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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 191-503 BACKGROUND denotes To determine and compare the reactive oxygen and nitrogen species (ROS and RNS) in pulmonary tissues of horses affected with recurrent airway obstruction (RAO) and clinically healthy horses, and to evaluate the effectiveness of potential therapeutic agents in reducing ROS and RNS in the tissues of these horses.
T2 516-1018 OBJECTIVE denotes We hypothesised that RAO-affected horses would have high levels of reactive species and that the test agents would reduce them. The objectives were as follows: 1) to determine the level of ROS and RNS in pulmonary tissues (bronchial and arterial rings) of RAO-affected and clinically healthy horses; and 2) to determine the ability of pentoxifylline, pyrrolidine-dithiocarbamate and a combined use of endothelin A and B receptor antagonists (BQ123 and BQ788, respectively) in reducing reactive species.
T3 1028-1298 METHODS denotes Arterial and bronchial rings were collected from the diaphragmatic lung lobe of each horse immediately after euthanasia. The levels of ROS and RNS were measured in control tissues and those incubated with test agents, using an electron paramagnetic resonance instrument.
T4 1308-1746 RESULTS denotes The levels of ROS and RNS were significantly greater in arterial and bronchial tissues of RAO-affected than of clinically healthy horses. Pentoxifylline and endothelin antagonists reduced both ROS and RNS in tissues from RAO-affected horses. Basal levels of reactive species in clinically healthy horses were not affected by these agents. No difference in the level of reactive species was observed between arterial and bronchial tissues.
T5 1760-1956 CONCLUSIONS denotes Horses affected by RAO had higher ROS and RNS than clinically healthy horses. Pentoxifylline and endothelin antagonists effectively reduced ROS and RNS in pulmonary tissues of RAO-affected horses.
T6 1978-2195 CONCLUSIONS denotes The study suggested a potential use for pentoxifylline and endothelin antagonists in treating RAO-affected horses. As endothelin is involved in physiological functions, therapeutic use of its antagonists is cautioned.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 153-159 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T2 295-301 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T3 374-380 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T4 496-502 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T5 516-518 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T6 550-556 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T7 808-814 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T8 816-821 CVCL_B527|Embryonic_stem_cell|Homo sapiens denotes and 2
T9 899-900 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 928-929 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T11 934-935 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T12 1113-1118 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horse
T13 1252-1254 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T14 1252-1254 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T15 1438-1444 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T16 1542-1548 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T17 1605-1611 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T18 1760-1766 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes Horses
T19 1830-1836 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T20 1949-1955 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses
T21 1998-1999 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T22 2085-2091 CVCL_9124|Undefined_cell_line_type|Cricetulus griseus denotes horses

GoldHamster

Id Subject Object Predicate Lexical cue
T1 102-108 UBERON:0000117 denotes airway
T2 102-108 UBERON:0001005 denotes airway
T3 102-120 D000402 denotes airway obstruction
T4 102-120 D000402 denotes airway obstruction
T5 169-172 PR:000001036 denotes FOR
T6 169-172 PR:Q9NZC7 denotes FOR
T8 229-235 7806 denotes oxygen
T7 229-235 CHEBI:25805 denotes oxygen
T9 240-248 7456 denotes nitrogen
T10 240-248 CHEBI:25555 denotes nitrogen
T11 240-248 CHEBI:29351 denotes nitrogen
T12 258-261 PR:P08922 denotes ROS
T14 258-261 PR:000014165 denotes ROS
T13 258-261 CHEBI:26523 denotes ROS
T16 266-269 CHEBI:62764 denotes RNS
T15 266-269 C535282 denotes RNS
T17 326-332 UBERON:0000117 denotes airway
T18 326-332 UBERON:0001005 denotes airway
T19 326-344 D000402 denotes airway obstruction
T20 326-344 D000402 denotes airway obstruction
T21 346-349 O75106 denotes RAO
T22 346-349 Q812C9 denotes RAO
T23 346-349 PR:000004086 denotes RAO
T24 460-463 PR:P08922 denotes ROS
T26 460-463 PR:000014165 denotes ROS
T25 460-463 CHEBI:26523 denotes ROS
T28 468-471 CHEBI:62764 denotes RNS
T27 468-471 C535282 denotes RNS
T29 537-540 O75106 denotes RAO
T30 537-540 Q812C9 denotes RAO
T31 537-540 PR:000004086 denotes RAO
T32 705-708 PR:P08922 denotes ROS
T34 705-708 PR:000014165 denotes ROS
T33 705-708 CHEBI:26523 denotes ROS
T36 713-716 CHEBI:62764 denotes RNS
T35 713-716 C535282 denotes RNS
T37 772-775 O75106 denotes RAO
T38 772-775 Q812C9 denotes RAO
T39 772-775 PR:000004086 denotes RAO
T44 851-865 8013 denotes pentoxifylline
T41 851-865 CHEBI:7986 denotes pentoxifylline
T42 851-865 D010431 denotes pentoxifylline
T43 851-865 D010431 denotes pentoxifylline
T48 867-894 C020972 denotes pyrrolidine-dithiocarbamate
T49 867-894 CHEBI:78782 denotes pyrrolidine-dithiocarbamate
T50 867-894 C020972 denotes pyrrolidine-dithiocarbamate
T51 917-927 D016232 denotes endothelin
T52 917-927 D016232 denotes endothelin
T53 945-956 CHEBI:48706 denotes antagonists
T54 958-963 C072247 denotes BQ123
T55 958-963 C072247 denotes BQ123
T56 958-963 CHEBI:2965 denotes BQ123
T57 968-973 C086539 denotes BQ788
T58 968-973 C086539 denotes BQ788
T60 1095-1104 UBERON:0000101 denotes lung lobe
T63 1113-1118 CVCL_9124 denotes horse
T61 1113-1118 D006736 denotes horse
T62 1113-1118 9796 denotes horse
T64 1163-1166 PR:P08922 denotes ROS
T66 1163-1166 PR:000014165 denotes ROS
T65 1163-1166 CHEBI:26523 denotes ROS
T68 1171-1174 CHEBI:62764 denotes RNS
T67 1171-1174 C535282 denotes RNS
T69 1255-1263 CHEBI:10545 denotes electron
T70 1322-1325 PR:P08922 denotes ROS
T72 1322-1325 PR:000014165 denotes ROS
T71 1322-1325 CHEBI:26523 denotes ROS
T74 1330-1333 CHEBI:62764 denotes RNS
T73 1330-1333 C535282 denotes RNS
T75 1398-1401 O75106 denotes RAO
T76 1398-1401 Q812C9 denotes RAO
T77 1398-1401 PR:000004086 denotes RAO
T81 1446-1460 8013 denotes Pentoxifylline
T78 1446-1460 CHEBI:7986 denotes Pentoxifylline
T79 1446-1460 D010431 denotes Pentoxifylline
T80 1446-1460 D010431 denotes Pentoxifylline
T84 1465-1487 D065128 denotes endothelin antagonists
T85 1465-1487 D065128 denotes endothelin antagonists
T87 1501-1504 PR:P08922 denotes ROS
T89 1501-1504 PR:000014165 denotes ROS
T88 1501-1504 CHEBI:26523 denotes ROS
T91 1509-1512 CHEBI:62764 denotes RNS
T90 1509-1512 C535282 denotes RNS
T92 1529-1532 O75106 denotes RAO
T93 1529-1532 Q812C9 denotes RAO
T94 1529-1532 PR:000004086 denotes RAO
T95 1760-1766 D006736 denotes Horses
T96 1779-1782 O75106 denotes RAO
T97 1779-1782 Q812C9 denotes RAO
T98 1779-1782 PR:000004086 denotes RAO
T99 1794-1797 PR:P08922 denotes ROS
T101 1794-1797 PR:000014165 denotes ROS
T100 1794-1797 CHEBI:26523 denotes ROS
T103 1802-1805 CHEBI:62764 denotes RNS
T102 1802-1805 C535282 denotes RNS
T107 1838-1852 8013 denotes Pentoxifylline
T104 1838-1852 CHEBI:7986 denotes Pentoxifylline
T105 1838-1852 D010431 denotes Pentoxifylline
T106 1838-1852 D010431 denotes Pentoxifylline
T110 1857-1879 D065128 denotes endothelin antagonists
T111 1857-1879 D065128 denotes endothelin antagonists
T113 1900-1903 PR:P08922 denotes ROS
T115 1900-1903 PR:000014165 denotes ROS
T114 1900-1903 CHEBI:26523 denotes ROS
T117 1908-1911 CHEBI:62764 denotes RNS
T116 1908-1911 C535282 denotes RNS
T118 1936-1939 O75106 denotes RAO
T119 1936-1939 Q812C9 denotes RAO
T120 1936-1939 PR:000004086 denotes RAO
T124 2018-2032 8013 denotes pentoxifylline
T121 2018-2032 CHEBI:7986 denotes pentoxifylline
T122 2018-2032 D010431 denotes pentoxifylline
T123 2018-2032 D010431 denotes pentoxifylline
T127 2037-2059 D065128 denotes endothelin antagonists
T128 2037-2059 D065128 denotes endothelin antagonists
T130 2072-2075 O75106 denotes RAO
T131 2072-2075 Q812C9 denotes RAO
T132 2072-2075 PR:000004086 denotes RAO
T133 2096-2106 D016232 denotes endothelin
T134 2096-2106 D016232 denotes endothelin
T135 2170-2181 CHEBI:48706 denotes antagonists

Allie

Id Subject Object Predicate Lexical cue
SS1_22506732_2_0 220-256 expanded denotes reactive oxygen and nitrogen species
SS2_22506732_2_0 258-269 abbr denotes ROS and RNS
SS1_22506732_2_1 316-344 expanded denotes recurrent airway obstruction
SS2_22506732_2_1 346-349 abbr denotes RAO
AE1_22506732_2_0 SS1_22506732_2_0 SS2_22506732_2_0 abbreviatedTo reactive oxygen and nitrogen species,ROS and RNS
AE1_22506732_2_1 SS1_22506732_2_1 SS2_22506732_2_1 abbreviatedTo recurrent airway obstruction,RAO