal I), we studied their expression in parental, vector-transfected and MUC1-transfected MDA-MB-231 and 4T1 cells as well as T47D cells transduced with small hairpin RNA targeted MUC1 mRNA. |
| T6 | 1270-1453 | Sentence | denotes | It was found that the expression of C2GnT1 and ST3Gal I is highly decreased in MUC1-expressing MDA-MB-231 and 4T1 cells and increased in T47D cells with suppressed expression of MUC1. |
| T7 | 1454-1864 | Sentence | denotes | Therefore, we found that changes in the structure of O-linked oligosaccharides, resulting in the occurrence of T antigen, are at least partially associated with MUC1 overexpression which down-regulates the expression of C2GnT1 and ST3Gal I. We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. |
| T1 | 0-162 | Sentence | denotes | MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. |
| T2 | 163-346 | Sentence | denotes | A good correlation between the expression of mucin1 (MUC1) and T antigen was found in breast cancer tumors and breast cancer cell lines, especially after treatment with neuraminidase. |
| T3 | 347-623 | Sentence | denotes | The association between the appearance of T antigen and the overexpression of MUC1 was further confirmed by transfecting MDA-MB-231 cells and murine 4T1 mammary carcinoma cells with cDNA for MUC1 and using an RNAi approach to inhibit the expression of MUC1 gene in T47D cells. |
| T4 | 624-817 | Sentence | denotes | Furthermore, we discovered that in 4T1 cells which express the sialyl Le(X) antigen, overexpression of MUC1 caused not only appearance of T antigen, but also loss of the sialyl Le(X) structure. |
| T5 | 818-1269 | Sentence | denotes | As the observed changes in O-glycan synthesis can be associated with changes in the expression of specific glycosyltransferases, core 1 β1,3-galactosyltransferase, core 2 β1,6-N-acetylglucosaminyltransferase (C2GnT1) and β-galactoside α2,3-sialyltransferase (ST3Gal I), we studied their expression in parental, vector-transfected and MUC1-transfected MDA-MB-231 and 4T1 cells as well as T47D cells transduced with small hairpin RNA targeted MUC1 mRNA. |
| T6 | 1270-1453 | Sentence | denotes | It was found that the expression of C2GnT1 and ST3Gal I is highly decreased in MUC1-expressing MDA-MB-231 and 4T1 cells and increased in T47D cells with suppressed expression of MUC1. |
| T7 | 1454-1694 | Sentence | denotes | Therefore, we found that changes in the structure of O-linked oligosaccharides, resulting in the occurrence of T antigen, are at least partially associated with MUC1 overexpression which down-regulates the expression of C2GnT1 and ST3Gal I. |
| T8 | 1695-1864 | Sentence | denotes | We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. |
Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| Lectin_T1 | 1832-1842 | https://acgg.asia/db/lfdb/LfDB0043 | denotes | E-selectin |
| Lectin_T2 | 1834-1842 | https://acgg.asia/db/lfdb/LfDB0013 | denotes | selectin |
| Lectin_T3 | 1834-1842 | https://acgg.asia/db/lfdb/LfDB0142 | denotes | selectin |
GlycoBiology-Epitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoEpitope-B_T1 | 226-235 | http://www.glycoepitope.jp/epitopes/EP0020 | denotes | T antigen |
| PD-GlycoEpitope-B_T2 | 389-398 | http://www.glycoepitope.jp/epitopes/EP0020 | denotes | T antigen |
| PD-GlycoEpitope-B_T3 | 762-771 | http://www.glycoepitope.jp/epitopes/EP0020 | denotes | T antigen |
| PD-GlycoEpitope-B_T4 | 1565-1574 | http://www.glycoepitope.jp/epitopes/EP0020 | denotes | T antigen |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 249-255 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T2 | 274-280 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 25-42 | Disease | denotes | mammary carcinoma | http://purl.obolibrary.org/obo/MONDO_0004989 |
| T2 | 249-262 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T3 | 263-269 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 274-287 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T5 | 500-517 | Disease | denotes | mammary carcinoma | http://purl.obolibrary.org/obo/MONDO_0004989 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 33-42 | Phenotype | denotes | carcinoma | HP:0030731 |
| T2 | 249-262 | Phenotype | denotes | breast cancer | HP:0003002 |
| T3 | 274-287 | Phenotype | denotes | breast cancer | HP:0003002 |
| T4 | 508-517 | Phenotype | denotes | carcinoma | HP:0030731 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 77-83 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T2 | 226-235 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T3 | 389-398 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T4 | 762-771 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T5 | 947-953 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T6 | 982-988 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T7 | 1565-1574 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 226-235 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
| T2 | 389-398 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
| T3 | 762-771 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
| T4 | 1565-1574 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 33-42 | Phenotype | denotes | carcinoma | HP:0030731 |
| T2 | 249-262 | Phenotype | denotes | breast cancer | HP:0003002 |
| T3 | 274-287 | Phenotype | denotes | breast cancer | HP:0003002 |
| T4 | 508-517 | Phenotype | denotes | carcinoma | HP:0030731 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 25-42 | Disease | denotes | mammary carcinoma | http://purl.obolibrary.org/obo/MONDO_0004989 |
| T2 | 249-262 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T3 | 263-269 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 274-287 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T5 | 500-517 | Disease | denotes | mammary carcinoma | http://purl.obolibrary.org/obo/MONDO_0004989 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 8-13 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 281-292 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 249-255 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T2 | 274-280 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-162 | Sentence | denotes | MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. |
| TextSentencer_T2 | 163-346 | Sentence | denotes | A good correlation between the expression of mucin1 (MUC1) and T antigen was found in breast cancer tumors and breast cancer cell lines, especially after treatment with neuraminidase. |
| TextSentencer_T3 | 347-623 | Sentence | denotes | The association between the appearance of T antigen and the overexpression of MUC1 was further confirmed by transfecting MDA-MB-231 cells and murine 4T1 mammary carcinoma cells with cDNA for MUC1 and using an RNAi approach to inhibit the expression of MUC1 gene in T47D cells. |
| TextSentencer_T4 | 624-817 | Sentence | denotes | Furthermore, we discovered that in 4T1 cells which express the sialyl Le(X) antigen, overexpression of MUC1 caused not only appearance of T antigen, but also loss of the sialyl Le(X) structure. |
| TextSentencer_T5 | 818-1269 | Sentence | denotes | As the observed changes in O-glycan synthesis can be associated with changes in the expression of specific glycosyltransferases, core 1 β1,3-galactosyltransferase, core 2 β1,6-N-acetylglucosaminyltransferase (C2GnT1) and β-galactoside α2,3-sialyltransferase (ST3Gal I), we studied their expression in parental, vector-transfected and MUC1-transfected MDA-MB-231 and 4T1 cells as well as T47D cells transduced with small hairpin RNA targeted MUC1 mRNA. |
| TextSentencer_T6 | 1270-1453 | Sentence | denotes | It was found that the expression of C2GnT1 and ST3Gal I is highly decreased in MUC1-expressing MDA-MB-231 and 4T1 cells and increased in T47D cells with suppressed expression of MUC1. |
| TextSentencer_T7 | 1454-1694 | Sentence | denotes | Therefore, we found that changes in the structure of O-linked oligosaccharides, resulting in the occurrence of T antigen, are at least partially associated with MUC1 overexpression which down-regulates the expression of C2GnT1 and ST3Gal I. |
| TextSentencer_T8 | 1695-1864 | Sentence | denotes | We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. |
| T1 | 0-162 | Sentence | denotes | MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. |
| T2 | 163-346 | Sentence | denotes | A good correlation between the expression of mucin1 (MUC1) and T antigen was found in breast cancer tumors and breast cancer cell lines, especially after treatment with neuraminidase. |
| T3 | 347-623 | Sentence | denotes | The association between the appearance of T antigen and the overexpression of MUC1 was further confirmed by transfecting MDA-MB-231 cells and murine 4T1 mammary carcinoma cells with cDNA for MUC1 and using an RNAi approach to inhibit the expression of MUC1 gene in T47D cells. |
| T4 | 624-817 | Sentence | denotes | Furthermore, we discovered that in 4T1 cells which express the sialyl Le(X) antigen, overexpression of MUC1 caused not only appearance of T antigen, but also loss of the sialyl Le(X) structure. |
| T5 | 818-1269 | Sentence | denotes | As the observed changes in O-glycan synthesis can be associated with changes in the expression of specific glycosyltransferases, core 1 β1,3-galactosyltransferase, core 2 β1,6-N-acetylglucosaminyltransferase (C2GnT1) and β-galactoside α2,3-sialyltransferase (ST3Gal I), we studied their expression in parental, vector-transfected and MUC1-transfected MDA-MB-231 and 4T1 cells as well as T47D cells transduced with small hairpin RNA targeted MUC1 mRNA. |
| T6 | 1270-1453 | Sentence | denotes | It was found that the expression of C2GnT1 and ST3Gal I is highly decreased in MUC1-expressing MDA-MB-231 and 4T1 cells and increased in T47D cells with suppressed expression of MUC1. |
| T7 | 1454-1864 | Sentence | denotes | Therefore, we found that changes in the structure of O-linked oligosaccharides, resulting in the occurrence of T antigen, are at least partially associated with MUC1 overexpression which down-regulates the expression of C2GnT1 and ST3Gal I. We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. |
| T1 | 0-162 | Sentence | denotes | MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. |
| T2 | 163-346 | Sentence | denotes | A good correlation between the expression of mucin1 (MUC1) and T antigen was found in breast cancer tumors and breast cancer cell lines, especially after treatment with neuraminidase. |
| T3 | 347-623 | Sentence | denotes | The association between the appearance of T antigen and the overexpression of MUC1 was further confirmed by transfecting MDA-MB-231 cells and murine 4T1 mammary carcinoma cells with cDNA for MUC1 and using an RNAi approach to inhibit the expression of MUC1 gene in T47D cells. |
| T4 | 624-817 | Sentence | denotes | Furthermore, we discovered that in 4T1 cells which express the sialyl Le(X) antigen, overexpression of MUC1 caused not only appearance of T antigen, but also loss of the sialyl Le(X) structure. |
| T5 | 818-1269 | Sentence | denotes | As the observed changes in O-glycan synthesis can be associated with changes in the expression of specific glycosyltransferases, core 1 β1,3-galactosyltransferase, core 2 β1,6-N-acetylglucosaminyltransferase (C2GnT1) and β-galactoside α2,3-sialyltransferase (ST3Gal I), we studied their expression in parental, vector-transfected and MUC1-transfected MDA-MB-231 and 4T1 cells as well as T47D cells transduced with small hairpin RNA targeted MUC1 mRNA. |
| T6 | 1270-1453 | Sentence | denotes | It was found that the expression of C2GnT1 and ST3Gal I is highly decreased in MUC1-expressing MDA-MB-231 and 4T1 cells and increased in T47D cells with suppressed expression of MUC1. |
| T7 | 1454-1694 | Sentence | denotes | Therefore, we found that changes in the structure of O-linked oligosaccharides, resulting in the occurrence of T antigen, are at least partially associated with MUC1 overexpression which down-regulates the expression of C2GnT1 and ST3Gal I. |
| T8 | 1695-1864 | Sentence | denotes | We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-162 | Sentence | denotes | MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. |
| T2 | 163-346 | Sentence | denotes | A good correlation between the expression of mucin1 (MUC1) and T antigen was found in breast cancer tumors and breast cancer cell lines, especially after treatment with neuraminidase. |
| T3 | 347-623 | Sentence | denotes | The association between the appearance of T antigen and the overexpression of MUC1 was further confirmed by transfecting MDA-MB-231 cells and murine 4T1 mammary carcinoma cells with cDNA for MUC1 and using an RNAi approach to inhibit the expression of MUC1 gene in T47D cells. |
| T4 | 624-817 | Sentence | denotes | Furthermore, we discovered that in 4T1 cells which express the sialyl Le(X) antigen, overexpression of MUC1 caused not only appearance of T antigen, but also loss of the sialyl Le(X) structure. |
| T5 | 818-1269 | Sentence | denotes | As the observed changes in O-glycan synthesis can be associated with changes in the expression of specific glycosyltransferases, core 1 β1,3-galactosyltransferase, core 2 β1,6-N-acetylglucosaminyltransferase (C2GnT1) and β-galactoside α2,3-sialyltransferase (ST3Gal I), we studied their expression in parental, vector-transfected and MUC1-transfected MDA-MB-231 and 4T1 cells as well as T47D cells transduced with small hairpin RNA targeted MUC1 mRNA. |
| T6 | 1270-1453 | Sentence | denotes | It was found that the expression of C2GnT1 and ST3Gal I is highly decreased in MUC1-expressing MDA-MB-231 and 4T1 cells and increased in T47D cells with suppressed expression of MUC1. |
| T7 | 1454-1864 | Sentence | denotes | Therefore, we found that changes in the structure of O-linked oligosaccharides, resulting in the occurrence of T antigen, are at least partially associated with MUC1 overexpression which down-regulates the expression of C2GnT1 and ST3Gal I. We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 77-83 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T2 | 226-235 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T3 | 389-398 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T4 | 762-771 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T5 | 947-953 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T6 | 982-988 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T7 | 1565-1574 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 226-235 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
| T2 | 389-398 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
| T3 | 762-771 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
| T4 | 1565-1574 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 8-13 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 249-255 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T2 | 274-280 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 281-292 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |