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PubMed:22528484 JSON TXT

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GlyCosmos6-Glycan-Motif-Image

Id	Subject	Object	Predicate	Lexical cue	image
T1	0-11	Glycan_Motif	denotes	Sialic acid	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2	128-139	Glycan_Motif	denotes	Sialic acid	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-127	Sentence	denotes	Sialic acid associated with αvβ3 integrin mediates HIV-1 Tat protein interaction and endothelial cell proangiogenic activation.
T2	128-261	Sentence	denotes	Sialic acid (NeuAc) is a major anion on endothelial cells (ECs) that regulates different biological processes including angiogenesis.
T3	262-460	Sentence	denotes	NeuAc is present in the oligosaccharidic portion of integrins, receptors that interact with extracellular matrix components and growth factors regulating cell adhesion, migration, and proliferation.
T4	461-643	Sentence	denotes	Tat is a cationic polypeptide that, once released by HIV-1(+) cells, accumulates in the extracellular matrix, promoting EC adhesion and proangiogenic activation by engaging α(v)β(3).
T5	644-1105	Sentence	denotes	By using two complementary approaches (NeuAc removal by neuraminidase or its masking by NeuAc-binding lectin from Maackia amurensis, MAA), we investigated the presence of NeuAc on endothelial α(v)β(3) and its role in Tat interaction, EC adhesion, and proangiogenic activation. α(v)β(3) immunoprecipitation with biotinylated MAA or Western blot analysis of neuraminidase-treated ECs demonstrated that NeuAc is associated with both the α(v) and the β(3) subunits.
T6	1106-1241	Sentence	denotes	Surface plasmon resonance analysis demonstrated that the masking of α(v)β(3)-associated NeuAc by MAA prevents Tat/α(v)β(3) interaction.
T7	1242-1433	Sentence	denotes	MAA and neuraminidase prevent α(v)β(3)-dependent EC adhesion to Tat, the consequent FAK and ERK1/2 phosphorylation, and EC proliferation, migration, and regeneration in a wound-healing assay.
T8	1434-1536	Sentence	denotes	Finally, MAA inhibits Tat-induced neovascularization in the ex vivo human artery ring sprouting assay.
T9	1537-1643	Sentence	denotes	The inhibitions are specific because the NeuAc-unrelated lectin from Ulex europaeus is ineffective on Tat.
T10	1644-1766	Sentence	denotes	Also, MAA and neuraminidase affect only weakly integrin-dependent EC adhesion and proangiogenic activation by fibronectin.
T11	1767-1896	Sentence	denotes	In conclusion, NeuAc is associated with endothelial α(v)β(3) and mediates Tat-dependent EC adhesion and proangiogenic activation.
T12	1897-2028	Sentence	denotes	These data point to the possibility to target integrin glycosylation for the treatment of angiogenesis/AIDS-associated pathologies.

GlyCosmos6-Glycan-Motif-Structure

Id	Subject	Object	Predicate	Lexical cue
T1	0-11	https://glytoucan.org/Structures/Glycans/G81533KY	denotes	Sialic acid
T2	128-139	https://glytoucan.org/Structures/Glycans/G81533KY	denotes	Sialic acid

Glycosmos6-MAT

Id	Subject	Object	Predicate	Lexical cue
T1	1508-1514	http://purl.obolibrary.org/obo/MAT_0000034	denotes	artery

DisGeNET

Id	Subject	Object	Predicate	Lexical cue
T0	57-60	gene:6898	denotes	Tat
T1	51-54	disease:C0019693	denotes	HIV
T2	57-60	gene:79969	denotes	Tat
T3	51-54	disease:C0019693	denotes	HIV
R1	T0	T1	associated_with	Tat,HIV
R2	T2	T3	associated_with	Tat,HIV

Allie

Id	Subject	Object	Predicate	Lexical cue
SS1_22528484_1_0	168-185	expanded	denotes	endothelial cells
SS2_22528484_1_0	187-190	abbr	denotes	ECs
AE1_22528484_1_0	SS1_22528484_1_0	SS2_22528484_1_0	abbreviatedTo	endothelial cells,ECs

GlyCosmos15-Glycan

Id	Subject	Object	Predicate	Lexical cue	image
T1	141-146	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2	262-267	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3	683-688	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4	732-737	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T5	815-820	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T6	1044-1049	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T7	1194-1199	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T8	1578-1583	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T9	1782-1787	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	1413-1418	Disease	denotes	wound	http://purl.obolibrary.org/obo/MONDO_0021178
T2	2000-2004	Disease	denotes	AIDS	http://purl.obolibrary.org/obo/MONDO_0012268

Anatomy-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	1508-1514	Body_part	denotes	artery	http://purl.obolibrary.org/obo/MAT_0000034

Glycan-GlyCosmos

Id	Subject	Object	Predicate	Lexical cue	image
T1	141-146	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2	262-267	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3	683-688	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4	732-737	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T5	815-820	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T6	1044-1049	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T7	1194-1199	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T8	1578-1583	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T9	1782-1787	Glycan	denotes	NeuAc	https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-CL

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	85-101	Cell	denotes	endothelial cell	http://purl.obolibrary.org/obo/CL:0000115
T2	168-185	Cell	denotes	endothelial cells	http://purl.obolibrary.org/obo/CL:0000115
T3	187-190	Cell	denotes	ECs	http://purl.obolibrary.org/obo/CL:0000115
T4	1022-1025	Cell	denotes	ECs	http://purl.obolibrary.org/obo/CL:0000115

GlyCosmos15-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	85-101	Body_part	denotes	endothelial cell	http://purl.obolibrary.org/obo/CL_0000115
T2	168-185	Body_part	denotes	endothelial cells	http://purl.obolibrary.org/obo/CL_0000115
T3	187-190	Body_part	denotes	ECs	http://purl.obolibrary.org/obo/CL_0000115
T4	354-374	Body_part	denotes	extracellular matrix	http://purl.obolibrary.org/obo/GO_0031012
T5	549-569	Body_part	denotes	extracellular matrix	http://purl.obolibrary.org/obo/GO_0031012
T6	1022-1025	Body_part	denotes	ECs	http://purl.obolibrary.org/obo/CL_0000115
T7	1508-1514	Body_part	denotes	artery	http://purl.obolibrary.org/obo/UBERON_0001637

GlyCosmos15-Taxon

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	758-775	Organism	denotes	Maackia amurensis	37501
T2	1502-1507	Organism	denotes	human	9606
T3	1606-1620	Organism	denotes	Ulex europaeus	3902

GlyCosmos15-Sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-127	Sentence	denotes	Sialic acid associated with αvβ3 integrin mediates HIV-1 Tat protein interaction and endothelial cell proangiogenic activation.
T2	128-261	Sentence	denotes	Sialic acid (NeuAc) is a major anion on endothelial cells (ECs) that regulates different biological processes including angiogenesis.
T3	262-460	Sentence	denotes	NeuAc is present in the oligosaccharidic portion of integrins, receptors that interact with extracellular matrix components and growth factors regulating cell adhesion, migration, and proliferation.
T4	461-643	Sentence	denotes	Tat is a cationic polypeptide that, once released by HIV-1(+) cells, accumulates in the extracellular matrix, promoting EC adhesion and proangiogenic activation by engaging α(v)β(3).
T5	644-1105	Sentence	denotes	By using two complementary approaches (NeuAc removal by neuraminidase or its masking by NeuAc-binding lectin from Maackia amurensis, MAA), we investigated the presence of NeuAc on endothelial α(v)β(3) and its role in Tat interaction, EC adhesion, and proangiogenic activation. α(v)β(3) immunoprecipitation with biotinylated MAA or Western blot analysis of neuraminidase-treated ECs demonstrated that NeuAc is associated with both the α(v) and the β(3) subunits.
T6	1106-1241	Sentence	denotes	Surface plasmon resonance analysis demonstrated that the masking of α(v)β(3)-associated NeuAc by MAA prevents Tat/α(v)β(3) interaction.
T7	1242-1433	Sentence	denotes	MAA and neuraminidase prevent α(v)β(3)-dependent EC adhesion to Tat, the consequent FAK and ERK1/2 phosphorylation, and EC proliferation, migration, and regeneration in a wound-healing assay.
T8	1434-1536	Sentence	denotes	Finally, MAA inhibits Tat-induced neovascularization in the ex vivo human artery ring sprouting assay.
T9	1537-1766	Sentence	denotes	The inhibitions are specific because the NeuAc-unrelated lectin from Ulex europaeus is ineffective on Tat. Also, MAA and neuraminidase affect only weakly integrin-dependent EC adhesion and proangiogenic activation by fibronectin.
T10	1767-1896	Sentence	denotes	In conclusion, NeuAc is associated with endothelial α(v)β(3) and mediates Tat-dependent EC adhesion and proangiogenic activation.
T11	1897-2028	Sentence	denotes	These data point to the possibility to target integrin glycosylation for the treatment of angiogenesis/AIDS-associated pathologies.

Lectin-Jamboree-Sentence

Id	Subject	Object	Predicate	Lexical cue
T1	0-127	Sentence	denotes	Sialic acid associated with αvβ3 integrin mediates HIV-1 Tat protein interaction and endothelial cell proangiogenic activation.
T2	128-261	Sentence	denotes	Sialic acid (NeuAc) is a major anion on endothelial cells (ECs) that regulates different biological processes including angiogenesis.
T3	262-460	Sentence	denotes	NeuAc is present in the oligosaccharidic portion of integrins, receptors that interact with extracellular matrix components and growth factors regulating cell adhesion, migration, and proliferation.
T4	461-643	Sentence	denotes	Tat is a cationic polypeptide that, once released by HIV-1(+) cells, accumulates in the extracellular matrix, promoting EC adhesion and proangiogenic activation by engaging α(v)β(3).
T5	644-1105	Sentence	denotes	By using two complementary approaches (NeuAc removal by neuraminidase or its masking by NeuAc-binding lectin from Maackia amurensis, MAA), we investigated the presence of NeuAc on endothelial α(v)β(3) and its role in Tat interaction, EC adhesion, and proangiogenic activation. α(v)β(3) immunoprecipitation with biotinylated MAA or Western blot analysis of neuraminidase-treated ECs demonstrated that NeuAc is associated with both the α(v) and the β(3) subunits.
T6	1106-1241	Sentence	denotes	Surface plasmon resonance analysis demonstrated that the masking of α(v)β(3)-associated NeuAc by MAA prevents Tat/α(v)β(3) interaction.
T7	1242-1433	Sentence	denotes	MAA and neuraminidase prevent α(v)β(3)-dependent EC adhesion to Tat, the consequent FAK and ERK1/2 phosphorylation, and EC proliferation, migration, and regeneration in a wound-healing assay.
T8	1434-1536	Sentence	denotes	Finally, MAA inhibits Tat-induced neovascularization in the ex vivo human artery ring sprouting assay.
T9	1537-1766	Sentence	denotes	The inhibitions are specific because the NeuAc-unrelated lectin from Ulex europaeus is ineffective on Tat. Also, MAA and neuraminidase affect only weakly integrin-dependent EC adhesion and proangiogenic activation by fibronectin.
T10	1767-1896	Sentence	denotes	In conclusion, NeuAc is associated with endothelial α(v)β(3) and mediates Tat-dependent EC adhesion and proangiogenic activation.
T11	1897-2028	Sentence	denotes	These data point to the possibility to target integrin glycosylation for the treatment of angiogenesis/AIDS-associated pathologies.

GlyCosmos15-FMA

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	51-54	Body_part	denotes	HIV	FMA:278683
T2	85-101	Body_part	denotes	endothelial cell	FMA:66772
T3	168-185	Body_part	denotes	endothelial cells	FMA:66772
T4	187-190	Body_part	denotes	ECs	FMA:66772
T5	354-374	Body_part	denotes	extracellular matrix	FMA:9672
T6	514-517	Body_part	denotes	HIV	FMA:278683
T7	549-569	Body_part	denotes	extracellular matrix	FMA:9672
T8	1022-1025	Body_part	denotes	ECs	FMA:66772
T9	1508-1514	Body_part	denotes	artery	FMA:50720

GlyCosmos15-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	1508-1514	Body_part	denotes	artery	http://purl.obolibrary.org/obo/MAT_0000034

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	758-775	OrganismTaxon	denotes	Maackia amurensis	37501
T2	1502-1507	OrganismTaxon	denotes	human	9606
T3	1606-1620	OrganismTaxon	denotes	Ulex europaeus	3902

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	85-101	Body_part	denotes	endothelial cell	http://purl.obolibrary.org/obo/CL_0000115
T2	168-185	Body_part	denotes	endothelial cells	http://purl.obolibrary.org/obo/CL_0000115
T3	187-190	Body_part	denotes	ECs	http://purl.obolibrary.org/obo/CL_0000115
T4	354-374	Body_part	denotes	extracellular matrix	http://purl.obolibrary.org/obo/GO_0031012
T5	549-569	Body_part	denotes	extracellular matrix	http://purl.obolibrary.org/obo/GO_0031012
T6	1022-1025	Body_part	denotes	ECs	http://purl.obolibrary.org/obo/CL_0000115
T7	1508-1514	Body_part	denotes	artery	http://purl.obolibrary.org/obo/UBERON_0001637

CL-cell

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	85-101	Cell	denotes	endothelial cell	http://purl.obolibrary.org/obo/CL:0000115
T2	168-185	Cell	denotes	endothelial cells	http://purl.obolibrary.org/obo/CL:0000115
T3	187-190	Cell	denotes	ECs	http://purl.obolibrary.org/obo/CL:0000115
T4	1022-1025	Cell	denotes	ECs	http://purl.obolibrary.org/obo/CL:0000115