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PubMed:22507221 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 130-159 DRI_Background denotes 3-(5'-hydroxymethyl-2'-furyl)
T2 178-291 DRI_Background denotes (YC-1), the hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor, suppresses tumor proliferation and metastasis by
T3 315-351 DRI_Background denotes expression under hypoxic conditions.
T4 352-465 DRI_Outcome denotes Our previous studies demonstrated that YC-1 inhibited breast cancer cell proliferation under normoxic conditions.
T5 466-586 DRI_Approach denotes In the current study, we investigated the targets of YC-1 and mechanism of its action in MDA-MB-468 breast cancer cells.
T6 587-713 DRI_Outcome denotes In the in vitro experiments, we found that YC-1 significantly inhibited MDA-MB-468 cell proliferation in normoxia and hypoxia.
T7 714-902 DRI_Background denotes Under normoxic conditions, YC-1 induced apoptosis of MDA-MB-468 cells and blocked cell cycle in the G1 phase, and these effects were possibly related to caspase 8, p21, and p27 expression.
T8 903-1169 DRI_Background denotes RT-PCR and Western blotting results showed that YC-1 primarily inhibited HIF-1α at the mRNA and protein levels under hypoxic conditions, but suppressed the expression of epidermal growth factor receptor(EGFR) at the mRNA and protein levels under normoxic conditions.
T9 1170-1319 DRI_Background denotes In vivo, YC-1 prolonged survival, increased survival rate, decreased tumor size and metastasis rate, and inhibited tissue EGFR and HIF-1α expression.
T10 1320-1375 DRI_Background denotes However, YC-1 exerted no obvious effect on body weight.
T11 1376-1512 DRI_Outcome denotes These results indicate that YC-1 inhibits the proliferation of MDA-MB-468 cells by acting on multiple targets with minimal side effects.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 190-222 gene:3091 denotes hypoxia-inducible factor-1 alpha
T1 278-288 disease:C0027627 denotes metastasis
T2 190-222 gene:3091 denotes hypoxia-inducible factor-1 alpha
T3 278-288 disease:C2939420 denotes metastasis
T4 224-230 gene:3091 denotes HIF-1α
T5 278-288 disease:C0027627 denotes metastasis
T6 224-230 gene:3091 denotes HIF-1α
T7 278-288 disease:C2939420 denotes metastasis
T8 1301-1307 gene:3091 denotes HIF-1α
T9 1254-1264 disease:C0027627 denotes metastasis
T10 1301-1307 gene:3091 denotes HIF-1α
T11 1254-1264 disease:C2939420 denotes metastasis
R1 T0 T1 associated_with hypoxia-inducible factor-1 alpha,metastasis
R2 T2 T3 associated_with hypoxia-inducible factor-1 alpha,metastasis
R3 T4 T5 associated_with HIF-1α,metastasis
R4 T6 T7 associated_with HIF-1α,metastasis
R5 T8 T9 associated_with HIF-1α,metastasis
R6 T10 T11 associated_with HIF-1α,metastasis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 254-259 HP_0002664 denotes tumor
T2 406-419 HP_0003002 denotes breast cancer
T3 406-419 HP_0100013 denotes breast cancer
T4 413-419 HP_0002664 denotes cancer
T5 566-579 HP_0003002 denotes breast cancer
T6 566-579 HP_0100013 denotes breast cancer
T7 573-579 HP_0002664 denotes cancer
T8 1239-1244 HP_0002664 denotes tumor
T9 1555-1568 HP_0003002 denotes breast cancer
T10 1555-1568 HP_0100013 denotes breast cancer
T11 1562-1568 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_22507221_1_0 190-222 expanded denotes hypoxia-inducible factor-1 alpha
SS2_22507221_1_0 224-230 abbr denotes HIF-1α
SS1_22507221_6_0 1073-1105 expanded denotes epidermal growth factor receptor
SS2_22507221_6_0 1106-1110 abbr denotes EGFR
AE1_22507221_1_0 SS1_22507221_1_0 SS2_22507221_1_0 abbreviatedTo hypoxia-inducible factor-1 alpha,HIF-1α
AE1_22507221_6_0 SS1_22507221_6_0 SS2_22507221_6_0 abbreviatedTo epidermal growth factor receptor,EGFR

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
22507221-7#131#137#gene3091 1301-1307 gene3091 denotes HIF-1α
22507221-7#84#94#diseaseC0027627 1254-1264 diseaseC0027627 denotes metastasis
131#137#gene309184#94#diseaseC0027627 22507221-7#131#137#gene3091 22507221-7#84#94#diseaseC0027627 associated_with HIF-1α,metastasis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T649 1301-1307 gene:3091 denotes HIF-1α
T650 1254-1264 disease:C0027627 denotes metastasis
R1 T649 T650 associated_with HIF-1α,metastasis

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-129 Sentence denotes YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition.
TextSentencer_T2 130-351 Sentence denotes 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1), the hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor, suppresses tumor proliferation and metastasis by down-regulating HIF-1α expression under hypoxic conditions.
TextSentencer_T3 352-465 Sentence denotes Our previous studies demonstrated that YC-1 inhibited breast cancer cell proliferation under normoxic conditions.
TextSentencer_T4 466-586 Sentence denotes In the current study, we investigated the targets of YC-1 and mechanism of its action in MDA-MB-468 breast cancer cells.
TextSentencer_T5 587-713 Sentence denotes In the in vitro experiments, we found that YC-1 significantly inhibited MDA-MB-468 cell proliferation in normoxia and hypoxia.
TextSentencer_T6 714-902 Sentence denotes Under normoxic conditions, YC-1 induced apoptosis of MDA-MB-468 cells and blocked cell cycle in the G1 phase, and these effects were possibly related to caspase 8, p21, and p27 expression.
TextSentencer_T7 903-1169 Sentence denotes RT-PCR and Western blotting results showed that YC-1 primarily inhibited HIF-1α at the mRNA and protein levels under hypoxic conditions, but suppressed the expression of epidermal growth factor receptor(EGFR) at the mRNA and protein levels under normoxic conditions.
TextSentencer_T8 1170-1319 Sentence denotes In vivo, YC-1 prolonged survival, increased survival rate, decreased tumor size and metastasis rate, and inhibited tissue EGFR and HIF-1α expression.
TextSentencer_T9 1320-1375 Sentence denotes However, YC-1 exerted no obvious effect on body weight.
TextSentencer_T10 1376-1512 Sentence denotes These results indicate that YC-1 inhibits the proliferation of MDA-MB-468 cells by acting on multiple targets with minimal side effects.
TextSentencer_T11 1513-1569 Sentence denotes Thus, YC-1 is a promising target drug for breast cancer.
T1 0-129 Sentence denotes YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition.
T2 130-351 Sentence denotes 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1), the hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor, suppresses tumor proliferation and metastasis by down-regulating HIF-1α expression under hypoxic conditions.
T3 352-465 Sentence denotes Our previous studies demonstrated that YC-1 inhibited breast cancer cell proliferation under normoxic conditions.
T4 466-586 Sentence denotes In the current study, we investigated the targets of YC-1 and mechanism of its action in MDA-MB-468 breast cancer cells.
T5 587-713 Sentence denotes In the in vitro experiments, we found that YC-1 significantly inhibited MDA-MB-468 cell proliferation in normoxia and hypoxia.
T6 714-902 Sentence denotes Under normoxic conditions, YC-1 induced apoptosis of MDA-MB-468 cells and blocked cell cycle in the G1 phase, and these effects were possibly related to caspase 8, p21, and p27 expression.
T7 903-1169 Sentence denotes RT-PCR and Western blotting results showed that YC-1 primarily inhibited HIF-1α at the mRNA and protein levels under hypoxic conditions, but suppressed the expression of epidermal growth factor receptor(EGFR) at the mRNA and protein levels under normoxic conditions.
T8 1170-1319 Sentence denotes In vivo, YC-1 prolonged survival, increased survival rate, decreased tumor size and metastasis rate, and inhibited tissue EGFR and HIF-1α expression.
T9 1320-1375 Sentence denotes However, YC-1 exerted no obvious effect on body weight.
T10 1376-1512 Sentence denotes These results indicate that YC-1 inhibits the proliferation of MDA-MB-468 cells by acting on multiple targets with minimal side effects.
T11 1513-1569 Sentence denotes Thus, YC-1 is a promising target drug for breast cancer.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 45-51 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 406-412 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 566-572 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 1555-1561 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1285-1291 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1285-1291 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 45-51 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 406-412 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 566-572 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1555-1561 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast